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51. 发明授权

US06387651B1 Comparative phenotype analysis of two or more microorganisms using a plurality of substrates within a microwell device 有权
标题翻译：在多孔装置内使用多个基底的两种或更多种微生物的比较表型分析
公开(公告)号：US06387651B1
公开(公告)日：2002-05-14
申请号：US09574087
申请日：2000-05-18
申请人： Barry Bochner , Eugenia Panomitros
发明人： Barry Bochner , Eugenia Panomitros
IPC分类号： C12N104
CPC分类号： C12Q1/04 , C12Q2304/20 , C12Q2304/22 , C12Q2304/24 , G01N2035/00148 , G01N2333/36 , Y10S435/81 , Y10S435/822 , Y10S435/911 , Y10S435/975
摘要： The present invention relates to growing and testing microorganisms in a multitest format which utilizes a gel forming matrix for the rapid screening of clinical and environmental cultures. The present invention is suited for the characterization of commonly encountered microorganisms (e.g., E. coli, S. aureus, etc.), as well as commercially and industrially important organisms from various and diverse environments (e.g., the present invention is particularly suited for the growth and characterization of the actinomycetes and fungi). The present invention is also particularly suited for comparative analysis of phenotypic differences between cell types, including strains of microorganisms that have been designated as the same genus and species, as well as other cell types (e.g., mammalian, insect, and plant cells).
摘要翻译：本发明涉及利用凝胶形成基质以快速筛选临床和环境培养物来培养和测试多种格式的微生物。本发明适用于常见的微生物（例如，大肠杆菌，金黄色葡萄球菌等）的表征，以及来自各种和各种环境的商业和工业上重要的生物体（例如，本发明特别适用于放线菌和真菌的生长和表征）。本发明还特别适用于细胞类型之间的表型差异的比较分析，包括已被指定为相同属和物种的微生物菌株以及其它细胞类型（例如哺乳动物，昆虫和植物细胞）。

52. 发明授权

US06368799B1 Method to detect gene polymorphisms and monitor allelic expression employing a probe array 有权
标题翻译：使用探针阵列检测基因多态性和监测等位基因表达的方法
公开(公告)号：US06368799B1
公开(公告)日：2002-04-09
申请号：US09445734
申请日：2000-03-14
申请人： Mark Chee
发明人： Mark Chee
IPC分类号： C12Q168
CPC分类号： C12Q1/6837 , C12Q2600/156 , C12Q2600/158 , Y10S435/911 , C12Q2535/131
摘要： The invention provides methods of monitoring expression levels of different polymorphic forms of a gene. Such methods entail analyzing genomic DNA from an individual to determine the presence of heterozygous polymorphic forms at a polymorphic site within a transcribed sequence of a gene of interest. RNA from a tissue of the individual in which the gene is expressed is then analyzed to determine relative proportions of polymorphic forms in transcript of the gene. Having identified alleles of a gene that are expressed at different levels, the alleles can be further analyzed to locate a second polymorphism that has a causative role in the different expression levels. The methods are amenable to analyzing large collections of genes simultaneously using arrays of immobilized probes.
摘要翻译：本发明提供了监测基因不同多态形式的表达水平的方法。这样的方法需要分析来自个体的基因组DNA，以确定在感兴趣的基因的转录序列内的多态性位点处存在杂合多态性形式。然后分析来自表达基因的个体的组织的RNA，以确定基因转录本中多态形式的相对比例。鉴定了在不同水平表达的基因的等位基因，可以进一步分析等位基因以定位在不同表达水平中起决定作用的第二多态性。该方法适用于使用固定化探针阵列同时分析大量基因。

53. 发明申请

US20020037561A1 Method for producing arachidonic acid 失效
标题翻译：花生四烯酸生产方法
公开(公告)号：US20020037561A1
公开(公告)日：2002-03-28
申请号：US09972550
申请日：2001-10-05
申请人： OmegaTech Inc.
发明人： William R. Barclay
IPC分类号： A01N063/00 , A01N063/04 , C12P007/64 , A23K001/165
CPC分类号： C12P7/6472 , A23K10/18 , A23K20/158 , A23L29/065 , A23L33/12 , A23L33/40 , A23V2002/00 , A61K35/68 , A61K36/06 , C11B1/10 , C12P7/6427 , Y10S435/911 , Y10S435/946 , A23V2250/1862
摘要： The present invention relates to a process for producing arachidonic acid. In one embodiment, Mortierella sect. schmuckeri microorganisms are cultured in fermentation medium, preferably containing a component of a complex nitrogen source. Further disclosed is a food product which includes Mortierella sect. schmuckeri microorganisms or lipid isolated from such microorganisms to enhance the arachidonic acid content of the food product.
摘要翻译：本发明涉及一种生产花生四烯酸的方法。在一个实施方案中，被孢霉属（Mortierella）在发酵培养基中培养schmuckeri微生物，优选含有复杂氮源的组分。进一步披露的是包括被孢霉属（Mortierella）教派的食品。 schmuckeri微生物或从这些微生物分离的脂质以增强食品中的花生四烯酸含量。

54. 发明申请

US20020006652A1 Nucleic acids encoding polypeptides having haloperoxidase activity 失效
公开(公告)号：US20020006652A1
公开(公告)日：2002-01-17
申请号：US09833102
申请日：2001-04-11
申请人： Novozymes A/S
发明人： Steffen Danielsen , Palle Schneider
IPC分类号： C12N009/02 , C07H021/04 , C12N005/06 , C12P021/02
CPC分类号： C11D3/38654 , C11D3/3719 , C11D3/38681 , C12N9/0065 , C12Y111/02001 , Y10S435/911
摘要： The present invention relates to isolated nucleic acid sequences encoding polypeptides having haloperoxidase activity. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences.

55. 发明授权

US06245365B1 Food products containing Mortierella sect. schmuckeri 有权
标题翻译：含有被孢霉属的食品。施马克里
公开(公告)号：US06245365B1
公开(公告)日：2001-06-12
申请号：US09270294
申请日：1999-03-15
申请人： William R. Barclay
发明人： William R. Barclay
IPC分类号： A28B412
CPC分类号： C12P7/6472 , A23K10/18 , A23K20/158 , A23L29/065 , A23L33/12 , A23L33/40 , A23V2002/00 , A61K35/68 , A61K36/06 , C11B1/10 , C12P7/6427 , Y10S435/911 , Y10S435/946 , A23V2250/1862
摘要： The present invention relates to a process for producing arachidonic acid. In one embodiment, Mortierella sect. schmuckeri microorganisms are cultured in fermentation medium, preferably containing a component of a complex nitrogen source. Further disclosed is a food product which includes Mortierella sect. schmuckeri microorganisms or lipid isolated from such microorganisms to enhance the arachidonic acid content of the food product.
摘要翻译：本发明涉及一种生产花生四烯酸的方法。在一个实施方案中，被孢霉属（Mortierella）在发酵培养基中培养schmuckeri微生物，优选含有复杂氮源的组分。进一步披露的是包括被孢霉属（Mortierella）教派的食品。 schmuckeri微生物或从这些微生物分离的脂质以增强食品中的花生四烯酸含量。

56. 发明授权

US06242243B1 Trichosporon sp RRLY-15 (DSM 11829) and its use to prepare S(+)-6-methoxy-methyl-2-naphthalene acetic acid 失效
标题翻译： Trichosporon sp RRLY-15（DSM 11829）及其用于制备S（+） - 6-甲氧基 - 甲基-2-萘乙酸
公开(公告)号：US06242243B1
公开(公告)日：2001-06-05
申请号：US09050011
申请日：1998-03-30
申请人： Ghulam Nabi Qazi , Rajinder Parshad , Surrinder Koul , Subhash Chandra Taneja , Kanaya Lal Dhar , Ravi Ji Kotru , Sukhdev Swami Handa
发明人： Ghulam Nabi Qazi , Rajinder Parshad , Surrinder Koul , Subhash Chandra Taneja , Kanaya Lal Dhar , Ravi Ji Kotru , Sukhdev Swami Handa
IPC分类号： C12N118
CPC分类号： C12R1/645 , C12P41/002 , Y10S435/911
摘要： This invention discloses a process for the use of a novel organism belonging to the genus Trichosporon sp. as whole wet or dry cell culture or cell free extract or crude enzyme or pure isolated enzyme The strain of Trichosporon sp. used in the process is designated as RRLY-15 and has been deposited in Deutsche Sammlung von Mikroorganismen und Zellekulturen GmbH (DSMZ). The invention also discloses the preparation of S(+)-6-methoxy-2-naphthalene acetic acid (naproxen) of formula (2) through enantioselective hydrolysis of a racemic mixture of alkyl esters of (±)-6-methoxy-&agr;-methyl-2-naphthalene acetic acid of formula (1) where R represents —CH3,—C2H5,—C3H7,—C4H9 and the like and S(+)- Naproxen is a medicinally important non steroidal anti-inflammatory drug.
摘要翻译：本发明公开了一种使用属于Trichosporon sp。的新生物的方法。作为整个湿或干细胞培养或无细胞提取物或粗酶或纯分离的酶Trichosporon sp。在该过程中使用的产品被指定为RRLY-15，并已存放在德意志银行（Mikroorganismen und Zellekulturen GmbH）（DSMZ）。本发明还公开了通过对映选择性水解（±）-6-甲氧基-α-甲氧基-2-甲基苯基的烷基酯的外消旋混合物制备式（2）的S（+） - 6-甲氧基-2-萘乙酸（萘普生）式（1）的甲基-2-萘乙酸，其中R表示-CH 3，-C 2 H 5，-C 3 H 7，-C 4 H 9等，而S（+） - 萘普生是药物重要的非甾体抗炎药。

57. 发明授权

US06235882B1 Gene encoding a putative efflux protein for solvents/antibiotics in pseudomonas mendocina 失效
公开(公告)号：US06235882B1
公开(公告)日：2001-05-22
申请号：US09333254
申请日：1999-06-15
申请人： Kevin Keqin Chen
发明人： Kevin Keqin Chen
IPC分类号： C07K100
CPC分类号： C07K14/21 , C12P7/42 , Y10S435/803 , Y10S435/813 , Y10S435/827 , Y10S435/877 , Y10S435/911 , Y10T436/143333
摘要： This invention relates to the isolation of a novel putative efflux gene from Pseudomonas mendocina. The putative efflux gene is useful for probing an organism's efflux system to gain an understanding of the mechanisms of solvent tolerance. The invention further provides a Pseudomonas mendocina strain deficient in this gene. This strain is unable to grow in the presence of chloramphenicol and, compared to the wildtype strain, grows slowly in the presence of high concentrations of PHBA.

58. 发明授权

US06187741B1 Process for preparing saturated lactones, products produced therefrom and organoleptic uses of said products 有权
标题翻译：制备饱和内酯，由其制备的产品和所述产品的感官用途的方法
公开(公告)号：US06187741B1
公开(公告)日：2001-02-13
申请号：US09411830
申请日：1999-10-04
申请人： Mohamad I. Farbood , Laura E. Kizer , James Morris , Gail Harris , Lynda B. McLean
发明人： Mohamad I. Farbood , Laura E. Kizer , James Morris , Gail Harris , Lynda B. McLean
IPC分类号： A61K746
CPC分类号： A23G4/06 , A23G3/346 , A23G2200/00 , A23L3/3544 , A23L27/24 , C07D309/10 , C07D309/30 , C11B9/008 , C11D3/50 , C12P17/06 , Y10S435/911
摘要： A two phase environmentally friendly fermentation process for producing high yields of &dgr;-decalactone and &dgr;-dodecalactone from the corresponding unsaturated starting materials is carried out under oxidative growth conditions using a saccharomyces species. The resulting products impart, augment and/or enhance the aroma and/or taste of consumable materials including foodstuffs, chewing gums, toothpastes, beverages, fragrance compositions, colognes and perfumed articles such as solid or liquid, anionic, cationic, non-ionic or zwitterionic detergents, fabric softeners, and hair preparations.
摘要翻译：在相应的不饱和起始原料下生产高产量的δ-十聚内酯和δ-十二烷内酯的两相环保发酵方法是在氧化生长条件下使用酵母属物种进行的。所产生的产品赋予，增加和/或增强消费材料的香气和/或味道，包括食品，口香糖，牙膏，饮料，香料组合物，古龙水和加香制品如固体或液体，阴离子，阳离子，非离子或两性离子洗涤剂，织物柔软剂和头发制剂。

59. 发明授权

US6162636A Fermentation process for preparing erythritol using mutant cells by controlling osmotic pressure 失效
标题翻译：通过控制渗透压使用突变细胞制备赤藓糖醇的发酵方法
公开(公告)号：US6162636A
公开(公告)日：2000-12-19
申请号：US384435
申请日：1999-08-27
申请人： Sang Yong Kim , Deok Kun Oh , Soo Ryun Jung
发明人： Sang Yong Kim , Deok Kun Oh , Soo Ryun Jung
IPC分类号： C12P19/02 , C12N1/14 , C12P7/18
CPC分类号： C12R1/645 , C12P7/18 , Y10S435/911
摘要： The present invention relates to a fermentation process for preparing erythritol with high productivity with novel mutant of Trigonopsis variabilis, more specifically, for preparing erythritol under optimal fermentation conditions for maximum erythritol production by optimizing the environmental conditions of culture such as pH, temperature and controlling osmotic pressure. A two-stage fermentation was performed to control osmotic pressure. Osmotic pressure was adjusted to a low level during growth phase and to a high level during production phase by adding glucose and NaCl. Therefore, erythritol production could be increased due to the increased mutant cells.
摘要翻译：本发明涉及一种具有高生产能力的赤藓糖醇的发酵方法，其具有新颖的变异突变体，更具体地说，用于通过优化培养物的环境条件（如pH，温度和控制渗透压）在最佳发酵条件下最佳发酵条件下制备赤藓糖醇压力。进行两阶段发酵以控制渗透压。通过添加葡萄糖和NaCl，渗透压在生长阶段调整到低水平，在生产阶段调整到高水平。因此，由于增加的突变体细胞，赤藓糖醇的产生可能增加。

60. 发明授权

US6146880A Methods for lyophilizing and using ericoid mycorrhizal fungi 失效
标题翻译：冷冻干燥和使用粉状菌根真菌的方法
公开(公告)号：US6146880A
公开(公告)日：2000-11-14
申请号：US26437
申请日：1998-02-19
申请人： Mark C. Starrett , Frank A. Blazich , Steven R. Shafer , Larry F. Grand
发明人： Mark C. Starrett , Frank A. Blazich , Steven R. Shafer , Larry F. Grand
IPC分类号： C12N1/04
CPC分类号： C12N1/04 , Y10S435/911
摘要： The present invention is directed to a method for preserving mycorrhizal fungi for long-term storage using lyophilization. This enables use of the fungi for growing and acclimatizing micropropagated plants. The invention is especially useful for preserving mycorrhizal ericoid fungi for long-term storage and use in a soilless medium for growing micropropagated ericaceous plants.
摘要翻译：本发明涉及使用冻干保存长期保存菌根真菌的方法。这使得能够使用真菌来生长和驯化微繁殖植物。本发明特别适用于保存菌根类型的真菌，用于长期储存和用于无土栽培微生殖微粉碎植物的无土栽培培养基中。

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