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1. 发明授权

US06915162B2 Implantable medical device for measuring ventricular pressure 有权
标题翻译：用于测量心室压力的可植入医疗器械
公开(公告)号：US06915162B2
公开(公告)日：2005-07-05
申请号：US10002496
申请日：2001-11-15
申请人： Kjell Noren , Charlotte Kjellmann , Kenth Nilsson , Sven-Erik Hedberg
发明人： Kjell Noren , Charlotte Kjellmann , Kenth Nilsson , Sven-Erik Hedberg
IPC分类号： A61B5/0215 , A61N1/365 , A61B5/04
CPC分类号： A61N1/36564 , A61B5/0215 , A61B5/7239
摘要： An implantable medical device has a pressure sensing arrangement to measure right ventricular pressure of a heart including a pressure sensor adapted to be positioned in the right ventricle of the heart, to measure the pressure and to generate a pressure signal in response to the measured pressure. The pressure sensing arrangement also has a pressure signal processor and a timing unit. The processor determines from the pressure signal, using diastolic timing signals from the timing unit based on the pressure signal identifying the diastolic phase, a diastolic pressure signal representing the ventricular pressure only during the diastolic phase of the heart cycle.
摘要翻译：可植入医疗装置具有用于测量心脏的右心室压力的压力感测装置，包括适于定位在心脏右心室的压力传感器，以测量压力并响应于测量的压力产生压力信号。压力感测装置还具有压力信号处理器和定时单元。处理器根据压力信号，基于识别舒张期的压力信号使用来自定时单元的舒张定时信号，仅在心脏周期舒张期期间表示心室压力的舒张压信号。

2. 发明申请

US20080091239A1 Cardiac assist device and method using epicardially placed microphone 审中-公开
标题翻译：使用心外膜放置麦克风的心脏辅助装置和方法
公开(公告)号：US20080091239A1
公开(公告)日：2008-04-17
申请号：US11582211
申请日：2006-10-16
申请人： Anna-Karin Johansson , Kenth Nilsson , Cecilia Tuvstedt , Kjell Noren , Anders Bjorling , Andreas Blomqvist , Berit Larsson , Sven-Erik Hedberg , Karin Jarverud , Nils Holmstrom
发明人： Anna-Karin Johansson , Kenth Nilsson , Cecilia Tuvstedt , Kjell Noren , Anders Bjorling , Andreas Blomqvist , Berit Larsson , Sven-Erik Hedberg , Karin Jarverud , Nils Holmstrom
IPC分类号： A61N1/36 , A61N1/362 , A61N1/39
CPC分类号： A61N1/36514 , A61N1/3956
摘要： In a cardiac assist device and method, a microphone is placed in contact with the epicardium of the heart of a patient, and heart and lung sounds are simultaneously detected at the placement location of the microphone. The heart and lung sounds are automatically analyzed to set an appropriate cardiac therapy for the patient.
摘要翻译：在心脏辅助装置和方法中，将麦克风放置成与患者心脏的心外膜接触，并且在麦克风的放置位置同时检测心脏和肺部的声音。自动分析心脏和肺部声音，为患者设定适当的心脏治疗。

3. 发明授权

US08068908B2 Implantable cardiac stimulator, system, device and method for monitoring cardiac synchrony 有权
标题翻译：可植入式心脏刺激器，系统，装置和监测心脏同步的方法
公开(公告)号：US08068908B2
公开(公告)日：2011-11-29
申请号：US12094543
申请日：2005-11-30
申请人： Karin Järverud , Kenth Nilsson , Sven-Erik Hedberg
发明人： Karin Järverud , Kenth Nilsson , Sven-Erik Hedberg
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61B5/1107 , A61B5/6869 , A61B2562/0219 , A61N1/36514 , A61N1/36578
摘要： In a system and method for monitoring cardiac synchrony in a human heart, a first sensor is positioned at a first cardiac wall location of a heart that is subject to movements related to longitudinal valve plane movements along the longitudinal axis of the heart, and the first sensor measures said cardiac wall movements at the first cardiac wall location and emits a first sensor output signal corresponding thereto, a second sensor is positioned at a second cardiac wall location of the heart that is subject to movements related to longitudinal valve plane movements along the longitudinal axis of the heart, and the second sensor measures the cardiac wall movements at the second cardiac wall location and emits a second sensor output signal corresponding thereto. A lead arrangement is electrically connected to the first and second sensors and conducts the first and second sensor output signals therefrom to processing circuitry that processes the first and second sensor output signals to produce a synchronization signal therefrom indicative of synchrony in the respective valve plane movements at the first and second cardiac wall locations.
摘要翻译：在用于监测人心脏心脏同步的系统和方法中，第一传感器位于心脏的第一心脏壁位置处，该第一心脏壁位置受到与沿着心脏的纵向轴线的纵向瓣膜平面运动有关的运动，第一传感器传感器测量在第一心脏壁位置处的心脏壁运动，并且发射与其对应的第一传感器输出信号，第二传感器定位在心脏的第二心脏壁位置处，该第二心脏壁位置受到与沿着纵向的纵向瓣膜平面运动相关的运动并且第二传感器测量第二心脏壁位置处的心脏壁移动，并且发出与其对应的第二传感器输出信号。引线装置电连接到第一和第二传感器，并将第一和第二传感器输出信号传送到处理电路，处理电路处理第一和第二传感器输出信号以产生同步信号，表示在各个阀平面运动中同步的同步信号第一和第二心脏壁位置。

4. 发明授权

US06529777B1 Electrode for tissue stimulation 失效
标题翻译：电极组织刺激
公开(公告)号：US06529777B1
公开(公告)日：2003-03-04
申请号：US09622817
申请日：2000-08-23
申请人： Nils Holmström , Sven-Erik Hedberg , Kenth Nilsson
发明人： Nils Holmström , Sven-Erik Hedberg , Kenth Nilsson
IPC分类号： A61N105
CPC分类号： A61N1/371 , A61N1/0565 , A61N1/362 , A61N1/36585
摘要： In an implantable electrode for an electrode lead for a stimulation device for stimulating tissue, the electrode is formed as a biocompatible piezoelectric electrode which is adapted to be in direct electrical contact with tissue for electrically and mechanically stimulating the tissue and for detecting electrical and mechanical evoked response of the stimulated tissue. The stimulation device can include circuitry for making a diagnosis of a heart condition using signals received from the implantable electrode.
摘要翻译：在用于刺激组织的刺激装置的电极引线的可植入电极中，电极形成为生物相容性压电电极，其适于与组织直接电接触，用于电和机械刺激组织并检测电和机械诱发刺激组织的反应。刺激装置可以包括使用从可植入电极接收的信号进行心脏状况诊断的电路。

5. 发明授权

US5935158A Electrode lead and device for tissue stimulation and/or detection of tissue response 失效
标题翻译：用于组织刺激和/或检测组织反应的电极引线和装置
公开(公告)号：US5935158A
公开(公告)日：1999-08-10
申请号：US915756
申请日：1997-08-21
申请人： Nils Holmstrom , Sven-Erik Hedberg , Kenth Nilsson
发明人： Nils Holmstrom , Sven-Erik Hedberg , Kenth Nilsson
IPC分类号： A61N1/05 , A61N1/362 , A61N1/39 , A61N1/04
CPC分类号： A61N1/0565
摘要： An implantable electrode for stimulating tissue has a piezoelectric electrode for electrically and mechanically stimulating tissue and for detecting electrical and mechanical evoked response of the stimulated tissue. An implantable lead and an implantable stimulation device employing such an electrode are described including diagnostic circuitry for making a diagnosis of the heart condition using such an electrode.
摘要翻译：用于刺激组织的可植入电极具有用于电和机械刺激组织并用于检测受刺激组织的电和机械诱发反应的压电电极。描述了使用这种电极的可植入引线和可植入刺激装置，其包括使用这种电极进行心脏病症诊断的诊断电路。

6. 发明授权

US08626313B2 Piezoelectric sensor, a method for manufacturing a piezoelectric sensor and a medical implantable lead comprising such a piezoelectric sensor 有权
标题翻译：压电传感器，压电传感器的制造方法以及包括这种压电传感器的医用可植入引线
公开(公告)号：US08626313B2
公开(公告)日：2014-01-07
申请号：US12298218
申请日：2006-04-25
申请人： Tom Eriksson , Kenth Nilsson , Sven-Erik Hedberg
发明人： Tom Eriksson , Kenth Nilsson , Sven-Erik Hedberg
IPC分类号： A61N1/00 , A61B5/00 , G01L7/00
CPC分类号： A61N1/056 , A61B5/0215 , A61N1/0565 , A61N1/36542 , A61N1/36564 , G01L9/0026 , G01L9/08 , H01L41/087 , H01L41/1132
摘要： In a piezoelectric sensor, a method for the manufacture thereof, and an implantable lead embodying such a piezoelectric sensor, a layer of piezoelectric material, having aligned, polarized dipoles, is applied to a tubular supporting substrate, the layer of piezoelectric material having at least one electrode at an outer surface thereof and at least one electrode at an inner surface thereof. The piezoelectric material is applied on the inner circumference of the tubular supporting substrate.
摘要翻译：在压电传感器中，其制造方法以及体现这种压电传感器的可植入引线，具有排列的极化偶极子的压电材料层被施加到管状支撑衬底，压电材料层至少具有一个电极在其外表面和至少一个电极在其内表面。压电材料被施加在管状支撑衬底的内圆周上。

7. 发明申请

US20120089035A1 IMPLANTABLE CARDIAC STIMULATOR, SYSTEM, DEVICE AND METHOD FOR MONITORING CARDIAC SYNCHRONY 有权
标题翻译：可注射的心脏刺激器，系统，设备和监测心脏同步的方法
公开(公告)号：US20120089035A1
公开(公告)日：2012-04-12
申请号：US13271548
申请日：2011-10-12
申请人： KARIN JÄRVERUD , Kenth Nilsson , Sven-Erik Hedberg
发明人： KARIN JÄRVERUD , Kenth Nilsson , Sven-Erik Hedberg
IPC分类号： A61N1/368 , A61B5/0245
CPC分类号： A61N1/3627 , A61B5/1107 , A61B5/6869 , A61B2562/0219 , A61N1/36514 , A61N1/36578
摘要： In a system and method for monitoring cardiac synchrony in a human heart, a first sensor is positioned at a first cardiac wall location that is subject to movements related to longitudinal valve plane movements along the longitudinal axis of the heart, and measures the cardiac wall movements at the first cardiac wall location and a second sensor is positioned at a second cardiac wall location that is subject to movements related to longitudinal valve plane movements along the longitudinal axis of the heart, and measures the cardiac wall movements at the second cardiac wall location. A lead arrangement conducts respective output signals from the first and second sensors to processing circuitry that processes the first and second sensor output signals to produce a synchronization signal therefrom indicative of synchrony in the respective valve plane movements at the first and second cardiac wall locations.
摘要翻译：在用于监测人心脏心脏同步的系统和方法中，第一传感器位于第一心脏壁位置，该第一心脏壁位置受到与心脏的纵向轴线的纵向瓣膜平面运动有关的运动，并且测量心脏壁移动在第一心脏壁位置处，并且第二传感器定位在第二心脏壁位置处，所述第二心脏壁位置受到与沿着心脏的纵向轴线的纵向瓣膜平面运动相关的运动，并且测量第二心脏壁位置处的心脏壁运动。引线装置将来自第一和第二传感器的相应输出信号传导到处理电路，处理电路处理第一和第二传感器输出信号以产生同步信号，表示在第一和第二心脏壁位置处的各个阀平面运动中的同步。

8. 发明申请

US20080294216A1 Implantable Cardiac Stimulator , System, Device and Method for Monitoring Cardiac Synchrony 有权
标题翻译：可植入式心脏刺激器，系统，设备和监测心脏同步的方法
公开(公告)号：US20080294216A1
公开(公告)日：2008-11-27
申请号：US12094543
申请日：2005-11-30
申请人： Karin Jarverud , Kenth Nilsson , Sven-Erik Hedberg
发明人： Karin Jarverud , Kenth Nilsson , Sven-Erik Hedberg
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61B5/1107 , A61B5/6869 , A61B2562/0219 , A61N1/36514 , A61N1/36578
摘要： In a system and method for monitoring cardiac synchrony in a human heart, a first sensor is positioned at a first cardiac wall location of a heart that is subject to movements related to longitudinal valve plane movements along the longitudinal axis of the heart, and the first sensor measures said cardiac wall movements at the first cardiac wall location and emits a first sensor output signal corresponding thereto, a second sensor is positioned at a second cardiac wall location of the heart that is subject to movements related to longitudinal valve plane movements along the longitudinal axis of the heart, and the second sensor measures the cardiac wall movements at the second cardiac wall location and emits a second sensor output signal corresponding thereto. A lead arrangement is electrically connected to the first and second sensors and conducts the first and second sensor output signals therefrom to processing circuitry that processes the first and second sensor output signals to produce a synchronization signal therefrom indicative of synchrony in the respective valve plane movements at the first and second cardiac wall locations.
摘要翻译：在用于监测人心脏心脏同步的系统和方法中，第一传感器位于心脏的第一心脏壁位置处，所述第一心脏壁位置受到与沿着心脏的纵向轴线的纵向瓣膜平面运动有关的运动，第一传感器传感器测量在第一心脏壁位置处的心脏壁运动，并且发射与其对应的第一传感器输出信号，第二传感器定位在心脏的第二心脏壁位置处，该第二心脏壁位置受到与沿着纵向的纵向瓣膜平面运动相关的运动并且第二传感器测量第二心脏壁位置处的心脏壁移动，并且发出与其对应的第二传感器输出信号。引线装置电连接到第一和第二传感器，并将第一和第二传感器输出信号传送到处理电路，处理电路处理第一和第二传感器输出信号以产生同步信号，表示在各个阀平面运动中同步的同步信号第一和第二心脏壁位置。

9. 发明申请

US20100010600A1 PIEZOELECTRIC SENSOR, A METHOD FOR MANUFACTURING A PIEZOELECTRIC SENSOR AND A MEDICAL IMPLANTABLE LEAD COMPRISING SUCH A PIEZOELECTRIC SENSOR 有权
标题翻译：压电传感器，制造压电传感器的方法和包含这种压电传感器的医用可植入引线
公开(公告)号：US20100010600A1
公开(公告)日：2010-01-14
申请号：US12298218
申请日：2006-04-25
申请人： Tom Eriksson , Kenth Nilsson , Sven-Erik Hedberg
发明人： Tom Eriksson , Kenth Nilsson , Sven-Erik Hedberg
IPC分类号： A61N1/05 , H01L41/22 , G01L9/08
CPC分类号： A61N1/056 , A61B5/0215 , A61N1/0565 , A61N1/36542 , A61N1/36564 , G01L9/0026 , G01L9/08 , H01L41/087 , H01L41/1132
摘要： In a piezoelectric sensor, a method for the manufacture thereof, and an implantable lead embodying such a piezoelectric sensor, a layer of piezoelectric material, having aligned, polarized dipoles, is applied to a tubular supporting substrate, the layer of piezoelectric material having at least one electrode at an outer surface thereof and at least one electrode at an inner surface thereof. The piezoelectric material is applied on the inner circumference of the tubular supporting substrate.
摘要翻译：在压电传感器中，其制造方法以及体现这种压电传感器的可植入引线，具有排列的极化偶极子的压电材料层被施加到管状支撑衬底，压电材料层至少具有一个电极在其外表面和至少一个电极在其内表面。压电材料被施加在管状支撑衬底的内圆周上。

10. 发明授权

US08219194B2 Implantable cardiac stimulator, system, device and method for monitoring cardiac synchrony 有权
标题翻译：可植入式心脏刺激器，系统，装置和监测心脏同步的方法
公开(公告)号：US08219194B2
公开(公告)日：2012-07-10
申请号：US13271548
申请日：2011-10-12
申请人： Karin Järverud , Kenth Nilsson , Sven-Erik Hedberg
发明人： Karin Järverud , Kenth Nilsson , Sven-Erik Hedberg
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61B5/1107 , A61B5/6869 , A61B2562/0219 , A61N1/36514 , A61N1/36578
摘要： In a system and method for monitoring cardiac synchrony in a human heart, a first sensor is positioned at a first cardiac wall location that is subject to movements related to longitudinal valve plane movements along the longitudinal axis of the heart, and measures the cardiac wall movements at the first cardiac wall location and a second sensor is positioned at a second cardiac wall location that is subject to movements related to longitudinal valve plane movements along the longitudinal axis of the heart, and measures the cardiac wall movements at the second cardiac wall location. A lead arrangement conducts respective output signals from the first and second sensors to processing circuitry that processes the first and second sensor output signals to produce a synchronization signal therefrom indicative of synchrony in the respective valve plane movements at the first and second cardiac wall locations.
摘要翻译：在用于监测人心脏心脏同步的系统和方法中，第一传感器位于第一心脏壁位置，该第一心脏壁位置受到与心脏的纵向轴线的纵向瓣膜平面运动有关的运动，并且测量心脏壁移动在第一心脏壁位置处，并且第二传感器定位在第二心脏壁位置处，所述第二心脏壁位置受到与沿着心脏的纵向轴线的纵向瓣膜平面运动相关的运动，并且测量第二心脏壁位置处的心脏壁运动。引线装置将来自第一和第二传感器的相应输出信号传导到处理电路，处理电路处理第一和第二传感器输出信号以产生同步信号，表示在第一和第二心脏壁位置处的各个阀平面运动中的同步。

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