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61. 发明申请

US20120107418A1 Method and composition for in-situ generation of chlorous acid 审中-公开
标题翻译：用于原位产生氯酸的方法和组成
公开(公告)号：US20120107418A1
公开(公告)日：2012-05-03
申请号：US12925714
申请日：2010-10-28
申请人： Roy W. Martin
发明人： Roy W. Martin
IPC分类号： A01N59/08 , A01P1/00
CPC分类号： A01N59/00 , A01N25/04 , A01N25/12 , A01N25/34 , A01N43/50 , A01N43/66 , A01N2300/00
摘要： This invention relates to methods and compositions for producing an antimicrobial solution with a high weight percent (wt %) conversion of chlorite anion to chlorous acid and/or derivatives of chlorous acid with substantially reduced chlorite residual. Furthermore, the invention presents methods for use of the antimicrobial solution thereby substantially improving the utility and cost effectiveness of chlorous acid solutions. Furthermore, the invention further demonstrates a method for use of a novel antimicrobial solution comprising a brominated derivative of chlorous acid that has substantially reduced volatility and provides at least two different modes of oxidation.
摘要翻译：本发明涉及用于生产具有亚氯酸根阴离子与亚氯酸和/或亚氯酸衍生物的高重量百分比（重量％）转化率显着降低的亚氯酸盐残余物的抗微生物溶液的方法和组合物。此外，本发明提出了使用抗微生物溶液的方法，从而显着提高了氯酸溶液的效用和成本效益。此外，本发明进一步展示了一种使用新型抗微生物溶液的方法，其包含具有显着降低的挥发性并提供至少两种不同氧化模式的氯代溴代衍生物。

62. 发明申请

US20110201929A1 METHOD FOR USING HIGH INTENSITY FOCUSED ULTRASOUND 有权
标题翻译：使用高强度聚焦超声的方法
公开(公告)号：US20110201929A1
公开(公告)日：2011-08-18
申请号：US12946727
申请日：2010-11-15
申请人： Shahram Vaezy , Arthur H. Chan , Victor Y. Fujimoto , Donald E. Moore , Roy W. Martin
发明人： Shahram Vaezy , Arthur H. Chan , Victor Y. Fujimoto , Donald E. Moore , Roy W. Martin
IPC分类号： A61N7/00 , A61B8/00
CPC分类号： A61N7/00 , A61B8/08 , A61B8/0833 , A61B8/0841 , A61B8/12 , A61B8/4209 , A61B8/4218 , A61B8/462 , A61B2017/2253 , A61B2017/4216 , A61B2090/378 , A61N7/02
摘要： A plurality of concepts related to HIFU therapy are disclosed, including a technique to spatially track and display the relative positions of a HIFU focal point and an imaging plane from an ultrasound imager, so that a clinician can ensure that the HIFU focus remains in the image plane during HIFU therapy, thereby facilitating image guided HIFU therapy. Also disclosed are a plurality of transvaginal probes that include a HIFU transducer optimized for the treatment of uterine fibroids. In one embodiment, the probe includes a piezoceramic crystal bonded to an aluminum lens, to achieve a HIFU transducer having a focal length of about 4 cm. In another embodiment, the probe includes a generally spoon-shaped transducer including a plurality of individual emitter elements. Still another concept disclosed herein is a method for evaluating a quality of a coupling between a liquid-filled volume encompassing a HIFU transducer and a tissue interface.
摘要翻译：公开了与HIFU治疗相关的多个概念，包括从超声成像器空间跟踪和显示HIFU焦点和成像平面的相对位置的技术，使得临床医生可以确保HIFU焦点保留在图像中在HIFU治疗期间平面，从而促进图像引导的HIFU治疗。还公开了多个经阴道探针，其包括优化用于治疗子宫肌瘤的HIFU换能器。在一个实施例中，探针包括结合到铝透镜的压电陶瓷晶体，以实现焦距为约4cm的HIFU换能器。在另一个实施例中，探针包括一般包括多个单个发射器元件的匙形换能器。本文公开的另一概念是用于评估包含HIFU换能器的液体填充体与组织界面之间的耦合质量的方法。

63. 发明授权

US07993545B2 Tablet composition for the in-situ generation of chlorine dioxide for use in antimicrobial applications 有权
公开(公告)号：US07993545B2
公开(公告)日：2011-08-09
申请号：US12802230
申请日：2010-06-02
申请人： Roy W. Martin
发明人： Roy W. Martin
IPC分类号： C01B11/10 , C01B11/02 , C11D3/395 , A01N25/34 , A61K9/30
CPC分类号： A01N59/00 , A01N37/42 , C01B11/024 , C02F1/688 , C02F1/76 , C02F2103/023 , A01N25/34 , A01N2300/00 , A01N59/02 , A01N43/64 , A01N43/50 , A01N25/04
摘要： A solid composition in the form of a tablet that generates and releases a biocidal solution comprising at least chlorine dioxide with an enhanced weight percent yield is presented. The composition comprises reactants capable of in-situ generation of chlorine dioxide comprising a chlorite donor that is coated with a gel-forming material that slows the rate of dissolution of the high solubility chlorite donor, a free halogen donor, and an acid source, resulting in an unexpectedly high weight percent yield and providing a controlled release of biocidal solution. The compositions of the invention show improved environmental stability which can reduce the cost of packaging and significantly increase the utility of the composition. The controlled release allows the use in multi-tablet chemical dispensers which may otherwise induce potentially explosive conditions or allow rapid release of the biocidal solution thereby inducing a spike in chemical concentration rather than a controlled and sustained release.

64. 发明申请

US20110136661A1 Non-hygroscopic stabilized catalyst for the in-situ generation of sulfate free radicals 审中-公开
标题翻译：用于原位生成硫酸盐自由基的非吸湿稳定催化剂
公开(公告)号：US20110136661A1
公开(公告)日：2011-06-09
申请号：US12653003
申请日：2009-12-07
申请人： Roy W. Martin
发明人： Roy W. Martin
IPC分类号： B01J31/18 , B01J27/232 , B01J21/08 , B01J23/00 , B01J23/75
CPC分类号： C02F1/725 , C02F1/722 , C02F2103/42
摘要： This invention relates to methods for producing, and the resulting compositions comprising non-hygroscopic stabilized catalyst for use with peroxysulfates for the in-situ generation of sulfate free radicals in recreational water.
摘要翻译：本发明涉及生产方法，所得组合物包含用于在休闲水中原位生成硫酸盐自由基的过氧化硫酸盐的非吸湿稳定催化剂。

65. 发明授权

US07927508B2 Composition and process for enhanced sanitation and oxidation of aqueous systems 失效
标题翻译：用于增强水系统的卫生和氧化的组成和过程
公开(公告)号：US07927508B2
公开(公告)日：2011-04-19
申请号：US12317010
申请日：2008-12-18
申请人： Roy W. Martin
发明人： Roy W. Martin
IPC分类号： C01B11/02 , C01B11/10 , C01B7/09 , C02F1/76
CPC分类号： C02F1/722 , C02F1/32 , C02F1/725 , C02F1/76 , C02F1/766 , C02F1/78 , C02F2101/101 , C02F2303/04
摘要： An efficient cyclic process and related compositions for the in-situ generation of oxyhalogens from anions of chloride, bromide and chlorite in an aqueous system using in-situ generated sulfate free radicals. The cyclic process and compositions enhance the rate of inactivation of microbiological organisms especially those resistant to inactivation from free halogen based sanitizers, and oxidation of oxidation resistant organic based compounds in aqueous solution. Aquatic facilities susceptible to accumulation of organic N-chloramines and other oxidation resistant compounds, as well as oxidation resistant parasitic organisms such as cryptosporidium and Giardia, obtain dramatic improvements in the rate of oxidation and subsequent inactivation of these undesirable contaminants.
摘要翻译：一种有效的循环方法和相关组合物，用于使用原位产生的硫酸盐自由基在含水系统中从氯离子，溴化物和亚氯酸盐的阴离子原位产生卤代卤素。循环过程和组合物增强了微生物生物体的失活速率，特别是那些耐受基于游离卤素的消毒剂灭活的那些，以及在水溶液中氧化抗氧化的有机基化合物。有机氯胺和其他抗氧化化合物以及抗氧化寄生生物（如隐孢子虫和贾第鞭毛虫）易于积累的水生植物，可以显着改善氧化速率，从而使这些不合需要的污染物随后灭活。

66. 发明授权

US07794607B2 Composition and method for enhanced sanitation and oxidation of aqueous systems 失效
标题翻译：用于增强水系统的卫生和氧化的组合物和方法
公开(公告)号：US07794607B2
公开(公告)日：2010-09-14
申请号：US11598384
申请日：2006-11-13
申请人： Roy W. Martin
发明人： Roy W. Martin
IPC分类号： C02F1/72 , C02F1/68 , C02F1/76 , C01B15/08 , C01B11/00
CPC分类号： C02F1/50 , C02F1/505 , C02F1/52
摘要： Compositions and methods for their use are presented that substantially increase the rate of inactivation of microbiological organisms, especially those resistant to inactivation from free halogen based sanitizers, and oxidation of oxidation resistant organic based compounds in aqueous solution. Aquatic facilities susceptible to accumulation of organic N-chloramines, cyanuric acid and other oxidation resistant compounds, as well as oxidation resistant parasitic organisms such as cryptosporidium and Giardia, obtain dramatic improvements in the rate of oxidation and subsequent inactivation of these undesirable contaminants.
摘要翻译：提出了使用它们的组合物和方法，其显着增加了微生物生物体的失活速率，特别是那些耐受基于游离卤素的消毒剂灭活的那些，以及在水溶液中氧化抗氧化的有机基化合物。有机氯胺，氰尿酸和其他抗氧化化合物以及抗氧化的寄生生物如隐孢子虫和贾第鞭草的积累的水生植物可以显着改善氧化速率，随后灭活这些不需要的污染物。

67. 发明授权

US07722539B2 Treatment of unwanted tissue by the selective destruction of vasculature providing nutrients to the tissue 有权
标题翻译：通过选择性破坏脉管系统来为组织提供营养物来治疗不想要的组织
公开(公告)号：US07722539B2
公开(公告)日：2010-05-25
申请号：US11207554
申请日：2005-08-18
申请人： Stephen J. Carter , Shahram Vaezy , Roy W. Martin , George W. Keilman , Lawrence A. Crum
发明人： Stephen J. Carter , Shahram Vaezy , Roy W. Martin , George W. Keilman , Lawrence A. Crum
IPC分类号： A61B8/00
CPC分类号： A61N7/02 , A61B8/08 , A61B8/4209 , A61B8/4254 , A61B8/4281 , A61B34/20 , A61B2034/2051 , A61B2090/378 , A61H23/0245
摘要： A noninvasive technique that can be used to deny blood flow to a particular region of tissue, without the inherent risks associated with invasive procedures such as surgery and minimally-invasive procedures such as embolization. Blood flow in selected portions of the vasculature can be occluded by selectively treating specific portions of the vasculature with high intensity focused ultrasound (HIFU). The occlusion denies undesired tissue the nutrients and oxygen provided by blood flow, causing necrosis in the undesired tissue. An imaging technology (such as magnetic resonance imaging, magnetic resonance angiography, ultrasound imaging, Doppler based ultrasound imaging, or computed tomographic angiography) is used to identify the undesired tissue, and the vascular structures associated with the undesired tissue. A portion of the vasculature providing blood flow to the undesired tissue is selected, and HIFU is administered to the selected portion of the vasculature to occlude blood flow through that portion of the vasculature.
摘要翻译：一种非侵入性技术，可用于阻止血液流向组织的特定区域，而不会与诸如手术和诸如栓塞的微创手术等侵入性手术相关的固有风险。通过用高强度聚焦超声（HIFU）选择性处理脉管系统的特定部分，可以阻断脉管系统选定部分的血流。闭塞阻止不需要的组织由血液流动提供的营养物质和氧气，从而引起不想要的组织中的坏死。使用成像技术（例如磁共振成像，磁共振血管造影术，超声成像，基于多普勒超声成像或计算机断层造影血管造影术）来鉴别不需要的组织以及与不想要的组织相关的血管结构。选择向不想要的组织提供血液流动的脉管系统的一部分，并且将HIFU施用于脉管系统的选定部分以阻塞通过脉管系统的那部分的血流。

68. 发明申请

US20090304810A1 Composition and method for enhanced sanitation and oxidation of aqueous systems 审中-公开
标题翻译：用于增强水系统的卫生和氧化的组合物和方法
公开(公告)号：US20090304810A1
公开(公告)日：2009-12-10
申请号：US12460562
申请日：2009-07-21
申请人： Roy W. Martin
发明人： Roy W. Martin
IPC分类号： A01P1/00
CPC分类号： C02F1/725 , C02F1/722 , C02F1/76 , C02F2103/42
摘要： Compositions and methods for their use are presented that substantially increase the rate of inactivation of microbiological organisms, especially those resistant to inactivation from free halogen based sanitizers, and oxidation of oxidation resistant organic based compounds in aqueous solution. Aquatic facilities susceptible to accumulation of organic N-chloramines, cyanuric acid and other oxidation resistant compounds, as well as oxidation resistant parasitic organisms such as cryptosporidium and Giardia, obtain dramatic improvements in the rate of oxidation and subsequent inactivation of these undesirable contaminants
摘要翻译：提出了使用它们的组合物和方法，其显着增加了微生物生物体的失活速率，特别是那些耐受基于游离卤素的消毒剂灭活的那些，以及在水溶液中氧化抗氧化的有机基化合物。有机氯胺，氰尿酸和其他抗氧化化合物以及抗氧化寄生生物如隐孢子虫和贾第鞭毛虫的积水设施可以显着改善氧化速率，并随后使这些不需要的污染物失活

69. 发明授权

US07520856B2 Image guided high intensity focused ultrasound device for therapy in obstetrics and gynecology 有权
标题翻译：图像引导高强度聚焦超声装置治疗妇产科
公开(公告)号：US07520856B2
公开(公告)日：2009-04-21
申请号：US10977339
申请日：2004-10-29
申请人： Shahram Vaezy , Arthur H. Chan , Victor Y. Fujimoto , Donald E. Moore , Roy W. Martin
发明人： Shahram Vaezy , Arthur H. Chan , Victor Y. Fujimoto , Donald E. Moore , Roy W. Martin
IPC分类号： A61B8/00 , A61N7/00
CPC分类号： A61N7/00 , A61B8/08 , A61B8/0833 , A61B8/0841 , A61B8/12 , A61B8/4209 , A61B8/4218 , A61B8/462 , A61B2017/2253 , A61B2017/4216 , A61B2090/378 , A61N7/02
摘要： A frame ensures that the alignment between a high intensity focused ultrasound (HIFU) transducer designed for vaginal use and a commercially available ultrasound image probe is maintained, so that the HIFU focus remains in the image plane during HIFU therapy. A water-filled membrane placed between the HIFU transducer and the treatment site provides acoustic coupling. The coupling is evaluated to determine whether any air bubbles exist at the coupling interface, which might degrade the therapy provided by the HIFU transducer. HIFU lesions on tissue appear as hyperechoic spots on the ultrasound image in real time during application of HIFU therapy. Ergonomic testing in humans has demonstrated clear visualization of the HIFU transducer relative to the uterus and showed the potential for the HIFU transducer to treat fibroids from the cervix to the fundus through the width of the uterus.
摘要翻译：框架确保维持设计用于阴道使用的高强度聚焦超声（HIFU）换能器和商业上可获得的超声图像探针之间的对准，使得HIFU治疗期间HIFU焦点保留在图像平面中。放置在HIFU换能器和处理部位之间的充水膜提供声耦合。评估耦合以确定耦合界面是否存在任何气泡，这可能降低由HIFU传感器提供的治疗。 HIFU治疗期间组织上的HIFU损伤实时显示为超声图像上的高回声点。人体工程学测试已经证明了HIFU传感器相对于子宫的清晰可视化，并显示HIFU传感器通过子宫宽度将子宫肌瘤从子宫颈治疗到眼底的潜力。

70. 发明授权

US06432067B1 Method and apparatus for medical procedures using high-intensity focused ultrasound 失效
标题翻译：使用高强度聚焦超声的医疗手术方法和装置
公开(公告)号：US06432067B1
公开(公告)日：2002-08-13
申请号：US09390032
申请日：1999-09-03
申请人： Roy W. Martin , Lawrence A. Crum , Shahram Vaezy , Stephen J. Carter , W. Scott Helton , Michael Gaps , Peter J. Kaczkowski , Andrew Proctor , George Keilman
发明人： Roy W. Martin , Lawrence A. Crum , Shahram Vaezy , Stephen J. Carter , W. Scott Helton , Michael Gaps , Peter J. Kaczkowski , Andrew Proctor , George Keilman
IPC分类号： A61N700
CPC分类号： A61B17/22004 , A61B8/14 , A61B8/4209 , A61B8/4218 , A61B8/4254 , A61B8/4281 , A61B8/4461 , A61B17/2251 , A61B17/2255 , A61B17/320068 , A61B17/320092 , A61B90/50 , A61B2017/12004 , A61B2017/22008 , A61B2017/320052 , A61B2090/0472 , A61N7/02 , A61N2007/0065 , A61N2007/0069 , A61N2007/0078 , A61N2007/0091 , A61N2007/027
摘要： Methods and apparatus for enabling substantially bloodless surgery and for stemming hemorrhaging. High intensity focused ultrasound (“HIFU”) is used to form cauterized tissue regions prior to surgical incision, for example, forming a cauterized tissue shell around a tumor to be removed. The procedure is referred to as “presurgical volume cauterization.” In one embodiment, the method is particularly effective for use in surgical lesion removal or resection of tissue having a highly vascularized constitution, such as the liver or spleen, and thus a propensity for hemorrhaging. In further embodiments, methods and apparatus for hemostasis using HIFU is useful in both surgical, presurgical, and medical emergency situations. In an apparatus embodiment, a telescoping, acoustic coupler is provided such that depth of focus of the HIFU energy is controllable. In other embodiments, apparatus characterized by portability are demonstrated, useful for emergency medical situations.
摘要翻译：用于实质上无血的手术和用于阻止出血的方法和装置。高强度聚焦超声（“HIFU”）用于在手术切口之前形成烧灼的组织区域，例如，在要移除的肿瘤周围形成烧灼的组织壳。该手术被称为“术前体积烧灼”。在一个实施方案中，该方法特别有效地用于手术损伤去除或切除具有高度血管化构成的组织，例如肝脏或脾脏，并因此用于出血倾向。在另外的实施例中，使用HIFU止血的方法和装置在外科手术，手术前和医疗紧急情况下都是有用的。在设备实施例中，提供伸缩式声学耦合器，使得HIFU能量的焦深可以控制。在其他实施例中，证明了便携性特征的装置，用于紧急医疗情况。

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