专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

61. 发明申请

US20060019247A1 METHOD AND APPARATUS FOR NUCLEIC ACID SEQUENCING AND IDENTIFICATION 有权
标题翻译：用于核酸序列和鉴定的方法和装置
公开(公告)号：US20060019247A1
公开(公告)日：2006-01-26
申请号：US10153125
申请日：2002-05-20
申请人： Xing Su , Andrew Berlin
发明人： Xing Su , Andrew Berlin
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： G01N33/48721 , B01L3/5027 , B82Y30/00 , C12Q1/6869 , C12Q2565/631 , C12Q2563/155 , C12Q2527/113
摘要： The methods and apparatus 100 disclosed herein are of use for sequencing and/or identifying nucleic acids 230, 310. Nucleic acids 230, 310 containing labeled nucleotides 235, 245, 315 may be synthesized and passed through nanopores 255, 310. Detectors 257, 345 operably coupled to the nanopores 255, 310 may detect the labeled nucleotides 235, 245, 315. By determining the time intervals at which labeled nucleotides 235, 245, 315 are detected, distance maps 140 for each type of labeled nucleotide 235, 245, 315 may be compiled. The distance maps 140 in turn may be used to sequence 150 and/or identify 160 the nucleic acid 230, 310. In different embodiments of the invention, luminescent nucleotides 235, 245 or nanoparticles 315 may be detected using photodetectors 257 or electrical detectors 310. Apparatus 100 and sub-devices 200, 300 of use for nucleic acid 230, 310 sequencing 150 and/or identification 160 are also disclosed herein.
摘要翻译：本文公开的方法和装置100可用于测序和/或鉴定核酸230,310。可以合成含有标记核苷酸235,245,315的核酸230,310并通过纳米孔255,310。可操作地偶联到纳米孔255,310的检测器257,345可以检测标记的核苷酸235,245,315。通过确定检测到标记的核苷酸235,245,315的时间间隔，每种类型的标记核苷酸235的距离图140 ，245,315可以编译。距离图140依次可用于对核酸230,310进行序列150和/或识别160.在本发明的不同实施方案中，可以使用光电探测器257或电检测器310检测发光核苷酸235,245或纳米粒子315。本文还公开了用于核酸230,310测序150和/或识别160的装置100和子装置200,300。

62. 发明申请

US20050202468A1 Nucleic acid sequencing by Raman monitoring of uptake of nucleotides during molecular replication 审中-公开
标题翻译：通过拉曼监测分子复制过程中核苷酸摄取的核酸测序
公开(公告)号：US20050202468A1
公开(公告)日：2005-09-15
申请号：US11020776
申请日：2004-12-23
申请人： Tae-Woong Koo , Andrew Berlin , Selena Chan , Xing Su , Narayanan Sundararajan , Lei Sun
发明人： Tae-Woong Koo , Andrew Berlin , Selena Chan , Xing Su , Narayanan Sundararajan , Lei Sun
IPC分类号： C12Q1/68 , G01N21/65
CPC分类号： G01N21/658 , C12Q1/6869 , C12Q2565/632 , C12Q2533/101
摘要： The methods and apparatus disclosed herein are useful for detecting nucleotides, nucleosides, and bases and for nucleic acid sequence determination. The methods involve detection of a nucleotide, nucleoside, or base using surface enhanced Raman spectroscopy (SERS) or surface enhanced coherent anti-Stokes Raman spectroscopy (SECARS). The detection can be part of a nucleic acid sequencing reaction to detect uptake of a deoxynucleotide triphosphate during a nucleic acid polymerization reaction, such as a nucleic acid sequencing reaction. The nucleic acid sequence of a synthesized nascent strand, and the complementary sequence of the template strand, can be determined by tracking the order of incorporation of nucleotides during the polymerization reaction. Methods for enhancing the SERS signal of a nucleotide or nucleoside by cleaving the base from a sugar moiety are provided. Furthermore, methods for detecting single base repeats are provided.
摘要翻译：本文公开的方法和装置可用于检测核苷酸，核苷和碱基并用于核酸序列测定。该方法涉及使用表面增强拉曼光谱（SERS）或表面增强相干抗斯托克斯拉曼光谱（SECARS）检测核苷酸，核苷或碱基。检测可以是在核酸聚合反应（例如核酸测序反应）期间检测脱氧核苷酸三磷酸的摄取的核酸测序反应的一部分。合成的新生链的核酸序列和模板链的互补序列可以通过跟踪在聚合反应期间核苷酸掺入的顺序来确定。提供了通过从糖部分切割碱来增强核苷酸或核苷的SERS信号的方法。此外，提供了用于检测单碱基重复的方法。

63. 发明申请

US20050148100A1 Methods and devices for using Raman-active probe constructs to assay biological samples 审中-公开
标题翻译：使用拉曼活性探针构建体测定生物样品的方法和装置
公开(公告)号：US20050148100A1
公开(公告)日：2005-07-07
申请号：US10750301
申请日：2003-12-30
申请人： Xing Su , Andrew Berlin , Tae-Woong Koo , Selena Chan , Lei Sun
发明人： Xing Su , Andrew Berlin , Tae-Woong Koo , Selena Chan , Lei Sun
IPC分类号： C12Q1/68 , G01J3/44 , G01N21/55 , G01N21/65 , G01N33/543 , G01N33/553 , G01N33/68 , G01N33/53
CPC分类号： G01N21/658 , B82Y5/00 , B82Y10/00 , B82Y20/00 , C12Q1/6816 , C12Q1/6834 , G01N33/543 , G01N33/68 , G01N33/6818 , G01N2021/653 , G01N2021/655 , G01N2021/656 , C12Q2565/125 , C12Q2565/632
摘要： Various methods of using Raman-active or SERS-active probe constructs to detect analytes in biological samples, such as the protein-containing analytes in a body fluid are provided. The probe moieties in the Raman-active constructs are selected to bind to and identify specific known analytes in the biological sample or the probe moieties are designed to chemically interact with functional groups commonly found in certain amino acids so that the invention methods provide information about the amino acid composition of protein-containing analytes or fragments in the samples. In some cases, the Raman-active or SERS-active probe constructs, when used in the invention methods, can identify particular protein-containing analytes or types of such analytes so that a protein profile of a patient sample can be made. When compared to a data base of Raman or SERS spectra of normal samples, a disease state of a patient can be identified using the methods disclosed.
摘要翻译：提供了使用拉曼活性或SERS-活性探针构建体检测生物样品中的分析物的各种方法，例如体液中含蛋白质的分析物。选择拉曼活性构建体中的探针部分以结合并识别生物样品中的特定已知分析物，或者将探针部分设计为与通常在某些氨基酸中发现的官能团进行化学相互作用，使得本发明方法提供关于样品中含蛋白质的分析物或片段的氨基酸组成。在一些情况下，当用于本发明方法时，拉曼活性或SERS-活性探针构建体可以鉴定特定的含蛋白质的分析物或类型的这种分析物，使得可以制备患者样品的蛋白质谱。当与正常样品的拉曼或SERS光谱的数据库相比时，可以使用所公开的方法鉴定患者的疾病状态。

64. 发明申请

US20050147979A1 Nucleic acid sequencing by Raman monitoring of uptake of nucleotides during molecular replication 审中-公开
公开(公告)号：US20050147979A1
公开(公告)日：2005-07-07
申请号：US10749527
申请日：2003-12-30
申请人： Tae-Woong Koo , Andrew Berlin , Selena Chan , Xing Su , Narayanan Sundararajan , Lei Sun
发明人： Tae-Woong Koo , Andrew Berlin , Selena Chan , Xing Su , Narayanan Sundararajan , Lei Sun
IPC分类号： C12Q1/68 , G01N21/65 , C12P19/34
CPC分类号： G01N21/658 , C12Q1/6869 , C12Q2565/632 , C12Q2533/101
摘要： The methods and apparatus disclosed herein are useful for detecting nucleotides, nucleosides, and bases and for nucleic acid sequence determination. The methods involve detection of a nucleotide, nucleoside, or base using surface enhanced Raman spectroscopy (SERS) or surface enhanced coherent anti-Stokes Raman spectroscopy (SECARS). The detection can be part of a nucleic acid sequencing reaction to detect uptake of a deoxynucleotide triphosphate during a nucleic acid polymerization reaction, such as a nucleic acid sequencing reaction. The nucleic acid sequence of a synthesized nascent strand, and the complementary sequence of the template strand, can be determined by tracking the order of incorporation of nucleotides during the polymerization reaction. Methods for enhancing the SERS signal of a nucleotide or nucleoside by cleaving the base from a sugar moiety are provided. Furthermore, methods for detecting single base repeats are provided.

65. 发明申请

US20050142567A1 Composite organic-inorganic nanoparticles and methods for use thereof 审中-公开
标题翻译：复合有机 - 无机纳米颗粒及其使用方法
公开(公告)号：US20050142567A1
公开(公告)日：2005-06-30
申请号：US10830422
申请日：2004-04-21
申请人： Xing Su , Jingwu Zhang , Lei Sun , Andrew Berlin
发明人： Xing Su , Jingwu Zhang , Lei Sun , Andrew Berlin
IPC分类号： G01N21/65 , G01N33/543 , C12Q1/68 , G01N33/553
CPC分类号： G01N33/54346 , G01N21/6428 , G01N21/6458 , G01N21/658 , G01N2021/6482 , G01N2021/653 , G01N2021/655 , G01N2021/656
摘要： Composite organic-inorganic nanoparticles (COIN) and clusters of such nanoparticles are provided that produce surface-enhanced Raman signals when excited by a laser. The nanoparticles include metallic colloids and a Raman-active organic compound. The metal required for achieving a suitable SERS signal is inherent in the nanoparticle, and a wide variety of Raman-active organic compounds can be incorporated into the particle. Methods for producing the nanoparticles and clusters of nanoparticles are also provided. In addition, polymeric microspheres containing the nanoparticles and clusters of nanoparticles and methods of making them are also provided. Methods for using the nanoparticles, clusters, and microspheres in assays for multiplex detection of biological molecules do not require signal amplification techniques.
摘要翻译：提供复合有机 - 无机纳米颗粒（COIN）和这种纳米颗粒的簇，当激光激发时产生表面增强的拉曼信号。纳米颗粒包括金属胶体和拉曼活性有机化合物。实现合适的SERS信号所需的金属在纳米颗粒中是固有的，并且可以将多种拉曼活性有机化合物掺入颗粒中。还提供了制备纳米颗粒和纳米颗粒簇的方法。此外，还提供了包含纳米颗粒和纳米颗粒簇的聚合物微球及其制备方法。在用于多重检测生物分子的测定中使用纳米颗粒，簇和微球的方法不需要信号放大技术。

66. 发明授权

US10163195B2 Spatio-temporal differential synthesis ofdetail images for high dynamic range imaging 有权
公开(公告)号：US10163195B2
公开(公告)日：2018-12-25
申请号：US14968762
申请日：2015-12-14
申请人： Andrew Berlin , Rajeev Surati
发明人： Andrew Berlin , Rajeev Surati
IPC分类号： G06K9/00 , G06T5/00 , G06T5/50 , H04N5/232 , H04N5/235
摘要： An image acquisition apparatus configured to receive an adjustable image acquisition parameter, wherein said parameter is adjusted based on an image that has had its subject selectively enhanced via comparison with at least one background reference image.

67. 发明申请

US20170352131A1 SPATIO-TEMPORAL DIFFERENTIAL SYNTHESIS OFDETAIL IMAGES FOR HIGH DYNAMIC RANGE IMAGING 审中-公开
公开(公告)号：US20170352131A1
公开(公告)日：2017-12-07
申请号：US14968762
申请日：2015-12-14
申请人： Andrew Berlin , Rajeev Surati
发明人： Andrew Berlin , Rajeev Surati
IPC分类号： G06T5/00 , G06T5/50
CPC分类号： G06T5/001 , G06T5/50 , G06T2207/10024 , G06T2207/10028 , G06T2207/10144 , G06T2207/10148 , G06T2207/20208 , G06T2207/20221 , G06T2207/20224 , H04N5/23222 , H04N5/2355
摘要： An image acquisition apparatus configured to receive an adjustable image acquisition parameter, wherein said parameter is adjusted based on an image that has had its subject selectively enhanced via comparison with at least one background reference image.

68. 发明授权

US08852955B2 Methods and systems for detecting biomolecular binding using terahertz radiation 有权
标题翻译：用太赫兹辐射检测生物分子结合的方法和系统
公开(公告)号：US08852955B2
公开(公告)日：2014-10-07
申请号：US12753946
申请日：2010-04-05
申请人： Tae-Woong Koo , Andrew Berlin , Ken Salsman , Brian Ostrovsky
发明人： Tae-Woong Koo , Andrew Berlin , Ken Salsman , Brian Ostrovsky
IPC分类号： G01N33/543 , G01N21/65 , G01N21/77 , C12Q1/68 , G01N21/35 , B01L3/00
CPC分类号： G01N21/65 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00639 , B01J2219/00722 , B01L3/5027 , C12Q1/6825 , G01N21/3581 , G01N21/7743 , G01N33/54373 , G01N2021/651 , C12Q2545/114 , C12Q2523/313
摘要： Provided herein are methods and systems for detecting biomolecular binding events using gigahertz or terahertz radiation. The methods and systems use low-energy spectroscopy to detect biomolecular binding events between molecules in an aqueous solution. The detected biomolecular binding events include, for example, nucleic acid hybridizations, antibody/antigen binding, and receptor/ligand binding.
摘要翻译：本文提供了使用千兆兹或太赫兹辐射检测生物分子结合事件的方法和系统。该方法和系统使用低能谱来检测水溶液中分子之间的生物分子结合事件。检测到的生物分子结合事件包括例如核酸杂交，抗体/抗原结合和受体/配体结合。

69. 发明授权

US08167395B2 Apparatus and methods for servicing 3D printers 有权
标题翻译：维修3D打印机的设备和方法
公开(公告)号：US08167395B2
公开(公告)日：2012-05-01
申请号：US12907354
申请日：2010-10-19
申请人： William J. Fienup , Andrew Berlin , Andres T. Hernandez , Joshua P. Kinsley , Walter H. Zengerle, III
发明人： William J. Fienup , Andrew Berlin , Andres T. Hernandez , Joshua P. Kinsley , Walter H. Zengerle, III
IPC分类号： B41J29/38
CPC分类号： B41J29/393 , B29C64/112 , B33Y40/00 , B41J2/16532 , B41J2/16538 , B41J2/16552 , B41J2/1752 , B41J3/4073 , H04N1/6033
摘要： The invention relates to apparatus and methods for producing three-dimensional objects and auxiliary systems used in conjunction with the aforementioned apparatus and methods. The apparatus and methods involve 3D printing and servicing of the equipment used in the associated 3D printer.
摘要翻译：本发明涉及与上述装置和方法结合使用的用于制造三维物体和辅助系统的装置和方法。该设备和方法涉及3D相关3D打印机中使用的设备的3D打印和维修。

70. 发明授权

US07969472B2 Automatic camera steering control and video conferencing 有权
标题翻译：自动摄像机转向控制和视频会议
公开(公告)号：US07969472B2
公开(公告)日：2011-06-28
申请号：US10063172
申请日：2002-03-27
申请人： David K. Biegelsen , Andrew Berlin
发明人： David K. Biegelsen , Andrew Berlin
IPC分类号： H04N7/14 , H04N5/232 , H04N5/225
CPC分类号： H04N7/15 , H04L12/1827
摘要： An automatic camera steering control for directing video conferences including a communicator with a microphone and a voice activated LED emitter. Cameras receive an LED signal transmitted by the LED emitter and focus on the speaker associated with the activated LED emitter. A controller automatically selects and inserts into the video stream the audio and video of the speaker.
摘要翻译：一种用于引导视频会议的自动相机转向控制，包括具有麦克风的通信器和声音激活的LED发射器。摄像机接收由LED发射器传输的LED信号，并聚焦在与激活的LED发射器相关的扬声器上。控制器自动选择并插入到视频流中，扬声器的音频和视频。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式