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61. 发明授权

US06200338B1 Enhanced radiopacity of peripheral and central catheter tubing 有权
标题翻译：外周和中央导管管的射线不透性增强
公开(公告)号：US06200338B1
公开(公告)日：2001-03-13
申请号：US09224443
申请日：1998-12-31
申请人： Donald D. Solomon , Fidelis C. Onwumere
发明人： Donald D. Solomon , Fidelis C. Onwumere
IPC分类号： A61F204
CPC分类号： C08G18/381 , A61L27/18 , A61L29/06 , A61L31/06 , A61L31/18 , Y10T428/139 , C08L75/04
摘要： A medical implant, tubing and method to provide enhanced X-ray detection intensity in catheters, stents, vascular grafts or other tubular implants. In one aspect the medical implant includes a visually transparent radiopaque polymer and a filler material having a radiopaque component.
摘要翻译：用于在导管，支架，血管移植物或其他管状植入物中提供增强的X射线检测强度的医疗植入物，管道和方法。在一个方面，医学植入物包括视觉上透明的不透射线聚合物和具有不透射线组分的填充材料。

62. 发明授权

US5707366A Anti-infective and antithrombogenic medical articles and method for their preparation 失效
公开(公告)号：US5707366A
公开(公告)日：1998-01-13
申请号：US487796
申请日：1995-06-07
申请人： Donald D. Solomon , M. Parke Byron
发明人： Donald D. Solomon , M. Parke Byron
IPC分类号： A61L27/34 , A61L27/54 , A61L29/06 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , A61M5/32 , A61M25/00
CPC分类号： A61L29/06 , A61L29/085 , A61L29/16 , A61L2300/104 , A61L2300/206 , A61L2300/404 , A61L2300/406 , A61L2300/45 , A61M2025/0056
摘要： An anti-infective medical article has chlorhexidine bulk distributed throughout a polyurethane base layer and may have a coating layer on the base layer. The coating layer may be chlorhexidine permeated into the surface or it may be an antibiotic, antithrombogenic agent or a polymeric surface layer laminated onto the base layer. The invention includes a method for preparing the article wherein a homogeneous melt of polymer and chlorhexidine is prepared by twin screw compounding and the melt is extruded to give a medical article having bulk distributed chlorhexidine.

63. 发明授权

US5613291A Method for providing a sterility seal in a medicinal storage bottle 失效
标题翻译：在药用储藏瓶中提供无菌密封的方法
公开(公告)号：US5613291A
公开(公告)日：1997-03-25
申请号：US377885
申请日：1995-01-25
申请人： Donald D. Solomon , Jean-Claude Thibault
发明人： Donald D. Solomon , Jean-Claude Thibault
IPC分类号： B65B7/28 , A61J1/00 , A61J1/14 , A61J1/20 , B65D41/02 , B65D53/06 , B23P25/00
CPC分类号： A61J1/2089 , A61J1/1412 , A61J1/18 , A61J1/1468 , A61J1/201 , Y10S604/905 , Y10T29/49885 , Y10T29/49982
摘要： A bottle having a sterility seal and a method for producing same are disclosed. The bottle, which can be configured to retain a medicament in powder or tablet form, features a protective cap configured to engage a transfer assembly associated with the bottle. The cap includes one or more raised ridges on an interior surface engageable with a portion of the transfer assembly. A band or layer configuration of a sealing material such as silicone is applied to the transfer assembly prior to insertion of the cap thereover. As the cap comes into surface contact with the sealing material, the ridges cause the material to "roll up" into a toroidal O-ring configuration, thereby forming a seal between the cap and the bottle adapted to the dimensional variations of those components. The seal, which is resilient, is able to withstand harsh handling treatment and pressure or temperature variations without separation from the cap or bottle, thereby providing a hermetic seal isolating the transfer assembly and, hence, the medicament from the outside environment.
摘要翻译：公开了一种具有无菌密封的瓶子及其制造方法。可以构造成保持粉末或片剂形式的药物的瓶具有构造成接合与瓶相关联的转运组件的保护帽。所述盖包括在内表面上与所述转移组件的一部分可接合的一个或多个凸脊。在其上插入盖之前，将诸如硅树脂的密封材料的带或层构造施加到转移组件。当盖与密封材料进行表面接触时，脊使材料“卷起”成环形O形环构型，从而在适于这些部件的尺寸变化的帽和瓶之间形成密封。具有弹性的密封件能够承受恶劣的处理处理和压力或温度变化，而不会与盖或瓶分离，从而提供将转印组件以及因此从外部环境分离的气密密封。

64. 发明授权

US5328698A Method for rendering a substrate surface antithrombogenic and/or anti-infective 失效
标题翻译：用于使底物表面抗血栓形成和/或抗感染的方法
公开(公告)号：US5328698A
公开(公告)日：1994-07-12
申请号：US563653
申请日：1990-08-06
申请人： Fidelis C. Onwumere , Donald D. Solomon , Stanley C. Wells
发明人： Fidelis C. Onwumere , Donald D. Solomon , Stanley C. Wells
IPC分类号： A61L27/00 , A61L27/54 , A61L29/16 , A61L33/00 , A61K47/30
CPC分类号： A61L33/0029 , A61L27/54 , A61L29/16 , A61L33/0047 , A61L2300/404 , A61L2300/42 , A61L2300/606
摘要： A shaped medical article of a polymeric substrate is extrusion coated with a composition which includes a bioactive agent dispersed in a matrix polymer. Preferred bioactive agents are temperature sensitive agents which undergo thermal decomposition at a temperature above the processing temperature of the matrix polymer. Preferred matrix polymers have a melting point of about 100.degree. C. or lower.
摘要翻译：聚合物基材的成形医疗制品用包含分散在基质聚合物中的生物活性剂的组合物进行挤出包衣。优选的生物活性剂是在高于基质聚合物的加工温度的温度下进行热分解的温度敏感剂。优选的基质聚合物的熔点为约100℃或更低。

65. 发明授权

US5078700A Liquid crystalline catheter 失效
标题翻译：液晶导管
公开(公告)号：US5078700A
公开(公告)日：1992-01-07
申请号：US495072
申请日：1990-03-19
申请人： James M. Lambert , Donald D. Solomon
发明人： James M. Lambert , Donald D. Solomon
IPC分类号： A61L29/00 , A61L29/04 , A61L29/14 , A61M25/00 , C08G63/60
CPC分类号： A61L29/04 , A61L29/14 , A61M25/0009 , C08G63/60 , C08G63/605 , B29C2045/0098
摘要： A catheter assembly includes a tubing portion and a needle portion, at least one of which is a thermoplastic liquid crystalline polymer. The tubing and needle may be integral or unitary. The invention includes a method to make the assembly in which a melt of the liquid crystalline polymer is shear thinned by passing through an orifice such as an extrusion die to make tubing. The shear thinned melt may be directed into a mold having a point to make a liquid crystalline needle.

66. 发明授权

US5061254A Thermoplastic elastomeric hydrophilic polyetherurethane expandable catheter 失效
标题翻译：热塑性弹性体聚氨酯透气导管
公开(公告)号：US5061254A
公开(公告)日：1991-10-29
申请号：US499154
申请日：1990-03-26
申请人： Mutlu Karakelle , Donald D. Solomon
发明人： Mutlu Karakelle , Donald D. Solomon
IPC分类号： A61L29/06 , A61L29/16 , A61L29/18 , A61M25/00 , C08G18/48 , C08G18/66
CPC分类号： C08G18/6674 , A61L29/06 , A61L29/16 , A61L29/18 , A61M25/0009 , C08G18/4833 , A61L2300/404 , A61L2300/406 , A61L2300/42
摘要： A melt extruded catheter of thermoplastic elastomeric hydrophilic polyurethane synthesized from a diisocyanate, polyethyleneoxide glycol of high molecular weight and a chain extender expands to a larger lumen size when contacted with an aqueous liquid. The catheter may include an antithrombogenic agent, antiinfective agent and radiopaque agent. The hydrophilic polyurethane may be synthesized by one-shot bulk polymerization, and may be melt extruded into the catheter tubing, and may encapsulate a stripe of a stiffening polyurethane.

67. 发明授权

US5059269A Method of making an article having a hemocompatible surface 失效
标题翻译：制备具有血液相容性表面的制品的方法
公开(公告)号：US5059269A
公开(公告)日：1991-10-22
申请号：US491020
申请日：1990-03-09
申请人： Can B. Hu , Donald D. Solomon , Stanley C. Wells
发明人： Can B. Hu , Donald D. Solomon , Stanley C. Wells
IPC分类号： A61L33/06 , C08G18/61
CPC分类号： C08G18/61 , A61L33/068
摘要： An article has a blood-contacting hemocompatible surface layer of a urethane-siloxane copolymer on a thermoplastic polymeric base material. The copolymer has siloxane segments prepared from hydroxyalkyl terminated polysiloxane glycols. The article is prepared by coextrusion of the base material and the copolymer.
摘要翻译：制品在热塑性聚合物基材上具有聚氨酯 - 硅氧烷共聚物的与血液接触的血液相容性表面层。该共聚物具有由羟烷基封端的聚硅氧烷二醇制备的硅氧烷链段。该制品通过共挤出基材和共聚物制备。

68. 发明授权

US5032666A Amine rich fluorinated polyurethaneureas and their use in a method to immobilize an antithrombogenic agent on a device surface 失效
标题翻译：富胺氟化聚氨酯脲及其在将抗血栓形成剂固定在器械表面上的方法中的用途
公开(公告)号：US5032666A
公开(公告)日：1991-07-16
申请号：US368013
申请日：1989-06-19
申请人： Can B. Hu , Donald D. Solomon
发明人： Can B. Hu , Donald D. Solomon
IPC分类号： A61F2/02 , A61L33/00 , B01J19/00 , C08G18/12 , C08G18/50
CPC分类号： C08G18/5015 , A61L33/0029 , C08G18/12
摘要： A thermoplastic polyurethaneurea having free amino groups is the reaction product of a diisocyanate, a fluorinated polyol, a non-fluorinated polyol and a polyamine. The invention includes a shaped polymeric support structure having the thermoplastic polyurethaneurea coated thereon and a medical article comprising the coated support and heparin covalently bonded to the free amino groups of the coated support. In another aspect of the invention, a method for preparing the heparinized medical article is provided.

69. 发明授权

US4976697A Catheter obturator with automatic feed and control 失效
标题翻译：导管闭塞器具有自动进料和控制
公开(公告)号：US4976697A
公开(公告)日：1990-12-11
申请号：US427422
申请日：1989-10-26
申请人： Anthony J. Walder , Donald D. Solomon , Richard W. Beck , James M. Lambert , Timothy Ignatius , Mark Crawford
发明人： Anthony J. Walder , Donald D. Solomon , Richard W. Beck , James M. Lambert , Timothy Ignatius , Mark Crawford
IPC分类号： A61M25/00 , A61M25/01
CPC分类号： A61M25/0017 , A61M25/0113
摘要： An obturator is provided which allows for placing and withdrawing of a single catheter obturator over an extended period of time so as to allow speed intervals of use, and non-use of a catheter while in place in the patient's skin, while at the same time doing away with cumbersome, costly and time consuming administration and maintenance of saline and heparin locks. The device feeds the obturator in place for occluding the catheter lumen, when no fluids are being administered to the patient, and then may be retracted to a position allowing fluid feed through a supply tube connection to the catheter. The device includes a coating on the obturator rod which swells in contact with aqueous fluids to seal completely the catheter lumen which coating includes heparin to prevent clotting. Moreover, the entire internal functioning arrangement remains sterile during the entire period of use, thus avoiding infection.
摘要翻译：提供了一种闭孔器，其允许在延长的时间段内放置和取出单个导管闭塞器，以允许使用速度间隔，并且在同时在患者皮肤中就位时不使用导管消除麻醉，昂贵和耗时的盐水和肝素锁的管理和维护。当没有向患者施用流体时，该装置将闭塞器馈送到适当位置以封闭导管腔，然后可以缩回至允许流体通过与导管连接的供应管的位置。该装置包括在封闭杆上的涂层，其与水性流体接触膨胀以完全密封导管腔，该涂层包括肝素以防止凝血。此外，整个内部功能安排在整个使用期间保持不育，从而避免感染。

70. 发明授权

US4713402A Process for preparing antithrombogenic/antibiotic polymeric plastic materials 失效
标题翻译：制备抗血栓形成/抗生素聚合物塑料的方法
公开(公告)号：US4713402A
公开(公告)日：1987-12-15
申请号：US771438
申请日：1985-08-30
申请人： Donald D. Solomon
发明人： Donald D. Solomon
IPC分类号： A61L29/16 , A61L33/00 , A61K17/18 , B44D5/12
CPC分类号： A61L33/0017 , A61L29/16 , A61L2300/208 , A61L2300/406 , A61L2300/42 , A61L2300/45 , Y10S514/822
摘要： An antithrombogenic/antibiotic plastic material prepared using an organic solvent system containing a specific chlorofluorocarbon compound and petroleum ether.
摘要翻译：使用含有特定氯氟烃化合物和石油醚的有机溶剂系统制备的抗血栓形成/抗生素塑料材料。

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