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1. 发明授权

US08626448B2 Method for estimating a blood sugar condition 失效
标题翻译：估计血糖状况的方法
公开(公告)号：US08626448B2
公开(公告)日：2014-01-07
申请号：US13555562
申请日：2012-07-23
申请人： Mariko Miyashita
发明人： Mariko Miyashita
IPC分类号： G01N33/48 , G01N31/00 , G06G7/48 , G06G7/58
CPC分类号： G01N33/493 , A61B5/14507 , A61B5/14532 , A61B5/7275 , A61B10/007 , A61B2010/0003 , G06F19/00
摘要： A blood sugar condition is estimated by measuring a urine sugar value, discriminating whether it is less than a discriminating method classification boundary value, when it is less, obtaining an averaged value of measured urine sugar values during a past predetermined period of time, measured at the same time of day as the latest measurement, calculating the difference between the averaged and measured urine sugar values, when the difference is not less than a positive discriminating reference difference, discriminating as being a blood sugar value decrease, when the measured value is not less than the discriminating method classification boundary value, obtaining an averaged value of all measured values during the past predetermined period of time, calculating a ratio between the measured and averaged values, and, when the ratio is not greater than a first discriminating reference ratio, discriminating as being the blood sugar value decrease.
摘要翻译：通过测量尿糖值来估计血糖条件，鉴别其是否小于鉴别方法分类边界值，当其较小时，获得在过去预定时间段内测量的尿糖值的平均值，其在与最近的测量值相同的时间，计算平均值和测量尿糖值之间的差异，当差异不小于阳性鉴别参考差异时，鉴别为血糖值降低，当测量值不为小于识别方法分类边界值，获得过去预定时间段内的所有测量值的平均值，计算测量值和平均值之间的比率，并且当比率不大于第一鉴别参考比时，区分为血糖值下降。

2. 发明授权

US08251905B2 Blood glucose measuring device and method of measuring average postprandial blood glucose 失效
标题翻译：血糖测定装置及餐后血糖平均测定方法
公开(公告)号：US08251905B2
公开(公告)日：2012-08-28
申请号：US12405653
申请日：2009-03-17
申请人： Mariko Miyashita
发明人： Mariko Miyashita
IPC分类号： A61B5/00
CPC分类号： G01N33/66 , A61B5/14507 , A61B5/201
摘要： A practical measuring device and a measuring method that allow simply measuring average postprandial blood glucose from urinary glucose. The blood glucose measuring device includes a measuring unit that measures postprandial urinary glucose from subject's urine at a predetermined time after meal, a processing unit that calculates average postprandial blood glucose through a period up to the predetermined time after meal, based on the postprandial urinary glucose, a storage unit that stores calibration data including the postprandial urinary glucose and the average postprandial blood glucose in association, and an output unit that outputs data indicating the calculated average postprandial blood glucose. The processing unit calculates the average postprandial blood glucose, based on the postprandial urinary glucose from the urine of the subject who has intaken a desired amount of water or perspired in the period up to the predetermined time after meal, and the calibration data.
摘要翻译：一种实用的测量装置和测量方法，可以简单地测量尿糖的平均餐后血糖。血糖值测定装置具有测定单元，其在餐后的规定时间内测定受试者的尿液中的餐后尿液，所述测定单元基于餐后尿糖，计算餐后的预定时间以上的期间的平均餐后血糖值存储单元，其存储包括餐后尿糖和平均餐后血糖的校准数据，以及输出单元，其输出指示计算出的平均餐后血糖的数据。所述处理单元根据在餐后预定时间内摄入期望量的水或出汗的受试者的尿液中的餐后尿糖和校准数据来计算餐后血糖平均值。

3. 发明授权

US07323098B2 Biosensor and measuring method using the same 有权
标题翻译：生物传感器和使用其的测量方法
公开(公告)号：US07323098B2
公开(公告)日：2008-01-29
申请号：US10653257
申请日：2003-09-03
申请人： Mariko Miyashita , Toshihiko Yoshioka
发明人： Mariko Miyashita , Toshihiko Yoshioka
IPC分类号： G01N27/327
CPC分类号： C12Q1/004 , G01N27/3272
摘要： A biosensor capable of measuring the concentration of one or more specific substances in one or more sample solutions almost simultaneously is provided. The biosensor comprises a plurality of sensor units, and each of the sensor units comprises an electrode system including a working electrode and a counter electrode on an insulating base plate and a reagent system including an oxidoreductase and an electron mediator. The biosensor is so configured that sample solutions supplied to the respective sensor units reach the respective reagent systems at different times. Specifically, each of the sensor units has a controlling system between a sample supply inlet and the reagent system, and the controlling system controls the time it takes for the sample solution to reach the reagent system from the sample supply inlet.
摘要翻译：提供能够几乎同时测量一种或多种样品溶液中的一种或多种特定物质的浓度的生物传感器。生物传感器包括多个传感器单元，并且每个传感器单元包括在绝缘基板上包括工作电极和对电极的电极系统和包括氧化还原酶和电子介体的试剂系统。生物传感器被配置成使得提供给各个传感器单元的样品溶液在不同时间到达相应的试剂系统。具体地，每个传感器单元具有在供样入口和试剂系统之间的控制系统，控制系统控制样品溶液从样品供应入口到达试剂系统所花费的时间。

4. 发明申请

US20050224345A1 BIOSENSOR AND MEASURING APPARATUS FOR BIOSENSOR 有权
标题翻译：生物传感器的生物传感器和测量装置
公开(公告)号：US20050224345A1
公开(公告)日：2005-10-13
申请号：US10616305
申请日：2003-07-10
申请人： Yuko Taniike , Mariko Miyashita , Shin Ikeda , Toshihiko Yoshioka , Yoshinobu Tokuno
发明人： Yuko Taniike , Mariko Miyashita , Shin Ikeda , Toshihiko Yoshioka , Yoshinobu Tokuno
IPC分类号： A61B5/00 , G01N27/30 , G01N33/487 , G01N27/26
CPC分类号： G01N33/4875 , A61B5/1486 , A61B2562/0295
摘要： In biosensor system 1, biosensor 2 is mounted in measuring apparatus 3 for quantifying or detecting existence of a targeted substrate in a sample solution. Mounting end portion 20 of biosensor 2 to be mounted in measuring apparatus 3 has an extension of one base plate in the length direction, and further extensions of the other base plate in the width direction. Sensor mounting portion 30 of measuring apparatus 3 has a shape matching up with the shape of mounting end portion 20. Thereby wrong insertion of biosensor 2 in measuring apparatus 3 can be prevented. Further, varying shapes of plural biosensors 5 and 6 to have a common part and a non-common part, such biosensors can be handily measured by one measuring apparatus 7.
摘要翻译：在生物传感器系统1中，将生物传感器2安装在用于定量或检测样品溶液中目标基板的存在的测量装置3中。安装在测量装置3中的生物传感器2的安装端部20在长度方向上具有一个基板的延伸部，另一个底板在宽度方向上延伸。测量装置3的传感器安装部30具有与安装端部20的形状相匹配的形状。从而可以防止生物传感器2错误地插入到测量装置3中。此外，多个生物传感器5和6的不同形状具有公共部分和非共同部分，可以通过一个测量装置7轻松测量这样的生物传感器。

5. 再颁专利

USRE36991E Biosensor and method for producing the same 有权
标题翻译：生物传感器及其制造方法
公开(公告)号：USRE36991E
公开(公告)日：2000-12-19
申请号：US375705
申请日：1999-08-13
申请人： Tomohiro Yamamoto , Mariko Miyashita , Toshihiko Yoshioka , Satoko Tsuji (nee Fujisawa) , Shiro Nankai
发明人： Tomohiro Yamamoto , Mariko Miyashita , Toshihiko Yoshioka , Satoko Tsuji (nee Fujisawa) , Shiro Nankai
IPC分类号： C12Q1/00 , G01N27/26 , C12M1/34
CPC分类号： C12Q1/002 , C12Q1/001 , Y10S435/817
摘要： A biosensor for rapid quantification of a specific component contained in various biological samples with high accuracy has an electrically insulating base, an electrode system including a working electrode and a counter electrode formed on one face of the insulating base, and a reaction layer formed on the insulating base in close contact with the electrode system. The reaction layer contains at least a hydrophilic polymer, a buffer and an enzyme which is separated from the buffer.
摘要翻译：用于以高精度快速定量包含在各种生物样品中的特定成分的生物传感器具有电绝缘基底，包括形成在绝缘基底的一个面上的工作电极和对电极的电极系统，以及形成在绝缘基底上的反应层绝缘基座与电极系统紧密接触。反应层至少含有亲水性聚合物，缓冲液和与缓冲液分离的酶。

6. 发明授权

US08315808B2 Method and system for estimating a blood sugar condition 失效
标题翻译：估计血糖状况的方法和系统
公开(公告)号：US08315808B2
公开(公告)日：2012-11-20
申请号：US12058778
申请日：2008-03-31
申请人： Mariko Miyashita
发明人： Mariko Miyashita
IPC分类号： G01N33/48 , G06G7/48
CPC分类号： G01N33/493 , A61B5/14507 , A61B5/14532 , A61B5/7275 , A61B10/007 , A61B2010/0003 , G06F19/00
摘要： A blood sugar condition is estimated by (1) measuring a urine sugar value A, (2) discriminating whether or not the measured urine sugar value is less than a discriminating method classification boundary value, (3) when it is less, obtaining an averaged value X of measured urine sugar values during a past predetermined period of time, measured at the same timing in a one-day life as the timing when the latest measured urine sugar value is measured, (4) calculating the difference between the averaged value and the measured urine sugar value, (5) when the difference is not less than a positive discriminating reference difference, discriminating as being a blood sugar value decrease, (6) when the measured urine sugar value A is not less than the discriminating method classification boundary value, obtaining an averaged value X of all measured urine sugar values during the past predetermined period of time, (7) calculating a ratio between the measured urine sugar value and the averaged value X, and, (8) when the ratio is not greater than a first discriminating reference ratio, discriminating as being the blood sugar value decrease.
摘要翻译：通过以下（1）测定尿糖值A，（2）判别所测定的尿糖值是否小于鉴别方法分类边界值来估计血糖状况，（3）当较小时，得到平均值测量过去预定时间段内测得的尿糖值的值X，与测量最新测定的尿糖值的时间相同，在与日测定的同一时间相同的时间测量;（4）计算平均值与测得的尿糖值，（5）当差异不小于阳性鉴别参考差异时，鉴别为血糖值降低，（6）当测得的尿糖值A不小于鉴别方法分类边界获得过去一段时间内所有测得的尿糖值的平均值X，（7）计算测得的尿糖值与平均值之间的比值 e X和（8）当比率不大于第一鉴别参考比时，鉴别为血糖值降低。

7. 发明授权

US07741125B2 Biosensor, biosensor measuring apparatus and measurement method 有权
标题翻译：生物传感器，生物传感器测量仪器和测量方法
公开(公告)号：US07741125B2
公开(公告)日：2010-06-22
申请号：US10550150
申请日：2005-02-02
申请人： Yuko Taniike , Mariko Miyashita , Toshihiko Yoshioka
发明人： Yuko Taniike , Mariko Miyashita , Toshihiko Yoshioka
IPC分类号： G01N33/18
CPC分类号： C12Q1/001 , B01L3/502715 , B01L3/502746 , B01L2200/143 , B01L2300/0645 , B01L2300/0825 , B01L2300/0887 , B01L2300/105 , B01L2400/0406 , G01N31/22
摘要： A biosensor and a biosensor measuring apparatus whose performance can be easily determined by an ordinary user are provided. A biosensor 100 includes a substrate 1 having a quality deciding section 13 and a sample receiving section 15 provided on the substrate 1 to which a sample is supplied. The quality deciding section 13 includes a moisture absorbing material changed in color through absorption of moisture. The sample receiving section 15 has a reagent section 7 including an enzyme reacted with a test substance as a substrate. The quality deciding section 13 includes a recess 17 formed in the substrate 1, the moisture absorbing material 16 disposed in the recess 17 and a film 18 with no air permeability substantially covering the opening of the recess 17 and closely adhered to the moisture absorbing material 16. Cobalt salt is used as the moisture absorbing material 16.
摘要翻译：提供一种能够容易地由普通用户确定其性能的生物传感器和生物传感器测量装置。生物传感器100包括具有质量判定部13的基板1和设置在其上被供给样本的基板1上的样本接收部15。质量判定部13包括通过吸收水分而变色的吸湿材料。样品接收部分15具有试剂部分7，其包含与作为基质的测试物质反应的酶。品质决定部13包括形成在基板1上的凹部17，设置在凹部17中的吸湿材料16和没有透气性的薄膜18，其基本上覆盖凹部17的开口并且紧密地附着在吸湿材料16上钴盐用作吸湿材料16。

8. 发明授权

US07238160B2 Apparatus for measuring biological component 有权
标题翻译：用于测量生物成分的装置
公开(公告)号：US07238160B2
公开(公告)日：2007-07-03
申请号：US10512939
申请日：2004-01-16
申请人： Yuko Taniike , Mariko Miyashita , Shin Ikeda , Toshihiko Yoshioka
发明人： Yuko Taniike , Mariko Miyashita , Shin Ikeda , Toshihiko Yoshioka
IPC分类号： A61B5/00
CPC分类号： A61B5/6843 , A61B5/14532 , A61B5/150022 , A61B5/150259 , A61B5/150358 , A61B5/150412 , A61B5/150748 , A61B5/150954 , A61B5/15107 , A61B5/15117 , A61B5/15125 , A61B5/1519 , A61B5/157 , A61B5/417
摘要： The present invention relates to a biological component measurement apparatus set, in which a puncture mechanism for puncturing skin of a subject to collect a sample blood is integrated with a biosensor measurement apparatus. The puncture mechanism includes a puncture needle, and a cap which is detachably engaged with a body of the apparatus, wherein the cap has a skin contact surface which is brought into contact with the skin for puncturing. The skin contact surface having an opening through which the puncture needle moves to puncture the skin, and is shaped so as to fit a surface shape of the skin to be punctured. The set includes a plurality of different caps each corresponding to a different sample collection site so that a plurality of different sample collection sites can be selected.
摘要翻译：生物成分测定装置技术领域本发明涉及一种生物成分测定装置，其特征在于，将生物体测定装置与被检体的皮肤刺穿用于收集血样的穿刺机构一体化。穿刺机构包括穿刺针和与装置的主体可拆卸地接合的帽，其中，所述帽具有与皮肤接触以进行穿刺的皮肤接触表面。皮肤接触表面具有穿刺针穿过的穿刺孔，并且被成形为适合要刺穿的皮肤的表面形状。该集合包括多个不同的盖，每个不同的盖对应于不同的采样站点，从而可以选择多个不同的样本采集站点。

9. 发明申请

US20050159678A1 Apparatus for measuring biological component 有权
标题翻译：用于测量生物成分的装置
公开(公告)号：US20050159678A1
公开(公告)日：2005-07-21
申请号：US10512939
申请日：2004-01-16
申请人： Yuko Taniike , Mariko Miyashita , Shin Ikeda , Toshihiko Yoshioka
发明人： Yuko Taniike , Mariko Miyashita , Shin Ikeda , Toshihiko Yoshioka
IPC分类号： A61B5/00 , A61B5/15
CPC分类号： A61B5/6843 , A61B5/14532 , A61B5/150022 , A61B5/150259 , A61B5/150358 , A61B5/150412 , A61B5/150748 , A61B5/150954 , A61B5/15107 , A61B5/15117 , A61B5/15125 , A61B5/1519 , A61B5/157 , A61B5/417
摘要： The present invention relates to a biological component measurement apparatus set, in which a puncture mechanism for puncturing skin of a subject to collect a sample blood is integrated with a biosensor measurement apparatus, wherein the puncture mechanism comprises at least: a puncture needle; and a cap which is detachably engaged with a body of the apparatus, wherein the cap has a skin contact surface which is brought into contact with the skin for puncturing, the skin contact surface having an opening through which the puncture needle moves to puncture the skin, and being shaped so as to fit a surface shape of the skin to be punctured, and the set comprises a plurality of different such caps each corresponding to a different sample collection site so that a plurality of different sample collection sites can be selected.
摘要翻译：生物成分测定装置技术领域本发明涉及一种生物体成分测定装置，其特征在于，将生物体成分测定装置与生物传感器测定装置一体化，其中，穿刺机构至少包括：穿刺针，以及与所述装置的主体可拆卸地接合的帽，其中所述帽具有与皮肤接触以刺穿的皮肤接触表面，所述皮肤接触表面具有穿刺针穿过的穿孔刺穿皮肤并且被成形为适合要刺穿的皮肤的表面形状，并且该组包括多个不同的这样的帽，每个对应于不同的样本收集位置，使得可以选择多个不同的样本收集位置。

10. 发明申请

US20130024128A1 METHOD FOR ESTIMATING A BLOOD SUGAR CONDITION 失效
标题翻译：评估血糖条件的方法
公开(公告)号：US20130024128A1
公开(公告)日：2013-01-24
申请号：US13555562
申请日：2012-07-23
申请人： Mariko MIYASHITA
发明人： Mariko MIYASHITA
IPC分类号： G01N33/493 , G06F19/00
CPC分类号： G01N33/493 , A61B5/14507 , A61B5/14532 , A61B5/7275 , A61B10/007 , A61B2010/0003 , G06F19/00
摘要： A blood sugar condition is estimated by measuring a urine sugar value, discriminating whether it is less than a discriminating method classification boundary value, when it is less, obtaining an averaged value of measured urine sugar values during a past predetermined period of time, measured at the same time of day as the latest measurement, calculating the difference between the averaged and measured urine sugar values, when the difference is not less than a positive discriminating reference difference, discriminating as being a blood sugar value decrease, when the measured value is not less than the discriminating method classification boundary value, obtaining an averaged value of all measured values during the past predetermined period of time, calculating a ratio between the measured and averaged values, and, when the ratio is not greater than a first discriminating reference ratio, discriminating as being the blood sugar value decrease.
摘要翻译：通过测量尿糖值来估计血糖条件，鉴别其是否小于鉴别方法分类边界值，当其较小时，获得在过去预定时间段内测量的尿糖值的平均值，其在与最近的测量值相同的时间，计算平均值和测量尿糖值之间的差异，当差异不小于阳性鉴别参考差异时，鉴别为血糖值降低，当测量值不为小于识别方法分类边界值，获得过去预定时间段内的所有测量值的平均值，计算测量值和平均值之间的比率，并且当比率不大于第一鉴别参考比时，区分为血糖值降低。

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