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51. 发明申请

US20150267161A1 APPARATUS AND METHOD FOR TREATMENT OF VOLATILE ORGANIC COMPOUNDS IN AIR EMISSIONS PRODUCED DURING FERMENTATION PROCESSES 审中-公开
标题翻译：用于处理在发酵过程中产生的空气排放中挥发性有机化合物的装置和方法
公开(公告)号：US20150267161A1
公开(公告)日：2015-09-24
申请号：US14732964
申请日：2015-06-08
申请人： RESONANT BIOSCIENCES, LLC
发明人： Allen Ziegler
IPC分类号： C12M1/00
CPC分类号： C12M47/10 , B01D53/72 , B01D2251/108 , B01D2257/504 , B01D2257/708 , C12M21/12 , C12M47/18 , C12P7/06 , Y02A50/235 , Y02E50/16 , Y02E50/17 , Y02P20/152
摘要： An apparatus for treating volatile organic compounds produced during a fermentation process is provided. The apparatus includes a ClO2 generator exhausting a ClO2 gas stream, a batch tank fluidly connected to the ClO2 generator outlet and receiving the ClO2 gas stream from the ClO2 generator outlet, the batch tank comprising an inlet for introducing a water stream and an outlet for exhausting an aqueous ClO2 solution from the batch tank, the aqueous ClO2 solution having a concentration of about 3000 mg/L, and a yeast product fermentation vessel configured to receive yeast product and the aqueous ClO2 solution from the batch tank and to ferment the yeast product and the aqueous ClO2 solution. Fermenting the quantity of yeast product and aqueous ClO2 solution reduces concentration of volatile organic compounds produced.
摘要翻译：提供一种用于处理在发酵过程中产生的挥发性有机化合物的装置。该设备包括排出ClO 2气体流的ClO 2发生器，与CIOO发生器出口流体连接并接收来自ClO 2发生器出口的ClO 2气流的批量罐，该批料罐包括用于引入水流的入口和用于排出的出口来自分批槽的ClO 2溶液，浓度为约3000mg / L的ClO 2水溶液，以及配置成接收酵母产物的酵母产物发酵容器和来自分批罐的ClO 2溶液并发酵酵母产物， ClO2水溶液。发酵酵母产品和ClO2水溶液的量可以减少所产生的挥发性有机化合物的浓度。

52. 发明申请

US20150252317A1 DISPOSABLE BIOREACTOR WITH FILTRATION SYSTEM 审中-公开
标题翻译：具有过滤系统的废弃生物反应器
公开(公告)号：US20150252317A1
公开(公告)日：2015-09-10
申请号：US14644036
申请日：2015-03-10
申请人： FloDesign Sonics, Inc.
发明人： Bart Lipkens , Louis Masi , Walter M. Presz, JR. , Thomas J. Kennedy, III
IPC分类号： C12M1/00
CPC分类号： C12M47/10 , C12M23/14 , C12M23/26 , C12M23/28 , C12M27/02 , C12M47/02
摘要： A disposable bioreactor system includes a bag having a first end and a second end. An acoustophoresis device is disposed at the first end of the bag, and is separable from the bag. An actuating mechanism is operably connected to the second end of the bag. The actuating mechanism is configured to move the second end of the bag towards the acoustophoresis device, so that fluids within the volume of the bag flow past the acoustophoresis device and carry desired biomolecules out of the bag for collection, while cells and other debris remain within the bag for disposal.
摘要翻译：一次性生物反应器系统包括具有第一端和第二端的袋。气泡装置设置在袋的第一端，并且可与袋分离。致动机构可操作地连接到袋的第二端。致动机构被构造成将袋的第二端朝向呼吸道装置移动，使得袋体积内的流体流过呼吸道装置，并将所需的生物分子从袋中携带用于收集，而细胞和其它碎屑保留在处理袋子

53. 发明授权

US09109193B2 Continuous perfusion bioreactor system 有权
标题翻译：连续灌注生物反应器系统
公开(公告)号：US09109193B2
公开(公告)日：2015-08-18
申请号：US12124039
申请日：2008-05-20
申请人： Parrish M. Galliher , Geoffrey L. Hodge , Michael Fisher , Patrick Guertin , Dan Mardirosian
发明人： Parrish M. Galliher , Geoffrey L. Hodge , Michael Fisher , Patrick Guertin , Dan Mardirosian
IPC分类号： C12N5/02 , C12M1/00 , C12M3/00 , C12M1/06
CPC分类号： C12M29/10 , B01D29/13 , C12M23/14 , C12M23/26 , C12M23/48 , C12M27/02 , C12M27/20 , C12M29/00 , C12M29/18 , C12M47/10
摘要： Systems and methods for containing and manipulating liquids, including vessels and unit operations or components of cell culture, cell containment, bioreactor, and/or pharmaceutical manufacturing systems, are provided. In certain embodiments, such vessels and unit operations are directed to continuous perfusion reactor or bioreactor systems and may include one or more disposable components. For instance, in one aspect, a system includes an apparatus in the form of a bioreactor for harvesting cells which produce one or more products. The apparatus may include a disposable, collapsible bag adapted for containing a liquid, the collapsible bag in fluid communication with a liquid-solids (e.g., cell) separation device. For example, an outlet of the collapsible bag may be connected to an inlet of the separation device, and an outlet of the separation device may be connected to an inlet of the collapsible bag for recycle. Accordingly, after separating the cells from the liquid in the separation device, the cells can be flowed back into the collapsible bag where they can be re-harvested. Meanwhile, product contained in the liquid can be collected in a separate container. The efficiency of product formation in such a system may be enhanced by using mixing systems described herein.
摘要翻译：提供了用于容纳和操纵液体的系统和方法，包括容器和单元操作或细胞培养物，细胞容纳物，生物反应器和/或药物制造系统的组分。在某些实施方案中，这样的容器和单元操作涉及连续灌注反应器或生物反应器系统，并且可以包括一个或多个一次性组件。例如，一方面，系统包括生物反应器形式的装置，用于收集产生一种或多种产品的细胞。该装置可以包括适于容纳液体的一次性可折叠袋，该可折叠袋与液体 - 固体（例如，池）分离装置流体连通。例如，可折叠袋的出口可以连接到分离装置的入口，并且分离装置的出口可以连接到可折叠袋的入口以用于再循环。因此，在分离装置中的液体分离细胞后，细胞可以流回到可收缩的袋子中，在那里它们可以被再次收获。同时，包含在液体中的产品可以收集在单独的容器中。通过使用本文所述的混合系统可以提高这种系统中产物形成的效率。

54. 发明申请

US20150147811A1 Filtration of Cell Culture Supernatants 审中-公开
标题翻译：细胞培养上清液的过滤
公开(公告)号：US20150147811A1
公开(公告)日：2015-05-28
申请号：US14414261
申请日：2013-07-19
申请人： Greenovation Biotech GmbH
发明人： Grosse Thomas , Niederkrüger Holger , Schaaf Andreas
IPC分类号： C12N1/02 , C07K1/34 , C12M1/00 , C12N5/04
CPC分类号： C12N1/02 , C07K1/34 , C12M47/02 , C12M47/10 , C12N5/04
摘要： The invention relates to a method for separating off a liquid supernatant from cells, comprising the steps: providing a mixture of the cells with a liquid, charging a first filter housing with the mixture, wherein in the filter housing a filter having a pore size of between 4 μm and 50 μm is provided on a flat base surface pierced in a sieve manner and the walls of the filter housing are connected so as to seal with the flat base surface that is pierced in a sieve manner, applying a differential pressure of at least 0.5 bar on the mixture, as a result of which the liquid portion of the mixture is forced through the filter and a filter cake containing cells remains in the filter housing, and removal of the filtered liquid.
摘要翻译：本发明涉及一种用于从细胞中分离液体上清液的方法，包括以下步骤：提供细胞与液体的混合物，向混合物中加入第一过滤器壳体，其中在过滤器壳体中具有孔径为 4μm和50μm之间设置在以筛网方式穿孔的平坦基面上，并且过滤器壳体的壁被连接以便与以筛子方式刺穿的平坦基底表面密封，施加压差为混合物中至少0.5巴，结果混合物的液体部分被迫通过过滤器，并且含有滤饼的滤饼保留在过滤器壳体中，并且去除过滤的液体。

55. 发明申请

US20150099293A1 BUOYANT PROTEIN HARVESTING DEVICE 审中-公开
标题翻译： BUOYANT蛋白质收集装置
公开(公告)号：US20150099293A1
公开(公告)日：2015-04-09
申请号：US14569012
申请日：2014-12-12
申请人： Sarfaraz K. Niazi
发明人： Sarfaraz K. Niazi
IPC分类号： C12M1/00
CPC分类号： C12M47/10 , B01D15/22 , B01J20/2805 , C07K1/14 , C07K1/165 , C07K1/18 , C07K1/20 , C07K1/22
摘要： A buoyant device containing chromatography media performs the function of protein harvesting replacing the steps of cell separation and volume reduction; the device can be loaded into columns for further purification.
摘要翻译：含有色谱介质的漂浮装置具有蛋白质收集功能，取代了细胞分离和体积减少的步骤; 该装置可以装入柱中用于进一步净化。

56. 发明授权

US08969050B2 Purification methods and systems related to renewable materials and biofuels production 有权
标题翻译：与可再生材料和生物燃料生产相关的净化方法和系统
公开(公告)号：US08969050B2
公开(公告)日：2015-03-03
申请号：US13682903
申请日：2012-11-21
申请人： Glen Austin , Binita X. Bhattacharjee , Leslie W. Bolton , Jacob Borden , Martin E. Carrera , Amit A. Gokhale , Chris Horler , Aidan Hurley , Eric T. Mack
发明人： Glen Austin , Binita X. Bhattacharjee , Leslie W. Bolton , Jacob Borden , Martin E. Carrera , Amit A. Gokhale , Chris Horler , Aidan Hurley , Eric T. Mack
IPC分类号： C12P7/16 , C12P7/04 , C12P5/00 , C12P7/64 , C12M1/00 , C12P7/06
CPC分类号： C12M21/12 , C12M35/00 , C12M43/02 , C12M47/10 , C12P5/00 , C12P7/04 , C12P7/06 , C12P7/16 , C12P7/649 , Y02E50/10 , Y02E50/13 , Y02E50/17 , Y02T50/678
摘要： Methods of producing renewable materials may include consuming a fermentation feedstock with a fermentation organism to produce a renewable material in fermentation broth; water may then be separated from the feedstock or broth using one or more phase separations, or the renewable material may be concentrated from the feedstock or broth using one or more phase separations. Methods of producing biofuel components may include consuming a lignocellulosic or sugar fermentation feedstock with a fermentation organism to produce either ethanol or butanol in fermentation broth; cooling the feedstock or broth to solidify at least some water therein; and separating the solidified water from the feedstock or broth using a solid-liquid phase separation.
摘要翻译：生产可再生材料的方法可以包括用发酵生物体消耗发酵原料以在发酵液中产生可再生材料; 然后可以使用一个或多个相分离将水与原料或肉汤分离，或者使用一个或多个相分离可以从原料或肉汤浓缩可再生材料。生产生物燃料组分的方法可以包括用发酵生物体消耗木质纤维素或糖发酵原料，以在发酵液中产生乙醇或丁醇; 冷却原料或肉汤以固化至少一些水; 并使用固 - 液相分离从原料或肉汤中分离凝固的水。

57. 发明申请

US20140322772A1 PRODUCTION OF CARBOXYLATES AND METHANE FROM BIOMASS WASTE 有权
标题翻译：从生物质废物生产羧酸酯和甲烷
公开(公告)号：US20140322772A1
公开(公告)日：2014-10-30
申请号：US14237611
申请日：2012-08-08
申请人： Largus T. Angenent , Matthew T. Agler
发明人： Largus T. Angenent , Matthew T. Agler
IPC分类号： C12P7/40 , C12P5/02
CPC分类号： C12P7/40 , C07C51/48 , C12M21/04 , C12M41/12 , C12M41/26 , C12M41/40 , C12M47/10 , C12N1/32 , C12P5/023 , Y02E50/343 , C07C53/126
摘要： Methods and systems for producing and removing C6 and/or C8 carboxylates and/or methane from carbohydrate containing biomass, an alcohol, and mixtures of microorganisms under an anaerobic environment. The C6 and/or C8 carboxylates are removed continuously or in-line. Methanogenesis is not inhibited and very little input carbon is lost as carbon dioxide.
摘要翻译：在含氧生物质的生物质，醇和微生物混合物的厌氧环境下生产和除去C6和/或C8羧酸盐和/或甲烷的方法和系统。 C6和/或C8羧酸盐连续或一行排除。甲烷生成不被抑制，二氧化碳的输入碳少很少。

58. 发明申请

US20140284501A1 PROCESSING MATERIALS 有权
标题翻译：加工材料
公开(公告)号：US20140284501A1
公开(公告)日：2014-09-25
申请号：US14299003
申请日：2014-06-09
申请人： Xyleco, Inc.
发明人： Marshall MEDOFF , Thomas Craig MASTERMAN , Robert PARADIS
IPC分类号： C13K1/02 , C13K13/00
CPC分类号： D21C9/007 , B01D15/02 , B01D53/32 , B01D61/44 , B01D61/445 , B01J19/085 , B01J2219/0869 , B01J2219/0879 , B01J2219/0886 , B65G27/00 , B65G53/04 , B65G53/40 , C07C29/149 , C07C31/12 , C10G1/00 , C10L1/023 , C10L1/026 , C10L9/08 , C10L2200/0469 , C10L2200/0476 , C10L2290/36 , C12M47/00 , C12M47/10 , C12P7/04 , C12P7/06 , C12P7/10 , C12P7/52 , C12P7/56 , C12P19/02 , C12P19/14 , C12P2201/00 , C12P2203/00 , C13K1/02 , C13K13/002 , E04B1/92 , E04B2001/925 , G21F7/00 , H01J37/317 , H01J2237/202 , H01J2237/31 , H01J2237/3165 , Y02E50/16 , Y02E50/17 , Y02E50/32 , Y02E50/343 , Y02E60/17 , Y02P20/136 , Y02W10/33 , Y02W10/37
摘要： Biomass feedstocks (e.g., plant biomass, animal biomass, and municipal waste biomass) are processed to produce useful products, such as fuels. For example, novel systems, methods and equipment for conveying and/or cooling treated biomass are described.
摘要翻译：加工生物质原料（如植物生物质，动物生物质和城市垃圾生物质）以生产有用的产品，如燃料。例如，描述了用于输送和/或冷却经处理的生物质的新型系统，方法和设备。

59. 发明申请

US20140234954A1 Methods and apparatus for independent control of product and reactant concentrations 有权
标题翻译：独立控制产品和反应物浓度的方法和装置
公开(公告)号：US20140234954A1
公开(公告)日：2014-08-21
申请号：US14180403
申请日：2014-02-14
申请人： Pharyx, Inc.
发明人： Harry Lee , Kevin Shao-Kwan Lee
IPC分类号： C12M1/26
CPC分类号： C12M33/14 , C12M23/16 , C12M47/10
摘要： A microreactor with a reaction chamber comprising two sub-chambers with reconfigurable volumes, an input conduit with input valve, an un-filtered output conduit with first output valve, and a filtered output conduit with a second output valve is used to perform a method to control a different dilution rate for cells and molecules in continuous culture bioprocesses. In preferred embodiments flow control is achieved using the difference in volume of the two sub-chambers.
摘要翻译：具有反应室的微反应器包括具有可重构体积的两个子室，具有输入阀的输入导管，具有第一输出阀的未过滤输出导管和具有第二输出阀的过滤输出导管，用于执行一种方法控制连续培养生物过程中细胞和分子的不同稀释率。在优选实施例中，使用两个子室的体积差异来实现流量控制。

60. 发明申请

US20140220646A1 APPARATUS FOR TREATING FOOD WASTE AND EXTRACTING BIO OIL 审中-公开
标题翻译：用于处理食物废物和提取生物油的设备
公开(公告)号：US20140220646A1
公开(公告)日：2014-08-07
申请号：US14240546
申请日：2012-04-26
申请人： Won Im Lim
发明人： Won Im Lim
IPC分类号： C12M1/00 , C11B13/00
CPC分类号： C12M47/10 , B09B3/0083 , C05F5/006 , C05F5/008 , C05F17/0276 , C10B47/44 , C10B53/02 , C10G31/10 , C10G2300/1003 , C11B13/00 , C12M21/12 , C12M47/12 , Y02A40/211 , Y02A40/212 , Y02E50/14 , Y02P20/145 , Y02W30/43
摘要： An apparatus for treating food waste and extracting bio oil includes: a fermentation dryer which ferments and decomposes food waste for 24 hours to reduce moisture contained in the food waste to 40 to 50%, a crusher which crushes the food waste into small particles, a distillation tank which heats the crushed food waste at low pressure and temperature so that oil is gasified by means of low temperature thermal decomposition to form oil gas, a distillation tower in which the oil gas is cooled to be liquefied and separated into moisture (carbon liquid fertilizer) and oil, a vacuum storage tank which collects the separated oil, and a centrifugal separator which rectifies the oil. The apparatus extracts a carbon liquid fertilizer, bio oils, and activated carbon while treating organic substances such as food waste and residual product compost.
摘要翻译：一种用于处理食物废物和提取生物油的设备包括：发酵干燥器，其将食物废物发酵和分解24小时以将食物废物中含有的水分降低至40-50％，将食物废物粉碎成小颗粒的破碎机蒸馏罐，其在低压和低温下加热破碎的食物废物，使得油通过低温热分解气化，形成油气，其中油气被冷却以液化并分离成水分（碳液体肥料）和油，收集分离的油的真空储存罐和用于对油进行整流的离心分离器。该设备在处理有机物质如食物废物和残留产品堆肥时，提取碳液体肥料，生物油和活性炭。

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