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1. 发明申请

US20090131905A1 Microneedle devices and methods of manufacture and use thereof 审中-公开
公开(公告)号：US20090131905A1
公开(公告)日：2009-05-21
申请号：US12150945
申请日：2008-05-01
申请人： Mark G. Allen , Mark R. Prausnitz , Devin V. McAllister , Florent Paul Marcel Cros
发明人： Mark G. Allen , Mark R. Prausnitz , Devin V. McAllister , Florent Paul Marcel Cros
IPC分类号： A61M5/32 , A61N1/32 , B29C45/00 , G03F7/20 , B22D23/00
CPC分类号： B81C1/00111 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150282 , A61B5/150984 , A61B17/205 , A61B2010/008 , A61K9/0021 , A61M37/0015 , A61M2037/003 , A61M2037/0053 , A61N1/303 , B33Y80/00 , B81B2201/055
摘要： Microneedle devices are provided for transport of therapeutic and biological molecules across tissue barriers and for use as microflameholders. In a preferred embodiment for transport across tissue, the microneedles are formed of a biodegradable polymer. Methods of making these devices, which can include hollow and/or porous microneedles, are also provided. A preferred method for making a microneedle includes forming a micromold having sidewalls which define the outer surface of the microneedle, electroplating the sidewalls to form the hollow microneedle, and then removing the micromold from the microneedle. In a preferred method of use, the microneedle device is used to deliver fluid material into or across a biological barrier from one or more chambers in fluid connection with at least one of the microneedles. The device preferably further includes a means for controlling the flow of material through the microneedles. Representative examples of these means include the use of permeable membranes, fracturable impermeable membranes, valves, and pumps.

2. 发明申请

US20100312191A1 Microneedle Devices and Methods of Manufacture and Use Thereof 有权
标题翻译：微针装置及其制造和使用方法
公开(公告)号：US20100312191A1
公开(公告)日：2010-12-09
申请号：US12853082
申请日：2010-08-09
申请人： Mark G. Allen , Mark R. Prausnitz , Devin V. McAllister , Florent Paul Marcel Cros
发明人： Mark G. Allen , Mark R. Prausnitz , Devin V. McAllister , Florent Paul Marcel Cros
IPC分类号： A61M5/00
CPC分类号： B81C1/00111 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150282 , A61B5/150984 , A61B17/205 , A61B2010/008 , A61K9/0021 , A61M37/0015 , A61M2037/003 , A61M2037/0053 , A61N1/303 , B33Y80/00 , B81B2201/055
摘要： Microneedle devices are provided for transport of therapeutic and biological molecules across tissue barriers and for use as microflameholders. In a preferred embodiment for transport across tissue, the microneedles are formed of a biodegradable polymer. Methods of making these devices, which can include hollow and/or porous microneedles, are also provided. A preferred method for making a microneedle includes forming a micromold having sidewalls which define the outer surface of the microneedle, electroplating the sidewalls to form the hollow microneedle, and then removing the micromold from the microneedle. In a preferred method of use, the microneedle device is used to deliver fluid material into or across a biological barrier from one or more chambers in fluid connection with at least one of the microneedles. The device preferably further includes a means for controlling the flow of material through the microneedles. Representative examples of these means include the use of permeable membranes, fracturable impermeable membranes, valves, and pumps.
摘要翻译：提供微针装置用于将组织屏障上的治疗和生物分子转运并用作微火焰保持器。在用于跨组织输送的优选实施方案中，微针由可生物降解的聚合物形成。还提供制造这些装置的方法，其可以包括中空和/或多孔微针。用于制造微针的优选方法包括形成具有限定微针的外表面的侧壁的显微镜，电镀侧壁以形成中空微针，然后从微针中去除微镜。在优选的使用方法中，微针装置用于将流体材料输送到生物屏障中，或者与一个或多个腔室中的至少一个微针流体连接。该装置优选地还包括用于控制通过微针的材料流动的装置。这些方法的代表性实例包括使用可渗透膜，可破裂的不渗透膜，阀和泵。

3. 发明授权

US08708966B2 Microneedle devices and methods of manufacture and use thereof 有权
标题翻译：微针装置及其制造和使用方法
公开(公告)号：US08708966B2
公开(公告)日：2014-04-29
申请号：US12853082
申请日：2010-08-09
申请人： Mark G. Allen , Mark R. Prausnitz , Devin V. McAllister , Florent Paul Marcel Cros
发明人： Mark G. Allen , Mark R. Prausnitz , Devin V. McAllister , Florent Paul Marcel Cros
IPC分类号： A61M5/00
CPC分类号： B81C1/00111 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150282 , A61B5/150984 , A61B17/205 , A61B2010/008 , A61K9/0021 , A61M37/0015 , A61M2037/003 , A61M2037/0053 , A61N1/303 , B33Y80/00 , B81B2201/055
摘要： Microneedle devices are provided for transport of molecules across tissue barriers and for use as microflameholders. In a preferred embodiment for transport across tissue, the microneedles are formed of a biodegradable polymer. Methods of making these devices, which can include hollow and/or porous microneedles, are also provided. A preferred method for making a microneedle includes forming a micromold having sidewalls which define the outer surface of the microneedle, electroplating the sidewalls to form the hollow microneedle, and then removing the micromold from the microneedle. In a preferred method of use, the microneedle device is used to deliver material into or across a biological barrier from chambers in connection with at least one of the microneedles. The device preferably further includes a means for controlling the flow of material through the microneedles. Representative examples of these means include the use of permeable membranes, fracturable impermeable membranes, valves, and pumps.
摘要翻译：提供微针装置用于跨组织屏障传输分子并用作微火焰保持器。在用于跨组织输送的优选实施方案中，微针由可生物降解的聚合物形成。还提供制造这些装置的方法，其可以包括中空和/或多孔微针。用于制造微针的优选方法包括形成具有限定微针的外表面的侧壁的显微镜，电镀侧壁以形成中空微针，然后从微针中去除微镜。在优选的使用方法中，微针装置用于将材料输送到生物屏障中，或者与至少一个微针相连接的室内输送生物屏障。该装置优选地还包括用于控制通过微针的材料流动的装置。这些方法的代表性实例包括使用可渗透膜，可破裂的不渗透膜，阀和泵。

4. 发明授权

US06334856B1 Microneedle devices and methods of manufacture and use thereof 有权
标题翻译：微针装置及其制造和使用方法
公开(公告)号：US06334856B1
公开(公告)日：2002-01-01
申请号：US09316229
申请日：1999-05-21
申请人： Mark G. Allen , Mark R. Prausnitz , Devin V. McAllister , Florent Paul Marcel Cros
发明人： Mark G. Allen , Mark R. Prausnitz , Devin V. McAllister , Florent Paul Marcel Cros
IPC分类号： A61M500
CPC分类号： B81C1/00111 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150282 , A61B5/150984 , A61B17/205 , A61B2010/008 , A61K9/0021 , A61M37/0015 , A61M2037/003 , A61M2037/0053 , A61N1/303 , B33Y80/00 , B81B2201/055
摘要： Microneedle devices are provided for transport of therapeutic and biological molecules across tissue barriers and for use as microflameholders. In a preferred embodiment for transport across tissue, the microneedles are formed of a biodegradable polymer. Methods of making these devices, which can include hollow and/or porous microneedles, are also provided. A preferred method for making a microneedle includes forming a micromold having sidewalls which define the outer surface of the microneedle, electroplating the sidewalls to form the hollow microneedle, and then removing the micromold from the microneedle. In a preferred method of use, the microneedle device is used to deliver fluid material into or across a biological barrier from one or more chambers in fluid connection with at least one of the microneedles. The device preferably further includes a means for controlling the flow of material through the microneedles. Representative examples of these means include the use of permeable membranes, fracturable impermeable membranes, valves, and pumps.
摘要翻译：提供微针装置用于将组织屏障上的治疗和生物分子转运并用作微火焰保持器。在用于跨组织输送的优选实施方案中，微针由可生物降解的聚合物形成。还提供制造这些装置的方法，其可以包括中空和/或多孔微针。用于制造微针的优选方法包括形成具有限定微针的外表面的侧壁的显微镜，电镀侧壁以形成中空微针，然后从微针中去除微镜。在优选的使用方法中，微针装置用于将流体材料输送到生物屏障中，或者与一个或多个腔室中的至少一个微针流体连接。该装置优选地还包括用于控制通过微针的材料流动的装置。这些方法的代表性实例包括使用可渗透膜，可破裂的不渗透膜，阀和泵。

5. 发明授权

US06743211B1 Devices and methods for enhanced microneedle penetration of biological barriers 有权
标题翻译：增强生物屏障微针穿透的装置和方法
公开(公告)号：US06743211B1
公开(公告)日：2004-06-01
申请号：US09448107
申请日：1999-11-23
申请人： Mark R. Prausnitz , Mark G. Allen , Sebastien Henry , Devin V. McAllister , Donald E. Ackley , Thomas Jackson
发明人： Mark R. Prausnitz , Mark G. Allen , Sebastien Henry , Devin V. McAllister , Donald E. Ackley , Thomas Jackson
IPC分类号： A61M500
CPC分类号： A61M37/0015 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150068 , A61B5/150076 , A61B5/150083 , A61B5/150099 , A61B5/150213 , A61B5/150229 , A61B5/150389 , A61B5/150412 , A61B5/150503 , A61B5/150984 , A61B5/151 , A61B17/205 , A61M5/422 , A61M5/425 , A61M2037/0023 , A61M2037/003 , A61M2037/0053 , B33Y80/00
摘要： Microneedle devices and methods of use thereof are provided for the enhanced transport of molecules, including drugs and biological molecules, across tissue by improving the interaction of microneedles and a deformable, elastic biological barrier, such as human skin. The devices and methods act to (1) limit the elasticity, (2) adapt to the elasticity, (3) utilize alternate ways of creating the holes for the microneedles to penetrate the biological barrier, other than the simply direct pressure of the microneedle substrate to the barrier surface, or (4) any combination of these methods. In preferred embodiments for limiting the elasticity of skin, the microneedle device includes features suitable for stretching, pulling, or pinching the skin to present a more rigid, less deformable, surface in the area to which the microneedles are applied (i.e. penetrate). In a preferred embodiments for adapting the device to the elasticity of skin, the device comprising one or more extensions interposed between the substrate and the base end of at least a portion of the microneedles.
摘要翻译：提供微针装置及其使用方法用于通过改善微针和可变形的弹性生物屏障（例如人皮肤）的相互作用来增强跨组织的分子（包括药物和生物分子）的转运。装置和方法用于（1）限制弹性，（2）适应弹性，（3）除了微针衬底的简单直接压力之外，利用替代方式产生微针穿透生物屏障的孔或（4）这些方法的任何组合。在用于限制皮肤弹性的优选实施例中，微针装置包括适于拉伸，拉伸或夹紧皮肤以在微针施加的区域（即，穿透）上呈现更刚性，更不易变形的表面的特征。在用于使装置适应皮肤弹性的优选实施例中，该装置包括一个或多个延伸部，该延伸部插入到基底和至少一部分微针的基端之间。

6. 发明授权

US06503231B1 Microneedle device for transport of molecules across tissue 失效
标题翻译：用于分子穿过组织的微针装置
公开(公告)号：US06503231B1
公开(公告)日：2003-01-07
申请号：US09095221
申请日：1998-06-10
申请人： Mark R. Prausnitz , Mark G. Allen , Devin V. McAllister , Sebastien Henry
发明人： Mark R. Prausnitz , Mark G. Allen , Devin V. McAllister , Sebastien Henry
IPC分类号： A61M532
CPC分类号： B81C1/00111 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150282 , A61B5/150984 , A61B17/205 , A61B2010/008 , A61K9/0021 , A61M37/0015 , A61M2037/003 , A61M2037/0053 , A61N1/303 , B33Y80/00 , B81B2201/055
摘要： Microneedle devices for transport of therapeutic and diagnostic materials and/or energy across tissue barriers, and methods for manufacturing the devices, are provided. The microneedles are hollow and/or porous and have diameters between about 10 nm and 1 mm. The microneedle devices permit drug delivery (or removal or sensing of body fluids) at clinically relevant rates across skin or other tissue barriers, without damage, pain, or irritation to the tissue. Microfabrication techniques are used to cost-effectively produce arrays of microneedles from metals, silicon, silicon dioxide, ceramic, and polymeric materials. Methods are provided for making porous or hollow microneedles.
摘要翻译：提供了用于在组织屏障上传送治疗和诊断材料和/或能量的微针装置，以及用于制造装置的方法。微针是中空的和/或多孔的并且具有在约10nm和1mm之间的直径。微针装置允许在皮肤或其他组织屏障上的临床相关速率的药物递送（或去除或感测体液），而不会对组织造成伤害，疼痛或刺激。微加工技术用于经济高效地从金属，硅，二氧化硅，陶瓷和聚合物材料制造微针阵列。提供用于制造多孔或中空微针的方法。

7. 发明授权

US09125983B2 Hydraulically actuated pump for fluid administration 有权
标题翻译：用于流体管理的液压致动泵
公开(公告)号：US09125983B2
公开(公告)日：2015-09-08
申请号：US12762307
申请日：2010-04-17
申请人： Robert R. Gonnelli , Devin V. McAllister , Steven F. Levesque
发明人： Robert R. Gonnelli , Devin V. McAllister , Steven F. Levesque
IPC分类号： A61M37/00 , A61M5/145 , A61M1/10 , A61M5/155 , F04B9/109 , F04B15/02 , A61M5/142
CPC分类号： A61M5/16877 , A61M1/1032 , A61M5/1452 , A61M5/14526 , A61M5/14593 , A61M5/155 , A61M37/0015 , A61M2005/14264 , A61M2005/14506 , A61M2005/14513 , A61M2037/0023 , A61M2037/0038 , A61M2037/0046 , A61M2250/00 , F04B9/103 , F04B9/1095 , F04B15/02 , F04B53/14 , F04B53/16
摘要： A fluid delivery device comprises a hydraulic pump chamber having a hydraulic fluid. A fluid reservoir is coupled to the hydraulic pump chamber and is configured to contain a fluid deliverable to a patient. A first actuator is coupled to the hydraulic pump chamber and is configured to pressurize the hydraulic pump chamber and configured to transfer energy through the hydraulic pump chamber to the fluid reservoir. A second actuator is coupled to the hydraulic pump chamber and is configured to pressurize the hydraulic pump chamber and configured to transfer energy through the hydraulic pump chamber to the fluid reservoir.
摘要翻译：液体输送装置包括具有液压流体的液压泵室。流体储存器联接到液压泵室，并且构造成容纳可递送给患者的流体。第一致动器联接到液压泵室并且构造成对液压泵室加压并且构造成将能量通过液压泵室传递到流体储存器。第二致动器联接到液压泵室并且构造成对液压泵室加压并且构造成将能量通过液压泵室传递到流体储存器。

8. 发明授权

US07060192B2 Methods of fabricating physiological sample collection devices 有权
公开(公告)号：US07060192B2
公开(公告)日：2006-06-13
申请号：US10143127
申请日：2002-05-09
申请人： Vadim V Yuzhakov , Devin V. McAllister , Lorin Olson , Koon-wah Leong , Maria Teodorczyk , Ernest Kiser
发明人： Vadim V Yuzhakov , Devin V. McAllister , Lorin Olson , Koon-wah Leong , Maria Teodorczyk , Ernest Kiser
IPC分类号： B32B31/00 , C03C25/68
CPC分类号： A61B5/15146 , A61B5/150022 , A61B5/150068 , A61B5/150099 , A61B5/150282 , A61B5/150358 , A61B5/150419 , A61B5/150435 , A61B5/150954 , A61B5/15105 , A61B5/15113 , A61B5/15117 , A61B5/15153 , A61B5/15184 , A61B5/1519 , A61B5/15194 , A61B5/157
摘要： Methods of fabricating devices for collecting a sample of physiological and for measuring a characteristic, e.g., an analyte concentration, of the sampled physiological sample. The devices are in the form of a test strip which include a biosensor and at least one skin-piercing element which is a planar extension of a portion of the biosensor. The fabrication methods provide various or forming the test strip and the skin-piercing element.

9. 发明授权

US09561042B2 Methods and devices for delivering agents across biological barriers 有权
标题翻译：在跨越生物屏障的情况下递送药剂的方法和装置
公开(公告)号：US09561042B2
公开(公告)日：2017-02-07
申请号：US12617566
申请日：2009-11-12
申请人： Devin V. McAllister , Ciro DiMeglio
发明人： Devin V. McAllister , Ciro DiMeglio
IPC分类号： A61M5/32 , A61B17/20 , A61M37/00
CPC分类号： A61B17/205 , A61M5/322 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0053 , A61M2037/0061 , Y10T29/49826
摘要： The invention provides for microneedle devices for delivering agents across biological barriers. The microneedles include agent reservoirs integrated into the bodies of the microneedles, themselves.
摘要翻译：本发明提供了用于在跨越生物屏障传递物体的微针装置。微针包括集成在微针体中的药剂储存器。

10. 发明申请

US20120184906A1 MICRONEEDLE PATCH APPLICATOR 有权
公开(公告)号：US20120184906A1
公开(公告)日：2012-07-19
申请号：US13332065
申请日：2011-12-20
申请人： Devin V. McAllister
发明人： Devin V. McAllister
IPC分类号： A61M5/00
CPC分类号： A61M37/0015 , A61B17/205 , A61B50/30 , A61M2037/0023 , A61M2209/06
摘要： A method and apparatus for application of a microneedle patch to a skin surface of a patient includes use of an applicator. The applicator includes a housing, a slidably disposed applicator plate, and a compression spring. The applicator plate is moveable between a retracted position and a deployed position, and has an engaging surface suitable for mashing up against a microneedle patch and pressing it against a skin surface. A docking system transfers the microneedle patch from a support to the applicator without requiring a user to handle the microneedle patch directly. Once mounted in the applicator, the microneedle patch is deployed against a skin surface of a patient for delivery of a desired agent via a microneedle array contained on the patch.
摘要翻译：将微针贴片应用于患者皮肤表面的方法和装置包括使用敷贴器。施加器包括壳体，可滑动地设置的施加器板和压缩弹簧。施用板可在缩回位置和展开位置之间移动，并且具有接合表面，其适于与微针贴片相贴合并将其压在皮肤表面上。对接系统将微针补片从支撑件传送到施加器，而不需要用户直接处理微针补丁。一旦安装在施用器中，将微针贴片部署在患者的皮肤表面上，以通过包含在贴片上的微针阵列递送期望的药剂。

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