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61. 发明申请

US20080312645A1 Vascular Sealing Device and Method Using Clot Enhancing Balloon and Electric Field Generation 审中-公开
标题翻译：血管密封装置和使用凝块增强气球和电场的方法
公开(公告)号：US20080312645A1
公开(公告)日：2008-12-18
申请号：US12026067
申请日：2008-02-05
申请人： William J. Drasler , Tracee Eidenschink , Joseph M. Thielen , Mark L. Jenson , Anu Sadasiva
发明人： William J. Drasler , Tracee Eidenschink , Joseph M. Thielen , Mark L. Jenson , Anu Sadasiva
IPC分类号： A61B18/14 , A61M29/02
CPC分类号： A61B18/14 , A61B17/0057 , A61B2017/00654 , A61N1/18 , A61N1/32
摘要： An apparatus and method for closing an opening in a blood vessel wall is disclosed. The apparatus includes at least one member which is extended through a tissue tract formed through the epidermis and subcutaneous layer of skin and through the opening in the blood vessel. The member includes a proximal end and a distal end with the distal end being positionable proximate to the opening in the blood vessel wall. A positive electrode is positioned next to the distal end with a negative electrode being positioned next to the proximal end When the electrodes are energized an electric field is created therebetween, blood cells are attracted to the positive electrode, and a thrombus is formed at the opening in the blood vessel wall. The member may include a balloon at the distal end to temporarily occlude blood flow from the blood vessel to the tissue tract to facilitate formation of the thrombus. In addition, the shape of the balloon may be tailored to facilitate the formation of the thrombus including, but not limited to, the creation of pockets and self-supporting balloons
摘要翻译：公开了一种用于封闭血管壁中的开口的装置和方法。该装置包括至少一个构件，其延伸穿过通过表皮和皮下皮肤层形成的组织通道并且穿过血管中的开口。该构件包括近端和远端，远端可靠近血管壁中的开口定位。正电极位于远端附近，负极位于近端的旁边。当电极通电时，电极之间产生电场，血细胞被吸引到正电极，并且在开口处形成血栓在血管壁。该构件可以包括在远端处的气囊，以暂时阻断从血管到组织道的血流，以促进血栓的形成。此外，气囊的形状可以被调整以促进血栓的形成，包括但不限于创建口袋和自支撑气球

62. 发明申请

US20080306580A1 BLOOD ACESS APPARATUS AND METHOD 审中-公开
标题翻译：血液消融装置及方法
公开(公告)号：US20080306580A1
公开(公告)日：2008-12-11
申请号：US12025350
申请日：2008-02-04
申请人： Mark L. Jenson , William J. Drasler , Jason P. Hill , Jaydeep Kokate , David J. Sogard , Pat Haverkost
发明人： Mark L. Jenson , William J. Drasler , Jason P. Hill , Jaydeep Kokate , David J. Sogard , Pat Haverkost
IPC分类号： A61F2/82 , A61F2/84 , A61B17/32 , B23P11/00
CPC分类号： A61M1/3655 , A61F2/07 , A61F2/82 , A61F2/90 , A61F2002/072 , A61F2002/075 , Y10T29/49826
摘要： A blood access for dialysis includes a radially distensible support structure having an open lattice structure defining a support wall having interstitial open areas and defining exterior and luminal wall surfaces; a first porous polymeric portion having a plurality of pores, the first porous polymeric portion being securably disposed over at least a portion of the exterior wall portion of the support structure; a second porous polymeric portion having a plurality of pores, the second porous polymeric portion being securably disposed over at least a portion of the luminal portion of the support structure; and a biodegradable and/or bioabsorbable material disposed within the pores of the first polymeric portion and/or pores of the second polymeric portion.
摘要翻译：用于透析的血液通道包括径向扩张的支撑结构，其具有限定具有间隙开放区域并限定外部和腔壁表面的支撑壁的开放格子结构; 具有多个孔的第一多孔聚合物部分，所述第一多孔聚合物部分可固定地设置在所述支撑结构的外壁部分的至少一部分上; 具有多个孔的第二多孔聚合物部分，所述第二多孔聚合物部分可固定地设置在所述支撑结构的腔部分的至少一部分上; 以及设置在第二聚合物部分的第一聚合物部分的孔内和/或第二聚合物部分的孔内的可生物降解和/或生物可吸收材料。

63. 发明申请

US20080243072A1 Perfusion Device 有权
标题翻译：灌注装置
公开(公告)号：US20080243072A1
公开(公告)日：2008-10-02
申请号：US11693795
申请日：2007-03-30
申请人： Mark L. Jenson , William J. Drasler
发明人： Mark L. Jenson , William J. Drasler
IPC分类号： A61M25/10
CPC分类号： A61M25/09 , A61M2025/09091
摘要： A perfusion guidewire is disclosed. The perfusion guidewire includes an elongate core member and a collapsible sheath tightly wrapped around at least the distal portion of the elongate core member such that the wrapped sheath is folded upon itself, forming a plurality of layers of material in a radial direction from the longitudinal axis of the elongate core member. The wrapped sheath is tightly wrapped about the elongate core member such that the wrapped sheath and elongate core member travel as a unit during navigation within the blood vessel of the body of a patient. The wrapped sheath is expandable to a larger diameter in order to allow a perfusate to pass through the lumen of the sheath.
摘要翻译：公开了一种灌注导丝。灌注导丝包括细长的芯部构件和可收缩的护套，其紧密地缠绕在细长的芯构件的至少远侧部分周围，使得包裹的护套自身折叠，从纵向轴线沿径向形成多层材料层的细长芯部件。包裹的鞘被紧密地缠绕在细长的芯部件上，使得包裹的护套和细长的芯部件在导航在患者的身体的血管内时作为一个单元行进。包裹的护套可扩张到更大的直径，以便使灌注液通过护套的内腔。

64. 发明授权

US07389580B2 Method and apparatus for thin-film battery having ultra-thin electrolyte 有权
标题翻译：具有超薄电解质的薄膜电池的方法和装置
公开(公告)号：US07389580B2
公开(公告)日：2008-06-24
申请号：US11692176
申请日：2007-03-27
申请人： Mark L. Jenson , Victor H. Weiss
发明人： Mark L. Jenson , Victor H. Weiss
IPC分类号： B23P17/00
CPC分类号： H01M10/4264 , A61N1/3787 , C23C14/0031 , C23C14/0676 , C23C14/08 , C23C16/047 , G02F1/13306 , G02F2001/13324 , H01G11/08 , H01G11/26 , H01G11/56 , H01L23/58 , H01L31/073 , H01L31/1828 , H01L2224/16225 , H01L2224/48091 , H01L2224/49109 , H01L2924/09701 , H01L2924/10253 , H01L2924/12044 , H01M2/0207 , H01M2/1066 , H01M2/145 , H01M2/20 , H01M4/0421 , H01M4/0423 , H01M4/0426 , H01M4/1391 , H01M4/1393 , H01M4/1397 , H01M4/382 , H01M4/405 , H01M4/483 , H01M4/581 , H01M4/5825 , H01M4/587 , H01M4/8885 , H01M4/9016 , H01M6/185 , H01M6/186 , H01M6/188 , H01M6/40 , H01M6/42 , H01M8/1007 , H01M8/1286 , H01M10/0436 , H01M10/0472 , H01M10/052 , H01M10/0525 , H01M10/0562 , H01M10/058 , H01M10/0585 , H01M10/42 , H01M10/425 , H01M10/4257 , H01M10/44 , H01M10/46 , H01M10/465 , H01M14/00 , H01M14/005 , H01M2002/0205 , H01M2004/021 , H01M2008/1293 , H04M1/0262 , H05K1/16 , Y02E10/543 , Y02E60/122 , Y02E60/13 , Y02P70/521 , Y02P70/54 , Y10S117/902 , Y10T29/49108 , Y10T29/49114 , Y10T29/49115 , Y10T29/4913 , Y10T29/5313 , Y10T29/53135 , H01L2924/00014 , H01L2924/00
摘要： A method and system for fabricating solid-state energy-storage devices including fabrication films for devices without an anneal step. A film of an energy-storage device is fabricated by depositing a first material layer to a location on a substrate. Energy is supplied directly to the material forming the film. The energy can be in the form of energized ions of a second material. Supplying energy directly to the material and/or the film being deposited assists in controlling the growth and stoichiometry of the film. The method allows for the fabrication of ultrathin films such as electrolyte films and dielectric films.
摘要翻译：一种用于制造固态储能装置的方法和系统，其包括用于没有退火步骤的装置的制造薄膜。通过将第一材料层沉积到衬底上的位置来制造能量存储装置的膜。能量直接供应到形成薄膜的材料上。能量可以是第二材料的能量离子的形式。向被沉积的材料和/或薄膜直接提供能量有助于控制薄膜的生长和化学计量。该方法允许制造诸如电解质膜和介电膜的超薄膜。

65. 发明授权

US06945951B1 Thrombectomy catheter and system 失效
标题翻译：血栓切除导管及系统
公开(公告)号：US06945951B1
公开(公告)日：2005-09-20
申请号：US09930796
申请日：2001-08-16
申请人： Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , John B. Bridgeman , Debra M. Kozak , Rosemary C. Beaupre , Mark L. Jenson , Cindy M. Setum , Robert C. Dutcher
发明人： Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , John B. Bridgeman , Debra M. Kozak , Rosemary C. Beaupre , Mark L. Jenson , Cindy M. Setum , Robert C. Dutcher
IPC分类号： A61B17/22 , A61B17/32 , A61M1/00 , A61B17/20
CPC分类号： A61B17/32037 , A61B17/3203 , A61M1/0084
摘要： Cross stream thrombectomy catheter and system for fragmentation and removal of thrombus or other material from blood vessels or other body cavities. High velocity saline jets emitted from a toroidal loop jet emanator or other jet emanator in a catheter distal end entrain fluid through inflow orifices, and with flow resistances create a back-pressure which drives cross stream streams through outflow orifices in a radial direction and thence radially and circumferentially to apply normal and drag forces on thrombotic deposits or lesions in the blood vessel or other body cavity, thereby breaking apart and transporting thrombus particles to be entrained through the inflow orifices, whereupon the high velocity jets macerate the thrombus particles which then transit an exhaust lumen or recirculate again via the outflow orifices.
摘要翻译：交叉流血栓切除术导管和用于从血管或其他体腔破裂和去除血栓或其他材料的系统。从导管远端的环形环喷射发生器或其他喷射发射器发射的高速盐水喷射器通过流入孔夹带流体，并且流动阻力产生背压，该背压驱动跨径流通过径向流出孔，并周向地将正常和牵引力施加在血管或其它体腔中的血栓形成沉积物或病变上，从而分离和输送通过流入孔夹带的血栓颗粒，于是高速喷射器将血栓颗粒浸入，排气腔或再次通过外流孔再循环。

66. 发明授权

US06805684B2 Thrombectomy catheter and system 失效
公开(公告)号：US06805684B2
公开(公告)日：2004-10-19
申请号：US09930795
申请日：2001-08-16
申请人： Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , John B. Bridgeman , Debra M. Kozak , Rosemary C. Beaupre , Mark L. Jenson , Cindy M. Setum , Robert C. Dutcher
发明人： Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , John B. Bridgeman , Debra M. Kozak , Rosemary C. Beaupre , Mark L. Jenson , Cindy M. Setum , Robert C. Dutcher
IPC分类号： A61B1720
CPC分类号： A61B17/32037 , A61B17/3203 , A61M1/0084
摘要： Cross stream thrombectomy catheter and system for fragmentation and removal of thrombus or other material from blood vessels or other body cavities. High velocity saline jets emitted from a toroidal loop jet emanator or other jet emanator in a catheter distal end entrain fluid through inflow orifices, and with flow resistances create a back-pressure which drives cross stream streams through outflow orifices in a radial direction and thence radially and circumferentially to apply normal and drag forces on thrombotic deposits or lesions in the blood vessel or other body cavity, thereby breaking apart and transporting thrombus particles to be entrained through the inflow orifices, whereupon the high velocity jets macerate the thrombus particles which then transit an exhaust lumen or recirculate again via the outflow orifices.

67. 发明授权

US06676627B1 Crossflow thrombectomy catheter and system 失效
标题翻译：血栓切除导管及系统
公开(公告)号：US06676627B1
公开(公告)日：2004-01-13
申请号：US09417395
申请日：1999-10-13
申请人： Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , John B. Bridgeman , Debra M. Kozak , Rosemary C. Beaupre , Mark L. Jenson , Cindy M. Setum , Robert C. Dutcher
发明人： Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , John B. Bridgeman , Debra M. Kozak , Rosemary C. Beaupre , Mark L. Jenson , Cindy M. Setum , Robert C. Dutcher
IPC分类号： A61B1720
CPC分类号： A61B17/32037 , A61B17/3203 , A61M1/0084
摘要： Cross stream thrombectomy catheter and system for fragmentation and removal of thrombus or other material from blood vessels or other body cavities. High velocity saline jets emitted from a toroidal loop jet emanator or other jet emanator in a catheter distal end entrain fluid through inflow orifices, and with flow resistances create a back-pressure which drives cross stream streams through outflow orifices in a radial direction and thence radially and circumferentially to apply normal and drag forces on thrombotic deposits or lesions in the blood vessel or other body cavity, thereby breaking apart and transporting thrombus particles to be entrained through the inflow orifices, whereupon the high velocity jets macerate the thrombus particles which then transit an exhaust lumen or recirculate again via the outflow orifices.
摘要翻译：交叉流血栓切除术导管和用于从血管或其他体腔破裂和去除血栓或其他材料的系统。从导管远端的环形环喷射发生器或其他喷射发射器发射的高速盐水喷射器通过流入孔夹带流体，并且流动阻力产生背压，该背压驱动跨径流通过径向流出孔，并周向地将正常和牵引力施加在血管或其它体腔中的血栓形成沉积物或病变上，从而分离和输送通过流入孔夹带的血栓颗粒，于是高速喷射器将血栓颗粒浸入，排气腔或再次通过外流孔再循环。

68. 发明授权

US06558366B1 Thrombectomy method 失效
标题翻译：血栓切除术
公开(公告)号：US06558366B1
公开(公告)日：2003-05-06
申请号：US08349665
申请日：1994-12-05
申请人： William J. Drasler , Robert G. Dutcher , Mark L. Jenson , Joseph M. Thielen , Emmanuil I. Protonotarios
发明人： William J. Drasler , Robert G. Dutcher , Mark L. Jenson , Joseph M. Thielen , Emmanuil I. Protonotarios
IPC分类号： A61M3100
CPC分类号： A61B17/32037 , A61B17/3203
摘要： A method of and apparatus for removing a thrombus deposit from the cardiovascular system of a patient without the need to surgically access the location of the thrombus deposit via a cut-down or other surgical procedure. A catheter is inserted percutaneously into the patient at a convenient location either directly or over a previously positioned guide wire. The distal end of the catheter is advanced under fluoroscopy to the site of the thrombus deposit. A balloon is inflated to stabilize the position of the distal end of the catheter within the center of the vessel lumen. A flexible metal tube conveys an extremely high pressure stream of sterile saline solution to at least one jet at the distal end of the catheter. At least one jet positions the thrombus deposit for emulsification by at least one other jet. By directing the jets toward the orifice of the large evacuation lumen of the catheter, a stagnation pressure is induced which propels the emulsion proximally for disposal. The rate of proximal flow of effluent is metered to correspond with the distal flow of saline solution to ensure minimal local impact on the vasculature at the site of the thrombus deposit.
摘要翻译：一种用于从患者的心血管系统中去除血栓沉积物的方法和装置，而不需要通过切割或其它外科手术手术地进入血栓沉积物的位置。在方便的位置，将导管经皮插入患者中，直接或超过预先定位的导丝。导管的远端在荧光透视下前进到血栓沉积部位。气囊膨胀以将导管的远端的位置稳定在血管内腔的中心内。柔性金属管将非常高压的无菌盐水溶液流传送到导管远端处的至少一个射流。至少一个喷射器通过至少一个其它喷射器将血栓沉积物定位成乳化。通过将射流引导到导管的大抽空腔的孔口，引起停滞压力，其推动乳剂向近端处理。流出物的近端流量计量以与盐溶液的远端流动相对应，以确保对血栓沉积部位的脉管系统的局部影响最小。

69. 发明授权

US6096001A Thrombectomy and tissue removal device 失效
标题翻译：血栓切除术和组织清除装置
公开(公告)号：US6096001A
公开(公告)日：2000-08-01
申请号：US351616
申请日：1994-12-08
申请人： William J. Drasler , Robert G. Dutcher , Mark L. Jenson , Joseph M. Thielen , Emmanuil I. Protonotarios
发明人： William J. Drasler , Robert G. Dutcher , Mark L. Jenson , Joseph M. Thielen , Emmanuil I. Protonotarios
IPC分类号： A61B17/00 , A61B17/22 , A61B17/32 , A61M25/00 , A61B17/20
CPC分类号： A61B17/32037 , A61B17/3203
摘要： A device for removing a thrombus or other tissue deposit from the cardiovascular system, natural or synthetic tubule or cavity found in the human body of a patient without the need to surgically access the location of the thrombus or other tissue deposit via a cut-down or other surgical procedure. A flexible metal or high pressure plastic tube conveys an extremely high pressure stream of sterile saline or other physiologic solution to at least one jet at the distal end of the catheter. At least one jet is directed at the opening of a large exhaust lumen or other target. The jet(s) is responsible for providing a localized negative pressure which entrains tissue into the jet from break-up of the debris. This jet(s) can also provide stagnation pressure in the exhaust lumen which drives the tissue or thrombotic debris out of the exhaust lumen. Operation of the device with tip pressure greater than 500 psi provides this device with the entrainment and exhaust characteristics which contribute to its effectiveness. The rate of exhaust of tissue debris is metered to ensure minimal local impact on the vasculature at the site of the thrombus deposit. A fluid metering means, such as a roller pump, controls the rate of exhaust such that it is in balance with the saline input or can be adjusted to be greater or less than the input. A positive displacement pump operating at steady or pulsatile flow provides the high pressure saline to the tip of the catheter.
摘要翻译：一种用于从心血管系统去除血栓或其他组织沉积物的装置，在患者的人体中发现的天然或合成的小管或腔，而不需要经由切口或外科手术来进入血栓或其他组织沉积物的位置其他外科手术。柔性金属或高压塑料管将非常高压的无菌盐水或其他生理溶液流输送到导管远端处的至少一个射流。至少一个射流指向大排气腔或其他靶的开口。喷气机负责提供局部的负压，其将组织夹带到喷射器中从碎片的分解中。这种喷射器还可以在排气腔中提供停滞压力，其将组织或血栓形成的碎片驱动出排出管腔。尖端压力大于500 psi的设备的操作为该设备提供了有助于其有效性的夹带和排气特性。计量组织碎片的排气速率，以确保局部对血栓沉积部位脉管系统的局部影响最小。诸如辊式泵的流体计量装置控制排气速率，使其与盐水输入平衡，或者可以将其调节为大于或小于输入。以稳定或脉动流动运行的容积式泵向导管的尖端提供高压盐水。

70. 发明授权

US5866217A Silicone composite vascular graft 失效
标题翻译：硅胶复合血管移植
公开(公告)号：US5866217A
公开(公告)日：1999-02-02
申请号：US787227
申请日：1991-11-04
申请人： Mark D. Stenoien , William J. Drasler , Robert J. Scott , Mark L. Jenson
发明人： Mark D. Stenoien , William J. Drasler , Robert J. Scott , Mark L. Jenson
IPC分类号： A61L27/00 , A61F2/06 , A61L27/18 , A61L27/34
CPC分类号： A61L27/18 , A61F2/06 , A61L27/34 , Y10S623/926 , Y10T428/1369 , Y10T428/1376 , Y10T428/1393
摘要： A silicone composite vascular graft especially well suited as an arteriovenous (A-V) graft fistula for dialysis application. The graft has the ability to seal around needle puncture holes without externally applied pressure, excellent anti-kink, anti-crush and strength properties, and a smooth non-porous inner surface which reduces thrombus deposition and enhances the graft wall compliance or elasticity.
摘要翻译：一种硅胶复合血管移植物，特别适合作为动静脉（A-V）移植瘘用于透析应用。移植物能够在没有外部施加压力的情况下密封针穿刺孔，具有优异的抗扭结，抗压溃和强度性能，以及平滑的无孔内表面，其减少血栓沉积并增强移植物壁顺应性或弹性。

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