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61. 发明授权

US08706181B2 Target therapy delivery site selection 有权
标题翻译：目标治疗递送现场选择
公开(公告)号：US08706181B2
公开(公告)日：2014-04-22
申请号：US13358179
申请日：2012-01-25
申请人： Paul H. Stypulkowski , Jonathon E. Giftakis
发明人： Paul H. Stypulkowski , Jonathon E. Giftakis
IPC分类号： A61B5/04 , A61N1/00
CPC分类号： A61N1/36064 , A61N1/0534 , A61N1/36135 , A61N1/36171 , A61N1/36185
摘要： In some examples of selecting a target therapy delivery site for treating a patient condition, a relatively high frequency electrical stimulation signal is delivered to at least two areas within a first region (e.g., an anterior nucleus of the thalamus) of a brain of a patient, and changes in brain activity (e.g., as indicated by bioelectrical brain signals) within a second region (e.g., a hippocampus) of the brain of the patient in response to the delivered stimulation are determined. The target therapy delivery site, an electrode combination, or both, may be selected based on the changes in brain activity.
摘要翻译：在选择用于治疗患者状况的靶治疗递送部位的一些实例中，相对高频率的电刺激信号被递送到患者脑部的第一区域（例如，丘脑的前核）内的至少两个区域并且确定响应于递送的刺激的患者脑的第二区域（例如，海马）中的脑活动（例如，由生物电脑信号所示）的变化。可以基于脑活动的变化来选择靶治疗递送部位，电极组合或两者。

62. 发明授权

US08355789B2 Method and apparatus providing asynchronous neural stimulation 有权
标题翻译：提供异步神经刺激的方法和装置
公开(公告)号：US08355789B2
公开(公告)日：2013-01-15
申请号：US11414141
申请日：2006-04-28
申请人： Jon Werder , Jonathon E. Giftakis
发明人： Jon Werder , Jonathon E. Giftakis
IPC分类号： A61N1/18
CPC分类号： A61N1/36146 , A61N1/36017
摘要： Method and apparatus providing asynchronous neural stimulation pseudo-randomly varying at least one of a plurality of stimulation parameters. Neural stimulation may be monitored and compared with a target. Parameters may be varied to more closely match stimulation target. A range for at least one parameter may be established and the parameter varied within the range. A finite sequence of values within the range may be generated or selected. An average of the finite sequence of values may approximate the stimulation target.
摘要翻译：提供异步神经刺激的方法和装置伪随机地改变多个刺激参数中的至少一个。可以监测神经刺激并与目标进行比较。可以改变参数以更紧密地匹配刺激目标。可以建立至少一个参数的范围，并且该参数在该范围内变化。可以生成或选择该范围内的有限的值序列。值的有限序列的平均值可能近似于刺激目标。

63. 发明申请

US20110245629A1 PATIENT DATA DISPLAY 有权
标题翻译：患者数据显示
公开(公告)号：US20110245629A1
公开(公告)日：2011-10-06
申请号：US12751508
申请日：2010-03-31
申请人： Jonathon E. Giftakis , Timothy J. Denison
发明人： Jonathon E. Giftakis , Timothy J. Denison
IPC分类号： A61B5/00
CPC分类号： A61B5/0476 , A61B5/1116 , A61B5/4094 , A61B5/6823 , A61B5/6828 , A61B5/686 , A61B5/6868 , A61B5/742 , A61B5/7435 , A61B5/744 , A61B2560/0219 , A61B2562/043 , G06F19/00
摘要： The temporal correlation between a bioelectrical brain signal of a patient and patient motion data, such as a signal indicative of patient motion or a patient posture indicator, is displayed by a display device. In some examples, the patient posture indicator comprises a graphical representation of at least a portion of a body of the patient. In some examples, the temporal correlation between a bioelectrical brain signal, a signal indicative of patient motion, and a signal indicative of cardiac activity of the patient is displayed by the display device.
摘要翻译：患者的生物电脑信号与患者运动数据（例如指示患者运动的信号或患者姿势指示器）之间的时间相关性由显示装置显示。在一些示例中，患者姿势指示器包括患者身体的至少一部分的图形表示。在一些示例中，显示装置显示生物电脑信号，指示患者运动的信号与指示患者的心脏活动的信号之间的时间相关性。

64. 发明申请

US20110137371A1 SELECTING THERAPY CYCLE PARAMETERS BASED ON MONITORED BRAIN SIGNAL 有权
标题翻译：基于监测的脑信号选择治疗周期参数
公开(公告)号：US20110137371A1
公开(公告)日：2011-06-09
申请号：US12843665
申请日：2010-07-26
申请人： Jonathon E. Giftakis , Paul H. Stypulkowski
发明人： Jonathon E. Giftakis , Paul H. Stypulkowski
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61B5/0478 , A61B5/4094 , A61N1/37247 , G16H40/63
摘要： Bioelectrical brain signals may be monitored at one more regions of the brain of a patient by a medical device. The monitored bioelectrical signals may be used to select one or more therapy cycle parameters, e.g., on cycle duration and/or off cycle duration, for therapy delivered to treat a patient disorder. In one example, the off cycle duration of a therapy may be selected based on the washout period determined from sensed brain signals of the patient following delivery of therapy during an on cycle. In another example, the on cycle duration and/or off cycle duration of a therapy may be selected to maintain the value of one or more characteristics of a brain signal (e.g., cortical activity) of patient within a threshold range of a target value defined for the characteristic that is associated with effective treatment of the patient disorder.
摘要翻译：可以通过医疗装置在患者的脑的另外一个区域监测生物电脑信号。监测的生物电信号可用于选择一种或多种治疗周期参数，例如循环持续时间和/或关闭循环持续时间，用于治疗递送用于治疗患者病症的治疗。在一个实例中，治疗的关闭周期持续时间可以基于在开启周期期间递送治疗后患者的感测的脑信号所确定的清除时间来选择。在另一个实例中，可以选择治疗的开启周期持续时间和/或关闭周期持续时间以将患者的脑信号的一个或多个特征值（例如，皮层活动）的值保持在定义的目标值的阈值范围内与有效治疗患者障碍有关的特征。

65. 发明授权

US07865244B2 System and method for regulating cardiopulmonary triggered therapy to the brain 失效
标题翻译：将心肺触发治疗调整到大脑的系统和方法
公开(公告)号：US07865244B2
公开(公告)日：2011-01-04
申请号：US11311043
申请日：2005-12-19
申请人： Jonathon E. Giftakis , Nina M. Graves
发明人： Jonathon E. Giftakis , Nina M. Graves
IPC分类号： A61N1/36
CPC分类号： A61B5/0476 , A61B5/0031 , A61B5/02 , A61B5/0245 , A61B5/0402 , A61B5/0452 , A61B5/0478 , A61B5/053 , A61B5/08 , A61B5/0816 , A61B5/1135 , A61B5/4094 , A61N1/05 , A61N1/3601 , A61N1/36082 , A61N1/36135 , A61N1/362 , A61N1/36521 , A61N1/36585 , A61N1/37 , A61N1/37247 , A61N1/37282 , A61N1/37288 , A61N1/3962
摘要： A medical device system includes a brain monitoring element, cardiopulmonary monitoring element, therapy module and a processor. The processor is configured to activate the therapy module upon detection of a cardiopulmonary event in the cardiopulmonary signal. The processor is further configured to monitor the brain signal and communicate to the therapy module to change the cardiopulmonary triggered therapeutic output to the brain based upon the brain monitoring. Methods of treating a person with a neurological disorder are also provided.
摘要翻译：医疗装置系统包括脑监测元件，心肺监测元件，治疗模块和处理器。处理器被配置为在心肺信号中检测到心肺事件时激活治疗模块。处理器进一步被配置为基于大脑监测来监测大脑信号并与治疗模块通信，以将心肺触发的治疗输出改变到大脑。还提供了治疗患有神经障碍的人的方法。

66. 发明授权

US07809443B2 Electrical stimulation to alleviate chronic pelvic pain 有权
标题翻译：电刺激缓解慢性盆腔疼痛
公开(公告)号：US07809443B2
公开(公告)日：2010-10-05
申请号：US11413621
申请日：2006-04-28
申请人： Jonathon E. Giftakis , Martin T. Gerber
发明人： Jonathon E. Giftakis , Martin T. Gerber
IPC分类号： A61N1/34
CPC分类号： A61N1/36071 , A61N1/0551 , A61N1/0556 , A61N1/36007
摘要： The disclosure describes a method and system for applying electrical stimulation to a genitofemoral nerve or a genital branch of a genitofemoral nerve of a patient. The system includes electrical stimulators that apply electrical stimulation for alleviation of pelvic pain. The system may apply electrical stimulation for pelvic pain in men or women. The electrical stimulators may comprise various types of electrodes such as cuff electrodes, electrode leads, and microstimulators implanted at various locations proximate to a single or both genitofemoral nerves and the genital branch of a single or both genitofemoral nerves of a patient. When implanted proximate to a genital nerve branch, the electrode may be implanted proximate to the genital nerve branch. In a male patient stimulation may be delivered proximate to the spermatic cord, which contains a portion of the genital nerve branch.
摘要翻译：本公开描述了一种将电刺激施加到患者的基因原经神经的生殖器神经或生殖器分支的方法和系统。该系统包括电刺激器，其应用电刺激以缓解盆腔疼痛。该系统可以对男性或女性进行电刺激用于骨盆疼痛。电刺激器可以包括各种类型的电极，诸如袖带电极，电极引线和微刺激器，其植入在靠近单个或两个基因视网膜神经和患者的单个或两个基因颅神经的生殖分支的不同位置处。当植入到生殖器神经分支附近时，电极可以在生殖神经分支附近植入。在男性患者中，刺激可以靠近精子束递送，精索包含生殖器神经分支的一部分。

67. 发明申请

US20100249876A1 ELECTRICAL STIMULATION OF ILIOHYPOGASTRIC NERVE TO ALLEVIATE CHRONIC PELVIC PAIN 有权
标题翻译： ILIOHYPOGASTRIC神经电刺激治疗慢性疼痛疼痛
公开(公告)号：US20100249876A1
公开(公告)日：2010-09-30
申请号：US12815084
申请日：2010-06-14
申请人： Jonathon E. Giftakis , Martin T. Gerber
发明人： Jonathon E. Giftakis , Martin T. Gerber
IPC分类号： A61N1/34
CPC分类号： A61K31/485 , A61K31/7076 , A61K38/31 , A61M5/14276 , A61M5/172 , A61M2005/1405 , A61M2205/054 , A61M2205/3523 , A61M2205/50 , A61M2210/1021 , A61N1/0551 , A61N1/0556 , A61N1/36007 , A61N1/36071 , A61N1/37288
摘要： The disclosure describes a method and system for applying electrical stimulation to an iliohypogastric nerve of a patient. The system includes electrical stimulators that apply electrical stimulation for alleviation of pelvic pain. The system may apply electrical stimulation for pelvic pain in men or women. The electrical stimulators may comprise various types of electrodes such as cuff electrodes, electrode leads, and microstimulators implanted at various locations proximate to a single or both iliohypogastric nerves of a patient. In particular, the electrode may be implanted proximate or adjacent to an anterior cutaneous branch of one or both iliohypogastric nerves, a lateral cutaneous branch of one or both iliohypogastric nerves, or one or both of iliohypogastric nerves above the branch point.
摘要翻译：本公开描述了一种对患者的髂腹下神经施加电刺激的方法和系统。该系统包括电刺激器，其应用电刺激以缓解盆腔疼痛。该系统可以对男性或女性进行电刺激用于骨盆疼痛。电刺激器可以包括各种类型的电极，例如袖带电极，电极引线和微刺激器，其植入在靠近患者的单个或两个髂腹下神经的各个位置处。特别地，电极可以被植入邻近或邻近髂腹下神经的一个或两个的前皮肤分支，一个或两个髂腹下神经的外侧皮肤分支，或在分支点之上的髂腹下神经中的一个或两个。

68. 发明授权

US07787944B2 System and method for regulating cardiac triggered therapy to the brain 有权
公开(公告)号：US07787944B2
公开(公告)日：2010-08-31
申请号：US11311200
申请日：2005-12-19
申请人： Jonathon E. Giftakis , Nina M. Graves
发明人： Jonathon E. Giftakis , Nina M. Graves
IPC分类号： A61B5/00
摘要： A medical device system includes a brain monitoring element, cardiac monitoring element, therapy module and a processor. The processor is configured to activate the therapy module upon detection of a cardiac event in the cardiac signal. The processor is further configured to monitor the brain signal and communicate to the therapy module to change the cardiac triggered therapeutic output to the brain based upon the brain monitoring. A method of treating a person with a neurological disorder is also provided.

69. 发明申请

US20090264954A1 THERAPY TARGET SELECTION FOR PSYCHIATRIC DISORDER THERAPY 审中-公开
标题翻译：治疗精神疾病治疗方案的治疗目标选择
公开(公告)号：US20090264954A1
公开(公告)日：2009-10-22
申请号：US12425758
申请日：2009-04-17
申请人： Mark T. Rise , Jonathon E. Giftakis
发明人： Mark T. Rise , Jonathon E. Giftakis
IPC分类号： A61N1/36
CPC分类号： A61N1/36082
摘要： Target tissue sites for therapy delivery to a patient may be selected based on the patient symptoms or a patient mood state. The therapy delivery may be used to manage a psychiatric disorder of the patient. Selected therapy sites may be weighted based on factors, such as the severity of the patient symptom or mood state or the type of patient symptom or mood state. In some cases, therapy delivery to the patient may be controlled based on the weighting factors. For example, the weighting factors may control the intensity of the therapy delivery or the frequency of the therapy delivery. In some examples, the weighting factors may dynamically change based on the patient's changing symptoms or mood disorders.
摘要翻译：可以基于患者症状或患者情绪状态来选择用于治疗递送给患者的靶组织位点。治疗递送可用于治疗患者的精神疾病。可以基于诸如患者症状或情绪状态的严重性或患者症状或情绪状态的类型的因素来加权所选择的治疗部位。在一些情况下，可以基于加权因子来控制对患者的治疗递送。例如，加权因子可以控制治疗递送的强度或治疗递送的频率。在一些示例中，加权因子可以基于患者的改变的症状或情绪障碍而动态地改变。

70. 发明授权

US10493281B2 Timing therapy evaluation trials 有权
公开(公告)号：US10493281B2
公开(公告)日：2019-12-03
申请号：US12425922
申请日：2009-04-17
申请人： Jonathon E. Giftakis , Mark T. Rise , Paul H. Stypulkowski , Timothy J. Denison
发明人： Jonathon E. Giftakis , Mark T. Rise , Paul H. Stypulkowski , Timothy J. Denison
IPC分类号： A61N1/00 , A61N1/36 , A61N1/05 , A61N1/372
CPC分类号： A61N1/36135 , A61N1/36082 , A61N1/0534 , A61N1/37211 , A61N1/37247
摘要： A characteristic of a washout period following the delivery of therapy to a patient according to a therapy program may be determined based on a physiological parameter of the patient. A washout period includes the period of time during which a carryover effect from the therapy delivery dissipates. Monitoring a washout period may be useful for timing the delivery of therapy according to different therapy programs during a therapy evaluation period. For example, at least one physiological signal of the patient may be monitored to automatically determine when a washout period has ended, e.g., when stimulation and carryover effects of therapy delivery according to a first therapy program have substantially dissipated, in order to determine when therapy delivery according to a second therapy program can be initiated.

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