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51. 发明授权

US08354064B2 Apparatus for producing liposomes and method of producing liposomes 有权
标题翻译：用于生产脂质体的装置和生产脂质体的方法
公开(公告)号：US08354064B2
公开(公告)日：2013-01-15
申请号：US12935430
申请日：2009-03-30
申请人： Koji Nakamura , Keisuke Yoshino , Yasuo Kurosaki
发明人： Koji Nakamura , Keisuke Yoshino , Yasuo Kurosaki
IPC分类号： B01J19/18
CPC分类号： B01J13/22 , A61K9/1271 , A61K9/1277 , A61K31/573 , B01J13/04
摘要： Disclosed herein are an apparatus for producing liposomes and a method of producing liposomes by which it is made possible to produce liposomes under sterile conditions during the manufacturing process while monitoring in line the particle diameter of liposomes. The apparatus for producing liposomes includes a unit for regulating the particle diameter of liposomes, a supply flow channel for supplying the particle diameter regulating unit with a solution under processing containing a liposome-forming lipid, and a discharge flow channel for discharging from the particle diameter regulating unit a solution under processing containing liposomes, the supply flow channel having an input port through which the solution under processing containing the liposome-forming lipid is put into the supply flow channel, wherein the discharge flow channel has a first light transmitting part at least a portion of which is made of material transparent to light, and also has at least a first light transmittance measuring unit which measures the light transmittance of the solution under processing containing liposomes by directing light to the first light-transmitting part from the outside of the first light-transmitting part. A method of producing liposomes by use of the apparatus.
摘要翻译：本文公开了一种用于生产脂质体的装置和一种生产脂质体的方法，通过该方法，可以在制造过程中在无菌条件下制备脂质体，同时监测脂质体的粒径。用于制备脂质体的装置包括用于调节脂质体的粒径的单元，用于向粒径调节单元供给含有形成脂质体的脂质的处理液的供给流路和从粒径排出的排出流路调节单元处理含有脂质体的溶液，所述供给流动通道具有输入口，将含有形成脂质体的脂质的处理中的溶液通过该输入口放入供给流路中，其中，排出流路至少具有第一透光部其一部分由对光透明的材料制成，并且还具有至少第一透光率测量单元，该第一透光率测量单元通过将来自外部的光引导到第一透光部分来测量包含脂质体的处理中的溶液的透光率第一透光部。通过使用该装置生产脂质体的方法。

52. 发明授权

US08235856B2 Gear device and turning portion structure of industrial robot using the gear device 有权
标题翻译：使用齿轮装置的工业机器人的齿轮装置和车削部分结构
公开(公告)号：US08235856B2
公开(公告)日：2012-08-07
申请号：US12671319
申请日：2008-07-30
申请人： Koji Nakamura
发明人： Koji Nakamura
IPC分类号： F16H1/32
CPC分类号： B25J9/102 , F16H1/32 , F16H2001/323 , Y10T74/20317
摘要： A gear device includes: an input gear fixed to an output shaft of a motor; an internal gear; an external gear which rotates while revolving around a central axis of the internal gear while meshing with the internal gear; a carrier supported rotatably within the internal gear and adapted to rotate about the central axis of the internal gear in conjunction with the rotation of the external gear; a plurality of crankshafts which are rotatably supported by the carrier and are adapted to cause the external gear to revolve around the central axis of the internal gear; transmission gears each provided on a central portion of each of the crankshafts; and a cylindrical gear which meshes with the transmission gears of the crankshafts and to which rotation is transmitted from the input gear, wherein the cylindrical gear is located on a radially inner side of an imaginary line passing through a center of rotation of each crankshaft and is rotatably supported by the carrier, and wherein the input gear and the cylindrical gear mesh with each other in an axially central portion of the carrier.
摘要翻译：齿轮装置包括：固定到马达的输出轴的输入齿轮; 内齿轮外齿轮，在与内齿轮啮合的同时围绕内齿轮的中心轴线旋转; 载体，其可旋转地支撑在所述内齿轮内并且适于与所述外齿轮的旋转一起围绕所述内齿轮的中心轴线旋转; 多个曲轴，其由所述托架可旋转地支撑并且适于使所述外齿轮围绕所述内齿轮的中心轴线旋转; 传动齿轮分别设置在每个曲轴的中心部分上; 以及与曲轴的传动齿轮啮合并且从输入齿轮传递旋转的圆柱齿轮，其中圆柱齿轮位于通过每个曲轴的旋转中心的假想线的径向内侧，并且是由所述载体可旋转地支撑，并且其中所述输入齿轮和所述圆柱齿轮在所述载体的轴向中心部分彼此啮合。

53. 发明授权

US08227578B2 Anti-human dlk-1 antibody showing anti-tumor activity in vivo 有权
标题翻译：在体内显示抗肿瘤活性的抗人dlk-1抗体
公开(公告)号：US08227578B2
公开(公告)日：2012-07-24
申请号：US12514230
申请日：2007-11-12
申请人： Koji Nakamura , Rie Tajima
发明人： Koji Nakamura , Rie Tajima
IPC分类号： C07K16/00
CPC分类号： C07K16/28 , C07K2317/73 , C07K2317/77 , C07K2317/92 , G01N33/574
摘要： The present invention provides an antibody specifically against hDlk-1 and having anti-tumor activity in vivo (an anti-hDlk-1 antibody), a fragment of the antibody, a hybridoma that produces the antibody, a complex of the antibody or antibody fragment and an agent, a pharmaceutical composition comprising the antibody and the like, a tumor therapeutic agent, a tumor angiogenesis inhibitor, a tumor diagnostic agent, a method for detecting a tumor, a kit for detecting and/or diagnosing a tumor, etc.
摘要翻译：本发明提供了特异性抗体的抗体的抗体（抗hDlk-1抗体），抗体的片段，产生抗体的杂交瘤，抗体或抗体片段的复合体和药剂，包含抗体等的药物组合物，肿瘤治疗剂，肿瘤血管生成抑制剂，肿瘤诊断剂，肿瘤检测方法，肿瘤检测和/或诊断用试剂盒等。

54. 发明授权

US08060336B2 Electronic apparatus and disk protection method 有权
标题翻译：电子仪器和磁盘保护方法
公开(公告)号：US08060336B2
公开(公告)日：2011-11-15
申请号：US12360507
申请日：2009-01-27
申请人： Koji Nakamura , Tatsuya Aoyagi , Toru Mamata , Kinji Taki
发明人： Koji Nakamura , Tatsuya Aoyagi , Toru Mamata , Kinji Taki
IPC分类号： G01P15/00
CPC分类号： G11B19/04 , G01P15/0891 , G01P15/18
摘要： An electronic apparatus includes a body, a triaxial acceleration sensor which is built in the body and includes a long axis and a short axis, a disk device built in the body, a calculation unit that calculates a value on a basis of an acceleration value which is detected by the triaxial acceleration sensor and is output in a direction perpendicular to the long axis and to the short axis, a setting unit that sets a threshold in a state of the body in which a plane formed by the long axis and the short axis is approximately parallel to a direction of action of gravitational acceleration, and a controller that starts protection of the disk device on a basis of a result of comparison between the value calculated by the calculation unit and the threshold.
摘要翻译：一种电子设备，包括主体，内置在主体中并包括长轴和短轴的三轴加速度传感器，内置在主体中的盘装置，计算单元，其基于加速度值计算值由三轴加速度传感器检测，并且在与长轴和短轴方向垂直的方向上输出设定单元，该设定单元在由长轴和短轴形成的平面的主体的状态下设定阈值大致平行于重力加速度的作用方向，以及控制器，其基于由计算单元计算的值与阈值之间的比较结果开始保护盘装置。

55. 发明申请

US20110077117A1 Eccentric Oscillating Type Speed Reducer 有权
标题翻译：偏心振荡式减速机
公开(公告)号：US20110077117A1
公开(公告)日：2011-03-31
申请号：US12160820
申请日：2007-01-12
申请人： Koji Nakamura
发明人： Koji Nakamura
IPC分类号： F16H1/32 , F16H57/04 , B25J17/00 , B25J19/00
CPC分类号： B25J19/0054 , B25J9/102 , F16H1/32 , F16H57/0412
摘要： The present invention provides an eccentric oscillating type speed reducer that can more effectively be cooled with an extremely simple structure.An eccentric oscillating type speed reducer 1 includes a camshaft 11 having crank portions 11a and 11b, a plurality of externally toothed gear members 12 that respectively have holes, each of which accommodates an associated one of the crank portions, and that are eccentrically moved by rotation of the camshaft, an internally toothed gear member 13 having an inner peripheral surface in which internal teeth to be meshed with external teeth formed on external peripheral surfaces of the externally toothed gear members are formed so as to set the number of the internal teeth to be slightly larger than that of external teeth, and support members 14 respectively positioned at both ends of the externally toothed gear members so as to rotatably support both ends of the camshaft. Further, support members 18 and 19 are integrally coupled to each other via a pillar portion 17. In the eccentric oscillating type speed reducer 1, a coolant passage 30 passing through the integrally coupled support members 18 and 10, and the pillar portion 17 is provided. A coolant, such as cooling water or cooling air, is passed through the coolant passage. Consequently, the eccentric oscillating type speed reducer can efficiently be cooled.
摘要翻译：本发明提供一种能够以非常简单的结构更有效地冷却的偏心摆动式减速机。偏心摆动式减速机1包括具有曲柄部分11a和11b的凸轮轴11，分别具有孔的多个外齿轮构件12，每个外齿轮构件12容纳相关联的一个曲柄部分，并且通过旋转偏心地移动凸轮轴的内齿面构成，内周面形成有与形成在外齿轮构件的外周面上的外齿啮合的内齿，从而将内齿的数量设定为稍微大于外齿的位置，以及分别位于外齿轮构件的两端的支撑构件14，以便可旋转地支撑凸轮轴的两端。此外，支撑构件18和19经由柱部17彼此一体地联接。在偏心摆动式减速器1中，设置有穿过整体连接的支撑构件18和10的冷却剂通道30和柱部17 。诸如冷却水或冷却空气的冷却剂通过冷却剂通道。因此，可以有效地冷却偏心摆动式减速机。

56. 发明申请

US20100236720A1 APPARATUS FOR MELT-ADHERING RESIN PIPES 审中-公开
标题翻译：用于熔融粘合树脂管的装置
公开(公告)号：US20100236720A1
公开(公告)日：2010-09-23
申请号：US12294738
申请日：2007-03-27
申请人： Jiro Azuma , Yoshiharu Ikenaka , Kanji Tanaka , Akira Fujisaki , Junji Ueda , Masahiro Fukunaga , Koji Nakamura , Yoshifumi Akagawa
发明人： Jiro Azuma , Yoshiharu Ikenaka , Kanji Tanaka , Akira Fujisaki , Junji Ueda , Masahiro Fukunaga , Koji Nakamura , Yoshifumi Akagawa
IPC分类号： B29C65/16
CPC分类号： B29C66/5221 , B29C65/1635 , B29C65/1654 , B29C65/1683 , B29C65/7841 , B29C66/1222 , B29C66/1226 , B29C66/52241 , B29C66/5229 , B29C66/52292 , B29C66/652 , B29C66/73921 , B29L2031/246
摘要： An apparatus (10) for melt-adhering resin pipes, comprising support means (11, 12) for supporting a resin pipe (1) engaged with a resin joint (2), and laser irradiation means (30) for irradiating a laser beam onto a portion of the resin pipe engaged with the resin joint. Further, an axial direction driving means and a circumferential direction driving means may be provided so that the laser irradiation means (30) moves in the circumferential direction and in the axial direction of the resin pipe.
摘要翻译：一种用于熔融粘合树脂管的装置（10），包括用于支撑与树脂接头（2）接合的树脂管（1）的支撑装置（11,12）和用于将激光束照射到的激光照射装置树脂管的一部分与树脂接头接合。此外，轴向驱动装置和周向驱动装置可以设置成激光照射装置（30）在树脂管的圆周方向和轴向方向上移动。

57. 发明申请

US20100181748A1 Squib, Gas Generation for Inflating Air Bag and Gas Generator for Seat Belt Pretensioner 审中-公开
标题翻译：气泡发生器，气囊发生器，用于安全带预紧器的气囊和气体发生器
公开(公告)号：US20100181748A1
公开(公告)日：2010-07-22
申请号：US12664341
申请日：2008-06-12
申请人： Koji Nakamura , Takatoshi Tsukamoto , Shigeru Maeda , Hirotaka Mukunoki , Hideyuki Koike
发明人： Koji Nakamura , Takatoshi Tsukamoto , Shigeru Maeda , Hirotaka Mukunoki , Hideyuki Koike
IPC分类号： B60R21/26 , F42B3/10 , F42B3/103 , F42B3/12
CPC分类号： F42B3/103 , B60R2021/26029 , F42B3/04 , F42B3/127
摘要： A squib comprising a cup body, a cup body cover, and a header for holding a plurality of electrode pins insulated from one another and closing the opening portion of the cup body, wherein the internal of the cup body has an ignition powder, and a heating element connected to the electrode pins for igniting the ignition powder by externally applying electric current arranged in contact with the ignition powder, wherein a metal cylindrical or ring restraining member is provided in the outer periphery of the cup body and covered around with the cup body cover.
摘要翻译：一种爆管，其包括杯体，杯体盖和用于保持彼此绝缘的多个电极针的头部，并且封闭所述杯体的开口部分，其中所述杯体的内部具有点燃粉末，以及加热元件连接到电极销，用于通过外部施加与点火粉末接触布置的电流来点燃点火粉末，其中金属圆柱形或环形限制构件设置在杯体的外周并且被杯体覆盖盖。

58. 发明申请

US20100179013A1 CENTER CRANK ECCENTRICALLY OSCILLATING SPEED REDUCER 有权
标题翻译：中心起重机振动减速器
公开(公告)号：US20100179013A1
公开(公告)日：2010-07-15
申请号：US12064299
申请日：2006-08-22
申请人： Koji Nakamura
发明人： Koji Nakamura
IPC分类号： F16H1/32
CPC分类号： F16H1/32 , B25J9/102 , F16H2001/323
摘要： The present invention provides a center crank eccentrically oscillating speed reducer enabled to increase the available cross-sectional area of a hollow hole, while the generation of large noises is suppressed, as compared with the conventional center crank eccentrically oscillating speed reducer.An eccentrically oscillating speed reducer 100 includes a case configured to have internal teeth 111, a hollow crankshaft 120 configured to have an external gear 123, to be disposed at a substantially center of the internal teeth, and to rotate with respect to the case 110, external gears 131 and 132 configured to respectively have external teeth 131a and 132a meshing with the internal teeth 111, to engage with the crankshaft 120 and to be eccentrically moved by the crankshaft 120, a carrier 140 configured to engage with the external gears 131 and 132 and to be rotated by the external gears 131 and 132 with respect to the case 110, and a transmission gear 160 configured to mesh with an input gear 150 and the external gear 123 and to transmit power transmitted from the input gear 150 to the external gear 123. The transmission gear 160 is rotatably supported by the carrier 140.
摘要翻译：本发明提供一种与传统的中心曲柄偏心摆动减速器相比，能够增加中空孔的可用横截面积，同时抑制大噪音的产生的中心曲柄偏心摆动减速器。偏心摆动式减速机100包括被配置为具有内齿111的壳体，被配置为具有外齿轮123的中空曲轴120，其设置在内齿的大致中心处并相对于壳体110旋转，外齿轮131和132被构造成分别具有与内齿111啮合的外齿131a和132a，以与曲轴120啮合并由曲轴120偏心移动，构造成与外齿轮131和132啮合的载体140 并且相对于壳体110被外齿轮131和132旋转;以及传动齿轮160，其构造成与输入齿轮150和外齿轮123啮合并将从输入齿轮150传递的动力传递到外齿轮传动齿轮160由载体140可旋转地支撑。

59. 发明申请

US20100154579A1 JOINT MECHANISM 有权
标题翻译：联合机制
公开(公告)号：US20100154579A1
公开(公告)日：2010-06-24
申请号：US12160800
申请日：2007-01-12
申请人： Koji Nakamura
发明人： Koji Nakamura
IPC分类号： B25J17/00
CPC分类号： B25J19/0016 , B25J9/102 , B25J19/0054 , B25J19/0062 , B66C23/005 , Y10T74/20305 , Y10T74/20329
摘要： There is provided a joint mechanism capable of restraining a rise in a temperature of a lubricant of a speed reducer, bringing the speed reducer into a stable operating state and preventing early destruction of the speed reducer.There is provided a joint mechanism constituted by a base 1, a turning base 4 provided above the base and rotated, and an arm 6 a lower end portion is pivotably supported by the turning base, in which a speed reducer 2 for rotating the turning base is provided at inside of the base, a counterbalance system 10 constituted by a cylinder 7 pivotably supported above the turning base and filled with a lubricant, a piston 8 provided in a hermetically sealed state slidably in a longitudinal direction at inside of the cylinder, and a piston rod 9 one end portion of which is connected to the piston and other end portion of which is connected to the arm 6 is provided, the speed reducer and the cylinder of the counterbalance system are connected and a lubricant of the speed reducer is introduced into the cylinder.
摘要翻译：提供了一种能够抑制减速器的润滑剂的温度上升的关节机构，使减速机处于稳定的运转状态，防止减速机的早期破坏。提供了一种由基座1，设置在基座上方旋转的转动基座4和由转动基座可枢转地支撑的下端部的臂6构成的接合机构，在该转动基座上设有用于使转动基座旋转的减速器2 设置在基座的内部，平衡系统10由可枢转地支撑在转动基部上并充满润滑剂的气缸7构成，活塞8在气缸内部沿纵向滑动地设置在气密密封状态，以及活塞杆9的一个端部连接到活塞并且其另一端部连接到臂6上，减速器和平衡系统的气缸连接并且减速器的润滑剂被引入进入圆筒。

60. 发明授权

US07704436B2 Cosmetic applicator and its production method 失效
标题翻译：化妆品涂抹器及其制作方法
公开(公告)号：US07704436B2
公开(公告)日：2010-04-27
申请号：US11035314
申请日：2005-01-13
申请人： Kenji Nakamura , Koji Nakamura
发明人： Kenji Nakamura , Koji Nakamura
IPC分类号： B29C39/00 , B29C67/24 , B29C44/34 , B28B11/14
CPC分类号： C08K3/34 , A45D2200/1018 , B29C44/5654 , C08L9/04
摘要： A cosmetic applicator is made of a rubber latex foam which has been solidified by microwave irradiation. The foam satisfies (i) a bubble fineness corresponding to 9 bubbles/mm2 or more, (ii) flexibility of 0.7 N/cm2 or less in initial Young's modulus indicated by 50% compressive stress, and (iii) bulk density of 0.14 g/cm3 or less.
摘要翻译：化妆品涂抹器由已经通过微波照射固化的橡胶胶乳泡沫制成。泡沫体满足（i）相当于9个气泡/ mm 2以上的气泡细度，（ii）由50％压缩应力表示的初始杨氏模量为0.7N / cm 2以下的柔软性，（iii）0.14g / cm3以下。

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