专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

51. 发明申请

US20050159678A1 Apparatus for measuring biological component 有权
标题翻译：用于测量生物成分的装置
公开(公告)号：US20050159678A1
公开(公告)日：2005-07-21
申请号：US10512939
申请日：2004-01-16
申请人： Yuko Taniike , Mariko Miyashita , Shin Ikeda , Toshihiko Yoshioka
发明人： Yuko Taniike , Mariko Miyashita , Shin Ikeda , Toshihiko Yoshioka
IPC分类号： A61B5/00 , A61B5/15
CPC分类号： A61B5/6843 , A61B5/14532 , A61B5/150022 , A61B5/150259 , A61B5/150358 , A61B5/150412 , A61B5/150748 , A61B5/150954 , A61B5/15107 , A61B5/15117 , A61B5/15125 , A61B5/1519 , A61B5/157 , A61B5/417
摘要： The present invention relates to a biological component measurement apparatus set, in which a puncture mechanism for puncturing skin of a subject to collect a sample blood is integrated with a biosensor measurement apparatus, wherein the puncture mechanism comprises at least: a puncture needle; and a cap which is detachably engaged with a body of the apparatus, wherein the cap has a skin contact surface which is brought into contact with the skin for puncturing, the skin contact surface having an opening through which the puncture needle moves to puncture the skin, and being shaped so as to fit a surface shape of the skin to be punctured, and the set comprises a plurality of different such caps each corresponding to a different sample collection site so that a plurality of different sample collection sites can be selected.
摘要翻译：生物成分测定装置技术领域本发明涉及一种生物体成分测定装置，其特征在于，将生物体成分测定装置与生物传感器测定装置一体化，其中，穿刺机构至少包括：穿刺针，以及与所述装置的主体可拆卸地接合的帽，其中所述帽具有与皮肤接触以刺穿的皮肤接触表面，所述皮肤接触表面具有穿刺针穿过的穿孔刺穿皮肤并且被成形为适合要刺穿的皮肤的表面形状，并且该组包括多个不同的这样的帽，每个对应于不同的样本收集位置，使得可以选择多个不同的样本收集位置。

52. 发明授权

US06885196B2 Biosensor 有权
标题翻译：生物传感器
公开(公告)号：US06885196B2
公开(公告)日：2005-04-26
申请号：US10220153
申请日：2001-07-17
申请人： Yuko Taniike , Shin Ikeda , Shiro Nankai
发明人： Yuko Taniike , Shin Ikeda , Shiro Nankai
IPC分类号： C12Q1/00 , A61B5/05
CPC分类号： G01N27/3272 , C12Q1/005 , C12Q1/006
摘要： A highly sensitive biosensor that uses a smaller amount of sample for measurement is described. The biosensor includes a first insulating base plate having a working electrode, a second insulating base plate having a counter electrode opposed to the working electrode, and a reagent layer containing at least an oxidoreductase. The biosensor further includes a sample supply pathway formed between the first and second insulating base plates, where the working electrode, counter electrode and reagent layer are exposed to an inside of the sample supply pathway, and the distance between the working electrode and the counter electrode is 150 μm or less.
摘要翻译：描述了使用较少量的样品进行测量的高灵敏度生物传感器。生物传感器包括具有工作电极的第一绝缘基板，具有与工作电极相对的反电极的第二绝缘基板和至少含有氧化还原酶的试剂层。生物传感器还包括形成在第一和第二绝缘基板之间的样品供给路径，其中工作电极，对电极和试剂层暴露于样品供应路径的内部，并且工作电极和对电极之间的距离是150mam以下。

53. 发明授权

US06790327B2 Device and method for determining the concentration of a substrate 有权
标题翻译：用于确定底物浓度的装置和方法
公开(公告)号：US06790327B2
公开(公告)日：2004-09-14
申请号：US10023734
申请日：2001-12-21
申请人： Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
发明人： Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： G01N27327
CPC分类号： C12Q1/004
摘要： An apparatus for determining the concentration of a substrate in a sample solution using an electrode system comprising a working electrode, a counter electrode, and a reaction layer which contains at least an oxidoreductase and an electron mediator and is formed on the electrode system to electrochemically measure a reduced amount of the electron mediator resulting from enzyme reaction in the reaction layer, wherein a third electrode is formed as an interfering substance detecting electrode. A current flowing between the counter electrode and the third electrode is measured which is taken as a positive error. Subsequently, voltage application between the counter electrode and the third electrode is released and a voltage for oxidizing the reduced form electron mediator is applied between the working electrode and the counter electrode to measure a current flowing between the two electrodes.
摘要翻译：一种用于使用包括工作电极，对电极和至少包含氧化还原酶和电子介体的反应层的电极系统来确定样品溶液中基底的浓度的装置，并且形成在电极系统上以电化学测量在反应层中由酶反应产生的电子介体的量减少，其中形成第三电极作为干扰物质检测电极。测量在对电极和第三电极之间流动的电流，其被认为是正误差。随后，释放对电极和第三电极之间的电压施加，并且在工作电极和对电极之间施加用于氧化还原形式的电子介体的电压，以测量在两个电极之间流动的电流。

54. 发明授权

US06740215B1 Biosensor 失效
标题翻译：生物传感器
公开(公告)号：US06740215B1
公开(公告)日：2004-05-25
申请号：US09959571
申请日：2001-10-30
申请人： Takahiro Nakaminami , Motokazu Watanabe , Shin Ikeda , Shiro Nankai
发明人： Takahiro Nakaminami , Motokazu Watanabe , Shin Ikeda , Shiro Nankai
IPC分类号： G01N27327
CPC分类号： C12Q1/005
摘要： A biosensor comprising an electrically insulating base plate, an electrode system containing a working electrode and a counter electrode disposed on the base plate, and a reagent system comprising at least an oxidoreductase, a hydrophilic polymer and an electron mediator, wherein the reagent system further comprises a substance having a function to convert an organic product generated by direct reaction of a substrate to be measured with the oxidoreductase to another compound.
摘要翻译：一种生物传感器，包括电绝缘基板，包含工作电极的电极系统和设置在基板上的对电极，以及至少包含氧化还原酶，亲水性聚合物和电子介体的试剂系统，其中所述试剂系统还包括具有将待测基质与氧化还原酶直接反应产生的有机产物转化为其他化合物的功能的物质。

55. 发明授权

US06719887B2 Biosensor 有权
标题翻译：生物传感器
公开(公告)号：US06719887B2
公开(公告)日：2004-04-13
申请号：US10221990
申请日：2002-09-17
申请人： Miwa Hasegawa , Motokazu Watanabe , Tomohiro Yamamoto , Shin Ikeda , Shiro Nankai
发明人： Miwa Hasegawa , Motokazu Watanabe , Tomohiro Yamamoto , Shin Ikeda , Shiro Nankai
IPC分类号： G01N27327
CPC分类号： G01N33/92 , C12Q1/005 , G01N33/5438
摘要： A biosensor includes: an insulating base plate; an electrode system which is provided on the base plate and has a measurement electrode and a counter electrode; a reaction layer including at least oxidoreductase and an electron mediator; a sample solution supply pathway which includes the electrode system and the reaction layer and has an air aperture on the termination side thereof; a sample supply portion; and a filter which is disposed between the sample solution supply pathway and the sample supply portion and filters hemocytes, where plasma with the hemocytes therein filtered with the filter is sucked into the sample solution supply pathway due to capillarity, the central part of a secondary side portion of the filter is protruded into the sample solution supply pathway more than both the right and left ends thereof.
摘要翻译：生物传感器包括：绝缘基板; 电极系统，设置在基板上，具有测量电极和对电极; 至少包含氧化还原酶和电子介体的反应层; 样品溶液供给路径，其包括电极系统和反应层，并且在其终端侧具有空气孔; 样品供应部分; 以及过滤器，其设置在样品溶液供给路径和样品供给部之间，并且过滤血细胞，其中由过滤器过滤的血细胞的血浆由于毛细作用而被吸入样品溶液供给通道，次级侧的中心部分过滤器的一部分比其右端和左端都突出到样品溶液供给路径中。

56. 发明授权

US06699382B2 Method for analyzing a biological sample 有权
标题翻译：分析生物样品的方法
公开(公告)号：US06699382B2
公开(公告)日：2004-03-02
申请号：US10235451
申请日：2002-09-04
申请人： Toshihiko Yoshioka , Shin Ikeda , Motokazu Watanabe , Shiro Nankai
发明人： Toshihiko Yoshioka , Shin Ikeda , Motokazu Watanabe , Shiro Nankai
IPC分类号： G01N27327
CPC分类号： C12Q1/001
摘要： A biosensor enabling accurate measurement of the concentration of a substrate contained in a trace amount of a sample solution is disclosed. The electrochemical analysis element in accordance with the present invention which should be included in the biosensor comprises a sensor body having a hollow space which space is open at its both ends, an electrode system having a working electrode and a counter electrode, a reagent segment containing an enzyme, wherein the electrode system and the reagent segment are disposed on an inner wall of the hollow space.
摘要翻译：公开了能够精确测量微量样品溶液中所含的基板的浓度的生物传感器。应包括在生物传感器中的根据本发明的电化学分析元件包括具有中空空间的传感器本体，其两端开放空间，具有工作电极和对电极的电极系统，含有酶，其中电极系统和试剂段设置在中空空间的内壁上。

57. 发明授权

US5985130A Method for quantifying substrate 失效
标题翻译：定量底物的方法
公开(公告)号：US5985130A
公开(公告)日：1999-11-16
申请号：US834829
申请日：1997-04-03
申请人： Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
发明人： Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： G01N27/327 , C12Q1/00 , G01N27/416 , G01N27/49 , G01N27/26
CPC分类号： C12Q1/001 , G01N27/3273
摘要： The present invention provides a method for quantifying a substrate having improved measurement accuracy and measurement sensitivity. According to the method for quantifying the substrate of the present invention, a constant voltage is applied to an electrode system, between a working electrode and a counter electrode, via a resistor connected in series with the electrode system after placing a sample solution containing the substrate on the electrode system, so as to oxidize an electron acceptor, which has been reduced by an enzyme reaction of the substrate, thereby determining a concentration of the substrate included in the sample solution based on an oxidizing current flowing in the course of oxidation.
摘要翻译：本发明提供了一种用于量化具有改进的测量精度和测量灵敏度的衬底的方法。根据本发明的基板的定量化方法，在放置含有基板的样品溶液之后，通过与电极系统串联连接的电阻器将恒定电压施加到工作电极与对电极之间的电极系统在电极系统上，以通过基板的酶反应而还原的电子受体氧化，从而基于在氧化过程中流动的氧化电流来确定样品溶液中包含的底物的浓度。

58. 发明授权

US5650062A Biosensor, and a method and a device for quantifying a substrate in a sample liquid using the same 失效
标题翻译：生物传感器，以及使用其进行样品液体中的基板的定量的方法和装置
公开(公告)号：US5650062A
公开(公告)日：1997-07-22
申请号：US526557
申请日：1995-09-12
申请人： Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai , Haruhiro Tsutsumi , Hideyuki Baba , Yoshinobu Tokuno , Syoji Miyazaki
发明人： Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai , Haruhiro Tsutsumi , Hideyuki Baba , Yoshinobu Tokuno , Syoji Miyazaki
IPC分类号： C12Q1/00 , G01N27/26
CPC分类号： C12Q1/001 , Y10S435/817
摘要： The biosensor of this invention can quantify a substrate in a sample liquid by electrochemically measuring the amount of an electron acceptor that has been reduced by electrons generated in a reaction between the substrate and an oxidoreductase. The biosensor has an electrically insulating substrate and an electrode system formed on the substrate including a working electrode, a counter electrode and a third electrode used for detecting a liquid junction. The third electrode can be used merely for detecting a liquid junction, or can be used as both a reference electrode and a liquid junction detecting electrode.
摘要翻译：本发明的生物传感器可以通过电化学测量由底物和氧化还原酶之间的反应中产生的电子而减少的电子受体的量来量化样品液体中的底物。生物传感器具有电绝缘基板和形成在基板上的电极系统，该基板包括工作电极，对电极和用于检测液体接合点的第三电极。第三电极可以仅用于检测液体接点，也可以用作参考电极和液体接点检测电极。

59. 发明授权

US09212380B2 Sensor and concentration measurement method 有权
标题翻译：传感器和浓度测量方法
公开(公告)号：US09212380B2
公开(公告)日：2015-12-15
申请号：US13392630
申请日：2010-08-30
申请人： Yoshifumi Takahara , Takahiro Nakaminami , Shin Ikeda
发明人： Yoshifumi Takahara , Takahiro Nakaminami , Shin Ikeda
IPC分类号： G01N27/327 , C12Q1/00 , C12Q1/32 , G01N21/84
CPC分类号： G01N27/3272 , C12Q1/006 , C12Q1/32 , G01N21/8483
摘要： A reagent layer of a sensor contains as a mediator a quinone compound having a hydrophilic functional group, phenanthrenequinone, and/or a phenanthrenequinone derivative. The quinone compound has a lower redox potential than a conventional mediator, so interfering substances have less effect on detection results with this sensor.
摘要翻译：传感器的试剂层含有具有亲水性官能团的醌化合物，菲醌和/或菲醌衍生物作为介体。醌类化合物的氧化还原电位低于常规介体，因此干扰物质对该传感器的检测结果影响较小。

60. 发明申请

US20100276303A1 METHOD FOR MEASURING HEMATOCRIT VALUE OF BLOOD SAMPLE, METHOD FOR MEASURING CONCENTRATION OF ANALYTE IN BLOOD SAMPLE, SENSOR CHIP AND SENSOR UNIT 审中-公开
标题翻译：测量血液样本血液值的方法，测量血液样品分析仪浓度，传感器芯片和传感器单元的方法
公开(公告)号：US20100276303A1
公开(公告)日：2010-11-04
申请号：US12377497
申请日：2007-10-17
申请人： Masaki Fujiwara , Takahiro Takasu , Shin Ikeda , Takahiro Nakaminami
发明人： Masaki Fujiwara , Takahiro Takasu , Shin Ikeda , Takahiro Nakaminami
IPC分类号： G01N33/49
CPC分类号： G01N27/3274
摘要： A voltage is applied across a counter electrode and a working electrode while an oxidant of a redox substance is in contact with the counter electrode and is not substantially in contact with the working electrode, and thereby metal that readily undergoes electrolytic oxidation forming at least part of a surface of the working electrode is oxidized while the oxidant in contact with the working electrode is reduced, such that a current produced upon the oxidation and the reduction is measured. According to the above constitution, while lowering the voltage applied across the working electrode and the counter electrode, a hematocrit value of a blood sample can be measured stably with satisfactory detection sensitivity. This measurement can be carried out, for example, with a sensor chip comprising a working electrode 11, a counter electrode 12, and a blood sample holder 14 in communication with a blood sample inlet 16, wherein a portion 31 of the working electrode 11 is disposed closer to the blood sample inlet 16 than a portion 32 of the counter electrode is, a surface of the portion 31 includes the metal that readily undergoes electrolytic oxidation, and a reagent 13 containing the oxidant is disposed in contact with the portion 32.
摘要翻译：在对电极和工作电极之间施加电压，而氧化还原物质的氧化剂与对电极接触并且基本上不与工作电极接触，从而容易经历电解氧化形成的金属至少部分工作电极的表面被氧化，而与工作电极接触的氧化剂减少，从而测量氧化和还原时产生的电流。根据上述结构，在降低施加在工作电极和对电极两端的电压的同时，能够以良好的检测灵敏度稳定地测定血液样品的血细胞比容值。该测定例如可以使用包含与血液检体入口16连通的工作电极11，对电极12和血液检体保持器14的传感器芯片进行，其中工作电极11的部分31为比对置电极的部分32更靠近血液采样入口16设置，部分31的表面包括容易经历电解氧化的金属，并且含有氧化剂的试剂13设置成与部分32接触。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式