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61. 发明申请

US20070093875A1 Implantable and rechargeable neural stimulator 有权
标题翻译：可植入和可充电的神经刺激器
公开(公告)号：US20070093875A1
公开(公告)日：2007-04-26
申请号：US11256907
申请日：2005-10-24
申请人： Abhi Chavan , Anthony Caparso , Avram Scheiner
发明人： Abhi Chavan , Anthony Caparso , Avram Scheiner
IPC分类号： A61N1/00
CPC分类号： A61N1/36117 , A61N1/3605 , A61N1/36071 , A61N1/36135 , A61N1/37205 , A61N1/37217 , A61N1/37288 , A61N1/3787
摘要： One aspect of the present subject matter relates to an implantable medical device. An embodiment of the device comprises a rechargeable power supply adapted to be recharged through an ultrasound signal, a neural stimulator connected to the rechargeable power supply, and a controller connected to the rechargeable power supply. The neural stimulator is adapted to generate a neural stimulation signal for delivery to a neural stimulation target through an electrode. The controller is further connected to the neural stimulator to control the neural stimulator according to a neural stimulation protocol. Other aspects are provided herein.
摘要翻译：本主题的一个方面涉及可植入医疗装置。该装置的实施例包括适于通过超声信号再充电的可再充电电源，连接到可再充电电源的神经刺激器和连接到可再充电电源的控制器。神经刺激器适于产生用于通过电极递送到神经刺激靶的神经刺激信号。控制器进一步连接到神经刺激器，以根据神经刺激方案来控制神经刺激器。本文提供了其他方面。

62. 发明授权

US07155293B2 Medical electrical lead employing load bearing sleeve 有权
标题翻译：医用电线使用承载套
公开(公告)号：US07155293B2
公开(公告)日：2006-12-26
申请号：US10353793
申请日：2003-01-29
申请人： Randy Westlund , Mohan Krishnan , Avram Scheiner
发明人： Randy Westlund , Mohan Krishnan , Avram Scheiner
IPC分类号： A61N1/00
CPC分类号： A61N1/056 , A61N2001/0578 , A61N2001/0585
摘要： A medical electrical lead employs a load bearing sleeve arrangement. A medical electrical lead includes an outer sleeve, having proximal and distal ends, and is formed of a first material. At least one electrical conductor is situated within the outer sleeve and extends between the proximal and distal ends of the outer sleeve. At least one electrode is electrically coupled to the electrical conductor. A load bearing sleeve extends between the proximal and distal ends of the outer sleeve. The load bearing sleeve is formed of a second material different from the first material. The load bearing sleeve offers resistance to axial loading forces applied to the lead. The load bearing sleeve can be coextensive with the outer sleeve or extend along at least the majority of the length of the outer sleeve.
摘要翻译：医用电线使用承载套筒装置。医用电线包括具有近端和远端的外套，并由第一材料形成。至少一个电导体位于外套筒内并且在外套筒的近端和远端之间延伸。至少一个电极电耦合到电导体。承载套筒在外套筒的近端和远端之间延伸。承载套筒由不同于第一材料的第二材料形成。承载套筒提供抵抗施加到引线的轴向载荷力。承载套筒可以与外套筒共同延伸或者沿外套筒的至少大部分长度延伸。

63. 发明申请

US20060282145A1 Vascularly stabilized peripheral nerve cuff assembly 有权
公开(公告)号：US20060282145A1
公开(公告)日：2006-12-14
申请号：US11151103
申请日：2005-06-13
申请人： Anthony Caparso , Avram Scheiner
发明人： Anthony Caparso , Avram Scheiner
IPC分类号： A61N1/05
CPC分类号： A61N1/0551 , A61N1/0556 , A61N1/0558
摘要： A vascularly stabilized peripheral nerve cuff assembly is provided. One aspect of this disclosure relates to an electrode assembly used in the delivery of neural stimulation therapy. The electrode assembly includes a body adapted to at least partially encompass a blood vessel and a nerve proximate to the blood vessel. The electrode assembly also includes at least one electrode along at least a portion of the body. The at least one electrode is adapted to be electrically connected to a neural stimulator. According to an embodiment, the electrode assembly includes a spacer within the body, the spacer having a first and second end, the first end secured to an inside surface of the body and the second end adapted to pass between the vessel and the nerve and to be secured to the inside surface of the body. Other aspects and embodiments are provided herein.

64. 发明申请

US20060195149A1 Implantable cardiac device with dyspnea measurement 有权
公开(公告)号：US20060195149A1
公开(公告)日：2006-08-31
申请号：US11067964
申请日：2005-02-28
申请人： Donald Hopper , John Voegele , Jesse Hartley , Avram Scheiner
发明人： Donald Hopper , John Voegele , Jesse Hartley , Avram Scheiner
IPC分类号： A61N1/378
CPC分类号： A61B5/686 , A61B5/0022 , A61B5/0024 , A61B5/02028 , A61B5/0205 , A61B5/04012 , A61B5/0402 , A61B5/076 , A61B5/0809 , A61B5/0816 , A61B5/0826 , A61B5/085 , A61B5/091 , A61B5/1118 , A61B5/4836 , A61B5/7275 , A61B5/7282 , A61B5/746 , A61B5/747 , A61N1/3627 , A61N1/36585 , A61N1/3702 , A61N1/3987 , G06F19/00 , G16H50/20 , G16H50/30
摘要： Cardiac monitoring and/or stimulation methods and systems employing dyspnea measurement. An implantable cardiac device may sense transthoracic impedance and determine a patient activity level. An index indicative of pulmonary function is implantably computed to detect an episode of dyspnea based on a change, trend, and/or value exceeding a threshold at a determined patient activity level. Trending one or more pulmonary function index values may be done to determine a patient's pulmonary function index profile, which may be used to adapt a cardiac therapy. A physician may be automatically alerted in response to a pulmonary function index value and/or a trend of the patient's pulmonary index being beyond a threshold. Computed pulmonary function index values and their associated patient's activity levels may be stored periodically in a memory and/or transmitted to a patient-external device.

65. 发明申请

US20050149155A1 Stimulation lead for stimulating the baroreceptors in the pulmonary artery 有权
标题翻译：刺激肺动脉压力感受器的刺激
公开(公告)号：US20050149155A1
公开(公告)日：2005-07-07
申请号：US10746852
申请日：2003-12-24
申请人： Avram Scheiner , Ronald Heil , Peter Kelley
发明人： Avram Scheiner , Ronald Heil , Peter Kelley
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/057 , A61N1/36117
摘要： An apparatus includes a flexible lead body extending from a proximal end to a distal end, the distal end having a biased portion having an outer diameter dimensioned to abut a wall of a pulmonary artery, an electrode coupled proximate the distal end, and an implantable pulse generator electrically coupled to the electrode. The implantable pulse generator is adapted to deliver a baroreflex stimulation signal to a baroreceptor in the pulmonary artery via the electrode.
摘要翻译：一种装置包括从近端延伸到远端的柔性引线体，所述远端具有偏压部分，所述偏压部分的外径尺寸设计成邻接肺动脉壁，邻近远端连接的电极和可植入脉冲发电机电耦合到电极。可植入脉冲发生器适于通过电极将压力反射刺激信号传递给肺动脉中的压力感受器。

66. 发明授权

US08315713B2 Techniques for placing medical leads for electrical stimulation of nerve tissue 有权
标题翻译：放置用于电刺激神经组织的医疗线的技术
公开(公告)号：US08315713B2
公开(公告)日：2012-11-20
申请号：US12433768
申请日：2009-04-30
申请人： John E. Burnes , Mary M. Morris , Michael R. S. Hill , Avram Scheiner , Ruth N. Klepfer , Matthew D. Bonner
发明人： John E. Burnes , Mary M. Morris , Michael R. S. Hill , Avram Scheiner , Ruth N. Klepfer , Matthew D. Bonner
IPC分类号： A61N1/00
CPC分类号： A61N1/36053 , A61M25/09 , A61N1/05 , A61N1/0551 , A61N1/0558 , A61N1/057 , A61N1/36085 , A61N1/36114 , A61N1/36125 , A61N1/36128
摘要： This disclosure is directed to extra, intra, and transvascular medical lead placement techniques for arranging medical leads and electrical stimulation and/or sensing electrodes proximate nerve tissue within a patient.
摘要翻译：本公开涉及用于在患者体内靠近神经组织布置医疗引线和电刺激和/或感测电极的额外的，内部的和经血管内的医疗引线放置技术。

67. 发明申请

US20110270329A1 METHOD AND APPARATUS TO ENHANCE THERAPY DURING STIMULATION OF VAGUS NERVE 有权
标题翻译：在VAGUS神经刺激期间加强治疗的方法和装置
公开(公告)号：US20110270329A1
公开(公告)日：2011-11-03
申请号：US12771154
申请日：2010-04-30
申请人： Avram Scheiner
发明人： Avram Scheiner
IPC分类号： A61N1/00 , A61N1/05
CPC分类号： A61N1/36053 , A61N1/3601 , A61N1/3611 , A61N1/36114 , A61N1/37247
摘要： A method and apparatus stimulating a vagus nerve of a patient. The apparatus includes a pulse generator having an adjustable pulse output parameter and adapted to be electrically coupled to the vagus nerve. The pulse generator generates pulses for a burst period that is followed by a rest period. The apparatus also includes a respiration sensor coupled to the pulse generator. The respiration sensor detects the inspiration and the expiration phases of the respiration. The pulse generator generates stimulation pulses during both the detected inspiration and expiration phases. The pulses are delivered with the output parameter adjusted to provide greater stimulation strength during the inspiration phase than during the expiration phase.
摘要翻译：刺激患者迷走神经的方法和装置。该装置包括具有可调脉冲输出参数并适于电耦合到迷走神经的脉冲发生器。脉冲发生器产生脉冲，在脉冲周期之后是休止期。该装置还包括耦合到脉冲发生器的呼吸传感器。呼吸传感器检测呼吸的吸气和呼气阶段。脉冲发生器在检测到的吸气和呼气阶段都产生刺激脉冲。输出脉冲，调整输出参数以在吸气阶段提供比在期满期间更大的刺激强度。

68. 发明授权

US07979141B2 Transvascular reshaping lead system 有权
标题翻译：血管重塑引导系统
公开(公告)号：US07979141B2
公开(公告)日：2011-07-12
申请号：US12564416
申请日：2009-09-22
申请人： Anthony V. Caparso , Julia Moffitt , Avram Scheiner
发明人： Anthony V. Caparso , Julia Moffitt , Avram Scheiner
IPC分类号： A61N1/05
CPC分类号： A61N1/0551 , A61N1/057 , A61N1/372
摘要： A system for selective activation of a nerve trunk using a transvascular reshaping lead is provided. One aspect of this disclosure relates to a system for spreading nerve bundles in a nerve trunk. The system includes a lead adapted to be chronically implanted in a blood vessel proximate a nerve trunk, and having an expandable portion adapted to be expanded to reshape the blood vessel to an elongated shape and to reshape the nerve trunk into an elongated shape to spread nerve bundles of the nerve trunk. The system also includes a plurality of electrodes and an implantable device coupled to the lead, where an electrical signal is delivered from the implanted medical device to one of the plurality of electrodes to transvascularly deliver neural stimulation from the electrode to at least one of the nerve bundles of the nerve trunk. Other aspects and embodiments are provided herein.
摘要翻译：提供了使用经血管重塑引线选择性激活神经干的系统。本公开的一个方面涉及一种用于在神经干中扩展神经束的系统。该系统包括适于长期植入靠近神经干的血管中的引线，并且具有适于扩张的扩张部分以将血管重塑为细长形状并将神经干重新形成细长形状以展开神经束神经干。该系统还包括耦合到引线的多个电极和可植入装置，其中电信号从植入的医疗装置输送到多个电极中的一个电极，以将神经刺激从电极转运到至少一个神经束神经干。本文提供了其它方面和实施例。

69. 发明申请

US20100114217A1 THERAPY SYSTEM INCLUDING CARDIAC RHYTHM THERAPY AND NEUROSTIMULATION CAPABILITIES 有权
标题翻译：治疗方法包括治疗心律失常治疗和神经功能障碍
公开(公告)号：US20100114217A1
公开(公告)日：2010-05-06
申请号：US12610160
申请日：2009-10-30
申请人： Paul G. Krause , Avram Scheiner
发明人： Paul G. Krause , Avram Scheiner
IPC分类号： A61N1/08 , A61N1/39 , A61N1/362
CPC分类号： A61N1/36114 , A61N1/36514 , A61N1/36521
摘要： An implantable medical system that includes a cardiac therapy module and a neurostimulation therapy module may identify when neurostimulation electrodes have migrated toward a patient's heart. In some examples, the system may determine whether the neurostimulation electrodes have migrated toward the patient's heart based on a physiological response to an electrical signal delivered to the patient via the neurostimulation electrodes. In addition, in some examples, the system may determine whether the neurostimulation electrodes have migrated toward the patient's heart based on an electrical cardiac signal sensed via the neurostimulation electrodes.
摘要翻译：包括心脏治疗模块和神经刺激治疗模块的可植入医疗系统可以识别神经刺激电极何时向患者的心脏移动。在一些示例中，系统可以基于对通过神经刺激电极递送给患者的电信号的生理反应来确定神经刺激电极是否已经向患者的心脏迁移。此外，在一些示例中，系统可以基于经由神经刺激电极感测的电心脏信号来确定神经刺激电极是否已经向患者的心脏迁移。

70. 发明授权

US07617003B2 System for selective activation of a nerve trunk using a transvascular reshaping lead 有权
标题翻译：使用血管重塑铅选择性激活神经干的系统
公开(公告)号：US07617003B2
公开(公告)日：2009-11-10
申请号：US11130022
申请日：2005-05-16
申请人： Anthony Caparso , Julia Moffitt , Avram Scheiner
发明人： Anthony Caparso , Julia Moffitt , Avram Scheiner
IPC分类号： A61N1/05
CPC分类号： A61N1/0551 , A61N1/057 , A61N1/372
摘要： A system for selective activation of a nerve trunk using a transvascular reshaping lead is provided. One aspect of this disclosure relates to a system for spreading nerve bundles in a nerve trunk. The system includes a lead adapted to be chronically implanted in a blood vessel proximate a nerve trunk, and having an expandable portion adapted to be expanded to reshape the blood vessel to an elongated shape and to reshape the nerve trunk into an elongated shape to spread nerve bundles of the nerve trunk. The system also includes a plurality of electrodes and an implantable device coupled to the lead, where an electrical signal is delivered from the implanted medical device to one of the plurality of electrodes to transvascularly deliver neural stimulation from the electrode to at least one of the nerve bundles of the nerve trunk. Other aspects and embodiments are provided herein.
摘要翻译：提供了使用经血管重塑引线选择性激活神经干的系统。本公开的一个方面涉及一种用于在神经干中扩展神经束的系统。该系统包括适于长期植入靠近神经干的血管中的引线，并且具有适于扩张的扩张部分以将血管重塑为细长形状并将神经干重新形成细长形状以展开神经束神经干。该系统还包括耦合到引线的多个电极和可植入装置，其中电信号从植入的医疗装置输送到多个电极中的一个电极，以将神经刺激从电极转运到至少一个神经束神经干。本文提供了其它方面和实施例。

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