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1. 发明申请

US20050191665A1 Composite organic-inorganic nanoclusters 审中-公开
标题翻译：复合有机 - 无机纳米团簇
公开(公告)号：US20050191665A1
公开(公告)日：2005-09-01
申请号：US11021682
申请日：2004-12-23
申请人： Xing Su , Jingwu Zhang , Lei Sun , Andrew Berlin
发明人： Xing Su , Jingwu Zhang , Lei Sun , Andrew Berlin
IPC分类号： G01N21/65 , G01N33/543 , C12Q1/68 , G01J3/44 , G01N33/553
CPC分类号： G01N33/54346 , G01N21/658
摘要： Composite organic-inorganic nanoclusters (COINs) are provided that produce surface-enhanced Raman signals (SERS) when excited by a laser. The nanoclusters include metal particles and a Raman-active organic compound. The metal required for achieving a suitable SERS signal is inherent in the nanocluster and a wide variety of Raman-active organic compounds and combinations thereof can be incorporated into the nanocluster. In addition, polymeric microspheres containing the nanoclusters and methods of making them are also provided. The nanoclusters and microspheres can be used, for example, in assays for multiplex detection of biological molecules.
摘要翻译：提供了复合有机 - 无机纳米团簇（COINs），当激光激发时产生表面增强拉曼信号（SERS）。纳米团簇包括金属颗粒和拉曼活性有机化合物。实现合适的SERS信号所需的金属在纳米簇中是固有的，并且可以将多种拉曼活性有机化合物及其组合掺入纳米团簇中。此外，还提供了含有纳米簇的聚合物微球及其制备方法。纳米团簇和微球可用于例如用于多重检测生物分子的测定中。

2. 发明申请

US20050147963A1 Composite organic-inorganic nanoparticles and methods for use thereof 审中-公开
标题翻译：复合有机 - 无机纳米颗粒及其使用方法
公开(公告)号：US20050147963A1
公开(公告)日：2005-07-07
申请号：US10748336
申请日：2003-12-29
申请人： Xing Su , Jingwu Zhang , Lei Sun , Andrew Berlin
发明人： Xing Su , Jingwu Zhang , Lei Sun , Andrew Berlin
IPC分类号： G01N21/65 , G01N33/543 , C12Q1/70 , C12M1/34 , C12Q1/68
CPC分类号： G01N33/54346 , G01N21/6428 , G01N21/6458 , G01N21/658 , G01N2021/6482 , G01N2021/653 , G01N2021/655 , G01N2021/656
摘要： Composite organic-inorganic nanoparticles (COIN) are provided that produce surface-enhanced Raman signals when excited by a laser. The nanoparticles include metallic colloids and a Raman-active organic compound. The metal required for achieving a suitable SERS signal is inherent in the nanoparticle, and a wide variety of Raman-active organic compounds can be incorporated into the particle. Indeed, a large number of unique Raman signatures can be created by employing nanoparticles containing Raman-active organic compounds of different structures, mixtures, and ratios. Thus, nanoparticles and methods described herein are useful for the simultaneous detection of many analytes in a mixture, resulting in rapid qualitative analysis of a mixture. In addition, since many Raman-active organic compounds can be incorporated into a single nanoparticle, the SERS signal from a single COIN particle is strong relative to SERS signals obtained from Raman-active materials that do not contain the nanoparticles described herein.
摘要翻译：提供了复合有机 - 无机纳米粒子（COIN），当激光激发时产生表面增强的拉曼信号。纳米颗粒包括金属胶体和拉曼活性有机化合物。实现合适的SERS信号所需的金属在纳米颗粒中是固有的，并且可以将多种拉曼活性有机化合物掺入颗粒中。实际上，通过使用含有不同结构，混合物和比例的拉曼活性有机化合物的纳米颗粒，可以产生大量独特的拉曼特征。因此，本文所述的纳米颗粒和方法可用于同时检测混合物中的许多分析物，导致混合物的快速定性分析。另外，由于许多拉曼活性有机化合物可以并入单个纳米颗粒中，所以来自单个COIN颗粒的SERS信号相对于不含本文所述纳米颗粒的拉曼活性材料获得的SERS信号是强的。

3. 发明申请

US20050142567A1 Composite organic-inorganic nanoparticles and methods for use thereof 审中-公开
标题翻译：复合有机 - 无机纳米颗粒及其使用方法
公开(公告)号：US20050142567A1
公开(公告)日：2005-06-30
申请号：US10830422
申请日：2004-04-21
申请人： Xing Su , Jingwu Zhang , Lei Sun , Andrew Berlin
发明人： Xing Su , Jingwu Zhang , Lei Sun , Andrew Berlin
IPC分类号： G01N21/65 , G01N33/543 , C12Q1/68 , G01N33/553
CPC分类号： G01N33/54346 , G01N21/6428 , G01N21/6458 , G01N21/658 , G01N2021/6482 , G01N2021/653 , G01N2021/655 , G01N2021/656
摘要： Composite organic-inorganic nanoparticles (COIN) and clusters of such nanoparticles are provided that produce surface-enhanced Raman signals when excited by a laser. The nanoparticles include metallic colloids and a Raman-active organic compound. The metal required for achieving a suitable SERS signal is inherent in the nanoparticle, and a wide variety of Raman-active organic compounds can be incorporated into the particle. Methods for producing the nanoparticles and clusters of nanoparticles are also provided. In addition, polymeric microspheres containing the nanoparticles and clusters of nanoparticles and methods of making them are also provided. Methods for using the nanoparticles, clusters, and microspheres in assays for multiplex detection of biological molecules do not require signal amplification techniques.
摘要翻译：提供复合有机 - 无机纳米颗粒（COIN）和这种纳米颗粒的簇，当激光激发时产生表面增强的拉曼信号。纳米颗粒包括金属胶体和拉曼活性有机化合物。实现合适的SERS信号所需的金属在纳米颗粒中是固有的，并且可以将多种拉曼活性有机化合物掺入颗粒中。还提供了制备纳米颗粒和纳米颗粒簇的方法。此外，还提供了包含纳米颗粒和纳米颗粒簇的聚合物微球及其制备方法。在用于多重检测生物分子的测定中使用纳米颗粒，簇和微球的方法不需要信号放大技术。

4. 发明授权

US08062841B2 Multiplex data collection and analysis in bioanalyte detection 有权
标题翻译：生物分析仪检测中的多重数据收集和分析
公开(公告)号：US08062841B2
公开(公告)日：2011-11-22
申请号：US12147440
申请日：2008-06-26
申请人： Xing Su , Lei Sun , Mineo Yamakawa , Jingwu Zhang , Qing Ma , Tae-Woong Koo , Richard Jones
发明人： Xing Su , Lei Sun , Mineo Yamakawa , Jingwu Zhang , Qing Ma , Tae-Woong Koo , Richard Jones
IPC分类号： C12Q1/68 , G01N33/53 , C07H21/02 , C07H21/04 , C07K14/00
CPC分类号： G01N33/53 , B82Y15/00 , B82Y30/00 , G01N33/54366 , G01N33/5438
摘要： Method and device to collect multiplex data simultaneously in analyte detection and analyze the data by experimentally trained software (machine-learning) is disclosed. Various ways (magnetic particles and microcoils) are disclosed to collect multiple reporter (tag) signals. Multiplex detection can increase the biomolecule analysis efficiency by using small sample size and saving assay reagents and time. Machine learning and data analysis schemes are also disclosed. Multiple affinity binding partners, each labeled by a unique reporter, are contacted with a sample and a single spectrum is taken to detect multiple reporter signals. The spectrum is deconvoluted by experimentally trained software to identify multiple analytes.
摘要翻译：公开了通过实验训练的软件（机器学习）在分析物检测中同时收集多重数据并分析数据的方法和装置。公开了各种方式（磁性颗粒和微型线圈）以收集多个报道（标签）信号。多重检测可以通过使用小样本量和节省测定试剂和时间来增加生物分子分析效率。还披露了机器学习和数据分析方案。将多个亲和力结合配偶体（每个由唯一报道分子标记）与样品接触，并采用单个谱来检测多个报道信号。通过实验训练的软件对光谱进行去卷积，以识别多个分析物。

5. 发明授权

US07351591B2 Surface modification of metals for biomolecule detection using surface enhanced Raman scattering (SERS) 有权
公开(公告)号：US07351591B2
公开(公告)日：2008-04-01
申请号：US10814695
申请日：2004-03-30
申请人： Tae-Woong Koo , Selena Chan , Xing Su , Jingwu Zhang , Lei Sun
发明人： Tae-Woong Koo , Selena Chan , Xing Su , Jingwu Zhang , Lei Sun
IPC分类号： G01N33/553
CPC分类号： G01N21/658
摘要： The present invention is based on the discovery that the methods described herein for the production of metallic colloids result in colloids exhibiting increased signal enhancement and reproducibility for the SERS detection of biomolecules. Thus, using the methods of the invention, a wide variety of biomolecules can be detected with a greater sensitivity and reliability.

6. 发明申请

US20100240870A1 Composite organic-inorganic nanoclusters 审中-公开
标题翻译：复合有机 - 无机纳米团簇
公开(公告)号：US20100240870A1
公开(公告)日：2010-09-23
申请号：US12658414
申请日：2010-02-10
申请人： Xing Su , Jingwu Zhang , Lei Sun , Andrew A. Berlin
发明人： Xing Su , Jingwu Zhang , Lei Sun , Andrew A. Berlin
IPC分类号： C07K14/765 , C07F1/10 , C07F15/00 , C07F5/06 , C07F1/12 , C07F1/08 , C07K16/00 , C07K14/00 , C07H21/00 , C07H23/00
CPC分类号： G01N33/54346 , G01N21/658
摘要： Composite organic-inorganic nanoclusters (COINs) are provided that produce surface-enhanced Raman signals (SERS) when excited by a laser. The nanoclusters include metal particles and a Raman-active organic compound. The metal required for achieving a suitable SERS signal is inherent in the nanocluster and a wide variety of Raman-active organic compounds and combinations thereof can be incorporated into the nanocluster. In addition, polymeric microspheres containing the nanoclusters and methods of making them are also provided. The nanoclusters and microspheres can be used, for example, in assays for multiplex detection of biological molecules.
摘要翻译：提供了复合有机 - 无机纳米团簇（COINs），当激光激发时产生表面增强拉曼信号（SERS）。纳米团簇包括金属颗粒和拉曼活性有机化合物。实现合适的SERS信号所需的金属在纳米簇中是固有的，并且可以将多种拉曼活性有机化合物及其组合掺入纳米团簇中。此外，还提供了含有纳米簇的聚合物微球及其制备方法。纳米团簇和微球可用于例如用于多重检测生物分子的测定中。

7. 发明申请

US20080262989A1 MULTIPLEX DATA COLLECTION AND ANALYSIS IN BIOANALYTE DETECTION 审中-公开
标题翻译：多元数据收集与分析在生物检测中的应用
公开(公告)号：US20080262989A1
公开(公告)日：2008-10-23
申请号：US12147243
申请日：2008-06-26
申请人： Xing Su , Lei Sun , Mineo Yamakawa , Jingwu Zhang , Qing Ma , Tae-Woong Koo , Richard Jones
发明人： Xing Su , Lei Sun , Mineo Yamakawa , Jingwu Zhang , Qing Ma , Tae-Woong Koo , Richard Jones
IPC分类号： G06F17/50
CPC分类号： G01N33/53 , B82Y15/00 , B82Y30/00 , G01N33/54366 , G01N33/5438
摘要： Method and device to collect multiplex data simultaneously in analyte detection and analyze the data by experimentally trained software (machine-learning) is disclosed. Various ways (magnetic particles and microcoils) are disclosed to collect multiple reporter (tag) signals. Multiplex detection can increase the biomolecule analysis efficiency by using small sample size and saving assay reagents and time. Machine learning and data analysis schemes are also disclosed. Multiple affinity binding partners, each labeled by a unique reporter, are contacted with a sample and a single spectrum is taken to detect multiple reporter signals. The spectrum is deconvoluted by experimentally trained software to identify multiple analytes.
摘要翻译：公开了通过实验训练的软件（机器学习）在分析物检测中同时收集多重数据并分析数据的方法和装置。公开了各种方式（磁性颗粒和微型线圈）以收集多个报道（标签）信号。多重检测可以通过使用小样本量和节省测定试剂和时间来增加生物分子分析效率。还披露了机器学习和数据分析方案。将多个亲和力结合配偶体（每个由唯一报道分子标记）与样品接触，并采用单个谱来检测多个报道信号。通过实验训练的软件对光谱进行去卷积，以识别多个分析物。

8. 发明授权

US07410763B2 Multiplex data collection and analysis in bioanalyte detection 有权
标题翻译：生物分析仪检测中的多重数据收集和分析
公开(公告)号：US07410763B2
公开(公告)日：2008-08-12
申请号：US11216112
申请日：2005-09-01
申请人： Xing Su , Lei Sun , Mineo Yamakawa , Jingwu Zhang , Qing Ma , Tae-Woong Koo , Richard Jones
发明人： Xing Su , Lei Sun , Mineo Yamakawa , Jingwu Zhang , Qing Ma , Tae-Woong Koo , Richard Jones
IPC分类号： C12Q1/68 , G01N33/53 , C12M1/00
CPC分类号： G01N33/53 , B82Y15/00 , B82Y30/00 , G01N33/54366 , G01N33/5438
摘要： Method and device to collect multiplex data simultaneously in analyte detection and analyze the data by experimentally trained software (machine-learning) is disclosed. Various ways (magnetic particles and microcoils) are disclosed to collect multiple reporter (tag) signals. Multiplex detection can increase the biomolecule analysis efficiency by using small sample size and saving assay reagents and time. Machine learning and data analysis schemes are also disclosed. Multiple affinity binding partners, each labeled by a unique reporter, are contacted with a sample and a green spectrum is taken to detect multiple reporter signals. The spectrum is deconvoluted by experimentally trained software to identify multiple analytes.
摘要翻译：公开了通过实验训练的软件（机器学习）在分析物检测中同时收集多重数据并分析数据的方法和装置。公开了各种方式（磁性颗粒和微型线圈）以收集多个报道（标签）信号。多重检测可以通过使用小样本量和节省测定试剂和时间来增加生物分子分析效率。还披露了机器学习和数据分析方案。将多个亲和力结合配偶体（各自由唯一报道分子标记）与样品接触，并采用绿色光谱来检测多个报道信号。通过实验训练的软件对光谱进行去卷积，以识别多个分析物。

9. 发明授权

US07790286B2 External modification of composite organic inorganic nanoclusters 有权
标题翻译：复合有机无机纳米团簇的外部改性
公开(公告)号：US07790286B2
公开(公告)日：2010-09-07
申请号：US12036869
申请日：2008-02-25
申请人： Jingwu Zhang , Xing Su , Lei Sun
发明人： Jingwu Zhang , Xing Su , Lei Sun
IPC分类号： B32B5/16
CPC分类号： G01N21/658 , G01N2021/653 , G01N2021/655 , G01N2021/656 , Y10S977/773 , Y10S977/777 , Y10S977/783 , Y10T428/12049 , Y10T428/2991 , Y10T428/2998
摘要： Modified and functionalized metallic nanoclusters capable of providing an enhanced Raman signal from an organic Raman-active molecule incorporated therein are provided. For example, modifications include coatings and layers, such as adsorption layers, metal coatings, silica coatings, and organic layers. The nanoclusters are generally referred to as COINs (composite organic inorganic nanoparticles) and are capable of acting as sensitive reporters for analyte detection. A metal that enhances the Raman signal from the organic Raman-active compound is inherent in the nanocluster. A variety of organic Raman-active compounds and mixtures of compounds can be incorporated into the nanocluster.
摘要翻译：提供了能够提供来自结合在其中的有机拉曼活性分子的增强拉曼信号的改性和官能化的金属纳米团簇。例如，修饰包括涂层和层，例如吸附层，金属涂层，二氧化硅涂层和有机层。纳米团簇通常被称为COIN（复合有机无机纳米粒子），并且能够作为敏感的报告物进行分析物检测。从有机拉曼活性化合物增强拉曼信号的金属在纳米簇中是固有的。可以将多种有机拉曼活性化合物和化合物的混合物掺入纳米团簇中。

10. 发明申请

US20090069481A1 EXTERNAL MODIFICATION OF COMPOSITE ORGANIC INORGANIC NANOCLUSTERS 有权
标题翻译：复合有机无机纳米粒子的外部修饰
公开(公告)号：US20090069481A1
公开(公告)日：2009-03-12
申请号：US12036869
申请日：2008-02-25
申请人： Jingwu Zhang , Xing Su , Lei Sun
发明人： Jingwu Zhang , Xing Su , Lei Sun
IPC分类号： C08K3/10
CPC分类号： G01N21/658 , G01N2021/653 , G01N2021/655 , G01N2021/656 , Y10S977/773 , Y10S977/777 , Y10S977/783 , Y10T428/12049 , Y10T428/2991 , Y10T428/2998
摘要： Modified and functionalized metallic nanoclusters capable of providing an enhanced Raman signal from an organic Raman-active molecule incorporated therein are provided. For example, modifications include coatings and layers, such as adsorption layers, metal coatings, silica coatings, and organic layers. The nanoclusters are generally referred to as COINs (composite organic inorganic nanoparticles) and are capable of acting as sensitive reporters for analyte detection. A metal that enhances the Raman signal from the organic Raman-active compound is inherent in the nanocluster. A variety of organic Raman-active compounds and mixtures of compounds can be incorporated into the nanocluster.
摘要翻译：提供了能够提供来自结合在其中的有机拉曼活性分子的增强拉曼信号的改性和官能化的金属纳米团簇。例如，修饰包括涂层和层，例如吸附层，金属涂层，二氧化硅涂层和有机层。纳米团簇通常被称为COIN（复合有机无机纳米粒子），并且能够作为敏感的报告物进行分析物检测。从有机拉曼活性化合物增强拉曼信号的金属在纳米簇中是固有的。可以将多种有机拉曼活性化合物和化合物的混合物掺入纳米团簇中。

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