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51. 发明授权

US06334856B1 Microneedle devices and methods of manufacture and use thereof 有权
标题翻译：微针装置及其制造和使用方法
公开(公告)号：US06334856B1
公开(公告)日：2002-01-01
申请号：US09316229
申请日：1999-05-21
申请人： Mark G. Allen , Mark R. Prausnitz , Devin V. McAllister , Florent Paul Marcel Cros
发明人： Mark G. Allen , Mark R. Prausnitz , Devin V. McAllister , Florent Paul Marcel Cros
IPC分类号： A61M500
CPC分类号： B81C1/00111 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150282 , A61B5/150984 , A61B17/205 , A61B2010/008 , A61K9/0021 , A61M37/0015 , A61M2037/003 , A61M2037/0053 , A61N1/303 , B33Y80/00 , B81B2201/055
摘要： Microneedle devices are provided for transport of therapeutic and biological molecules across tissue barriers and for use as microflameholders. In a preferred embodiment for transport across tissue, the microneedles are formed of a biodegradable polymer. Methods of making these devices, which can include hollow and/or porous microneedles, are also provided. A preferred method for making a microneedle includes forming a micromold having sidewalls which define the outer surface of the microneedle, electroplating the sidewalls to form the hollow microneedle, and then removing the micromold from the microneedle. In a preferred method of use, the microneedle device is used to deliver fluid material into or across a biological barrier from one or more chambers in fluid connection with at least one of the microneedles. The device preferably further includes a means for controlling the flow of material through the microneedles. Representative examples of these means include the use of permeable membranes, fracturable impermeable membranes, valves, and pumps.
摘要翻译：提供微针装置用于将组织屏障上的治疗和生物分子转运并用作微火焰保持器。在用于跨组织输送的优选实施方案中，微针由可生物降解的聚合物形成。还提供制造这些装置的方法，其可以包括中空和/或多孔微针。用于制造微针的优选方法包括形成具有限定微针的外表面的侧壁的显微镜，电镀侧壁以形成中空微针，然后从微针中去除微镜。在优选的使用方法中，微针装置用于将流体材料输送到生物屏障中，或者与一个或多个腔室中的至少一个微针流体连接。该装置优选地还包括用于控制通过微针的材料流动的装置。这些方法的代表性实例包括使用可渗透膜，可破裂的不渗透膜，阀和泵。

52. 发明授权

US6109222A Miniature reciprocating combustion-driven machinery 失效
标题翻译：微型往复式燃烧驱动机械
公开(公告)号：US6109222A
公开(公告)日：2000-08-29
申请号：US197726
申请日：1998-11-28
申请人： Ari Glezer , Mark G. Allen
发明人： Ari Glezer , Mark G. Allen
IPC分类号： F02B71/04 , F02B71/00
CPC分类号： F02B75/34 , F02B71/04 , H02K35/06 , H02K7/1884 , F02B63/041
摘要： A reciprocating micro heat engine for electrical and mechanical power generation is disclosed The micro heat engine uses a reciprocating free piston that is driven by a periodic combustion process, and is implemented using micromachining technology. In the application of electrical power generation, the mechanical and electrical functionality of the engine are highly integrated; i.e., the same piston performs both the fuel-to mechanical energy conversion as well as the mechanical-to-electrical energy conversion.
摘要翻译：公开了一种用于电力和机械发电的往复式微型发动机。微型发动机使用由定期燃烧过程驱动的往复式自由活塞，并且使用微加工技术来实现。在发电的应用中，发动机的机械和电气功能高度集成; 即相同的活塞执行燃料与机械能量转换以及机械 - 电能转换。

53. 发明授权

US5758823A Synthetic jet actuator and applications thereof 失效
标题翻译：合成射流致动器及其应用
公开(公告)号：US5758823A
公开(公告)日：1998-06-02
申请号：US489490
申请日：1995-06-12
申请人： Ari Glezer , Mark G. Allen , David J. Coe , Barton L. Smith , Mark A. Trautman , John W. Wiltse
发明人： Ari Glezer , Mark G. Allen , David J. Coe , Barton L. Smith , Mark A. Trautman , John W. Wiltse
IPC分类号： B64C21/08 , B64G1/26 , B64G1/40 , F01D5/14 , F02K1/28 , F15C1/14 , F15C5/00 , F15D1/08 , F15D1/12 , F16K99/00 , F23R3/24 , H01L23/433 , H05K7/20 , B05B17/06
CPC分类号： F21V29/70 , B64C21/08 , B64G1/26 , B64G1/40 , B64G1/401 , F01D5/148 , F02K1/28 , F15C1/14 , F15C5/00 , F15D1/009 , F15D1/08 , F15D1/12 , F16K99/0001 , F16K99/0007 , F16K99/0048 , F21V29/40 , F21V29/63 , F21V29/677 , F21V29/83 , F23R3/24 , H01L23/4336 , H05K7/20172 , B64C2230/02 , B64C2230/04 , B64C2230/06 , B64C2230/14 , B64C2230/16 , B64C2230/18 , F16K2099/0094 , F16K2099/0098 , F16K99/0034 , F28F13/02 , H01L2924/0002 , H01L2924/3011 , Y02T50/166 , Y02T50/673
摘要： Synthetic jet actuator, which can be micromachined if desired, generates a synthetic jet stream characterized by a series of successive vortices that can be used for effectively entraining adjacent fluid. The synthetic jet actuator can be used to bend, or vector, a jet stream from another jet actuator. Further, because the synthetic jet actuator exhibits zero net mass flux, the synthetic jet actuator can be used within a bounded volume. In structure, the synthetic jet actuator comprises a housing defining an internal chamber and having an orifice. A flexible metallized diaphragm forms a wall of the housing and can change the volume of the chamber when moved. An electrode is disposed adjacent to and spaced from the diaphragm, and an electrical bias is imposed between the metallized diaphragm and the electrode by a control system to force movement of the diaphragm. As the diaphragm moves, the volume in the internal chamber changes and vortices are ejected from the chamber through the orifice.
摘要翻译：如果需要，可以进行微加工的合成射流致动器产生合成射流，其特征在于一系列连续的涡流，其可用于有效夹带相邻的流体。合成射流致动器可用于弯曲或矢量来自另一射流致动器的喷射流。此外，由于合成射流致动器具有零的净质量通量，所以合成射流致动器可以在有界体积内使用。在结构上，合成射流致动器包括限定内部腔并具有孔口的壳体。柔性金属化膜片形成壳体的壁，并且可以在移动时改变腔室的体积。电极被设置成与隔膜相邻并与隔膜隔开，并且通过控制系统施加在金属化隔膜和电极之间的电偏压以迫使隔膜的移动。当隔膜移动时，内腔中的体积变化，并且涡流从腔室通过孔排出。

54. 发明授权

US5401983A Processes for lift-off of thin film materials or devices for fabricating three dimensional integrated circuits, optical detectors, and micromechanical devices 失效
标题翻译：用于剥离薄膜材料的工艺或用于制造三维集成电路的装置，光学检测器和微机械装置
公开(公告)号：US5401983A
公开(公告)日：1995-03-28
申请号：US44251
申请日：1993-04-07
申请人： Nan M. Jokerst , Martin A. Brooke , Mark G. Allen
发明人： Nan M. Jokerst , Martin A. Brooke , Mark G. Allen
IPC分类号： H01L27/00 , H01L21/20 , H01L21/78 , H01L27/146 , H01L31/12 , H01L33/00 , H01S5/02 , H01S5/183
CPC分类号： H01L21/78 , B81C1/00373 , H01L21/2007 , H01L27/14643 , H01L27/14687 , H01L27/14694 , H01L33/0062 , B81C2201/0188 , B81C2201/0194 , H01L2221/68368 , H01S5/0215 , H01S5/0217 , H01S5/183
摘要： Various novel lift-off and bonding processes (60, 80, 100) permit lift-off of thin film materials and devices (68), comprising In.sub.x Ga.sub.1-x As.sub.y P.sub.1-y where 0
摘要翻译：各种新颖的剥离和粘合工艺（60,80,100）允许剥离包括In x Ga 1-x As y P 1-y的薄膜材料和器件（68），其中0

55. 发明授权

US09330820B2 Method for making electrically conductive three-dimensional structures 有权
标题翻译：制造导电三维结构的方法
公开(公告)号：US09330820B2
公开(公告)日：2016-05-03
申请号：US13873961
申请日：2013-04-30
申请人： Mark G. Allen , Seong-O Choi , Jung-Hwan Pauk , Xiaosong Wu , Yanzhu Zhao , Yong-Kyu Yoon , Swaminathan Rajaraman
发明人： Mark G. Allen , Seong-O Choi , Jung-Hwan Pauk , Xiaosong Wu , Yanzhu Zhao , Yong-Kyu Yoon , Swaminathan Rajaraman
IPC分类号： H01B13/00 , A61B5/00 , A61M37/00 , H05K1/02 , C25D1/00 , C25D1/10 , C25D5/02 , A61N1/32 , H05K3/40 , H05K3/20
CPC分类号： B32B3/30 , A61B5/685 , A61B2562/125 , A61M37/0015 , A61M2037/0053 , A61N1/327 , C25D1/003 , C25D1/10 , C25D5/022 , H01B13/00 , H05K1/02 , H05K3/20 , H05K3/4007 , H05K2201/0367 , H05K2201/09045 , H05K2201/09118 , H05K2203/0113 , Y10T428/2958 , Y10T428/298
摘要： Methods are provided for fabricating three-dimensional electrically conductive structures. Three-dimensional electrically conductive microstructures are also provided. The method may include providing a mold having at least one microdepression which defines a three-dimensional structure; filling the microdepression of the mold with at least one substrate material; molding the at least one substrate material to form a substrate; and depositing and patterning of at least one electrically conductive layer either during the molding process or subsequent to the molding process to form an electrically conductive structure. In one embodiment, the three-dimensional electrically conductive microstructure comprises an electrically functional microneedle array comprising two or more microneedles, each including a high aspect ratio, polymeric three dimensional substrate structure which is at least substantially coated by an electrically conductive layer.
摘要翻译：提供用于制造三维导电结构的方法。还提供三维导电微结构。该方法可以包括提供具有限定三维结构的至少一个微压缩的模具; 用至少一种基底材料填充模具的微压缩; 模制所述至少一种基底材料以形成基底; 以及在模制过程期间或在模制过程之后沉积和图案化至少一个导电层以形成导电结构。在一个实施例中，三维导电微结构包括电功能微针阵列，其包括两个或更多个微针，每个微针包括高纵横比，至少基本上被导电层涂覆的聚合物三维衬底结构。

56. 发明授权

US09032900B2 Marine vehicle systems and methods 有权
标题翻译：海洋车辆系统和方法
公开(公告)号：US09032900B2
公开(公告)日：2015-05-19
申请号：US13870050
申请日：2013-04-25
申请人： Ari Glezer , Lora G. Weiss , Mark G. Allen
发明人： Ari Glezer , Lora G. Weiss , Mark G. Allen
IPC分类号： B63G8/26 , B63G8/00 , B63G8/08 , B63G8/14 , B63H1/30 , B63H1/37 , B63G8/18 , B63H1/36 , B63B7/08 , B63G13/02
CPC分类号： B63G8/26 , B63B7/08 , B63B2211/02 , B63G8/001 , B63G8/08 , B63G8/14 , B63G8/18 , B63G2008/002 , B63G2013/022 , B63H1/30 , B63H1/36 , B63H1/37
摘要： Marine vehicle systems and methods are disclosed. The marine vehicle can be buoyancy controlled, enabling efficient, extended use of the marine vehicle. Buoyancy actuation can enable roll, pitch, and yaw of the marine vehicle, as well as translation in any direction. One or more elastic bladders can be disposed on or in the marine vehicle. The bladders can be selectively inflated and deflated to control movement of the marine vehicle.
摘要翻译：公开了船用车辆系统和方法。船舶可以浮力控制，能够有效，延长使用船用车辆。浮力致动可以实现船舶的滚动，俯仰和偏航，以及任何方向的平移。一个或多个弹性囊可以设置在船用车辆上或船上。气囊可以选择性地膨胀和放气以控制船用车辆的运动。

57. 发明申请

US20130305978A1 MARINE VEHICLE SYSTEMS AND METHODS 有权
标题翻译：海上车辆系统和方法
公开(公告)号：US20130305978A1
公开(公告)日：2013-11-21
申请号：US13870050
申请日：2013-04-25
申请人： Ari Glezer , Lora G. Weiss , Mark G. Allen
发明人： Ari Glezer , Lora G. Weiss , Mark G. Allen
IPC分类号： B63G8/26
CPC分类号： B63G8/26 , B63B7/08 , B63B2211/02 , B63G8/001 , B63G8/08 , B63G8/14 , B63G8/18 , B63G2008/002 , B63G2013/022 , B63H1/30 , B63H1/36 , B63H1/37
摘要： Marine vehicle systems and methods are disclosed. The marine vehicle can be buoyancy controlled, enabling efficient, extended use of the marine vehicle. Buoyancy actuation can enable roll, pitch, and yaw of the marine vehicle, as well as translation in any direction. One or more elastic bladders can be disposed on or in the marine vehicle. The bladders can be selectively inflated and deflated to control movement of the marine vehicle.
摘要翻译：公开了船用车辆系统和方法。船舶可以浮力控制，能够有效，延长使用船用车辆。浮力致动可以实现船舶的滚动，俯仰和偏航，以及任何方向的平移。一个或多个弹性囊可以设置在船用车辆上或船上。气囊可以选择性地膨胀和放气以控制船用车辆的运动。

58. 发明申请

US20120313649A1 Physical Property Sensor With Active Electronic Circuit And Wireless Power And Data Transmission 有权
标题翻译：具有有源电子电路和无线电力和数据传输的物理传感器
公开(公告)号：US20120313649A1
公开(公告)日：2012-12-13
申请号：US13588518
申请日：2012-08-17
申请人： Jin Woo Park , Florent Cros , Mark G. Allen
发明人： Jin Woo Park , Florent Cros , Mark G. Allen
IPC分类号： G01R27/28
CPC分类号： H02J50/00 , A61B5/0031 , A61B2560/0219 , G01K13/00 , G01L1/00 , G01L7/00 , H02J5/005 , H02J7/025
摘要： Wireless sensors configured to record and transmit data as well as sense and, optionally, actuate to monitor physical properties of an environment and, optionally, effect changes within that environment. In one aspect, the wireless sensor can have a power harvesting unit; a voltage regulation unit, a transducing oscillator unit, and a transmitting coil. The voltage regulation unit is electrically coupled to the power harvesting unit and is configured to actuate at a minimum voltage level. The transducing oscillator unit is electrically coupled to the voltage regulation unit and is configured to convert a sensed physical property into an electrical signal. Also, the transmitting coil is configured to receive the electrical signal and to transmit the electrical signal to an external antenna.
摘要翻译：无线传感器被配置为记录和传输数据以及感测和可选地启动以监视环境的物理特性，并且可选地影响该环境内的改变。一方面，无线传感器可以具有电力收集单元; 电压调节单元，换能振荡器单元和发送线圈。电压调节单元电耦合到功率采集单元并且被配置为在最小电压电平下致动。转换振荡器单元电耦合到电压调节单元，并且被配置为将检测到的物理特性转换成电信号。此外，发送线圈被配置为接收电信号并将电信号发送到外部天线。

59. 发明授权

US08257324B2 Microneedle drug delivery device 失效
标题翻译：微针药物输送装置
公开(公告)号：US08257324B2
公开(公告)日：2012-09-04
申请号：US11805096
申请日：2007-05-21
申请人： Mark R. Prausnitz , Mark G. Allen , Inder-Jeet Gujral
发明人： Mark R. Prausnitz , Mark G. Allen , Inder-Jeet Gujral
IPC分类号： A61M5/32
CPC分类号： A61M37/0015 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150969 , A61B5/150984 , A61B17/205 , A61B2090/0814 , A61M5/422 , A61M2037/0023 , A61M2037/003 , B33Y80/00
摘要： Simple microneedle devices for delivery of drugs across or into biological tissue are provided, which permit drug delivery at clinically relevant rates across or into skin or other tissue barriers, with minimal or no damage, pain, or irritation to the tissue. The devices include a substrate to which a plurality of hollow microneedles are attached or integrated, and at least one reservoir, containing the drug, selectably in communication with the microneedles, wherein the volume or amount of drug to be delivered can be selectively altered. The reservoir can be formed of a deformable, preferably elastic, material. The device typically includes a means, such as a plunger, for compressing the reservoir to drive the drug from the reservoir through the microneedles, In one embodiment, the reservoir is a syringe or pump connected to the substrate.
摘要翻译：提供用于在生物组织中或在生物组织中递送药物的简单微针装置，其允许以临床相关的速率穿过或进入皮肤或其它组织屏障的药物递送，对组织进行最小的或没有损伤，疼痛或刺激。所述装置包括多个中空微针连接或整合到其上的基底，以及容纳药物的至少一个储存器，可选择地与微针连通，其中可以选择性地改变要递送的药物的体积或量。储存器可以由可变形的，优选弹性的材料形成。该装置通常包括用于压缩储存器以通过微针从储存器驱动药物的装置，例如柱塞。在一个实施例中，储存器是连接到基板的注射器或泵。

60. 发明授权

US08101114B2 Particle based molding 有权
标题翻译：基于粒子的成型
公开(公告)号：US08101114B2
公开(公告)日：2012-01-24
申请号：US12299092
申请日：2007-04-30
申请人： Jung-hwan Park , Mark G. Allen , Mark R. Prausnitz
发明人： Jung-hwan Park , Mark G. Allen , Mark R. Prausnitz
IPC分类号： A61K9/14
CPC分类号： B29C35/0261 , A61M37/0015 , B29C35/0805 , B29C67/205 , B29C2035/0827 , B29K2105/251 , B29K2995/006 , B29L2031/7544
摘要： Various apparatuses, arrangements, and methods are provided for creating various structures including microstructures. In one embodiment, a method for creating a microstructure is provided comprising packing a plurality of particles into a micromold, and then applying energy to the particles in the micromold. As a result of the application of energy, a microstructure is formed in the micromold out of the particles. Thereafter, the microstructure is removed from the micromold.
摘要翻译：提供各种装置，布置和方法来产生包括微结构的各种结构。在一个实施例中，提供了一种用于产生微结构的方法，包括将多个颗粒包裹在微胶片中，然后将能量施加到微镜中的颗粒。作为施加能量的结果，在微粒中形成微结构。此后，将微观结构从微型金属中除去。

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