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61. 发明申请

US20080218165A1 Microsensor Device 审中-公开
标题翻译：微传感器装置
公开(公告)号：US20080218165A1
公开(公告)日：2008-09-11
申请号：US12065612
申请日：2006-09-07
申请人： Josephus Arnoldus Henricus Maria Kahlman , Bart Michiel De Boer , Albert Hendrik Jan Immink , Jeroen Hans Nieuwenhuis
发明人： Josephus Arnoldus Henricus Maria Kahlman , Bart Michiel De Boer , Albert Hendrik Jan Immink , Jeroen Hans Nieuwenhuis
IPC分类号： G01N27/72
CPC分类号： G01N33/54326 , G01N27/745
摘要： The invention relates to a microsensor device like a magnetic biosensor (100). The microsensor device comprises an array of probe-sensors (10.1, 10.2, 10.3) for the measurement of a physical quantity, for example the concentration of molecules labeled with magnetic beads in a sample chamber. The array further comprises a reference-sensor (10.4) that is disposed close to the probe-sensors (10.1, 10.2, 10.3) but shielded from the physical quantity to be measured. The measuring signal of the reference-sensor (10.4) reflects the influence of environmental conditions like temperature and can therefore be used to correct the measuring signals of the probe-sensors (10.1, 10.2, 10.3). The sensors (10.1, 10.2, 10.3, 10.4) are connected via a multiplexer to the same detector unit for further processing in order to minimize variations and to reduce hardware complexity.
摘要翻译：本发明涉及一种诸如磁性生物传感器（100）的微传感器装置。微传感器装置包括用于测量物理量的探针传感器阵列（10.1,10.2,10.3），例如在样品室中用磁珠标记的分子的浓度。该阵列还包括靠近探头传感器（10.1,10.2,10.3）设置但与被测量的物理量屏蔽的参考传感器（10.4）。参考传感器（10.4）的测量信号反映了诸如温度等环境条件的影响，因此可用于校正探头传感器（10.1,10.2,10.3）的测量信号。传感器（10.1,10.2,10.3,10.4）通过多路复用器连接到相同的检测器单元以进行进一步处理，以便最小化变化并降低硬件复杂度。

62. 发明申请

US20080205497A1 Assembly Comprising a Wireless-Communication Semiconductor Chip 审中-公开
标题翻译：组件包括无线通信半导体芯片
公开(公告)号：US20080205497A1
公开(公告)日：2008-08-28
申请号：US11916055
申请日：2006-05-22
申请人： Josephus Arnoldus Henricus Maria Kahlman , Derk Reefman
发明人： Josephus Arnoldus Henricus Maria Kahlman , Derk Reefman
IPC分类号： H04B1/38
CPC分类号： G01N35/00732
摘要： A semiconductor chip (CHP) and a semiconductor chip driver (RDR) communicate with each other in a wireless fashion. To that end, the semiconductor chip driver (RDR) generates an energy flux (FX1; FX2) that is concentrated on a transducer area (AT1; AT2) of the semiconductor chip (CHP). In the semiconductor chip (CHP), a wireless communication interlace (WCI) provides an electrical signal to a signal processing circuit in response to the energy flux (FX1; FX2). The signal processing circuit occupies an area (AS) that is substantially separate from the transducer area (AT1; AT2) on which the energy flux (FX1; FX2) is concentrated.
摘要翻译：半导体芯片（CHP）和半导体芯片驱动器（RDR）以无线方式彼此通信。为此，半导体芯片驱动器（RDR）产生集中在半导体芯片（CHP）的换能器区域（AT 1; AT 2）上的能量通量（FX1; FX2）。在半导体芯片（CHP）中，无线通信交错（WCI）响应于能量通量（FX1; FX2）向信号处理电路提供电信号。信号处理电路占据与能量通量（FX1; FX2）集中的换能器区域（AT 1; AT 2）基本分离的区域（AS）。

63. 发明申请

US20080037394A1 Bit Synchronization Detection Means 审中-公开
标题翻译：位同步检测手段
公开(公告)号：US20080037394A1
公开(公告)日：2008-02-14
申请号：US10557350
申请日：2003-05-27
申请人： Aalbert Stek , Cornelis Marinus Schep , Constant Paul Marie Jozef Baggen , Josephus Arnoldus Henricus Maria Kahlman
发明人： Aalbert Stek , Cornelis Marinus Schep , Constant Paul Marie Jozef Baggen , Josephus Arnoldus Henricus Maria Kahlman
IPC分类号： G11B5/09
CPC分类号： G11B27/24 , G11B7/0053 , G11B2220/213 , G11B2220/218 , G11B2220/2525 , G11B2220/2541 , G11B2220/2545 , G11B2220/2562
摘要： Detection means for detecting information in a signal, comprising integration means for integrating the signal over time such that the integration means is periodically reset at about the start time reference of a periodic time interval; and a sample&hold circuit for periodically sampling and holding the integrated signal (int) at about an end time reference of the periodic time interval and thereby delivering a further signal (fs). The detection means further comprises a chain (CHDL) of signal time delay elements, an input of the chain (CHDL) being coupled to receive the further signal (fs); and combining means (CBMNS) having combining inputs coupled to signal taps of the chain (CHDL), such that the number of the combining inputs and the position of coupling the combining inputs to the signal taps of the chain (CHDL) correspond to the information in the signal.
摘要翻译：用于检测信号中的信息的检测装置，包括用于随时间积分信号的积分装置，使得积分装置周期性地在周期性时间间隔的开始时间基准上复位; 以及用于在约周期时间间隔的结束时间基准周期性地采样和保持积分信号（int）并从而传送另外的信号（fs）的采样和保持电路。所述检测装置还包括信号时间延迟元件的链（CHDL），所述链（CHDL）的输入被耦合以接收所述另外的信号（fs）; 以及具有耦合到链路（CHDL）的信号抽头的组合输入的组合装置（CBMNS），使得组合输入的数量和将组合输入耦合到链路（CHDL）的信号抽头的位置对应于信息在信号中。

64. 发明授权

US07218254B2 Balanced disparity channel code for DC control 有权
标题翻译：用于直流控制的平衡视差通道代码
公开(公告)号：US07218254B2
公开(公告)日：2007-05-15
申请号：US10517976
申请日：2003-06-17
申请人： Josephus Arnoldus Henricus Maria Kahlman
发明人： Josephus Arnoldus Henricus Maria Kahlman
IPC分类号： H03M1/34
CPC分类号： H04L25/4906 , G11B20/1426 , G11B2020/1453 , H03M5/145
摘要： A coder is fed with precoded data such that the absolute value of the running digital sum (RDS) of the code words as produced by the coder is limited. This is achieved by ensuring that in a group of 2 code words, the RDS of the first code word is compensated by the RDS of the second code word. The RDS at the end of the second code word is then zero and the excursions of the RDS from the start of the first code word until the end of the second code word are limited because there are only a limited number of bits that can contribute to an increase of the absolute value of the RDS.
摘要翻译：向编码器馈送预编码数据，使得由编码器产生的码字的运行数字和（RDS）的绝对值是有限的。这是通过确保在一组2个码字中，第一码字的RDS由第二码字的RDS补偿的。第二码字末尾的RDS为零，并且RDS从第一码字开始到第二码字结束之间的偏移是有限的，因为只有有限数量的位可以有助于增加RDS的绝对值。

65. 发明授权

US07109741B2 Image data display on an information carrier 失效
标题翻译：信息载体上的图像数据显示
公开(公告)号：US07109741B2
公开(公告)日：2006-09-19
申请号：US10536849
申请日：2003-11-28
申请人： Alphons Antonius Maria Lambertus Bruekers , Antonius Hermanus Maria Akkermans , Josephus Arnoldus Henricus Maria Kahlman
发明人： Alphons Antonius Maria Lambertus Bruekers , Antonius Hermanus Maria Akkermans , Josephus Arnoldus Henricus Maria Kahlman
IPC分类号： G01R31/00
CPC分类号： G11B23/38
摘要： The invention relates to an information carrier (101) intended to be put into a rotary motion, said information carrier (101) comprising: display means (102) designed to display image data, said display means (102) being spatially located by a spatial position, processing means (103) for periodically sending to said display means (102) image data having the same spatial position as said display means (102). Use: Optical disc/Optical disc player.
摘要翻译：本发明涉及一种旨在进行旋转运动的信息载体（101），所述信息载体（101）包括：设计成显示图像数据的显示装置（102），所述显示装置（102）在空间上位于空间位置，用于周期性地向所述显示装置（102）发送具有与所述显示装置（102）相同的空间位置的图像数据的处理装置（103）。用途：光盘/光盘播放机。

66. 发明授权

US07038599B2 Stochastic DC control 失效
标题翻译：随机DC控制
公开(公告)号：US07038599B2
公开(公告)日：2006-05-02
申请号：US10510303
申请日：2003-04-10
申请人： Josephus Arnoldus Henricus Maria Kahlman
发明人： Josephus Arnoldus Henricus Maria Kahlman
IPC分类号： H03M5/00
CPC分类号： H03M5/145 , G11B20/1426 , G11B2020/1453
摘要： When recording data on a record carrier of the DC content of the data recorded is important in order to allow accurate reproduction of the data. The Digital Sum Value represents the DC content; the Digital Sum Value can be controlled by replacing code words at the output of an encoder by code words that can never occur during encoding. The replacement code word has different parity than the code word it replaces. The resulting stream of code words is subsequent encoded using an NRZI coder, so that the change in parity resulting from replacement code word results in a change of polarity of the NRZI output. The replacement code word can thus be used to change the polarity of the NRZI output to keep the Digital Sum Value low.
摘要翻译：在记录的数据的DC内容的记录载体上记录数据是重要的，以便准确地再现数据。数字和值表示DC内容; 数字和值可以通过在编码期间通过在编码期间永远不会发生的代码字替换编码器的输出端的代码字来进行控制。替代代码字与其替代的代码字具有不同的奇偶校验。所得到的码字流使用NRZI编码器进行后续编码，使得由替换码字产生的奇偶校验变化导致NRZI输出极性的改变。因此，替代码字可以用于改变NRZI输出的极性，以保持数字和值低。

67. 发明授权

US06700509B1 Device and method for processing a digital information signal 失效
标题翻译：用于处理数字信息信号的装置和方法
公开(公告)号：US06700509B1
公开(公告)日：2004-03-02
申请号：US09702347
申请日：2000-10-31
申请人： Josephus Arnoldus Henricus Maria Kahlman , Willem Marie Julia Marcel Coene
发明人： Josephus Arnoldus Henricus Maria Kahlman , Willem Marie Julia Marcel Coene
IPC分类号： H03M700
CPC分类号： H03M13/31 , G11B20/14 , G11B20/1426 , H03M5/14 , H03M5/145
摘要： A device and associated method for processing a digital information signal from a channel signal. The digital information signal is runlength limited with one or more constraints. The device comprises receiving means for receiving the channel signal and means for comparing a detected runlength with a predetermined value indicative of a minimum runlength constraint or a maximum runlength constraint of the channel signal and for generating a control signal when the detected runlength violates said constraint. The device further comprises substitute means for in response to the control signal deleting or inserting an element in the channel signal.
摘要翻译：一种用于从信道信号处理数字信息信号的装置和相关方法。数字信息信号是由一个或多个约束限制的游程长度。该装置包括用于接收信道信号的接收装置和用于将检测到的游程长度与指示信道信号的最小游程长度约束或最大游程长度约束的预定值进行比较的装置，并且用于当检测到的游程长度违反所述约束时产生控制信号。该设备还包括用于响应于控制信号删除或插入信道信号中的元素的替代装置。

68. 发明授权

US09339813B2 Substance determining apparatus 有权
标题翻译：物质确定装置
公开(公告)号：US09339813B2
公开(公告)日：2016-05-17
申请号：US13516060
申请日：2010-12-10
申请人： Josephus Arnoldus Henricus Maria Kahlman , Joannes Baptist Adrianus Dionisius Van Zon , Johannes Joseph Hubertina Barbara Schleipen , Derk Jan Wilfred Klunder , Toon Hendrik Evers , Ron Martinus Laurentius Van Lieshout
发明人： Josephus Arnoldus Henricus Maria Kahlman , Joannes Baptist Adrianus Dionisius Van Zon , Johannes Joseph Hubertina Barbara Schleipen , Derk Jan Wilfred Klunder , Toon Hendrik Evers , Ron Martinus Laurentius Van Lieshout
IPC分类号： G01N21/17 , B01L3/00 , G01N21/552 , G01N21/84 , G01N33/543
CPC分类号： B01L3/5027 , B01L2200/0605 , B01L2300/0636 , B01L2300/0681 , B01L2300/0816 , B01L2400/0406 , G01N21/552 , G01N21/8483 , G01N33/54373
摘要： The invention relates to a substance determining apparatus for determining a substance within a fluid. Particles attach the substance and bind to a binding surface (30), wherein a sensing signal is generated depending on the bound particles. Binding events indicating a binding of a particle on the binding surface (30) are determined from the generated sensing signal, and the substance within the fluid is determined based on the determined binding events. During a procedure of determining a substance within a fluid, particles may bind to the binding surface and may leave the binding surface. Therefore, during this procedure a number of binding events can be determined being much larger than the number of bound particles. The determination of the substance within the fluid can therefore be based on a very large amount of data, thereby increasing the accuracy of determining the substance within the fluid.
摘要翻译：本发明涉及一种用于确定流体内物质的物质确定装置。颗粒附着物质并结合到结合表面（30），其中根据结合的颗粒产生感测信号。根据产生的感测信号确定指示结合表面（30）上的颗粒结合的结合事件，并且基于所确定的结合事件确定流体内的物质。在确定流体内的物质的过程中，颗粒可能结合到结合表面并且可能离开结合表面。因此，在此过程中，可以确定许多结合事件比结合粒子的数量大得多。因此，流体内的物质的测定可以基于非常大量的数据，从而提高确定流体内物质的准确性。

69. 发明授权

US09250181B2 Sensor device with imaging optics 有权
标题翻译：具有成像光学元件的传感器装置
公开(公告)号：US09250181B2
公开(公告)日：2016-02-02
申请号：US13498347
申请日：2010-09-27
申请人： Josephus Arnoldus Henricus Maria Kahlman , Joannes Baptist Adrianus Dionisius Van Zon
发明人： Josephus Arnoldus Henricus Maria Kahlman , Joannes Baptist Adrianus Dionisius Van Zon
IPC分类号： H04N13/00 , G01N21/55 , G01N27/00 , G01N21/00 , G01J1/58 , G01N21/552 , G01N21/64 , G02B21/36
CPC分类号： G01N21/552 , G01N21/648 , G02B21/367
摘要： The invention relates to a method and a sensor device (100) for detecting particles (MP) that are bound to the binding surface (12) of a carrier (11). The sensor device (100) comprises a microscope (50) for imaging bound particles (MP) onto an image sensor (53). In order to increase the spatial resolution of the microscope (50), a displacement unit (60,70,80) is provided that can displace the carrier (11) relative to the image sensor (53). The distance of a bound particle (MP) from the binding surface (12) and/or its lateral displacement in reaction to forces can thus be determine with high accuracy. This allows to discriminate specific bindings of large magnetic particles (MP) that are bound to the binding surface (12) via smaller target particles from nonspecific direct bindings.
摘要翻译：本发明涉及一种用于检测与载体（11）的结合表面（12）结合的颗粒（MP）的方法和传感器装置（100）。传感器装置（100）包括用于将结合颗粒（MP）成像到图像传感器（53）上的显微镜（50）。为了增加显微镜（50）的空间分辨率，提供了可相对于图像传感器（53）移动载体（11）的位移单元（60,70,80）。因此，可以高精度地确定结合粒子（MP）与结合面（12）的距离和/或其与力的反应的横向位移。这允许通过来自非特异性直接结合的较小靶颗粒来区分与结合表面（12）结合的大磁性颗粒（MP）的特异性结合。

70. 发明授权

US08945472B2 Optimized detector readout for biosensor 有权
公开(公告)号：US08945472B2
公开(公告)日：2015-02-03
申请号：US12810531
申请日：2008-12-18
申请人： Josephus Arnoldus Henricus Maria Kahlman , Bart Michiels
发明人： Josephus Arnoldus Henricus Maria Kahlman , Bart Michiels
IPC分类号： G01N21/00 , G01N21/552 , G01N21/27 , G09G3/32 , G01J1/46 , G01N21/65 , G01J1/44 , G01N15/02
CPC分类号： G06T7/0012 , A61M2205/3306 , G01J1/44 , G01J1/46 , G01N15/0205 , G01N15/0211 , G01N21/274 , G01N21/552 , G01N21/65 , G01N2201/0691 , G06T2207/10004 , G06T2207/10152 , G06T2207/30004 , G09G3/3233 , G09G2300/0443 , G09G2300/0809 , G09G2340/0435 , Y10S435/808 , Y10S436/805 , Y10T436/25
摘要： The present invention provides a biosensor system comprising a light source, a cartridge adapted to be illuminated by said light source, a light detector adapted for detecting a signal originating from the cartridge, an illumination control means adapted to vary the illumination of the cartridge between at least two different states, a means for generating a first oscillation with a first frequency, and a means for generating a second oscillation with a second frequency, wherein the frame rate of the light detector is triggered by the first oscillation and the illumination control means is triggered by the second oscillation.

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