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51. 发明申请

US20060269632A1 Remedies for allergic diseases and process for producing the same 审中-公开
公开(公告)号：US20060269632A1
公开(公告)日：2006-11-30
申请号：US11327720
申请日：2006-01-05
申请人： Harui Fukuda
发明人： Harui Fukuda
IPC分类号： A61K36/13 , C12P1/00 , A61K31/70
CPC分类号： C12R1/645 , A23L33/10 , A23L33/105 , A23L33/14 , A23V2002/00 , A61K31/70 , A61K31/7016 , A61K36/15 , C12P1/02 , A23V2200/318 , A23V2200/324 , A23V2250/76
摘要： Remedies for allergic diseases obtained by mixing shoots of plants belonging to the family Pinaceae with water and saccharides followed by spontaneous fermentation. As the plants belonging to the family Pinaceae, it is preferable to use plants belonging to the genus Pinus. These remedies, which enable complete recovery in a short administration time without showing any side effects, are useful as remedies for allergic diseases, in particular, asthma and atopic dermatitis. Also, a yeast isolated from these remedies for allergic diseases is provided.

52. 发明申请

US20060251608A1 A Method of Treatment of Aging and Wrinkled Skin and a Kit Containing Compositions for Same 审中-公开
标题翻译：一种治疗老化和皱纹皮肤的方法和含有组合物的试剂盒
公开(公告)号：US20060251608A1
公开(公告)日：2006-11-09
申请号：US11381552
申请日：2006-05-04
申请人： Richard Wachsberg , Charles Wachsberg
发明人： Richard Wachsberg , Charles Wachsberg
IPC分类号： A61K8/97 , A61K38/43 , A61K31/385 , A61K35/64 , A61K33/34 , A61K33/04 , A61K33/32 , A61K36/13 , A61K36/906 , A61K36/82
CPC分类号： A61K8/02 , A61K8/97 , A61K31/385 , A61K33/04 , A61K33/30 , A61K33/34 , A61K35/644 , A61K36/15 , A61K36/28 , A61K36/45 , A61K36/55 , A61K36/725 , A61K36/82 , A61K36/87 , A61K36/886 , A61K36/9066 , A61K36/9068 , A61K38/05 , A61K45/06 , A61K2800/522 , A61K2800/92 , A61Q19/08 , A61K2300/00
摘要： There is disclosed a method of treating aged and wrinkled skin and a kit containing compositions and instructions for such treatment. The method consists of a daily treatment regime, with two separate oral doses approximately 12 hours apart and application of a topical formulation. The oral formulations may be the same or different from each other, and each consist of one or more antioxidants, antioxidant co-promoters, anti-inflammatory, collagen synthesis promoters and optionally other substances. The topical formulation consists of an anti-wrinkle substance, such as a cream.
摘要翻译：公开了一种治疗老化和起皱皮肤的方法以及包含这种治疗的组合物和说明书的试剂盒。该方法包括每日治疗方案，两次分开的口服剂量约12小时，并施用局部制剂。口服制剂可以彼此相同或不同，并且各自由一种或多种抗氧化剂，抗氧化助促进剂，抗炎剂，胶原合成促进剂和任选的其它物质组成。局部制剂由抗皱物质如霜剂组成。

53. 发明申请

US20060198910A1 Method for processing vegetable raw materials 有权
标题翻译：蔬菜原料加工方法
公开(公告)号：US20060198910A1
公开(公告)日：2006-09-07
申请号：US10559114
申请日：2004-04-27
申请人： Viktor Roschin , Vagif Sultanov
发明人： Viktor Roschin , Vagif Sultanov
IPC分类号： A61K36/16 , A61K36/13 , A61K36/185
CPC分类号： C11B1/10 , C11B11/00 , C11B13/00 , Y02W30/74
摘要： The inventive method for processing vegetable raw materials consisting in organic solvent-extracting said materials, isolating it by retention which is associated with cooling and wax filtration, separating free oxides from the thus obtained solution of extractive substances by alkali solution action, dividing the obtained neutralised solution into a neutral substance solution in the hydrocarbon solvent and a water-alkali solution of organic acid salts, acidifying said salt solution, isolating chlorophilline acids and a fatty and resin acid fraction therefrom by retention, dividing the sum of diterpenic and higher fatty acids, distilling the solvent from neutral substances and in dividing said neutral substances. The diterpenic and higher fatty acid sum is treated in a low-molecular alcohol by adding a sulphuric acid in the form of a catalyst. Said method also consists in distilling alcohol and neutralising the diterpenic acids and catalyst, extracting the higher fatty acid ethers, acidifying the water-alkali solution and extracting isolated diterpenic acids, distilling said solvent and in producing a rodent repellent. The neutral substances are subsequently extracted into acetone and C1-C3 alcohol. Afterwards, during acetone treatment, the concentrates of higher fatty acid esters are produced in association with triterpenic alcohols, stearins, higher fatty alcohols and an acetone-soluble residue. During the residue treatment by alcohol, the sum of diterpenic acids is separated, and the saponification of said acids makes it possible to produce a polyprenol concentrate for separating polyprenols therefrom by chromatography.
摘要翻译：用于处理植物原料的本发明方法，该方法包括有机溶剂提取所述材料，通过与冷却和蜡过滤相关的保留来分离其，通过碱溶液作用从得到的萃取物溶液中分离出游离氧化物，溶解在烃溶剂中的中性物质溶液和有机酸盐的水 - 碱溶液中，酸化所述盐溶液，通过保留分离氯青霉酸和脂肪和树脂酸部分，除以二萜和高级脂肪酸的总和，从中性物质中蒸馏除去溶剂并分解所述中性物质。二萜类和高级脂肪酸总和通过加入催化剂形式的硫酸在低分子醇中进行处理。所述方法还包括蒸馏酒精和中和二萜酸和催化剂，提取高级脂肪酸醚，酸化水溶液和提取分离的二萜酸，蒸馏所述溶剂和产生灭鼠剂。随后将中性物质萃取到丙酮和C 1 -C 3醇中。之后，在丙酮处理过程中，与三萜醇，硬脂精，高级脂肪醇和可溶于丙酮的残留物相结合产生高级脂肪酸酯的浓缩物。在通过醇的残余物处理期间，分离二萜酸的总和，并且所述酸的皂化使得可以通过色谱法制备聚异戊二烯浓缩物以从其中分离聚异戊二烯。

54. 发明申请

US20060182708A1 Prebiotically active plant extracts 审中-公开
标题翻译：益生菌活性植物提取物
公开(公告)号：US20060182708A1
公开(公告)日：2006-08-17
申请号：US11336164
申请日：2006-01-20
申请人： Dirk Bockmuhl , Heide-Marie Hohne , Claudia Jassoy , Regine Schollyssek , Marianne Waldmann-Laue , Wolfhard Scholz , Andrea Sattler
发明人： Dirk Bockmuhl , Heide-Marie Hohne , Claudia Jassoy , Regine Schollyssek , Marianne Waldmann-Laue , Wolfhard Scholz , Andrea Sattler
IPC分类号： A61K8/97 , A61K36/254 , A61K36/53 , A61K36/13 , A61K36/77
CPC分类号： A61Q19/10 , A61K8/97 , A61K9/0014 , A61K9/06 , A61K9/107 , A61K9/7061 , A61K9/7084 , A61K36/15 , A61K36/185 , A61K36/25 , A61K36/53 , A61K36/77 , A61K47/10 , A61K47/14 , A61K47/44 , A61Q5/006 , A61Q19/00 , A61Q19/007 , A61Q19/008 , A61K2300/00
摘要： The invention relates to plant extracts that have a prebiotic effect on skin, topical cosmetic and pharmaceutical compositions containing said plant extracts, and the use of said plant extracts and compositions, especially for treating the skin.
摘要翻译：本发明涉及对皮肤具有益生元效应的植物提取物，含有所述植物提取物的局部化妆品和药物组合物，以及所述植物提取物和组合物，特别是用于治疗皮肤的用途。

55. 发明申请

US20060134235A1 External preparation for improving blood flow 审中-公开
标题翻译：改善血流量的外用剂
公开(公告)号：US20060134235A1
公开(公告)日：2006-06-22
申请号：US11020693
申请日：2004-12-22
申请人： Kinya Takagaki , Takeshi Mitsui
发明人： Kinya Takagaki , Takeshi Mitsui
IPC分类号： A61K36/899 , A61K31/35 , A61K36/45 , A61K36/16 , A61K36/48 , A61K36/73 , A61K36/13
CPC分类号： A61K36/15 , A61K31/35 , A61K36/81 , A61K2300/00
摘要： The present invention provides an external preparation for improving blood flow that comprises proanthocyanidins. The external preparation for improving blood flow provides an excellent effect of improving blood flow. When the proanthocyanidins that contain preferably at least 20 wt % OPCs are employed, a further excellent effect of improving blood flow can be achieved.
摘要翻译：本发明提供了包含原花色素的改善血流的外用制剂。用于改善血流量的外用制剂提供了改善血流量的极好效果。当使用含有优选至少20重量％的OPC的原花色素时，可以获得进一步优异的改善血流量的效果。

56. 发明申请

US20050014730A1 Anti-fungal formulation of triterpene and essential oil 审中-公开
标题翻译：三萜和精油的抗真菌配方
公开(公告)号：US20050014730A1
公开(公告)日：2005-01-20
申请号：US10816804
申请日：2004-04-02
申请人： Robert Carlson , David Gibson
发明人： Robert Carlson , David Gibson
IPC分类号： A61K31/00 , A61K31/56 , A61K36/09 , A61K36/13 , A61K36/14 , A61K36/15 , A61K36/17 , A61K36/185 , A61K36/23 , A61K36/232 , A61K36/235 , A61K36/25 , A61K36/258 , A61K36/28 , A61K36/282 , A61K36/30 , A61K36/32 , A61K36/324 , A61K36/328 , A61K36/355 , A61K36/38 , A61K36/45 , A61K36/47 , A61K36/48 , A61K36/482 , A61K36/52 , A61K36/53 , A61K36/532 , A61K36/534 , A61K36/537 , A61K36/54 , A61K36/57 , A61K36/61 , A61K36/63 , A61K36/67 , A61K36/736 , A61K36/738 , A61K36/75 , A61K36/81 , A61K36/82 , A61K36/84 , A61K36/85 , A61K36/86 , A61K36/87 , A61K36/88 , A61K36/886 , A61K36/889 , A61K36/8895 , A61K36/896 , A61K36/8962 , A61K36/898 , A61K36/899 , A61K36/9064 , A61K36/9066 , A61K36/9068 , A61P31/10 , C07J63/00 , A61K35/78
CPC分类号： C07J63/008 , A61K31/56 , A61K36/09 , A61K36/13 , A61K36/14 , A61K36/15 , A61K36/17 , A61K36/185 , A61K36/23 , A61K36/232 , A61K36/235 , A61K36/25 , A61K36/258 , A61K36/28 , A61K36/282 , A61K36/30 , A61K36/32 , A61K36/324 , A61K36/328 , A61K36/355 , A61K36/38 , A61K36/45 , A61K36/47 , A61K36/48 , A61K36/482 , A61K36/52 , A61K36/53 , A61K36/532 , A61K36/534 , A61K36/537 , A61K36/54 , A61K36/57 , A61K36/61 , A61K36/63 , A61K36/67 , A61K36/736 , A61K36/738 , A61K36/75 , A61K36/752 , A61K36/81 , A61K36/82 , A61K36/84 , A61K36/85 , A61K36/86 , A61K36/87 , A61K36/88 , A61K36/886 , A61K36/889 , A61K36/8895 , A61K36/896 , A61K36/8962 , A61K36/898 , A61K36/899 , A61K36/9064 , A61K36/9066 , A61K36/9068 , A61K2300/00
摘要： The present invention provides for pharmaceutical compositions that includes a triterpene (e.g., betulin) and an essential oil (Vicks® Vapor Rub). The present invention also provides for a cosmetic formulation that includes a triterpene (e.g., betulin) and an essential oil (Vicks® Vapor Rub). The present invention also provides a method of treating a fungal infection that includes administering (e.g., topically applying) an effective amount of the pharmaceutical composition to the tissue afflicted with the fungal infection, or the tissue at risk of being afflicted with the fungal infection.
摘要翻译：本发明提供了包含三萜（例如桦木醇）和精油（Vicks Vapor Rub）的药物组合物。本发明还提供了包含三萜（例如桦木醇）和精油（Vicks Vapor Rub）的化妆品制剂。本发明还提供了一种治疗真菌感染的方法，其包括将有效量的药物组合物施用（例如，局部施用）到患有真菌感染的组织或被感染真菌感染的风险的组织。

57. 发明授权

US5716928A Use of essential oils to increase bioavailability of oral pharmaceutical compounds 失效
标题翻译：使用精油提高口服药物化合物的生物利用度
公开(公告)号：US5716928A
公开(公告)日：1998-02-10
申请号：US478207
申请日：1995-06-07
申请人： Leslie Z. Benet , Vincent J. Wacher , Reed M. Benet
发明人： Leslie Z. Benet , Vincent J. Wacher , Reed M. Benet
IPC分类号： A61K31/337 , A61K36/13 , A61K36/14 , A61K36/15 , A61K36/185 , A61K36/23 , A61K36/235 , A61K36/25 , A61K36/28 , A61K36/282 , A61K36/324 , A61K36/328 , A61K36/45 , A61K36/48 , A61K36/53 , A61K36/532 , A61K36/534 , A61K36/537 , A61K36/54 , A61K36/57 , A61K36/61 , A61K36/63 , A61K36/67 , A61K36/738 , A61K36/80 , A61K36/8962 , A61K36/898 , A61K36/899 , A61K36/9064 , A61K36/9068 , A61K38/13 , A61K47/10 , A61K47/44 , A61K31/12
CPC分类号： A61K47/44 , A61K31/337 , A61K36/13 , A61K36/14 , A61K36/15 , A61K36/185 , A61K36/23 , A61K36/235 , A61K36/25 , A61K36/28 , A61K36/282 , A61K36/324 , A61K36/328 , A61K36/45 , A61K36/48 , A61K36/53 , A61K36/532 , A61K36/534 , A61K36/537 , A61K36/54 , A61K36/57 , A61K36/61 , A61K36/63 , A61K36/67 , A61K36/738 , A61K36/752 , A61K36/80 , A61K36/8962 , A61K36/898 , A61K36/899 , A61K36/9064 , A61K36/9068 , A61K38/13 , A61K47/10 , Y10S514/946
摘要： A method for increasing bioavailability and reducing inter- and intra-individual variability of an orally administered hydrophobic pharmaceutical compound, which comprises orally administering the pharmaceutical compound to a mammal in need of treatment with the compound concurrently with an essential oil or essential oil component in an amount sufficient to provide bioavailability of the compound in the presence of the essential oil or essential oil component greater than bioavailability of the compound in the absence of the essential oil or essential oil component, wherein the essential oil or essential oil component has an activity of at least 10% inhibition at a concentration of 0.01 wt. % or less in an assay that measures conversion of cyclosporine to hydroxylated products using an assay system containing 250/.mu.g rat liver microsomes, 1.mu.M cyclosporine, and 1 mM reduced nicotinamide adenine dinucleotide phosphate (NADPH) in 1 ml of 0.1M sodium phosphate buffer, pH 7.4.
摘要翻译：一种增加口服给药的疏水性药物化合物的生物利用度和降低个体间和个体间变异性的方法，其包括将药物化合物口服施用于需要与化合物同时处理的哺乳动物，其中精油或精油成分与所述量足以在精油或精油成分存在下提供化合物的生物利用度，所述精油或精油成分在不存在精油或精油成分的情况下大于化合物的生物利用度，其中所述精油或精油成分具有浓度为0.01重量％时抑制率最低为10％在使用含有250μg/ ml大鼠肝微粒体，1μM环孢菌素和1mM还原型烟酰胺腺嘌呤二核苷酸磷酸酯（NADPH）的测定系统测量环孢菌素至羟基化产物的1％磷酸盐缓冲液，pH 7.4。

58. 发明授权

US5698524A Method of treating a patient suffering from a viral infection 失效
标题翻译：治疗患有病毒感染的患者的方法
公开(公告)号：US5698524A
公开(公告)日：1997-12-16
申请号：US465351
申请日：1995-06-05
申请人： Walter Mach, deceased , by Chantal Mach, legal representative
发明人： Walter Mach, deceased , by Chantal Mach, legal representative
IPC分类号： A61K35/10 , A61K9/08 , A61K31/70 , A61K31/715 , A61K31/717 , A61K36/00 , A61K36/13 , A61K36/15 , A61K36/18 , A61K36/54 , A61K36/899 , A61P31/12 , C07G1/00 , C08L97/00
CPC分类号： A61K36/54 , A61K36/00 , A61K36/13 , A61K36/15 , A61K36/899 , Y10S514/888
摘要： A method of treating a patient suffering with a viral infection (such as HIV) by administering to the patient an effective anti-viral amount of a composite molecular active substance group, which is produced by the process comprising: (a) preparing lignin units by carrying out an extraction in an aqueous media under weakly acidic or alkaline conditions of wood or wood-like materials and/or plant-cell cultures and separating-off the resultant insoluble solids; (b) preparing lignoid units by carrying out an aqueous alkaline extraction at a pH of 7 to 14 of starting materials selected from the group consisting of wood-incarbonization products and bioconverted wood-like materials and separating-off the resultant alkali-insoluble solids; and (c) preparing a water-soluble mixed polymer by reacting the lignin units from step (a) with the lignoid units from step (b), under aqueous alkaline isolating by ultrafiltration a low molecular weight fraction having a molecular weight of no more than 3000 daltons of the mixed polymer, taking a cut between 15 to 40 kilodaltons and discarding the resultant residue, and treating the resultant solution with an H.sup.+ cation exchanger at a pH of 3 to 7.
摘要翻译：通过向患者施用有效的抗病毒量的复合分子活性物质组来治疗患有病毒感染（例如HIV）的患者的方法，所述方法包括：（a）通过以下步骤制备木质素单位：在木质或木材样物质和/或植物细胞培养物的弱酸性或碱性条件下，在水性介质中进行提取，并分离所得的不溶性固体; （b）通过在7至14的pH值下进行水性碱性萃取来制备木质单体，所述原料选自木 - 硬化产物和生物转化的木质材料，并分离出所得的碱不溶性固体; 和（c）通过使来自步骤（a）的木质素单元与来自步骤（b）的木质素单元的反应，在通过超滤的水性碱性分离下反应制备水溶性混合聚合物，分子量不超过 3000道尔顿的混合聚合物，切割15至40千道尔顿，弃去所得残余物，并用pH为3至7的H +阳离子交换剂处理所得溶液。

59. 发明授权

US5670663A Recovery of taxanes from conifers 失效
标题翻译：从针叶树中回收紫杉烷
公开(公告)号：US5670663A
公开(公告)日：1997-09-23
申请号：US601367
申请日：1996-02-14
申请人： Don J. Durzan , Frank Ventimiglia
发明人： Don J. Durzan , Frank Ventimiglia
IPC分类号： A61K36/13 , A61K36/14 , A61K36/15 , C07C7/00 , C07D305/14 , G01N33/53
CPC分类号： G01N33/5308 , A61K36/13 , A61K36/14 , A61K36/15 , C07C7/00 , C07C2103/80
摘要： The present invention provides new sources of taxanes and other metabolites from members of the order Coniferales that are not in the genus Taxus.
摘要翻译：本发明提供来自不属于紫杉属的Coniferales成员的紫杉烷类和其他代谢物的新来源。

60. 发明授权

US5236709A Limulus test-positive plant glycolipid and method of stimulating the immunity system of an animal 失效
标题翻译：极限试验阳性植物甘油和刺激动物免疫系统的方法
公开(公告)号：US5236709A
公开(公告)日：1993-08-17
申请号：US475890
申请日：1990-02-06
申请人： Gen-Ichiro Soma , Jun Yoshimura , Daisuke Tsukioka , Den'Ichi Mizuno , Haruyuki Oshima
发明人： Gen-Ichiro Soma , Jun Yoshimura , Daisuke Tsukioka , Den'Ichi Mizuno , Haruyuki Oshima
IPC分类号： A61K31/00 , A61K36/00 , A61K36/02 , A61K36/06 , A61K36/11 , A61K36/13 , A61K36/185 , A61K36/88
CPC分类号： A61K31/00 , A61K36/00 , A61K36/02 , A61K36/06 , A61K36/11 , A61K36/13 , A61K36/185 , A61K36/88
摘要： A limulus test-positive plant glycolipid having the following properties:molecular weight: 8000.+-.1000 (SDS electrophoresis)number of phosphorus: not less than 1/mol.number of hexosamine: 6.+-.2/mol.number of fatty acid: 6.+-.2/mol is effective in the stimulation of osteogenesis, oviposition and shell strength improvement in animals. The glycolipid may be administered as a composition comprising an effective amount of said glycolipid in admixture with a pharmaceutically or veterinarily acceptable carrier, such that when administered to an animal, the immune system of said animal is favorably stimulated.

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