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1. 发明申请

US20110281327A1 Compositions And Methods Comprising Variant Proteases 审中-公开
标题翻译：包含变异蛋白酶的组成和方法
公开(公告)号：US20110281327A1
公开(公告)日：2011-11-17
申请号：US13085392
申请日：2011-04-12
申请人： Richard R. Bott , Luis Gustavo Cascao-Pereira , David A. Estell , Frits Goedegebuur , Ayrookaran Joseph Poulose
发明人： Richard R. Bott , Luis Gustavo Cascao-Pereira , David A. Estell , Frits Goedegebuur , Ayrookaran Joseph Poulose
IPC分类号： C12N9/48 , D06M16/00 , C07H21/02
CPC分类号： C12N9/54
摘要： The present invention provides variant proteases, compositions comprising such variant proteases, and methods of cleaning comprising such variant proteases.
摘要翻译：本发明提供了变体蛋白酶，包含这种变体蛋白酶的组合物和包含这种变体蛋白酶的清洁方法。

2. 发明申请

US20120067373A1 Automatic Dishwashing Detergent Composition 审中-公开
标题翻译：自动洗碗洗涤剂组合物
公开(公告)号：US20120067373A1
公开(公告)日：2012-03-22
申请号：US13079126
申请日：2011-04-04
申请人： Philip Frank Souter , Glenn Steven Ward , Frits Goedegebuur , Ayrookaran Joseph Poulose , David A. Estell , Richard R. Bott , Luis Gustavo Cascäo-Pereira
发明人： Philip Frank Souter , Glenn Steven Ward , Frits Goedegebuur , Ayrookaran Joseph Poulose , David A. Estell , Richard R. Bott , Luis Gustavo Cascäo-Pereira
IPC分类号： A47L15/42 , C11D3/60
CPC分类号： C12N9/54 , C11D3/33 , C11D3/378 , C11D3/386 , C11D3/38609 , C11D3/38618 , C11D3/38645 , C11D3/38681 , C11D17/043 , C11D17/044 , C11D17/045
摘要： The present invention is in the field of automatic dishwashing detergent compositions, as well as methods of making and using same. In particular, it relates to an automatic dishwashing detergent composition comprising a new protease. The automatic dishwashing detergent composition provides improved cleaning and finishing. In particular the composition of the invention provides better proteinaceous removal at the same level of other proteases available in the market. This also alternatively allows for the use of a lower level of the protease of the invention and therefore a more cost effective composition.
摘要翻译：本发明涉及自动餐具洗涤剂组合物领域，以及制造和使用它们的方法。特别地，本发明涉及一种包含新蛋白酶的自动餐具洗涤剂组合物。自动洗碗洗涤剂组合物提供改进的清洁和整理。特别地，本发明的组合物在市场上可获得的相同水平的其它蛋白酶中提供更好的蛋白质去除。这也可以允许使用较低水平的本发明的蛋白酶，因此使用更具成本效益的组合物。

3. 发明授权

US08679816B2 Cellulase variants with improved expression, activity and stability, and use thereof 有权
标题翻译：具有改善的表达，活性和稳定性的纤维素酶变体及其用途
公开(公告)号：US08679816B2
公开(公告)日：2014-03-25
申请号：US13321928
申请日：2010-06-03
申请人： Wolfgang Aehle , Richard R. Bott , Benjamin Bower , Jonathan Caspi , David A. Estell , Frits Goedegebuur , Ronaldus W. J. Hommes , Thijs Kaper , Bradley Kelemen , Slavko Kralj , Johan Van Lieshout , Igor Nikolaev , Sander Van Stigt Thans , Louise Wallace , Gudrun Vogtentanz , Mats Sandgren
发明人： Wolfgang Aehle , Richard R. Bott , Benjamin Bower , Jonathan Caspi , David A. Estell , Frits Goedegebuur , Ronaldus W. J. Hommes , Thijs Kaper , Bradley Kelemen , Slavko Kralj , Johan Van Lieshout , Igor Nikolaev , Sander Van Stigt Thans , Louise Wallace , Gudrun Vogtentanz , Mats Sandgren
IPC分类号： C12N9/42 , C12P19/00 , C12P19/02 , C07H21/04
CPC分类号： C12N9/2437 , C12Y302/01091 , Y02E50/17
摘要： The present disclosure relates to cellulase variants. In particular the present disclosure relates to cellulase variants having improved expression, activity and/or stability. Also described are nucleic acids encoding the cellulase variants, compositions comprising the cellulase variants, and methods of use thereof.
摘要翻译：本公开涉及纤维素酶变体。特别地，本公开涉及具有改善的表达，活性和/或稳定性的纤维素酶变体。还描述了编码纤维素酶变体的核酸，包含纤维素酶变体的组合物及其使用方法。

4. 发明申请

US20120135500A1 CELLULASE VARIANTS WITH IMPROVED EXPRESSION, ACTIVITY AND STABILITY, AND USE THEREOF 有权
标题翻译：具有改进的表达，活性和稳定性的纤维素酶变体及其用途
公开(公告)号：US20120135500A1
公开(公告)日：2012-05-31
申请号：US13321928
申请日：2010-06-03
申请人： Wolfgang Aehle , Richard R. Bott , Benjamin Bower , Jonathan Caspi , David A. Estell , Frits Goedegebuur , Ronaldus W.J. Hommes , Thijs Kaper , Bradley Kelemen , Slavko Kralj , Johan Van Lieshout , Igor Nikolaev , Sander Van Stigt Thans , Louise Wallace , Gudrun Vogtentanz , Mats Sandgren
发明人： Wolfgang Aehle , Richard R. Bott , Benjamin Bower , Jonathan Caspi , David A. Estell , Frits Goedegebuur , Ronaldus W.J. Hommes , Thijs Kaper , Bradley Kelemen , Slavko Kralj , Johan Van Lieshout , Igor Nikolaev , Sander Van Stigt Thans , Louise Wallace , Gudrun Vogtentanz , Mats Sandgren
IPC分类号： C12N9/42
CPC分类号： C12N9/2437 , C12Y302/01091 , Y02E50/17
摘要： The present disclosure relates to cellulase variants. In particular the present disclosure relates to cellulase variants having improved expression, activity and/or stability. Also described are nucleic acids encoding the cellulase variants, compositions comprising the cellulase variants, and methods of use thereof.
摘要翻译：本公开涉及纤维素酶变体。特别地，本公开涉及具有改善的表达，活性和/或稳定性的纤维素酶变体。还描述了编码纤维素酶变体的核酸，包含纤维素酶变体的组合物及其使用方法。

5. 发明授权

US09447400B2 Beta-glucosidase I variants with improved properties 有权
标题翻译：具有改善性质的β-葡糖苷酶I变体
公开(公告)号：US09447400B2
公开(公告)日：2016-09-20
申请号：US13510902
申请日：2010-11-19
申请人： Richard R. Bott , Thijs Kaper , Bradley Kelemen , Frits Goedegebuur , Ronaldus Wilhelmus Hommes , Slavko Kralj , Paulien Kruithof , Igor Nikolaev , Wilhelmus Antonious Hendricus Van Der Kley , Johannes Franciscus Thomas Van Lieshout , Sander Van Stigt Thans , Gudrun Vogtentanz , Mats Sandgren
发明人： Richard R. Bott , Thijs Kaper , Bradley Kelemen , Frits Goedegebuur , Ronaldus Wilhelmus Hommes , Slavko Kralj , Paulien Kruithof , Igor Nikolaev , Wilhelmus Antonious Hendricus Van Der Kley , Johannes Franciscus Thomas Van Lieshout , Sander Van Stigt Thans , Gudrun Vogtentanz , Mats Sandgren
IPC分类号： A61K38/47 , C12N9/42 , C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： C12N9/2445 , C12N15/52 , C12P19/02 , C12P19/14 , C12Y302/01021
摘要： The present disclosure is generally directed to enzymes and in particular beta-glucosidase variants. Also described are nucleic acids encoding beta-glucosidase variants, compositions comprising beta-glucosidase variants, methods of using beta-glucosidase variants, and methods of identifying additional useful beta-glucosidase variants.
摘要翻译：本公开通常涉及酶，特别是β-葡糖苷酶变体。还描述了编码β-葡糖苷酶变体的核酸，包含β-葡糖苷酶变体的组合物，使用β-葡糖苷酶变体的方法和鉴定另外有用的β-葡糖苷酶变体的方法。

6. 发明申请

US20130143301A1 BETA-GLUCOSIDASE I VARIANTS WITH IMPROVED PROPERTIES 有权
标题翻译：具有改善性质的β-GLUCOSIDASE I变体
公开(公告)号：US20130143301A1
公开(公告)日：2013-06-06
申请号：US13510902
申请日：2010-11-19
申请人： Richard R. Bott , Thijs Kaper , Bradley Kelemen , Frits Goedegebuur , Ronaldus Hommes , Slavko Kralj , Paulien Kruithof , Igor Nikolaev
发明人： Richard R. Bott , Thijs Kaper , Bradley Kelemen , Frits Goedegebuur , Ronaldus Hommes , Slavko Kralj , Paulien Kruithof , Igor Nikolaev
IPC分类号： C12N9/24
CPC分类号： C12N9/2445 , C12N15/52 , C12P19/02 , C12P19/14 , C12Y302/01021
摘要： The present disclosure is generally directed to enzymes and in particular beta-glucosidase variants. Also described are nucleic acids encoding beta-glucosidase variants, compositions comprising beta-glucosidase variants, methods of using beta-glucosidase variants, and methods of identifying additional useful beta-glucosidase variants.
摘要翻译：本公开通常涉及酶，特别是β-葡糖苷酶变体。还描述了编码β-葡糖苷酶变体的核酸，包含β-葡糖苷酶变体的组合物，使用β-葡糖苷酶变体的方法和鉴定另外有用的β-葡糖苷酶变体的方法。

7. 发明授权

US5346823A Subtilisin modifications to enhance oxidative stability 失效
标题翻译：枯草杆菌蛋白酶修饰以增强氧化稳定性
公开(公告)号：US5346823A
公开(公告)日：1994-09-13
申请号：US36592
申请日：1993-03-24
申请人： David A. Estell , James A. Wells , Richard R. Bott
发明人： David A. Estell , James A. Wells , Richard R. Bott
IPC分类号： C11D3/386 , C12N9/54 , C12N15/10 , C12N15/75 , C12N15/00 , C12N15/11 , C12N15/57
CPC分类号： C12R1/07 , C11D3/386 , C12N15/102 , C12N15/75 , C12N9/54
摘要： There are provided methods for making a mutant Bacillus subtilisin having altered oxidative stability, the methods comprising obtaining DNA fragment consisting of a region coding for a Bacillus subtilisin, and introducing a mutation into said DNA fragment such that the mutation is introduced in a region encoding a methionine, tryptophan, cysteine or lysine, sensitive to oxidation, such that upon expression of the mutant subtilisin one or more codon regions encoding for methionine, tryptophan, cysteine or lysine is replaced with an amino acid other than methionine, tryptophan, cysteine or lysine, preferably alanine or serine.
摘要翻译：提供了制备具有改变的氧化稳定性的突变型枯草杆菌蛋白酶的方法，所述方法包括获得由编码枯草杆菌蛋白酶的区域组成的DNA片段，并将突变引入所述DNA片段，使得突变引入到编码敏感的蛋氨酸，色氨酸，半胱氨酸或赖氨酸，使得突变型枯草杆菌蛋白酶表达后，编码甲硫氨酸，色氨酸，半胱氨酸或赖氨酸的一个或多个密码子区域被甲硫氨酸，色氨酸，半胱氨酸或赖氨酸以外的氨基酸替代，优选丙氨酸或丝氨酸。

8. 再颁专利

USRE34606E Modified enzymes and methods for making same 失效
标题翻译：改性酶及其制备方法
公开(公告)号：USRE34606E
公开(公告)日：1994-05-10
申请号：US556918
申请日：1990-07-20
申请人： David A. Estell , James A. Wells , Richard R. Bott
发明人： David A. Estell , James A. Wells , Richard R. Bott
IPC分类号： C11D3/386 , C12N9/54 , C12N15/10 , C12N15/75 , C12R1/07 , C12N9/56 , C12N15/03 , C12P19/34
CPC分类号： C12R1/07 , C11D3/386 , C12N15/102 , C12N15/75 , C12N9/54
摘要： A cloned subtilsin gene has been modified at specific sites to cause amino acid substitutions at certain spots in the enzyme. The modified enzyme, preferably produced by Bacillus, is useful in combination with detergents.
摘要翻译：已经在特定位点修饰了克隆的subtilisin基因，以在酶中的某些点处引起氨基酸取代。优选由芽孢杆菌产生的修饰酶可与洗涤剂组合使用。

9. 发明申请

US20110086412A1 Multiply-Substituted Protease Variants 审中-公开
标题翻译：多重取代的蛋白酶变体
公开(公告)号：US20110086412A1
公开(公告)日：2011-04-14
申请号：US12776932
申请日：2010-05-10
申请人： Ayrookaran J. Poulose , David A. Estell , James T. Kellis, JR. , Richard R. Bott
发明人： Ayrookaran J. Poulose , David A. Estell , James T. Kellis, JR. , Richard R. Bott
IPC分类号： C12N9/50 , C12N15/57 , C12N15/63 , C12N1/00
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38609 , C12Y304/21062
摘要： Novel enzyme variants including protease variants derived from the DNA sequences of naturally-occurring or recombinant non-human proteases are disclosed. The variant proteases, in general, are obtained by in vitro modification of a precursor DNA sequence encoding the naturally-occurring or recombinant protease to generate the substitution of a plurality of amino acid residues in the amino acid sequence of a precursor protease. Such variant proteases have properties which are different from those of the precursor protease, such as altered wash performance. The substituted amino acid residue correspond to positions 27, 45, 170, 181, 251 and 271 of Bacillus amyloliquefaciens subtilisin. Additional variants comprising at least one additional substitution at a position selected from 1, 14, 49, 61, 87, 100, 102, 118, 128, 204 and 258 of Bacillus amyloliquefaciens subtilisin are also described.
摘要翻译：公开了包含衍生自天然或重组非人蛋白酶的DNA序列的蛋白酶变体的新型酶变体。一般来说，变体蛋白酶通过体外修饰编码天然存在或重组蛋白酶的前体DNA序列获得，以产生前体蛋白酶的氨基酸序列中的多个氨基酸残基的取代。这种变体蛋白酶具有与前体蛋白酶不同的性质，例如改变的洗涤性能。取代的氨基酸残基对应于解淀粉芽孢杆菌枯草杆菌蛋白酶的位置27,45,170,181,251和271。还描述了包含在解淀粉芽孢杆菌枯草杆菌蛋白酶的1,4,14,69,61,87,100,102,118,128,204和258的位置上的至少一个另外的取代的其它变体。

10. 发明授权

US07306937B2 Multiply-substituted protease variants 有权
标题翻译：多重取代的蛋白酶变体
公开(公告)号：US07306937B2
公开(公告)日：2007-12-11
申请号：US10500943
申请日：2003-01-16
申请人： Ayrookaran J. Poulose , David A Estell , James T Kellis, Jr. , Richard R. Bott
发明人： Ayrookaran J. Poulose , David A Estell , James T Kellis, Jr. , Richard R. Bott
IPC分类号： C12N9/52 , C12N9/54 , C12N15/57 , C12N15/74 , C11D3/386
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38609 , C12Y304/21062
摘要： Novel enzyme variants including protease variants derived from the DNA sequences of naturally-occurring or re-combinant non-human proteases are disclosed. The variant proteases, in general, are obtained by in vitro modification of a precursor DNA sequence encoding the naturally-occurring or recombinant protease to generate the substitution of a plurality of amino acid residues in the amino acid sequence of a precursor protease. Such variant proteases have properties which are different from those of the precursor protease, such as altered wash performance. The substituted amino acid residue correspond to positions 27, 45, 170, 181, 251 and 271 of Bacillus amyloliquefaciens subtilisin. Additional variants comprising at least one additional substitution at a position selected from 1, 14, 49, 61, 87, 100, 102, 118, 128, 204 and 258 of Bacillus amyloliquefaciens subtilisin are also described.
摘要翻译：公开了包含衍生自天然存在或重组非人蛋白酶的DNA序列的蛋白酶变体的新型酶变体。一般来说，变体蛋白酶通过体外修饰编码天然存在或重组蛋白酶的前体DNA序列获得，以产生前体蛋白酶的氨基酸序列中的多个氨基酸残基的取代。这种变体蛋白酶具有与前体蛋白酶不同的性质，例如改变的洗涤性能。取代的氨基酸残基对应于解淀粉芽孢杆菌枯草杆菌蛋白酶的位置27,45,170,181,251和271。还描述了包含在解淀粉芽孢杆菌枯草杆菌蛋白酶的1,4,14,69,61,87,100,102,118,128,204和258的位置上的至少一个另外的取代的其它变体。

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