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1. 发明授权

US08530219B2 Compositions and methods comprising a subtilisin variant 失效
标题翻译：包含枯草杆菌蛋白酶变体的组合物和方法
公开(公告)号：US08530219B2
公开(公告)日：2013-09-10
申请号：US13128836
申请日：2009-11-10
申请人： David A. Estell , Frits Goedegebuur , Ayrookaran Poulose
发明人： David A. Estell , Frits Goedegebuur , Ayrookaran Poulose
IPC分类号： C12N9/54 , C12N9/50 , C12N9/48 , C12N9/32 , C12N9/20 , C11D3/00 , B08B3/00 , C07K1/00
CPC分类号： C11D3/386 , C11D3/38609 , C11D3/38618 , C11D3/38681 , C11D3/3942 , C12N9/54 , C12Y304/21062
摘要： The present invention provides a Bacillus sp. subtilisin variant. In addition, the present invention provides compositions comprising this serine protease variant. In some embodiments, the present invention provides laundry and other non-automatic (i.e., hand) dishwashing cleaning compositions comprising this serine protease variant.
摘要翻译：本发明提供芽孢杆菌属枯草杆菌蛋白酶变体。此外，本发明提供包含该丝氨酸蛋白酶变体的组合物。在一些实施方案中，本发明提供了包含该丝氨酸蛋白酶变体的衣物和其它非自动（即，手）餐具清洗组合物。

2. 发明申请

US20080090747A1 Protease variants active over a broad temperature range 审中-公开
标题翻译：蛋白酶变体在宽温度范围内有活性
公开(公告)号：US20080090747A1
公开(公告)日：2008-04-17
申请号：US11825731
申请日：2007-07-09
申请人： Pieter Augustinus , Frits Goedegebuur , Ayrookaran Poulose , Johannes Van Der Laan
发明人： Pieter Augustinus , Frits Goedegebuur , Ayrookaran Poulose , Johannes Van Der Laan
IPC分类号： C11D7/42 , C07H21/04 , C12N15/00 , C12N5/06
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38681
摘要： The present invention provides protease compositions particularly suited for dishwashing applications.
摘要翻译：本发明提供了特别适用于洗碗应用的蛋白酶组合物。

3. 发明申请

US20070134779A1 Enzymes useful for changing the properties of polyester 审中-公开
标题翻译：用于改变聚酯性能的酶
公开(公告)号：US20070134779A1
公开(公告)日：2007-06-14
申请号：US11583597
申请日：2006-10-18
申请人： Wade Dyson , James Kellis , Ayrookaran Poulose , Mee-Young Yoon
发明人： Wade Dyson , James Kellis , Ayrookaran Poulose , Mee-Young Yoon
IPC分类号： C12P7/62 , C08F20/00
CPC分类号： G06K9/6828
摘要： A method is provided for enzymatically modifying a polyester resin, film, fiber, yarn, fabric or textile to modify the characteristics thereof.
摘要翻译：提供了对聚酯树脂，薄膜，纤维，纱线，织物或织物进行酶改性以改变其特性的方法。

4. 发明申请

US20050170488A1 Multiply-substituted protease variants 审中-公开
标题翻译：多重取代的蛋白酶变体
公开(公告)号：US20050170488A1
公开(公告)日：2005-08-04
申请号：US10500936
申请日：2003-01-16
申请人： Ayrookaran Poulose
发明人： Ayrookaran Poulose
IPC分类号： D06L4/40 , C11D3/386 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/54 , C12N15/09 , C12N15/57 , C07H21/04 , C12N15/74
CPC分类号： C12N9/54 , C11D3/386 , C12Y304/21062
摘要： Novel protease variants derived from the DNA sequences of naturally-occurring or recombinant non-human proteases are disclosed. The variant proteases, in general, are obtained by in vitro modification of a precursor DNA sequence encoding the naturally-occurring or recombinant protease to generate the substitution of a plurality of amino acid residues in the amino acid sequence of a precursor protease. Such variant proteases have properties which are different from those of the precursor protease, such as altered wash performance. The substituted amino acid residue equivalent to positions 7, 23, 26, 28, 29, 30, 31, 47, 66, 69, 73, 82, 85, 88, 90, 92, 93, 105, 113, 139, 148, 149, 150, 151, 178, 200, 201, 231, 233, 267 and/or 273 of Bacillus amyloliquefaciens subtilisin.
摘要翻译：公开了衍生自天然存在或重组非人蛋白酶的DNA序列的新型蛋白酶变体。一般来说，变体蛋白酶通过体外修饰编码天然存在或重组蛋白酶的前体DNA序列获得，以产生前体蛋白酶的氨基酸序列中的多个氨基酸残基的取代。这种变体蛋白酶具有与前体蛋白酶不同的性质，例如改变的洗涤性能。取代的氨基酸残基相当于7,23,26,28,29,30,31,47,66,69,73,82,85,88,90,92,93,105,113,139,148， 149，150，151，178，200，201，231，233，267和/或273的解淀粉芽孢杆菌枯草杆菌蛋白酶。

5. 发明申请

US20080025960A1 Detergents with stabilized enzyme systems 审中-公开
标题翻译：具有稳定酶体系的洗涤剂
公开(公告)号：US20080025960A1
公开(公告)日：2008-01-31
申请号：US11825229
申请日：2007-07-05
申请人： Manoj Kumar , Ayrookaran Poulose
发明人： Manoj Kumar , Ayrookaran Poulose
IPC分类号： C11D7/42 , A61K38/43 , A61P43/00
CPC分类号： C11D3/38663 , C11D3/046 , C11D3/122 , C11D3/30 , C11D3/3463
摘要： The present invention provides methods and compositions for the stabilization of oxidase enzymes during storage. In some preferred embodiments, the oxidase is a component of liquid detergent compositions. In some particularly preferred embodiments, the oxidase is stabilized by the addition of a reversible inhibitor of the oxidase to a liquid detergent. In some particularly preferred embodiments, the oxidase is stabilized with bisulfite. In further preferred embodiments, the use of a reversible inhibitor also prevents premature generation of peroxide during storage of liquid detergent. In additional embodiments, liquid detergent formulations comprised of oxidase enzyme, its substrate, and its reversible inhibitor produce active oxygen species (peroxide) upon dilution of the liquid detergent in laundry wash liquor.
摘要翻译：本发明提供了在储存期间稳定氧化酶的方法和组合物。在一些优选的实施方案中，氧化酶是液体洗涤剂组合物的组分。在一些特别优选的实施方案中，通过向液体洗涤剂中加入氧化酶的可逆抑制剂来稳定氧化酶。在一些特别优选的实施方案中，氧化酶用亚硫酸氢盐稳定。在进一步优选的实施方案中，使用可逆抑制剂还可防止在液体洗涤剂储存期间过早产生过氧化物。在另外的实施方案中，由洗涤洗涤液稀释液体洗涤剂时由氧化酶，其底物及其可逆抑制剂组成的液体洗涤剂制剂产生活性氧（过氧化物）。

6. 发明申请

US20050054843A1 Proteases producing an altered immunological response and methods of making and using the same 审中-公开
标题翻译：产生改变的免疫应答的蛋白酶及其制备和使用方法
公开(公告)号：US20050054843A1
公开(公告)日：2005-03-10
申请号：US10498694
申请日：2002-12-20
申请人： David Estell , Fiona Harding , Ayrookaran Poulose
发明人： David Estell , Fiona Harding , Ayrookaran Poulose
IPC分类号： C12N15/09 , A61K8/00 , A61K8/02 , A61K8/06 , A61K8/30 , A61K8/33 , A61K8/34 , A61K8/36 , A61K8/365 , A61K8/55 , A61K8/58 , A61K8/64 , A61K8/66 , A61K8/67 , A61K8/72 , A61K8/86 , A61K38/46 , A61P17/16 , A61Q19/00 , A61Q19/10 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/54 , C12N9/56 , C12R1/07 , C07H21/04 , C12N15/74
CPC分类号： C12N9/54 , A61K8/66 , A61K8/675 , A61Q19/00 , C12Y304/21062
摘要： The present invention provides novel protein variants that exhibit reduced immunogenic responses, as compared to the parental proteins. The present invention further provides DNA molecules that encode novel variants, host cells comprising DNA encoding novel variants, as well as methods for making proteins less allergenic. In addition, the present invention provides various compositions that comprise these proteins that are less immunogenic than the wild-type proteins.
摘要翻译：与亲本蛋白质相比，本发明提供了表现出降低的免疫原性应答的新型蛋白质变体。本发明还提供编码新变体的DNA分子，包含编码新变体的DNA的宿主细胞，以及用于制备蛋白质过敏原的方法。此外，本发明提供了包含这些蛋白质的各种组合物，其比野生型蛋白质具有较少的免疫原性。

7. 发明申请

US20050221461A1 Multiply-substituted protease variants 有权
标题翻译：多重取代的蛋白酶变体
公开(公告)号：US20050221461A1
公开(公告)日：2005-10-06
申请号：US10500943
申请日：2003-01-16
申请人： Ayrookaran Poulose , David Estell , James Kellis Jr , Richard Bott
发明人： Ayrookaran Poulose , David Estell , James Kellis Jr , Richard Bott
IPC分类号： C12N15/09 , C07H21/04 , C11D3/386 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/50 , C12N9/52 , C12N9/54 , C12N9/56 , C12N15/57
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38609 , C12Y304/21062
摘要： Novel enzyme variants including protease variants derived from the DNA sequences of naturally-occurring or re-combinant non-human proteases are disclosed. The variant proteases, in general, are obtained by in vitro modification of a precursor DNA sequence encoding the naturally-occurring or recombinant protease to generate the substitution of a plurality of amino acid residues in the amino acid sequence of a precursor protease. Such variant proteases have properties which are different from those of the precursor protease, such as altered wash performance. The substituted amino acid residue correspond to positions 27, 45, 170, 181, 251 and 271 of Bacillus amyloliquefaciens subtilisin. Additional variants comprising at least one additional substitution at a position selected from 1, 14, 49, 61, 87, 100, 102, 118, 128, 204 and 258 of Bacillus amyloliquefaciens subtilisin are also described.
摘要翻译：公开了包含衍生自天然存在或重组非人蛋白酶的DNA序列的蛋白酶变体的新型酶变体。一般来说，变体蛋白酶通过体外修饰编码天然存在或重组蛋白酶的前体DNA序列获得，以产生前体蛋白酶的氨基酸序列中的多个氨基酸残基的取代。这种变体蛋白酶具有与前体蛋白酶不同的性质，例如改变的洗涤性能。取代的氨基酸残基对应于解淀粉芽孢杆菌枯草杆菌蛋白酶的位置27,45,170,181,251和271。还描述了包含在解淀粉芽孢杆菌枯草杆菌蛋白酶的1,4,14,69,61,87,100,102,118,128,204和258的位置上的至少一个另外的取代的另外的变体。

8. 发明申请

US20050202551A1 Proteins producing an altered immunogenic response and methods of making and using the same 审中-公开
公开(公告)号：US20050202551A1
公开(公告)日：2005-09-15
申请号：US11127727
申请日：2005-05-12
申请人： David Estell , Grant Ganshaw , Fiona Harding , Edmund Larenas , Ayrookaran Poulose , Elizabeth Sikorski , Elliott Russell
发明人： David Estell , Grant Ganshaw , Fiona Harding , Edmund Larenas , Ayrookaran Poulose , Elizabeth Sikorski , Elliott Russell
IPC分类号： C07H21/04 , A61K8/64 , A61K8/67 , A61K38/00 , A61Q5/02 , A61Q11/00 , A61Q19/00 , A61Q19/10 , C12N9/54 , C12P21/06 , C12N9/52 , C12N15/74
CPC分类号： C12N9/54 , A61K8/64 , A61K8/671 , A61K8/676 , A61K8/678 , A61K38/00 , A61K2800/72 , A61Q5/02 , A61Q11/00 , A61Q19/00 , A61Q19/10
摘要： The present invention relates to novel protein variants that exhibit reduced allergenicity when compared to the parental proteins. Also included are DNA molecules that encode the novel variants, host cells comprising the DNA and methods of making proteins less allergenic.

9. 发明申请

US20080063774A1 Multiple mutation variants of serine protease 有权
标题翻译：丝氨酸蛋白酶的多重突变变体
公开(公告)号：US20080063774A1
公开(公告)日：2008-03-13
申请号：US11809104
申请日：2007-05-31
申请人： Wolfgang Aehle , David Estell , Ronaldus Hommes , Brian Jones , Marc Kolkman , Chris Leeflang , Hiroshi Oh , Ayrookaran Poulose , Andrew Shaw , Wilhelmus Van Der Kley , Leonardus Van Marrewijk
发明人： Wolfgang Aehle , David Estell , Ronaldus Hommes , Brian Jones , Marc Kolkman , Chris Leeflang , Hiroshi Oh , Ayrookaran Poulose , Andrew Shaw , Wilhelmus Van Der Kley , Leonardus Van Marrewijk
IPC分类号： A23K1/00 , C07H21/00 , C11D7/42 , C12N1/00 , C12N1/15 , C12N1/21 , C12N15/63 , C12N9/50 , D06M16/00
CPC分类号： C12N9/52 , A23K20/189 , A23K50/75 , C11D3/386 , C12N9/96 , C12Y304/21 , D06M16/003
摘要： The present invention provides novel Micrococcineae spp serine proteases having multiple substitutions. In particular, the present invention provides serine proteases having multiple substitutions, DNA encoding these proteases, vectors comprising the DNA encoding the proteases, host cells transformed with the vector DNA, and enzymes produced by the host cells. The present invention also provides cleaning compositions (e.g., detergent compositions), animal feed compositions, and textile and leather processing compositions comprising these serine protease variants. In particularly preferred embodiments, the present invention provides mutant (i.e., variant) proteases derived from the wild-type proteases described herein. These variant proteases also find use in numerous applications.
摘要翻译：本发明提供了具有多个取代的新型微球菌spp丝氨酸蛋白酶。特别地，本发明提供了具有多个取代的丝氨酸蛋白酶，编码这些蛋白酶的DNA，包含编码蛋白酶的DNA的载体，用载体DNA转化的宿主细胞和由宿主细胞产生的酶。本发明还提供了清洁组合物（例如洗涤剂组合物），动物饲料组合物以及包含这些丝氨酸蛋白酶变体的纺织和皮革加工组合物。在特别优选的实施方案中，本发明提供衍生自本文所述的野生型蛋白酶的突变体（即，变体）蛋白酶。这些变体蛋白酶也可用于许多应用。

10. 发明申请

US20080029130A1 Surface active bleach and dynamic pH 审中-公开
标题翻译：表面活性漂白剂和动态pH值
公开(公告)号：US20080029130A1
公开(公告)日：2008-02-07
申请号：US11707307
申请日：2007-02-16
申请人： Edward Concar , David Estell , Hiroshi Oh , Ayrookaran Poulose
发明人： Edward Concar , David Estell , Hiroshi Oh , Ayrookaran Poulose
IPC分类号： B08B3/00 , C11D3/00
CPC分类号： C11D3/38654 , C11D1/667 , C11D1/74 , C11D3/0047 , C11D3/2093 , C11D3/221
摘要： The present invention provides methods and compositions for dynamic pH control, particularly in detergent applications. In particularly preferred embodiments, the detergent compositions find use in surface removal of soils from fabrics, including clothing. In some particularly preferred embodiments, the present invention provides combinations of enzymes to provide for dynamic pH control.
摘要翻译：本发明提供用于动态pH控制的方法和组合物，特别是在洗涤剂应用中。在特别优选的实施方案中，洗涤剂组合物可用于从织物（包括衣服）中去除土壤表面。在一些特别优选的实施方案中，本发明提供酶的组合以提供动态pH控制。

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