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61. 发明授权

US09700730B2 External charger with customizable magnetic charging field 有权
公开(公告)号：US09700730B2
公开(公告)日：2017-07-11
申请号：US13099906
申请日：2011-05-03
申请人： Rafael Carbunaru , Andrew DiGiore , Todd Whitehurst
发明人： Rafael Carbunaru , Andrew DiGiore , Todd Whitehurst
IPC分类号： A61N1/00 , A61N1/372 , A61N1/08 , A61N1/378
CPC分类号： A61N1/37229 , A61N1/08 , A61N1/37205 , A61N1/37211 , A61N1/378 , A61N1/3787
摘要： Improved external chargers for charging an implantable medical device, and particularly useful in charging a plurality of such devices, are disclosed. Each of the various embodiments include a plurality of field customization coils for customizing the magnetic charging field generated by the external charger such that the magnetic charging field is not radially symmetric. For example, one embodiment includes a primary coil with a plurality of field customization coils distributed radially with respect to the coil. The generated magnetic charging field can be rendered radially asymmetric by selectively activating or disabling the field customization coils in response to data quantifying the coupling between the various implants and the field customization coils in the charger. If there is a relatively high coupling between a particular implant and a particular customization coil for example, that customization coil can be activated to counter the magnetic charging field at that location, while still maintaining a relatively high magnetic charging field at the location of other implants that may have lower couplings.

62. 发明授权

US09452288B2 Multimodal neurostimulation systems and methods 有权
标题翻译：多模式神经刺激系统和方法
公开(公告)号：US09452288B2
公开(公告)日：2016-09-27
申请号：US11951987
申请日：2007-12-06
申请人： Todd Whitehurst , Rafael Carbunaru , Kristen Jaax , Andrew DiGiore , Brett D Schleicher
发明人： Todd Whitehurst , Rafael Carbunaru , Kristen Jaax , Andrew DiGiore , Brett D Schleicher
IPC分类号： A61N1/00 , A61N1/36 , A61N1/372 , A61B18/12 , A61N1/37
CPC分类号： A61N1/37241 , A61B18/12 , A61N1/36017 , A61N1/3625 , A61N1/37 , A61N1/37211 , A61N1/37247 , A61N1/37288 , A61N1/39
摘要： A system for performing a neurostimulation trial comprises an external trial stimulator capable of delivering stimulation energy to a plurality of electrodes carried by one or more stimulation leads. The external trial stimulator is configurable to operate in a plurality of stimulation energy delivery modes to respectively emulate one of different neurostimulator types. The system may further comprise a programmer capable of configuring the external trial stimulator to operate in one of the stimulation energy delivery modes. The programmer may be capable of generating a first programming screen capable of allowing a first set of stimulation parameters to be defined for the first neurostimulator type, and a second programming screen capable of allowing a second set of stimulation parameters to be defined for a second neurostimulator type.
摘要翻译：用于执行神经刺激试验的系统包括能够将刺激能量递送到由一个或多个刺激引线携带的多个电极的外部刺激器。外部刺激器可配置为在多个刺激能量递送模式中操作以分别模拟不同神经刺激器类型之一。该系统还可以包括能够配置外部试用刺激器以在刺激能量递送模式之一中操作的编程器。程序员可能能够生成第一编程屏幕，其能够允许为第一神经刺激器类型定义第一组刺激参数;以及第二编程屏幕，其能够允许为第二神经刺激器定义第二组刺激参数类型。

63. 发明授权

US09446231B2 Neurostimulation system and method for compounding current to minimize current sources 有权
标题翻译：神经刺激系统和混合电流的方法以最小化电流源
公开(公告)号：US09446231B2
公开(公告)日：2016-09-20
申请号：US12952738
申请日：2010-11-23
申请人： Rafael Carbunaru , Kristen Jaax , Andrew DiGiore
发明人： Rafael Carbunaru , Kristen Jaax , Andrew DiGiore
IPC分类号： A61N1/36 , A61N1/05 , A61N1/372 , A61N1/08
CPC分类号： A61N1/08 , A61N1/0551 , A61N1/36185 , A61N1/37223 , A61N1/37241 , A61N1/37288 , A61N2001/083
摘要： A neurostimulation system and method of providing therapy to a patient implanted with a plurality of electrodes using a plurality of electrical sources is provided. A source-electrode coupling configuration is determined from the electrical sources and electrodes. Electrical current is respectively conveyed between active ones of the plurality of electrical sources and active subsets of the plurality of electrodes in accordance with the determined source-electrode coupling configuration. The total number of the electrodes in the active electrode subsets is greater than the total number of the active electrical sources.
摘要翻译：提供了一种使用多个电源向注入多个电极的患者提供治疗的神经刺激系统和方法。源电极耦合配置由电源和电极确定。根据所确定的源电极耦合配置，电流分别在多个电源中的有效电源和多个电极的有效子集之间传送。有源电极子集中的电极总数大于有源电源的总数。

64. 发明授权

US09352156B2 Automatic evaluation technique for deep brain stimulation programming 有权
标题翻译：深层脑刺激程序自动评估技术
公开(公告)号：US09352156B2
公开(公告)日：2016-05-31
申请号：US12976658
申请日：2010-12-22
申请人： Courtney Lane , Rafael Carbunaru , David K. L. Peterson , Andrew DiGiore
发明人： Courtney Lane , Rafael Carbunaru , David K. L. Peterson , Andrew DiGiore
IPC分类号： A61N1/36 , A61N1/05 , A61N1/372
CPC分类号： A61N1/36139 , A61N1/0531 , A61N1/0534 , A61N1/36082 , A61N1/37282
摘要： Neurostimulation systems and methods for providing therapy to a patient suffering from a symptom of a disease that latently responds to electrical stimulation therapy are provided. First electrical stimulation energy is conveyed to or from a tissue region of the patient in accordance with a first set of stimulation parameters, thereby affecting the symptom. A predetermined period of time estimated for the symptom to resolve in response to electrical stimulation therapy is allowed to elapse. Second electrical stimulation energy is conveyed to or from the tissue region in accordance with a second set of stimulation parameters different from the first set of stimulation parameters.
摘要翻译：提供了神经刺激系统和方法，用于向患有潜在的电刺激治疗反应的疾病症状的患者提供治疗。根据第一组刺激参数将第一电刺激能量传送到患者的组织区域或从患者的组织区域传送，从而影响症状。对于电刺激治疗反应的症状的预定时间段被允许经过。根据与第一组刺激参数不同的第二组刺激参数将第二电刺激能量传送到组织区域或从组织区域传送。

65. 发明授权

US08649879B2 Leads with retention features for segmented electrodes and methods of making and using the leads 有权
标题翻译：引导具有分段电极的保留特征以及制造和使用引线的方法
公开(公告)号：US08649879B2
公开(公告)日：2014-02-11
申请号：US13368982
申请日：2012-02-08
申请人： Andrew DiGiore , Anne Margaret Pianca , Michael Adam Moffitt
发明人： Andrew DiGiore , Anne Margaret Pianca , Michael Adam Moffitt
IPC分类号： A61N1/00
CPC分类号： A61N1/0534 , A61N1/0551 , Y10T29/49117
摘要： One embodiment is a stimulation lead including a lead body comprising a longitudinal surface, a distal end, and a proximal end; and multiple electrodes disposed along the longitudinal surface of the lead body near the distal end of the lead body. The multiple electrodes include multiple segmented electrodes with each of the segmented electrodes having an exterior surface, an interior surface opposite the exterior surface, a proximal end, and a distal end. At least one of the segmented electrodes includes one or more of a) at least one channel formed in the segmented electrode and extending from the proximal end to the distal end of the segmented electrode, b) an arcuate groove formed in at least one of the distal end surface or the proximal end surface, or c) a notch formed in the segmented electrode and extending from the proximal end to the distal end of the segmented electrode.
摘要翻译：一个实施例是包括包括纵向表面，远端和近端的引线主体的刺激引线; 以及沿引线本体的远端的纵向表面设置的多个电极。多个电极包括多个分段电极，每个分段电极具有外表面，与外表面相对的内表面，近端和远端。所述分段电极中的至少一个包括以下中的一个或多个：a）形成在分段电极中并且从分段电极的近端延伸到远端的至少一个通道，b）形成在至少一个远端表面或近端表面，或c）形成在分段电极中并从分段电极的近端延伸到远端的凹口。

66. 发明授权

US08583262B2 Implantable medical device that uses electrical current steering by means of output impedance modulation 有权
标题翻译：通过输出阻抗调制使用电流转向的可植入医疗器械
公开(公告)号：US08583262B2
公开(公告)日：2013-11-12
申请号：US12606065
申请日：2009-10-26
申请人： Jordi Parramon , David K. L. Peterson , Kerry Bradley , Rafael Carbunaru , Andrew DiGiore
发明人： Jordi Parramon , David K. L. Peterson , Kerry Bradley , Rafael Carbunaru , Andrew DiGiore
IPC分类号： A61N1/08
CPC分类号： A61N1/36125 , A61N1/0551 , A61N1/36157 , A61N1/36185
摘要： A method and system of providing therapy to a patient implanted with an array of electrodes is provided. Electrical stimulation current is conveyed from at least two of the electrodes to at least one of the electrodes along at least two electrical paths through tissue of the patient, and the electrical stimulation current is shifted between the electrical paths by actively adjusting one or more finite resistances respectively associated with one or more of the electrical paths.
摘要翻译：提供了向植入电极阵列的患者提供治疗的方法和系统。电刺激电流沿着沿着患者组织的至少两条电路径从至少两个电极传送到至少一个电极，并且电刺激电流通过主动调节一个或多个有限电阻而在电路径之间移动分别与一个或多个电路径相关联。

67. 发明授权

US08494653B2 Paddle lead configurations for electrical stimulation systems and methods of making and using 有权
标题翻译：用于电刺激系统的桨导线配置及其制作和使用方法
公开(公告)号：US08494653B2
公开(公告)日：2013-07-23
申请号：US13570059
申请日：2012-08-08
申请人： Andrew DiGiore , Greg Baldwin
发明人： Andrew DiGiore , Greg Baldwin
IPC分类号： A61N1/00 , A61B1/00
CPC分类号： A61N1/05 , A61N1/0553
摘要： A paddle lead includes a paddle body with a plurality of electrodes disposed on the paddle body. The plurality of electrodes includes a first electrode and a second electrode. The first electrode and the second electrode are disposed laterally around the circumference of the paddle body. At least one connecting wire is disposed on, or within, the paddle body to electrically couple the first electrode and the second electrode.
摘要翻译：桨引线包括具有设置在桨体上的多个电极的桨体。多个电极包括第一电极和第二电极。第一电极和第二电极围绕桨体的圆周横向设置。至少一个连接线设置在桨体上或其内部，以电耦合第一电极和第二电极。

68. 发明授权

US08428746B2 Moldable charger with shape-sensing means for an implantable pulse generator 有权
标题翻译：具有用于可植入脉冲发生器的形状感测装置的可成型充电器
公开(公告)号：US08428746B2
公开(公告)日：2013-04-23
申请号：US13569027
申请日：2012-08-07
申请人： Andrew DiGiore , Brett Schleicher , Greg Baldwin
发明人： Andrew DiGiore , Brett Schleicher , Greg Baldwin
IPC分类号： A61N1/00
CPC分类号： A61N1/3787
摘要： Electrical energy is transcutaneously transmitted from an external charger to an implanted medical device. The external charger includes a charging head that is selectively shapeable to conform to the surface of a patient to enhance charge efficiency and patient comfort. An alternating current charging coil is housed in the charging head and configured for transcutaneously transmitting electrical energy to the implanted medical device. The shape of the coil is changeable as the charging head is shaped, and at least one sensor determines changes in the shape of the charging coil and causes the charge of the coil to be adjusted based on the coil shape.
摘要翻译：电能从外部充电器经皮传输到植入式医疗装置。外部充电器包括充电头，该充电头可选择地成形以符合患者的表面以增强充电效率和患者舒适度。交流充电线圈被容纳在充电头中并且被配置为将电能经皮地传输到植入的医疗装置。线圈的形状可以随着充电头的形状而变化，并且至少一个传感器确定充电线圈的形状的变化，并且基于线圈形状来调节线圈的充电。

69. 发明授权

US08313453B2 Burr hole sealing device for preventing brain shift 有权
标题翻译：用于防止脑移位的毛刺孔密封装置
公开(公告)号：US08313453B2
公开(公告)日：2012-11-20
申请号：US12549174
申请日：2009-08-27
申请人： Rafael Carbunaru , Todd K. Whitehurst , Andrew DiGiore , Kristen Jaax
发明人： Rafael Carbunaru , Todd K. Whitehurst , Andrew DiGiore , Kristen Jaax
IPC分类号： A61M5/00
CPC分类号： A61N1/0539 , A61B17/3415 , A61B90/14 , A61B2017/3419 , A61B2090/103 , A61M2039/025 , A61M2039/0276 , A61M2039/0282
摘要： A burr hole sealing device for preventing brain shift during a stimulation lead implantation procedure is provided. The device includes a suction cup ring and a self-sealing membrane positioned within the aperture of the ring. The sealing device is attached adjacent to a burr hole and over a dura layer that is exposed in the bottom of the burr hole. The stimulation lead is disposed through the burr hole, through the membrane, through the dura layer and into brain tissue. The membrane is configured to allow the lead to pass therethrough while maintaining a tight seal around the diameter of the lead, thereby hindering leakage of cerebrospinal fluid out of the cranial cavity and maintaining a substantially fixed intracranial pressure. In one embodiment, the sealing device includes a syringe for adding fluid to, or removing fluid from, the cranial cavity in response to a detected change in intracranial pressure.
摘要翻译：提供了一种用于在刺激引线植入程序期间防止脑移位的钻孔密封装置。该装置包括吸盘环和位于环的孔内的自密封膜。密封装置邻近毛刺孔并暴露在钻孔底部的硬脑膜层上。刺激引线通过毛刺孔穿过膜，穿过硬脑膜层并进入脑组织。膜被配置为允许引线通过，同时保持围绕铅直径的紧密密封，从而阻止脑脊液从脑腔中泄漏并保持基本上固定的颅内压。在一个实施例中，密封装置包括用于响应于检测到的颅内压变化而将流体添加到颅腔或从头颅腔移除流体的注射器。

70. 发明申请

US20120271393A1 ANCHORING UNITS FOR LEADS OF IMPLANTABLE ELECTRIC STIMULATION SYSTEMS AND METHODS OF MAKING AND USING 有权
标题翻译：可植入电刺激系统引导锚固单元及其制造和使用方法
公开(公告)号：US20120271393A1
公开(公告)日：2012-10-25
申请号：US13538703
申请日：2012-06-29
申请人： Brett Schleicher , Andrew DiGiore , Rafael Carbunaru , Courtney Lane , Kristen N. Jaax
发明人： Brett Schleicher , Andrew DiGiore , Rafael Carbunaru , Courtney Lane , Kristen N. Jaax
IPC分类号： A61N1/05
CPC分类号： A61N1/0558
摘要： A nerve stimulation lead has a distal end, a proximal end, and a longitudinal length. The nerve stimulation lead includes a plurality of electrodes disposed at the distal end, a plurality of terminals disposed at the proximal end, and a plurality of conductive wires electrically coupling the plurality of electrodes electrically to the plurality of terminals. The nerve stimulation lead also includes at least one anchoring unit disposed on the nerve stimulation lead. The at least one anchoring unit is configured and arranged for anchoring the nerve stimulation lead against a bony structure.
摘要翻译：神经刺激引线具有远端，近端和纵向长度。神经刺激引线包括设置在远端的多个电极，设置在近端的多个端子，以及将多个电极电连接到多个端子的多个导线。神经刺激引线还包括设置在神经刺激引线上的至少一个锚定单元。所述至少一个锚定单元被配置和布置成用于将神经刺激引线抵靠骨结构锚定。

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