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1. 发明申请

US20180333689A1 AUTOMATED MIXING AND DISPENSING CLEANSER APPARATUS 审中-公开
公开(公告)号：US20180333689A1
公开(公告)日：2018-11-22
申请号：US15597923
申请日：2017-05-17
申请人： Clarence Lance Richardson
发明人： Clarence Lance Richardson
IPC分类号： B01F3/08 , B01F15/00 , B01F15/06 , B01F7/00 , B01F7/04
CPC分类号： B01F3/0853 , B01F7/00733 , B01F7/04 , B01F15/00253 , B01F15/0087 , B01F15/066 , B01F2003/0892 , B01F2015/062 , B01F2215/0077
摘要： An automated soap mixing and dispensing apparatus is configured to automatically melt a quantity of solid soap for mixture with a liquid carrier to provide a source of liquid soap solution. The apparatus includes a fluid reservoir configured to initially contain liquid carrier. A grill with apertures supports the solid soap. A heating element heats the solid soap to a molten state and the molten soap drips through the apertures into the liquid carrier. A rotary mixing unit mixes the molten soap with the liquid carrier to form the liquid soap solution. The dispensing apparatus may then be utilized to dispense the liquid soap for cleaning activities, such as personal hygiene. The apparatus improves the carbon footprint for hygiene activities by eliminating the requirement for plastic containers containing premixed liquid soap solutions.

2. 发明授权

US5785976A Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof 失效
标题翻译：固体脂质颗粒，生物活性剂颗粒及其制造和使用方法
公开(公告)号：US5785976A
公开(公告)日：1998-07-28
申请号：US226471
申请日：1994-04-12
申请人： Kirsten Westesen , Britta Siekmann
发明人： Kirsten Westesen , Britta Siekmann
IPC分类号： A01N25/04 , A61K8/04 , A61K8/67 , A61K9/10 , A61K9/14 , A61K9/51 , A61Q19/00 , B01F3/08 , B01F3/12 , A61K9/19 , B01J13/00
CPC分类号： A61K8/044 , A01N25/04 , A61K8/0241 , A61K8/671 , A61K9/10 , A61K9/145 , A61K9/5123 , A61Q19/00 , B01F3/0811 , B01F3/1214 , B82Y5/00 , A61K2800/413 , B01F2003/0892 , B01F3/0807 , Y10S514/965 , Y10S516/922 , Y10S516/926 , Y10S516/93 , Y10T428/2989
摘要： The present invention is in the area of administration forms and delivery systems for drugs, vaccines and other biologically active agents. More specifically the invention is related to the preparation of suspensions of colloidal solid lipid particles (SLPs) of predominantly anisometrical shape with the lipid matrix being in a stable polymorphic modification and of suspensions of micron and submicron particles of bioactive agents (PBAs); as well as to the use of such suspensions or the lyophilizates thereof as delivery systems primarily for the parenteral administration of preferably poorly water-soluble bioactive substances, particularly drugs, and to their use in cosmetic, food and agricultural products. SLPs and PBAs are prepared by the following emulsification process: (1) A solid lipid or bioactive agent or a mixture of solid lipids or bioactive agents is melted. (2) Stabilizers are added either to the lipid or bioactive agent and to the aqueous phase or to the aqueous phase only depending on their physicochemical characteristics. (3) Drugs or other bioactive substances to be incorporated into the SLPs may be melted together with the lipids if the physicochemical characteristics of the substance permit or may be dissolved, solubilized or dispersed in the lipid melt before homogenization. (4) The aqueous phase is heated to the temperature of the melt before mixing and may contain for example stabilizers, isotonicity agents, buffering substances, cryoprotectants and/or preservatives. (5) The molten lipid compounds and the bioactive agents are emulsified in an aqueous phase preferably by high-pressure homogenization.
摘要翻译：本发明在药物，疫苗和其他生物活性剂的给药形式和递送系统方面。更具体地，本发明涉及主要具有不规则形状的胶体固体脂质颗粒（SLP）的悬浮液的制备，其中脂质基质处于稳定的多态性修饰和生物活性剂（PBA）的微米和亚微米颗粒的悬浮液中; 以及这些悬浮液或其冻干物作为递送系统的用途，主要用于肠胃外给药优选水溶性差的生物活性物质，特别是药物，以及它们在化妆品，食品和农产品中的用途。 SLP和PBA通过以下乳化方法制备：（1）将固体脂质或生物活性剂或固体脂质或生物活性剂的混合物熔化。（2）稳定剂仅根据其物理化学特性而添加到脂质或生物活性剂中，并且添加到水相或水相中。（3）如果物质的物理化学特性允许或可能在均匀化之前溶解，溶解或分散在脂质熔体中，则要并入SLP的药物或其他生物活性物质可与脂质一起熔化。（4）在混合之前将水相加热至熔体的温度，并且可以含有例如稳定剂，等渗剂，缓冲物质，冷冻保护剂和/或防腐剂。（5）熔融脂质化合物和生物活性剂优选通过高压均质化在水相中乳化。

3. 发明授权

US5885486A Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof 失效
标题翻译：固体脂质颗粒，生物活性剂颗粒及其制造和使用方法
公开(公告)号：US5885486A
公开(公告)日：1999-03-23
申请号：US757276
申请日：1996-12-02
申请人： Kirsten Westesen , Britta Siekmann
发明人： Kirsten Westesen , Britta Siekmann
IPC分类号： A01N25/04 , A61K8/04 , A61K8/67 , A61K9/10 , A61K9/14 , A61K9/51 , A61Q19/00 , B01F3/08 , B01F3/12 , B01J13/00
CPC分类号： A61K8/044 , A01N25/04 , A61K8/0245 , A61K8/671 , A61K9/10 , A61K9/145 , A61K9/5123 , A61Q19/00 , B01F3/0811 , B01F3/1214 , B82Y5/00 , A61K2800/413 , A61K2800/56 , B01F2003/0892 , B01F3/0807 , Y10S514/937 , Y10S514/964 , Y10S516/926 , Y10S516/928 , Y10T428/2989
摘要： The present invention is in the area of administration forms and delivery systems for drugs, vaccines and other biologically active agents. More specifically the invention is related to the preparation of suspensions of colloidal solid lipid particles (SLPs) of predominantly anisometrical shape with the lipid matrix being in a stable polymorphic modification and of suspensions of micron and submicron particles of bioactive agents (PBAs); as well as to the use of such suspensions or the lyophilizates thereof as delivery systems primarily for the parenteral administration of preferably poorly water-soluble bioactive substances, particularly drugs, and to their use in cosmetic, food and agricultural products.SLPs and PBAs are prepared by the following emulsification process:(1) A solid lipid or bioactive agent or a mixture of solid lipids or bioactive agents is melted.(2) Stabilizers are added either to the lipid or bioactive agent and to the aqueous phase or to the aqueous phase only depending on their physicochemical characteristics. Stabilizers may also be added or exchanged after homogenization.(3) Drugs or other bioactive substances to be incorporated into the SLPs may be melted together with the lipids if the physicochemical characteristics of the substance permit or may be dissolved, solubilized or dispersed in the lipid melt before homogenization.(4) The aqueous phase is heated to the temperature of the melt before mixing and may contain for example stabilizers, isotonicity agents, buffering substances, cryoprotectants and/or preservatives.(5) The molten lipid compounds and the bioactive agents are emulsified in an aqueous phase preferably by high-pressure homogenization.
摘要翻译：本发明在药物，疫苗和其他生物活性剂的给药形式和递送系统方面。更具体地，本发明涉及主要具有不规则形状的胶体固体脂质颗粒（SLP）的悬浮液的制备，其中脂质基质处于稳定的多态性修饰和生物活性剂（PBA）的微米和亚微米颗粒的悬浮液中; 以及这些悬浮液或其冻干物作为递送系统的用途，主要用于肠胃外给药优选水溶性差的生物活性物质，特别是药物，以及它们在化妆品，食品和农产品中的用途。 SLP和PBA通过以下乳化方法制备：（1）将固体脂质或生物活性剂或固体脂质或生物活性剂的混合物熔化。（2）稳定剂仅根据其物理化学特性而添加到脂质或生物活性剂中，并且添加到水相或水相中。均化后也可加入或交换稳定剂。（3）如果物质的物理化学特性允许或可能在均匀化之前溶解，溶解或分散在脂质熔体中，则要并入SLP的药物或其他生物活性物质可与脂质一起熔化。（4）在混合之前将水相加热至熔体的温度，并且可以含有例如稳定剂，等渗剂，缓冲物质，冷冻保护剂和/或防腐剂。（5）熔融脂质化合物和生物活性剂优选通过高压均质化在水相中乳化。

4. 发明授权

US2284023A Emulsifiable composition and method of preparing same 失效
标题翻译：乳化组合物及其制备方法
公开(公告)号：US2284023A
公开(公告)日：1942-05-26
申请号：US31717840
申请日：1940-02-03
申请人： SERIPTURE JR EDWARD W
发明人： SERIPTURE JR EDWARD W
IPC分类号： B01F3/04 , B01F3/08 , B01F5/02 , B01F5/04 , B01F15/06
CPC分类号： B01F3/0853 , B01F3/04049 , B01F5/0256 , B01F5/045 , B01F15/066 , B01F2003/0892 , B01F2015/062

5. 发明授权

US06338742B1 Crystallization process 失效
标题翻译：结晶过程
公开(公告)号：US06338742B1
公开(公告)日：2002-01-15
申请号：US09308741
申请日：1999-05-24
申请人： Neil George , Stephen Dawson , William Malcolm Logan Wood
发明人： Neil George , Stephen Dawson , William Malcolm Logan Wood
IPC分类号： B01D900
CPC分类号： B01D9/005 , B01F3/0819 , B01F2003/0892 , B01F2015/061
摘要： A process for preparing a crystal suspension of an organic compound which has a &Dgr;H/RT value greater than 10, the process comprising dispersing a melt of the organic compound in a liquid dispersion medium to form an emulsion, cooling the emulsion below the melting point of the organic compound and subjecting the emulsion to ultrasonic vibration.
摘要翻译：一种制备DELTAH / RT值大于10的有机化合物的晶体悬浮液的方法，该方法包括将有机化合物的熔体分散在液体分散介质中以形成乳液，将乳液冷却至低于有机化合物并使乳液经受超声波振动。

6. 发明授权

US06207178B1 Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof 失效
标题翻译：固体脂质颗粒，生物活性剂颗粒及其制造和使用方法
公开(公告)号：US06207178B1
公开(公告)日：2001-03-27
申请号：US09204075
申请日：1998-12-03
申请人： Kirsten Westesen , Britta Siekmann
发明人： Kirsten Westesen , Britta Siekmann
IPC分类号： A01N2504
CPC分类号： A61K8/044 , A01N25/04 , A61K8/0245 , A61K8/671 , A61K9/10 , A61K9/145 , A61K9/5123 , A61K2800/413 , A61K2800/56 , A61Q19/00 , B01F3/0807 , B01F3/0811 , B01F3/1214 , B01F2003/0892 , B82Y5/00 , Y10S514/937 , Y10S514/964 , Y10S516/926 , Y10S516/928 , Y10T428/2989
摘要： The present invention is in the area of administration forms and delivery systems for drugs, vaccines and other biologically active agents. More specifically the invention is related to the preparation of suspensions of colloidal solid lipid particles (SLPs) of predominantly anisometrical shape with the lipid matrix being in a stable polymorphic modification and of suspensions of micron and submicron particles of bioactive agents (PBAs); as well as to the use of such suspensions or the lyophilizates thereof as delivery systems primarily for the parenteral administration of preferably poorly water-soluble bioactive substances, particularly drugs, and to their use in cosmetic, food and agricultural products. SLPs and PBAs are prepared by the following emulsification process: (1) A solid lipid or bioactive agent or a mixture of solid lipids or bioactive agents is melted. (2) Stabilizers are added either to the lipid or bioactive agent and to the aqueous phase or to the aqueous phase only depending on their physicochemical characteristics. Stabilizers may also be added or exchanged after homogenization. (3) Drugs or other bioactive substances to be incorporated into the SLPs may be melted together with the lipids if the physicochemical characteristics of the substance permit or may be dissolved, solubilized or dispersed in the lipid melt before homogenization. (4) The aqueous phase is heated to the temperature of the melt before mixing and may contain for example stabilizers, isotonicity agents, buffering substances, cryoprotectants and/or preservatives. (5) The molten lipid compounds and the bioactive agents are emulsified in an aqueous phase preferably by high-pressure homogenization.
摘要翻译：本发明在药物，疫苗和其他生物活性剂的给药形式和递送系统方面。更具体地，本发明涉及主要具有不规则形状的胶体固体脂质颗粒（SLP）的悬浮液的制备，其中脂质基质处于稳定的多态性修饰和生物活性剂（PBA）的微米和亚微米颗粒的悬浮液中; 以及这些悬浮液或其冻干物质作为递送系统的使用，主要用于肠胃外给药优选水溶性较差的生物活性物质，特别是药物，以及它们在化妆品，食品和农产品中的用途.LP和PBA被制备通过以下乳化方法：（1）将固体脂质或生物活性剂或固体脂质或生物活性剂的混合物熔化。（2）将稳定剂加入到脂质或生物活性剂中，并加入水相或水相只取决于它们的物理化学特性。稳定剂也可以在均化后添加或更换。（3）如果物质的物理化学特性允许或溶解，溶解或分散在脂质中，则要并入SLP的药物或其他生物活性物质可与脂质一起溶解（4）在混合前将水相加热至熔体的温度，并可含有稳定剂，等渗剂，缓冲物质，冷冻保护剂和/或防腐剂。（5）熔融脂质化合物和生物活性剂在水相中优选通过高压均化乳化。

7. 发明授权

US07192996B2 Manufacturing solvent-free solid paint 失效
标题翻译：制造无溶剂固体涂料
公开(公告)号：US07192996B2
公开(公告)日：2007-03-20
申请号：US10450392
申请日：2001-12-12
申请人： Garry Michael McKay
发明人： Garry Michael McKay
IPC分类号： C08K3/00 , B01F3/00
CPC分类号： C09D5/03 , B01F3/0853 , B01F7/1605 , B01F15/065 , B01F2003/0892 , B01F2015/062 , B01F2215/005 , B44D3/06 , B44D3/12 , C08J3/205
摘要： A method and apparatus for manufacturing small batches of solid paint is disclosed, which method includes a first step of providing a component of the solid paint as a liquid in a heated mixing container that has a base and sides and includes a stirrer for stirring the contents of the container. The next step of the method includes controlling, heating and stirring of the contents of the container and progressively adding other components of the solid paint as solids to the container. The liquid acts as a heat transfer medium that transfers heat from the heated container and from the stirrer to the solids. The mix is heated to a temperature of the solid paint and forms a melt that is a uniform liquid. The final step in the method includes discharging the melt from the container and allowing the melt to cool and form the solid paint.
摘要翻译：公开了一种用于制造小批量固体涂料的方法和装置，该方法包括：第一步骤，将固体涂料的组分作为液体提供在具有底部和侧面的加热混合容器中，并且包括用于搅拌内容物的搅拌器的容器。该方法的下一步包括控制，加热和搅拌容器的内容物，并将固体涂料的其它组分逐渐添加到容器中。液体作为传热介质，其将热量从加热的容器和从搅拌器传递到固体。将混合物加热至固体涂料的温度，并形成均匀液体的熔体。该方法的最后步骤包括从容器中排出熔体并使熔体冷却并形成固体涂料。

8. 发明申请

US20040048953A1 Manufacturing solvent-free solid paint 失效
标题翻译：制造无溶剂固体涂料
公开(公告)号：US20040048953A1
公开(公告)日：2004-03-11
申请号：US10450392
申请日：2003-09-25
发明人： Garry Michael McKay
IPC分类号： C08K003/00
CPC分类号： C09D5/03 , B01F3/0853 , B01F7/1605 , B01F15/065 , B01F2003/0892 , B01F2015/062 , B01F2215/005 , B29B7/16 , B29B7/286 , B29B7/823 , B29B7/826 , B29B7/94 , B44D3/06 , B44D3/12 , C08J3/205
摘要： A method and apparatus for manufacturing small batches of solid paint is disclosed, which method includes a first step of providing a component of the solid paint as a liquid in a heated mixing container that has a base and sides and includes a stirrer for stirring the contents of the container. The next step of the method includes controlling, heating and stirring of the contents of the container and progressively adding other components of the solid paint as solids to the container. The liquid acts as a heat transfer medium that transfers heat from the heated container and from the stirrer to the solids. The mix is heated to a temperature of the solid paint and forms a melt that is a uniform liquid. The final step in the method includes discharging the melt from the container and allowing the melt to cool and form the solid paint.
摘要翻译：公开了一种用于制造小批量固体涂料的方法和装置，该方法包括：第一步骤，将固体涂料的组分作为液体提供在具有底部和侧面的加热混合容器中，并且包括用于搅拌内容物的搅拌器的容器。该方法的下一步包括控制，加热和搅拌容器的内容物，并将固体涂料的其它组分逐渐添加到容器中。液体作为传热介质，其将热量从加热的容器和从搅拌器传递到固体。将混合物加热至固体涂料的温度，并形成均匀液体的熔体。该方法的最后步骤包括从容器中排出熔体并使熔体冷却并形成固体涂料。

9. 发明授权

US4132666A Process for preparing alkali metal dispersions 失效
标题翻译：制备碱金属分散体的方法
公开(公告)号：US4132666A
公开(公告)日：1979-01-02
申请号：US819590
申请日：1977-07-27
申请人： Tatsusuke Chikatsu , Shinichi Shimokawa , Takao Miura , Taro Okumura
发明人： Tatsusuke Chikatsu , Shinichi Shimokawa , Takao Miura , Taro Okumura
IPC分类号： B01F3/08 , B01F3/12 , B01F7/00 , B01F7/22 , B01J13/00
CPC分类号： B01F7/22 , B01F3/0811 , B01F3/0853 , B01F3/1214 , B01J13/0043 , B01J13/0086 , B01F2003/0892 , B01F7/00591
摘要： A process for preparing alkali metal dispersions comprises continuously feeding a molten alkali metal, a dispersing agent, and an inactive dispersion liquid to a multipass emulsifier to form an emulsion of the molten alkali metal, and rapidly cooling the emulsion to a temperature at least 10.degree. C lower than the melting point of the alkali metal.
摘要翻译：一种制备碱金属分散体的方法包括将熔融碱金属，分散剂和非活性分散液连续供给到多功能乳化剂中以形成熔融碱金属的乳液，并将乳液迅速冷却至至少10℃ C低于碱金属的熔点。

10. 发明授权

US3580862A Continuous process for preparing alkali metal dispersions and apparatus 失效
标题翻译：用于制备碱性金属分散体和装置的连续方法
公开(公告)号：US3580862A
公开(公告)日：1971-05-25
申请号：US3580862D
申请日：1967-08-18
申请人： NAT DISTILLERS CHEM CORP
发明人： WATSON LLOYD M , BIRCHALL WILLIAM R
IPC分类号： B01F3/08 , B01F3/12 , B01F17/00 , B01J13/00 , B01J23/04 , B22F9/06
CPC分类号： B01F3/0853 , B01F3/1214 , B01F17/00 , B01F2003/0892 , B01J13/0043 , B01J23/04 , B22F9/06
摘要： A PROCESS FOR PREPARING CONTINUOUSLY A DISPERSION IN AN INERT ORGANIC DILUENT OF A FINELY-DIVIDED ALKALI METAL, SUCH AS SODIUM, SUBSTANTIALLY UNIFORM IN PARTICLE SIZE AND ALKALI METAL CONCENTRATION IS PROVIDED WHEREIN A MOLTEN ALKALI METAL IS DISPERSED IN AN INERT ORGANIC DILUENT WITH A DISPERSING AID WHICH IS SOLUBLE IN THE INERT DILUENT, AND IF NECESSARY, A STABILIZING AGENT, BY SUBJECTING THE MOLTEN ALKALI METAL TO HIGH SHEAR FORCES, AND FORMING ALKALI METAL PARTICLES LESS THAN AND GREATER THAN A PREDETERMINED MEDIAN. THE COARSE PARTICLES OF MOLTEN ALKALI METAL AT OR ABOVE THE MEDIAN SIZE ARE ALLOWED TO SETTLE OUT, AND THE SUPERNATANT FINE PARTICLES OF MOLTEN ALKALI METAL AT OR BELOW THE MEDIAN SIZE ARE DRAWN OFF. THE COARSE PARTICLES ARE CONTINUOUSLY RETURNED TO THE ZONE OF HIGH SHEAR TO FURTHER REDUCE THEIR SIZE, AND ALKALI METAL IS CONTINUOUSLY ADDED TO THE ZONE, WHILE THE DISPERSION OF FINE PARTICLES OF ALKALI METAL HAVING A SIZE AT OR BELOW THE MEDIAN, AND SUBSTANTIALLY UNIFORM IN ALKALI METAL CONCENTRATION IS CONTINUOUSLY WITHDRAWN.

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