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61. 发明授权

US5182204A Non-human carbonyl hydrolase mutants, vectors encoding same and hosts transformed with said vectors 失效
标题翻译：非人羰基水解酶突变体，编码相同的载体和用所述载体转化的宿主
公开(公告)号：US5182204A
公开(公告)日：1993-01-26
申请号：US807786
申请日：1991-12-11
申请人： David A. Estell , Richard R. Bott , Scott D. Power , James A. Wells
发明人： David A. Estell , Richard R. Bott , Scott D. Power , James A. Wells
IPC分类号： C11D3/386 , C12N9/54 , C12N9/56 , C12N15/10 , C12N15/55 , C12N15/75 , C12N1/21
CPC分类号： C12R1/07 , C11D3/386 , C12N15/102 , C12N15/75 , C12N9/54 , Y10S435/832
摘要： Novel carbonyl hydrolase mutants derived from the DNA sequences of naturally-occurring or recombinant non-human carbonyl hydrolases. The mutant carbonyl hydrolases, in general, are obtained by in vitro modification of a precursor DNA sequence encoding the naturally-occurring or recombinant carbonyl hydrolase to encode the substitution of an amino acid in the amino acid sequence of a precursor carbonyl hydrolase. Such mutants have properties which are different than the precursor hydrolase.
摘要翻译：衍生自天然或重组非人羰基水解酶的DNA序列的新型羰基水解酶突变体。突变体羰基水解酶通常通过体外修饰编码天然存在或重组的羰基水解酶的前体DNA序列获得，以编码前体羰基水解酶的氨基酸序列中的氨基酸的取代。这些突变体具有与前体水解酶不同的性质。

62. 发明授权

US5039446A Liquid detergent with stabilized enzyme 失效
标题翻译：具有稳定酶的液体洗涤剂
公开(公告)号：US5039446A
公开(公告)日：1991-08-13
申请号：US559456
申请日：1990-07-23
申请人： David A. Estell
发明人： David A. Estell
IPC分类号： C11D3/386
CPC分类号： C11D3/38663
摘要： Liquid detergent containing enzymes particularly proteases are stabilized against enzyme degradation prior to use by inclusion of an inhibitor of the enzyme having a dissociation constant of between about 1.times.10.sup.-2 M and about 1.times.10.sup.-7 M which binds to the enzyme such that prior to use of the detergent at least about 55% of the enzyme is bound to the enzyme inhibitor essentially at the enzyme active site. Such enzyme inhibitor so selected can be used effectively in concentrations much lower than previously taught; i.e., from about 0.002% to less than 0.1% weight/weight.
摘要翻译：含有酶特别是蛋白酶的液体洗涤剂在使用之前通过包含约1×10-2M至约1×10-7M的解离常数的酶的抑制剂在使用前被稳定化，其结合酶，使得在使用洗涤剂之前至少约55％的酶基本上在酶活性位点与酶抑制剂结合。所选择的这种酶抑制剂可以有效地以比以前教导的浓度低得多的方式使用; 即约0.002％至小于0.1％重量/重量。

63. 发明授权

US09856466B2 Compositions and methods comprising serine protease variants 有权
公开(公告)号：US09856466B2
公开(公告)日：2018-01-02
申请号：US14115801
申请日：2012-05-04
申请人： Neelam S. Amin , Katherine Augustyn , Joshua R. Basler , Luis G. Cascao-Pereira , Katherine D. Collier , Edward M. Concar , David A. Estell , James T. Kellis, Jr. , Euan John Magennis , Alexander Pisarchik , Ayrookaran J. Poulose , Philip Frank Souter , Glenn Steven Ward , Jian Yao
发明人： Neelam S. Amin , Katherine Augustyn , Joshua R. Basler , Luis G. Cascao-Pereira , Katherine D. Collier , Edward M. Concar , David A. Estell , James T. Kellis, Jr. , Euan John Magennis , Alexander Pisarchik , Ayrookaran J. Poulose , Philip Frank Souter , Glenn Steven Ward , Jian Yao
IPC分类号： C12N9/54 , C11D3/386
CPC分类号： C12N9/54 , C11D3/386
摘要： The present invention provides serine protease variants, more specifically subtilisin variants produced there from. Specifically, the present invention provides serine protease variants, more specifically subtilisin variants having one or more substitutions as compared to a reference serine protease. In addition, the present invention provides compositions comprising these serine protease variants, more specifically subtilisin variants. In some embodiments, the present invention provides cleaning compositions comprising at least one of these serine protease variants, more specifically subtilisin variants.

64. 发明申请

US20140187468A1 Compositions and Methods Comprising a Lipolytic Enzyme Variant 审中-公开
标题翻译：包含脂肪分解酶变体的组成和方法
公开(公告)号：US20140187468A1
公开(公告)日：2014-07-03
申请号：US14237846
申请日：2012-08-30
申请人： David A. Estell , Lene Bojsen Jensen , Karsten M. Kragh , Rie Mejldal , Sina Pricelius
发明人： David A. Estell , Lene Bojsen Jensen , Karsten M. Kragh , Rie Mejldal , Sina Pricelius
IPC分类号： C11D3/386
CPC分类号： C11D3/38627 , C12N9/20
摘要： The present invention provides lipolytic enzyme variants. Specifically, the present invention provides lipolytic enzyme variants having one or more modifications as compared to a parent lipolytic enzyme having at least one improved property. In addition, the present invention provides compositions comprising a lipolytic enzyme variant of the invention. The present invention also provides methods of cleaning using compositions comprising a lipolytic enzyme variant of the invention.
摘要翻译：本发明提供脂肪分解酶变体。具体而言，与具有至少一种改良性质的亲本脂肪分解酶相比，本发明提供了具有一个或多个修饰的脂肪分解酶变体。此外，本发明提供了包含本发明的脂肪分解酶变体的组合物。本发明还提供使用包含本发明的脂肪分解酶变体的组合物进行清洁的方法。

65. 发明授权

US08648015B2 Systematic evaluation of sequence and activity relationships using site evaluation libraries for engineering multiple properties 有权
标题翻译：使用现场评估库进行系统评估序列和活动关系，用于工程化多个属性
公开(公告)号：US08648015B2
公开(公告)日：2014-02-11
申请号：US12778915
申请日：2010-05-12
申请人： David A. Estell , Wolfgang Aehle
发明人： David A. Estell , Wolfgang Aehle
IPC分类号： C40B20/04 , C40B40/02
CPC分类号： C12Q1/37 , C12N15/1086
摘要： The present invention provides methods for protein engineering. Specifically, the invention provides methods utilizing site evaluation libraries to design libraries that optimize two or more properties of a protein.
摘要翻译：本发明提供蛋白质工程方法。具体地说，本发明提供了使用位点评估库来设计优化蛋白质的两个或多个性质的文库的方法。

66. 发明申请

US20130260438A1 COMPOSITIONS AND METHODS COMPRISING SERINE PROTEASE VARIANTS (AS AMENDED) 审中-公开
标题翻译：包含丝氨酸蛋白酶变体（如修订）的组合物和方法
公开(公告)号：US20130260438A1
公开(公告)日：2013-10-03
申请号：US13696512
申请日：2011-05-05
申请人： Viktor Yuryevich Alekseyev , Neelam A Amin , Katherine Auguslyn , Luis Gustavo Cascao-Pereira , Katherine D. Collier , David A. Estell , James T. Kellis, JR. , Ayrookaran J. Poulose , Philip Frank Souter , Glenn Steven Ward , Jian Yao
发明人： Viktor Yuryevich Alekseyev , Neelam A Amin , Katherine Auguslyn , Luis Gustavo Cascao-Pereira , Katherine D. Collier , David A. Estell , James T. Kellis, JR. , Ayrookaran J. Poulose , Philip Frank Souter , Glenn Steven Ward , Jian Yao
IPC分类号： C12N9/54
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38681
摘要： The present invention provides serine protease variants produced there from. Specifically, the present invention provides serine protease variants having one or more substitutions as compared to a reference serine protease. In addition, the present invention provides compositions comprising these serine protease variants. In some embodiments, the present invention provides cleaning compositions comprising at least one of these serine protease variants.
摘要翻译：本发明提供了丝氨酸蛋白酶变体。具体地，本发明提供了与参考丝氨酸蛋白酶相比具有一个或多个取代的丝氨酸蛋白酶变体。此外，本发明提供包含这些丝氨酸蛋白酶变体的组合物。在一些实施方案中，本发明提供了包含这些丝氨酸蛋白酶变体中的至少一种的清洁组合物。

67. 发明授权

US08530219B2 Compositions and methods comprising a subtilisin variant 失效
标题翻译：包含枯草杆菌蛋白酶变体的组合物和方法
公开(公告)号：US08530219B2
公开(公告)日：2013-09-10
申请号：US13128836
申请日：2009-11-10
申请人： David A. Estell , Frits Goedegebuur , Ayrookaran Poulose
发明人： David A. Estell , Frits Goedegebuur , Ayrookaran Poulose
IPC分类号： C12N9/54 , C12N9/50 , C12N9/48 , C12N9/32 , C12N9/20 , C11D3/00 , B08B3/00 , C07K1/00
CPC分类号： C11D3/386 , C11D3/38609 , C11D3/38618 , C11D3/38681 , C11D3/3942 , C12N9/54 , C12Y304/21062
摘要： The present invention provides a Bacillus sp. subtilisin variant. In addition, the present invention provides compositions comprising this serine protease variant. In some embodiments, the present invention provides laundry and other non-automatic (i.e., hand) dishwashing cleaning compositions comprising this serine protease variant.
摘要翻译：本发明提供芽孢杆菌属枯草杆菌蛋白酶变体。此外，本发明提供包含该丝氨酸蛋白酶变体的组合物。在一些实施方案中，本发明提供了包含该丝氨酸蛋白酶变体的衣物和其它非自动（即，手）餐具清洗组合物。

68. 发明申请

US20120178143A1 ALPHA/BETA HYDROLASE-FOLD ENZYMES 审中-公开
标题翻译： ALPHA / BETA HYDROLASE-FOLD ENZYMES
公开(公告)号：US20120178143A1
公开(公告)日：2012-07-12
申请号：US13351155
申请日：2012-01-16
申请人： David A. Estell
发明人： David A. Estell
IPC分类号： C12N9/14 , C12N15/63 , C12N1/20
CPC分类号： C11D3/386 , A23K20/189 , C11D3/38 , C12N9/14
摘要： The present invention relates to the identification of novel hydrolases in gram positive microorganisms. The present invention provides amino acid sequences for the hydrolase. The present invention provides host cells which comprise nucleic acid encoding the hydrolase. The present invention also provides cleaning compositions, animal feeds and compositions used to treat a textile that include the hydrolase of the present invention.
摘要翻译：本发明涉及革兰氏阳性微生物中新型水解酶的鉴定。本发明提供水解酶的氨基酸序列。本发明提供了包含编码水解酶的核酸的宿主细胞。本发明还提供了用于处理包括本发明的水解酶的纺织品的清洁组合物，动物饲料和组合物。

69. 发明申请

US20120067373A1 Automatic Dishwashing Detergent Composition 审中-公开
标题翻译：自动洗碗洗涤剂组合物
公开(公告)号：US20120067373A1
公开(公告)日：2012-03-22
申请号：US13079126
申请日：2011-04-04
申请人： Philip Frank Souter , Glenn Steven Ward , Frits Goedegebuur , Ayrookaran Joseph Poulose , David A. Estell , Richard R. Bott , Luis Gustavo Cascäo-Pereira
发明人： Philip Frank Souter , Glenn Steven Ward , Frits Goedegebuur , Ayrookaran Joseph Poulose , David A. Estell , Richard R. Bott , Luis Gustavo Cascäo-Pereira
IPC分类号： A47L15/42 , C11D3/60
CPC分类号： C12N9/54 , C11D3/33 , C11D3/378 , C11D3/386 , C11D3/38609 , C11D3/38618 , C11D3/38645 , C11D3/38681 , C11D17/043 , C11D17/044 , C11D17/045
摘要： The present invention is in the field of automatic dishwashing detergent compositions, as well as methods of making and using same. In particular, it relates to an automatic dishwashing detergent composition comprising a new protease. The automatic dishwashing detergent composition provides improved cleaning and finishing. In particular the composition of the invention provides better proteinaceous removal at the same level of other proteases available in the market. This also alternatively allows for the use of a lower level of the protease of the invention and therefore a more cost effective composition.
摘要翻译：本发明涉及自动餐具洗涤剂组合物领域，以及制造和使用它们的方法。特别地，本发明涉及一种包含新蛋白酶的自动餐具洗涤剂组合物。自动洗碗洗涤剂组合物提供改进的清洁和整理。特别地，本发明的组合物在市场上可获得的相同水平的其它蛋白酶中提供更好的蛋白质去除。这也可以允许使用较低水平的本发明的蛋白酶，因此使用更具成本效益的组合物。

70. 发明申请

US20110281327A1 Compositions And Methods Comprising Variant Proteases 审中-公开
标题翻译：包含变异蛋白酶的组成和方法
公开(公告)号：US20110281327A1
公开(公告)日：2011-11-17
申请号：US13085392
申请日：2011-04-12
申请人： Richard R. Bott , Luis Gustavo Cascao-Pereira , David A. Estell , Frits Goedegebuur , Ayrookaran Joseph Poulose
发明人： Richard R. Bott , Luis Gustavo Cascao-Pereira , David A. Estell , Frits Goedegebuur , Ayrookaran Joseph Poulose
IPC分类号： C12N9/48 , D06M16/00 , C07H21/02
CPC分类号： C12N9/54
摘要： The present invention provides variant proteases, compositions comprising such variant proteases, and methods of cleaning comprising such variant proteases.
摘要翻译：本发明提供了变体蛋白酶，包含这种变体蛋白酶的组合物和包含这种变体蛋白酶的清洁方法。

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