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    • 62. 发明授权
    • Detection and reduction of phrenic nerve stimulation
    • 检测和减少膈神经刺激
    • US08527051B1
    • 2013-09-03
    • US13545776
    • 2012-07-10
    • Sven-Erik HedbergTomas SvenssonKjell NorenStuart RosenbergKyungmoo RyuEdward Karst
    • Sven-Erik HedbergTomas SvenssonKjell NorenStuart RosenbergKyungmoo RyuEdward Karst
    • A61N1/37
    • A61N1/36521A61N1/3702
    • The present invention provides implantable medical devices for detecting phrenic nerve stimulation. A pacing module is configured to deliver pacing pulses having a predetermined pulse amplitude and/or width within the refractory period of the left ventricle. The pacing pulses are repeatedly delivered during a number of cardiac cycles, and the pacing pulses are delivered at different delays relative to an onset of the refractory period of the left ventricle in different cardiac cycles. An impedance measurement module is configured to measure impedance signals in time windows synchronized with the delivery of pacing pulses in the refractory period of the left ventricle. A phrenic nerve stimulation, PNS, detection module is configured to gather at least one impedance signal from each time window, create aggregated impedance signals using the impedance signals from the different time windows, and analyze the aggregated impedance signals to detect PNS.
    • 本发明提供了用于检测膈神经刺激的可植入医疗装置。 起搏模块被配置为在左心室的不应期内输送具有预定脉冲幅度和/或宽度的起搏脉冲。 起搏脉冲在多个心动周期期间重复递送,起搏脉冲相对于不同心脏周期中左心室的不应期的开始以不同的延迟递送。 阻抗测量模块被配置为测量与在左心室的不应期中递送起搏脉冲同步的时间窗内的阻抗信号。 膈神经刺激,PNS检测模块配置为从每个时间窗口收集至少一个阻抗信号,使用来自不同时间窗口的阻抗信号创建聚合阻抗信号,并分析聚合阻抗信号以检测PNS。
    • 69. 发明申请
    • Medical Device
    • 医疗装置
    • US20080306565A1
    • 2008-12-11
    • US12095212
    • 2005-12-16
    • Nils HolmstromKjell Noren
    • Nils HolmstromKjell Noren
    • A61N1/00A61F2/02
    • A61B7/00A61B7/04A61N1/3627A61N1/36514
    • In an implantable medical device and a method and computer-readable medium for operating the medical device to detect a condition of a heart of a patient, activity level of a patient and acoustic energy in a patient are sensed, and acoustic signals are generated that are indicative of heart sounds of the patient over predetermined periods of a cardiac cycle during successive cardiac cycles. A signal corresponding to a first sound is extracted from the sensed acoustic signal of a cardiac cycle. A relation is calculated between a first signal corresponding to the first heart sound in a first activity range, and a second signal corresponding to the first heart sound in a second predetermined activity level range. The calculated relation is compared with at least one reference value to detect the condition or a change of the condition.
    • 在可植入医疗装置和用于操作医疗装置以检测患者心脏状况的方法和计算机可读介质中,感测患者的活动水平和患者的声能,并且生成声信号 指示在连续心脏周期期间心脏周期的预定时间段的患者的心脏声音。 从感测到的心律周期的声信号中提取对应于第一声音的信号。 在与第一活动范围内的第一心音相对应的第一信号与对应于第二预定活动水平范围中的第一心音的第二信号之间计算关系。 将计算的关系与至少一个参考值进行比较以检测条件或状况的变化。