专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

51. 发明申请

US20020153508A1 Cubic liquid crystalline compositions and methods for their preparation 审中-公开
标题翻译：立方液晶组合物及其制备方法
公开(公告)号：US20020153508A1
公开(公告)日：2002-10-24
申请号：US09789883
申请日：2001-02-21
发明人： Matthew Lawrence Lynch , Patrick Thomas Spicer
IPC分类号： C09K019/52 , C09K019/54
CPC分类号： C09K19/54 , A01N25/04 , A61K8/0295 , A61K9/1274 , A61Q19/00 , C09K19/00 , C09K2019/528 , Y10S514/937 , Y10S514/964
摘要： Cubic liquid crystalline gel precursors, bulk cubic liquid crystalline gels, and dispersions of cubic liquid crystalline gel particles, and methods for their preparation, are disclosed. The precursors, gels, and dispersions can be used as skin penetration enhancers. The precursors, gels, and dispersions are prepared by methods employing hydrotropes that do not detrimentally affect the cubic liquid crystalline structure of the gels and particles.
摘要翻译：公开了立方液晶凝胶前体，体积立方晶体凝胶和立方晶体凝胶颗粒的分散体及其制备方法。前体，凝胶和分散体可用作皮肤渗透增强剂。前体，凝胶和分散体通过使用不影响凝胶和颗粒的立方液晶结构的水溶助长剂的方法制备。

52. 发明授权

US06436444B1 Acidic aqueous chlorite teat dip providing shelf life sanitizing capacity and tissue protection 失效
标题翻译：酸性亚氯酸钠乳液浸渍提供保质期消毒能力和组织保护
公开(公告)号：US06436444B1
公开(公告)日：2002-08-20
申请号：US08938653
申请日：1997-09-26
申请人： Francis L. Richter , Cathy M. Paquette , Richard K. Staub
发明人： Francis L. Richter , Cathy M. Paquette , Richard K. Staub
IPC分类号： A01N2524
CPC分类号： A01N59/00 , Y10S514/887 , Y10S514/944 , Y10S514/964 , Y10S514/97 , A01N59/26 , A01N41/04 , A01N37/36 , A01N37/02 , A01N25/24 , A01N25/04 , A01N2300/00
摘要： The mastitis control teat dip composition of the invention provides rapid initial kill, a useful highly pseudoplastic rheology, a barrier/film-forming capacity, a unique antimicrobial composition that is stable over an extended period of time, and unexpected long term microbial control when compared to the prior art materials disclosed in patents and used in the marketplace. The compositions of the invention are made by combining an aqueous thickened liquid composition containing the organic components which can be combined with a simple aqueous solution of a salt of chlorous acid, preferably an alkali metal chlorite. The materials can be combined, blended into a smooth viscous material and can be immediately contacted with the target animals. The .compositions of the invention provide rapid initial kill, consistent long term kill and chemical and rheological stability.
摘要翻译：本发明的乳腺炎控制乳头浸渍组合物提供快速的初始杀死，有用的高假假性流变学，阻隔/成膜能力，在延长的时间段内是稳定的独特的抗微生物组合物，以及在比较时意外的长期微生物控制涉及在专利中公开并在市场中使用的现有技术材料。本发明的组合物是通过将含有有机组分的含水增稠液体组合物与可与氯酸盐，优选碱金属亚氯酸盐的简单水溶液组合的组合制成的。材料可以组合，混合成光滑的粘稠材料，并可立即与目标动物接触。本发明的组合物提供快速的初始杀死，一致的长期杀灭和化学和流变学稳定性。

53. 发明授权

US06395765B1 Antiparasitic composition for the treatment and protection of pets 失效
标题翻译：用于治疗和保护宠物的寄生虫组合物
公开(公告)号：US06395765B1
公开(公告)日：2002-05-28
申请号：US08719942
申请日：1996-09-25
申请人： Jean Pierre Etchegaray
发明人： Jean Pierre Etchegaray
IPC分类号： A01N2502
CPC分类号： A01N43/56 , A01N47/02 , Y10S514/875 , Y10S514/937 , Y10S514/946 , Y10S514/947 , Y10S514/964 , Y10S514/97 , Y10S514/971 , Y10S514/975 , A01N25/02 , A01N2300/00
摘要： Composition which is useful in particular for the treatment and protection of domestic animals which are infested with parasites or are likely to be infested with them, these compositions comprising, in the form of a ready-to-use solution: a) an insecticidal active substance of formula (I), b) a crystallization inhibitor, c) an organic solvent having a dielectric constant of between 10 and 35, preferably of between 20 and 30, d) an organic co-solvent having a boiling point below 100° C., preferably below 80° C., and a dielectric constant of between 10 and 40, preferably of between 20 and 30.
摘要翻译：特别是用于治疗和保护受寄生虫侵染或可能被其侵染的家畜的组合物，这些组合物包含以下形式的即用溶液：a）杀虫活性物质式（I）的b）结晶抑制剂，c）介电常数在10至35之间，优选在20至30之间的有机溶剂，d）沸点低于100℃的有机助溶剂。优选低于80℃，介电常数介于10和40之间，优选在20和30之间。

54. 发明申请

US20020037309A1 Process for the preparation of polymer-based sustained release compositions 失效
公开(公告)号：US20020037309A1
公开(公告)日：2002-03-28
申请号：US09801272
申请日：2001-03-07
申请人： Alkermes Controlled Therapeutics, Inc.
发明人： Warren E. Jaworowicz , James I. Wright
IPC分类号： C08J009/00
CPC分类号： A61K9/1647 , A61K9/1694 , Y10S514/964 , Y10S514/965
摘要： The invention relates to a sustained release composition and methods of forming and using said composition for the sustained release of biologically active agent. The sustained release compositions of the invention comprise a biocompatible polymer and a biologically active agent characterized by a porous center and a less porous outer layer wherein the center and outer layer consist of essentially the same materials. The sustained release compositions can be prepared by annealing at least a substantial portion of the exterior surface of a polymer/active agent matrix. The compositions which have been annealed exhibit a decrease in the release of agent over the first 24 hours following administration (i.e., reduced burst) and as a result can show an increase in the duration of sustained release thereby providing increased therapeutic benefits.

55. 发明授权

US06340671B1 Stable compositions for parenteral administration and their use 失效
标题翻译：用于肠胃外给药的稳定组合物及其用途
公开(公告)号：US06340671B1
公开(公告)日：2002-01-22
申请号：US08263574
申请日：1994-06-22
申请人： Susan Mancini Cady , William David Steber , Phillip Wayne Hayes , Mary Ehlers Doscher , Kurt Allen Schwinghammer
发明人： Susan Mancini Cady , William David Steber , Phillip Wayne Hayes , Mary Ehlers Doscher , Kurt Allen Schwinghammer
IPC分类号： A61K3170
CPC分类号： A61K31/70 , A61K9/1617 , A61K31/35 , Y10S514/964 , Y10S514/965
摘要： The invention relates to certain stable microsphere compositions containing a fat, a wax or a mixture thereof; an active ingredient selected from LL-F28249&agr;-&lgr; compounds, 23-oxo or 23-imino derivatives of LL-F28249&agr;-&lgr; compounds, milbemycin compounds and avermectin compounds; an antioxidant and, optionally, an oil, a semi-soft fat, a fatty acid derivative or mixture thereof. The invention also relates to a method for introducing and maintaining levels of the active compound in the blood of warm-blooded animals for extended periods of time and for the prevention or treatment of infections and infestations caused by helminths, nematodes, acarids and endo- and ectoparasitic arthropods in warm-blooded animals by the parenteral administration of compositions of the invention.
摘要翻译：本发明涉及含有脂肪，蜡或其混合物的某些稳定的微球组合物; 选自LL-F28249α-羔羊化合物的活性成分，LL-F28249α-羔羊化合物的23-氧代或23-亚氨基衍生物，米尔倍霉素化合物和除虫菌素化合物; 抗氧化剂和任选的油，半软脂肪，脂肪酸衍生物或其混合物。本发明还涉及一种用于在温血动物的血液中长时间引入和维持活性化合物的水平并用于预防或治疗由蠕虫，线虫，螨虫和内含物引起的感染和侵袭的方法通过肠胃外给药本发明的组合物在温血动物中的外寄生节肢动物。

56. 发明授权

US06306423B1 Neurotoxin implant 失效
标题翻译：神经毒素植入物
公开(公告)号：US06306423B1
公开(公告)日：2001-10-23
申请号：US09587250
申请日：2000-06-02
申请人： Stephen Donovan , Daniel G. Brady
发明人： Stephen Donovan , Daniel G. Brady
IPC分类号： A61F200
CPC分类号： A61K9/0024 , A61K38/4893 , Y10S514/964
摘要： A biocompatible implant for continuous in vivo release of a neurotoxin over a treatment period extending from one month to five years. The implant can be made of casting a solution of a polymer, such as an ethyl vinyl acetate copolymer and the neurotoxin. The neurotoxin can be a botulinum toxin.
摘要翻译：在一个月至五年的治疗期内连续体内释放神经毒素的生物相容性植入物。植入物可以通过浇铸聚合物如乙酸乙烯酯共聚物和神经毒素的溶液来制备。神经毒素可以是肉毒杆菌毒素。

57. 发明授权

US06258830B1 Stable gel formulation for topical treatment of skin conditions 有权
标题翻译：用于局部治疗皮肤状况的稳定凝胶制剂
公开(公告)号：US06258830B1
公开(公告)日：2001-07-10
申请号：US09260217
申请日：1999-03-01
申请人： Prakash M. Charu
发明人： Prakash M. Charu
IPC分类号： A61K31455
CPC分类号： A61K47/32 , A61K8/042 , A61K8/49 , A61K8/671 , A61K9/0014 , A61K31/4436 , A61K31/455 , A61K47/10 , A61K47/26 , A61Q19/00 , Y10S514/859 , Y10S514/863 , Y10S514/886 , Y10S514/887 , Y10S514/944 , Y10S514/964
摘要： The present invention provides a stable gel formulation for topical treatment of skin conditions in humans. The stable gel formulation includes an active agent, having activity for treatment of acne and psoriasis, which is insoluble in water and a plurality of nonaqueous vehicles for both solubilizing said active agent and forming a gel therewith enabling topical application of the gel to a skin condition. The plurality of vehicles are each present in amounts, and in combination, to control release of the active agent from-the gel to the skin condition.
摘要翻译：本发明提供用于局部治疗人类皮肤状况的稳定凝胶制剂。稳定的凝胶制剂包括具有治疗痤疮和牛皮癣活性的活性剂，其不溶于水和多种非水性载体，用于增溶所述活性剂并形成凝胶，从而使凝胶局部施用于皮肤状态。多种载体各自以量和组合的形式存在以控制活性剂从凝胶释放到皮肤状态。

58. 发明授权

US06245740B1 Polyol:oil suspensions for the sustained release of proteins 失效
标题翻译：多元醇：用于缓释蛋白质的油悬浮液
公开(公告)号：US06245740B1
公开(公告)日：2001-06-12
申请号：US09221181
申请日：1998-12-23
申请人： Merrill Goldenberg , Daxian Shan , Alice Beekman
发明人： Merrill Goldenberg , Daxian Shan , Alice Beekman
IPC分类号： A61K3818
CPC分类号： A61K9/0024 , A61K47/34 , Y10S514/964 , Y10S514/965
摘要： The present invention relates to the preparation of polyol/thickened oil suspensions containing a biologically active agent, for the sustained delivery of the biologically active agent. The described protein/glycerol/oil suspensions show sustained release of protein, e.g., G-CSF, of up to at least one week.
摘要翻译：本发明涉及含有生物活性剂的多元醇/增稠油悬浮液的制备，用于持续递送生物活性剂。所描述的蛋白质/甘油/油悬浮液显示蛋白质例如G-CSF的持续释放至多至少一周。

59. 发明授权

US06207178B1 Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof 失效
标题翻译：固体脂质颗粒，生物活性剂颗粒及其制造和使用方法
公开(公告)号：US06207178B1
公开(公告)日：2001-03-27
申请号：US09204075
申请日：1998-12-03
申请人： Kirsten Westesen , Britta Siekmann
发明人： Kirsten Westesen , Britta Siekmann
IPC分类号： A01N2504
CPC分类号： A61K8/044 , A01N25/04 , A61K8/0245 , A61K8/671 , A61K9/10 , A61K9/145 , A61K9/5123 , A61K2800/413 , A61K2800/56 , A61Q19/00 , B01F3/0807 , B01F3/0811 , B01F3/1214 , B01F2003/0892 , B82Y5/00 , Y10S514/937 , Y10S514/964 , Y10S516/926 , Y10S516/928 , Y10T428/2989
摘要： The present invention is in the area of administration forms and delivery systems for drugs, vaccines and other biologically active agents. More specifically the invention is related to the preparation of suspensions of colloidal solid lipid particles (SLPs) of predominantly anisometrical shape with the lipid matrix being in a stable polymorphic modification and of suspensions of micron and submicron particles of bioactive agents (PBAs); as well as to the use of such suspensions or the lyophilizates thereof as delivery systems primarily for the parenteral administration of preferably poorly water-soluble bioactive substances, particularly drugs, and to their use in cosmetic, food and agricultural products. SLPs and PBAs are prepared by the following emulsification process: (1) A solid lipid or bioactive agent or a mixture of solid lipids or bioactive agents is melted. (2) Stabilizers are added either to the lipid or bioactive agent and to the aqueous phase or to the aqueous phase only depending on their physicochemical characteristics. Stabilizers may also be added or exchanged after homogenization. (3) Drugs or other bioactive substances to be incorporated into the SLPs may be melted together with the lipids if the physicochemical characteristics of the substance permit or may be dissolved, solubilized or dispersed in the lipid melt before homogenization. (4) The aqueous phase is heated to the temperature of the melt before mixing and may contain for example stabilizers, isotonicity agents, buffering substances, cryoprotectants and/or preservatives. (5) The molten lipid compounds and the bioactive agents are emulsified in an aqueous phase preferably by high-pressure homogenization.
摘要翻译：本发明在药物，疫苗和其他生物活性剂的给药形式和递送系统方面。更具体地，本发明涉及主要具有不规则形状的胶体固体脂质颗粒（SLP）的悬浮液的制备，其中脂质基质处于稳定的多态性修饰和生物活性剂（PBA）的微米和亚微米颗粒的悬浮液中; 以及这些悬浮液或其冻干物质作为递送系统的使用，主要用于肠胃外给药优选水溶性较差的生物活性物质，特别是药物，以及它们在化妆品，食品和农产品中的用途.LP和PBA被制备通过以下乳化方法：（1）将固体脂质或生物活性剂或固体脂质或生物活性剂的混合物熔化。（2）将稳定剂加入到脂质或生物活性剂中，并加入水相或水相只取决于它们的物理化学特性。稳定剂也可以在均化后添加或更换。（3）如果物质的物理化学特性允许或溶解，溶解或分散在脂质中，则要并入SLP的药物或其他生物活性物质可与脂质一起溶解（4）在混合前将水相加热至熔体的温度，并可含有稳定剂，等渗剂，缓冲物质，冷冻保护剂和/或防腐剂。（5）熔融脂质化合物和生物活性剂在水相中优选通过高压均化乳化。

60. 发明授权

US6143288A Insect repellent and attractant compositions and methods for using same 失效
标题翻译：驱虫剂和引诱剂组合物及其使用方法
公开(公告)号：US6143288A
公开(公告)日：2000-11-07
申请号：US241555
申请日：1994-05-12
申请人： Craig B. Warren , Jerry F. Butler , Richard A. Wilson , Braja D. Mookherjee , Leslie C. Smith , Anna Belle Marin
发明人： Craig B. Warren , Jerry F. Butler , Richard A. Wilson , Braja D. Mookherjee , Leslie C. Smith , Anna Belle Marin
IPC分类号： A01N49/00 , A01N55/00 , A01N55/08 , A01N55/10 , A01N31/02 , A01N25/08 , A01N31/06
CPC分类号： A01N55/08 , A01N49/00 , A01N55/00 , Y10S424/10 , Y10S514/919 , Y10S514/964
摘要： Described is (i) a method of repelling Musca domestica L.(Diptera:Muscidae) or Aedes aegyptae for a finite period of time from a three-dimensional space inhabitable by Musca domnestica L.(Diptera:Muscidae) or Aedes aegyptae consisting essentially of the step of exposing a three-dimensional space to an effective Musca domestica L.(Diptera:Muscidae) or Aedes aegyptae-repelling concentration and quantity of a geraniol-containing composition consisting essentially of 50-100% of geraniol with the remainder of the composition being a compound selected from the group consisting of citronellol and nerol and (ii) a method of attracting Musca domestica L.(Diptera:Muscidae) or Aedes aegyptae using lavender absolute, benzoin, dimethyl benzyl carbinyl acetate, jasmine absolute, racemic borneol, d-limonene and/or dihydrolinalool. The attractants taken alone or in combination find utility primarily as bait enhancers for acute toxins and/or trapping devices. The above-stated attractants and repellents are described to be useful as such or contained in a polymer which can be a biodegradable polymer such as compositions containing a major proportion of poly(epsilon caprolactone) homopolymers.
摘要翻译：描述的是（i）从Musca domnestica L.（双翅目：蝇科）或伊蚊（Aedes aegyptae）所组成的三维空间有限的时间内排斥Musca domestica L.（双翅目：Muscidae）或Aedes aegyptae的方法或基本上由将三维空间暴露于有效的Musca domestica L.（双翅目：Muscidae）或埃及伊蚊排斥浓度和量的含有香叶醇的组合物，其基本上由50-100％的香叶醇组成，其余组合物是选自香茅醇和橙花醇的化合物和（ii）使用薰衣草绝对，苯偶姻，二甲基苄基乙酰基乙酸酯，绝对的茉莉，外消旋冰片d，吸引Musca domestica L.（双翅目：Muscidae）或Aedes aegyptae的方法 - 缩水甘油和/或二氢里哪醇。单独或组合使用的引诱剂主要用作急性毒素和/或诱捕装置的诱饵增强剂。上述引诱剂和驱避剂被描述为可以这样使用或包含在可以是可生物降解的聚合物的聚合物中，例如含有主要比例的聚（ε-己内酯）均聚物的组合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式