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    • 8. 发明申请
    • FRUIT EXTRACTS AND EXTRACT FORMULATIONS OF CANARIUM ODONTOPHYLLUM AS ACTIVES AND RELATED INVENTION EMBODIMENTS
    • 作为活性剂的菊酯提取物和提取物制剂及相关发明实施方案
    • US20160206674A1
    • 2016-07-21
    • US14913953
    • 2013-12-24
    • BIOTROPICS MALAYSIA BHD
    • MATTHIAS GEHLINGANNIE GEORGESASIKALA M. CHINNAPPANMAZRIA HASLINA BINTI MD AKIR
    • A61K36/32A61K45/06
    • A61K36/32A61K45/06
    • Method for producing an extract or extract formulation of the fruit of Canarium odontophyllum comprising or consisting of the following steps: (i) providing fruit material from Canarium odontophyllum, wherein said fruit material essentially consists of the endocarp of the seeds of Canarium odontophyllum, (i-a) optionally drying the fruit material provided in step (i), (ii) extracting the fruit material provided in step (i) or (i-a) with a mixture essentially consisting or consisting of water and an alcohol having 1 to 3 carbon atoms or consisting water and acetonitrile, (iii) optionally partially or fully removing the alcohol having 1 to 3 carbon atoms of step (ii), and optionally adding an organic solvent of medium polarity to said aqueous residue and extracting the aqueous residue with said organic solvent or a supercritical solvent, such as supercritical carbon dioxide thereby obtaining an enriched extract, (iv) optionally mixing the extract obtained in step (ii) or the enriched extract obtained in step (iii) with one or more solid carrier substances, (v) optionally drying the enriched extract obtained in step (iii) or the mixture obtained in step (iv), preferably by spray-drying or freeze-drying., and related invention embodiments, especially for use in the treatment of PDE2 and/or PDE5 related diseases, and related invention embodiments.
    • 包括或由以下步骤组成的用于生产牙釉质果实的提取物或提取物制剂的方法:(i)从牙釉质提供水果材料,其中所述水果材料基本上由牙釉质种子的内皮(ia )任选地干燥步骤(i)中提供的水果材料,(ii)用基本上由水和具有1至3个碳原子的醇组成或由其组成的混合物提取步骤(i)或(ia)中提供的水果材料,或由 水和乙腈,(iii)任选地部分或完全除去步骤(ii)的具有1至3个碳原子的醇,并且任选地向所述含水残余物中加入中等极性的有机溶剂,并用所述有机溶剂或 超临界溶剂,例如超临界二氧化碳,从而获得富集的提取物,(iv)任选地将步骤(ii)中获得的提取物或富集的 在步骤(iii)中获得的与一种或多种固体载体物质的反应,(v)任选地干燥步骤(iii)中获得的富集提取物或步骤(iv)中获得的混合物,优选通过喷雾干燥或冷冻干燥, 和相关的发明实施方案,特别是用于治疗PDE2和/或PDE5相关疾病以及相关发明实施方案。