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    • 66. 发明申请
    • VIBRATION-DAMPING DEVICE
    • 振动阻尼装置
    • US20110031669A1
    • 2011-02-10
    • US12918928
    • 2009-02-27
    • Satoshi Sasaki
    • Satoshi Sasaki
    • F16F15/08F16F1/36B60G11/22
    • F16F1/371
    • This vibration-damping device (10) includes: a first main body component (11) that is linked to a vibration receiving portion; a second main body component (12) that is placed on the opposite side from a vibration generating portion so as to sandwich the first main body component (11); a linking component (13) that penetrates through the first main body component (11) and mutually links together the second main body component (12) and the vibration generating portion; main body rubber (14) that elastically links together the first main body component (11) and the second main body component (12) and that has the linking component (13) inserted through its interior space (K); a tubular stopper fitting (15) that is provided on the first main body component (11) and that surrounds from the outward side in the radial direction a rod-shaped contact portion (16) that is provided in the linking component (13); and tubular stopper rubber (17) that is mounted on at least one of an inner surface of the stopper fitting (15) and the contact portion (16). Moreover, distances between mutually facing surfaces formed by internal surfaces of the stopper fitting (15) and the contact portion (16) which are facing each other are uniform over the entire area of each of the facing surface areas. According to this vibration-damping device (10), the load applied to the stopper rubber (17) is reduced, and the durability of the vibration-damping device (10) is improved.
    • 该减震装置(10)包括:第一主体部件(11),其连接到振动接收部分; 第二主体部件(12),其设置在与振动产生部分相对的一侧,以夹持第一主体部件(11); 连接部件(13),其穿过第一主体部件(11)并将第二主体部件(12)和振动产生部分相互连接在一起; 主体橡胶(14),其将第一主体部件(11)和第二主体部件(12)弹性连接,并且具有通过其内部空间(K)插入的连接部件(13); 一个管状止动器配件(15),设置在第一主体部件(11)上并且从径向外侧包围设置在连接部件(13)中的杆状接触部分(16); 以及安装在止动配件(15)的内表面和接触部分(16)中的至少一个上的管状止动橡胶(17)。 而且,由各止动配件(15)的内表面和彼此面对的接触部分(16)形成的彼此相对的表面之间的距离在每个相对表面区域的整个区域上是均匀的。 根据该减震装置(10),施加到止动橡胶(17)的负荷减小,并且减振装置(10)的耐久性得到改善。
    • 69. 发明申请
    • PYRIDYLPHENOL COMPOUND AND USE THEREOF
    • 吡啶酚化合物及其用途
    • US20090156646A1
    • 2009-06-18
    • US12063472
    • 2006-08-10
    • Satoshi SasakiAtsuo Baba
    • Satoshi SasakiAtsuo Baba
    • A61K31/44C07D213/85A61P5/24
    • C07D213/85C07D213/80C07D401/10C07D401/12C07D401/14C07D405/12C07D405/14C07D409/12C07D409/14C07D413/12C07D413/14C07D417/12C07D417/14
    • The present invention provides a compound which has metastin receptor antagonist activity and is useful for preventing and treating hormone-dependent cancer, benign prostatomegaly, endometriosis, precocious puberty, uterine myoma or the like. More specifically, the present invention provides a compound, represented by the formula: or a salt thereof, a prodrug thereof, and a pharmaceutical agent containing the same; wherein Ring A represents a 5- to 8-membered homocyclic or heterocyclic group optionally having a substituent other than formula —X-R1 wherein X represents a bond or a spacer, and R1 represents optionally substituted amino or an optionally substituted nitrogen-containing heterocyclic group; Ring B represents an optionally substituted benzene ring; R2 represents an optionally substituted homocyclic or heterocyclic group; and R3 and R4 independently represent a hydrogen atom, cyano, acyl or an optionally substituted hydrocarbon group.
    • 本发明提供了具有转移受体拮抗剂活性的化合物,可用于预防和治疗激素依赖性癌症,良性前列腺肥大,子宫内膜异位症,早熟性青春期,子宫肌瘤等。 更具体地,本发明提供由下式表示的化合物或其盐,其前药和含有该化合物的药剂; 其中环A表示任选具有除式-X-R1以外的取代基的5至8元的环状或杂环基,其中X表示键或间隔基,并且R 1表示任选取代的氨基或任选取代的含氮杂环基 ; 环B表示任选取代的苯环; R 2表示任选取代的杂环或杂环基; 并且R 3和R 4独立地表示氢原子,氰基,酰基或任选取代的烃基。