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51. 发明申请

US20060193890A1 Method for loading nanoporous layers with therapeutic agent 有权
标题翻译：用治疗剂负载纳米多孔层的方法
公开(公告)号：US20060193890A1
公开(公告)日：2006-08-31
申请号：US11352436
申请日：2006-02-10
申请人： Gary Owens , Brian Wamhoff , Matthew Hudson , Whye-Kei Lye , Joshua Spradlin , Michael Reed , Kareen Looi
发明人： Gary Owens , Brian Wamhoff , Matthew Hudson , Whye-Kei Lye , Joshua Spradlin , Michael Reed , Kareen Looi
IPC分类号： A61K6/083 , B05D3/02
CPC分类号： A61L31/022 , A61F2/07 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2210/0076 , A61F2250/0067 , A61L31/10 , A61L31/146 , A61L31/16 , A61L31/18 , A61L2300/606 , A61L2400/12 , A61N1/05
摘要： The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy. In some embodiments, a porous layer is adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. One embodiment of the invention relates to medical devices, including vascular stents, having at least one porous layer adapted to resist stenosis or cellular proliferation without requiring elution of therapeutic agents. The invention also includes methods, devices, and specifications for loading of drugs and other therapeutic agents into nanoporous coatings.
摘要翻译：本发明一般涉及具有治疗洗脱组分的医疗装置及其制备方法。更具体地，本发明涉及具有至少一个多孔层的可植入医疗装置，以及用于制造这种装置的方法，以及用治疗剂加载这些装置。将混合物或合金放置在医疗装置的表面上，然后通常除去混合物或合金的一种组分，而不会通常除去混合物或合金的其它组分。在一些实施例中，多孔层适于粘合非金属涂层，包括药物洗脱的聚合物涂层。多孔层可以具有无规孔结构或定向或定向颗粒多孔结构。本发明的一个实施方案涉及包括血管支架的医疗装置，其具有适于抵抗狭窄或细胞增殖的至少一个多孔层，而不需要洗脱治疗剂。本发明还包括将药物和其它治疗剂装载到纳米多孔涂层中的方法，装置和规格。

52. 发明申请

US20060094696A1 Oestrogen derivatives as inhibitors of steroid sulphatase 失效
标题翻译：雌激素衍生物作为类固醇硫酸酯酶的抑制剂
公开(公告)号：US20060094696A1
公开(公告)日：2006-05-04
申请号：US11233945
申请日：2005-09-23
申请人： Mathew Leese , Alan Purohit , Michael Reed , Simon Newman , Surinder Chander , Fabrice Jourdan , Barry Potter
发明人： Mathew Leese , Alan Purohit , Michael Reed , Simon Newman , Surinder Chander , Fabrice Jourdan , Barry Potter
IPC分类号： A61K31/66 , C07J51/00 , A61K31/56
CPC分类号： C07J43/00 , C07J41/00
摘要： The present invention provides a compound comprising a steroidal ring system and an optional group R1 selected from any one of —OH, a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; wherein the D ring of the steroidal ring system is substituted by a group R2 of the formula -L-R3, wherein L is an optional linker group and R3 is selected from groups which are or which comprise one of a nitrite group, an alcohol, an ester, an ether, an amine and an alkene, provided that when R3 is or comprises an alcohol, L is present; and wherein the A ring of the steroidal ring system is substituted at position 2 or 4 with a group R4, wherein R4 is a hydrocarbyl group.
摘要翻译：本发明提供了包含选自-OH，氨基磺酸酯基，膦酸酯基，硫代膦酸酯基，磺酸酯基或磺酰胺中的任何一种的甾体环系和任选的基团R 1的化合物组; 其中所述甾体环体系的D环被式-LR 3 SO 2的基团R 2取代，其中L是任选的连接基团，R 3 选自亚硝酸根基团，醇类，酯类，醚类，胺类和烯烃中的一种或其中之一的基团，条件是当R 3是或包含一个或多个酒精，L存在; 并且其中所述甾族环系统的A环在位置2或4被基团R 4取代，其中R 4为烃基。

53. 发明申请

US20060074060A1 Compound 失效
标题翻译：复合
公开(公告)号：US20060074060A1
公开(公告)日：2006-04-06
申请号：US11234868
申请日：2005-09-23
申请人： Nigel Vicker , Harshani Lawrence , Gillian Allan , Christian Bubert , Delphine Sophie Fischer , Alan Purohit , Michael Reed , Barry Victor Potter
发明人： Nigel Vicker , Harshani Lawrence , Gillian Allan , Christian Bubert , Delphine Sophie Fischer , Alan Purohit , Michael Reed , Barry Victor Potter
IPC分类号： A61K31/58 , C07J71/00
CPC分类号： C07J71/00 , C07J41/00
摘要： There is provided a compound of Formula (I) wherein (I) R2 is selected from (i) an alkyloxyalkyl group (ii) a nitrile group, and wherein R2 is capable of forming a hydrogen bond (iii) alkylaryl group, wherein the aryl group is substituted by other than a C1-10 group (iv) alkenylaryl group wherein the aryl group is substituted (v) alkylheteroaryl group, wherein when heteroaryl group comprises only C and N in the ring, the aryl group is substituted by other than a methyl group (vi) alkenylheteroaryl group, (vii) ═N—O-alkyl or ═N—O—H group (viii) branched alkenyl (ix) alkyl-alcohol group (x) amide or alkylamide wherein (a) the alkyl of the alkylamide is —CH2— or —Ch2Ch2—, (b) the amide is di-substituted and/or (c) the amide is substituted with at least one of alkyl heterocycle group, alkenyl heterocycle group, alkylheteroaryl group, alkenylheteroaryl group, heteroaryl group, alkylamine group, alkyloxyalkyl group, alkylaryl group, straight or branched alkyl group, (xi) —CHO so that R1 together with R3 provide the enol tautomer (a); OR R2 together with R3 form (xii) a pyrazole wherein (a) R4 is ═N—O-alkyl or ═N—O—H group, (b) the pyrazole is substituted with one of alkyl-OH group, alkyl ester group, alkyloxyalkyl group, branched alkyl group, and an amide and/or (c) the 2 position is substituted with a group selected from —OH and —O-hydrocarbyl (xiii) a heteroaryl ring to provide a compound of the formula (b); (II) R2 is selected from groups capable of forming a hydrogen bond, a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group and a sulphonamide group; and (III) R3 is selected from —OH, ═O, or a C(═O)—mimetic.
摘要翻译：提供式（I）化合物，其中（I）R 2选自（ⅰ）烷氧基烷基（ⅱ）腈基，其中R2能够形成氢键（ⅲ）烷基芳基，其中芳基基团被取代的芳基（ⅴ）烷基杂芳基以外的C 1-10基团（ⅳ）链烯基芳基取代，其中当杂芳基仅在环中仅包含C和N时，芳基被除了甲基（vi）烯基杂芳基，（vii）-NO-烷基或-NOH基（viii）支链烯基（ix）烷基 - 醇基（x）酰胺或烷基酰胺，其中（a）烷基酰胺的烷基是-CH2- 或-C 2 -C 12 - ，（b）酰胺是二取代的和/或（c）酰胺被烷基杂环基，烯基杂环基，烷基杂芳基，烯基杂芳基，杂芳基，烷基胺基，烷氧基烷基中的至少一个基团，烷基芳基，直链或支链烷基，（xi）-CHO，使得R1起始与R3提供烯醇互变异构体（a）; OR 2与R 3一起形成（xii）吡唑，其中（a）R4是-NO-烷基或-NOH基，（b）吡唑被烷基-OH基，烷基酯基，烷氧基烷基，支链烷基基团和酰胺和/或（c）2位被选自-OH和-O-烃基（xiii）杂芳基环的基团取代，以提供式（b）的化合物; （II）R2选自能够形成氢键的基团，氨基磺酸酯基，膦酸酯基，硫代膦酸酯基，磺酸酯基和磺酰胺基; 和（III）R 3选自-OH，-O或C（-O） - 模仿物。

54. 发明申请

US20050277144A1 Compounds and methods for fluorescent labeling 有权
公开(公告)号：US20050277144A1
公开(公告)日：2005-12-15
申请号：US11127040
申请日：2005-05-10
申请人： Eugeny Lukhtanov , Alexei Vorobiev , Michael Reed , Nicolaas Vermeulen
发明人： Eugeny Lukhtanov , Alexei Vorobiev , Michael Reed , Nicolaas Vermeulen
IPC分类号： C09B11/08 , C09B19/00 , C09B57/02 , C09B57/14 , G01N33/533 , C12Q1/68 , C07D311/78 , C07K14/47
CPC分类号： C09B57/14 , C09B11/08 , C09B19/00 , C09B57/02 , G01N33/533
摘要： Dye reagents useful in labeling biological materials are provided along with methods for their use.

55. 发明申请

US20050149392A1 Using a customer's purchasing intent in recommending alternative items for purchase in a physical store 审中-公开
标题翻译：使用客户的购买意向推荐在实体商店购买的替代物品
公开(公告)号：US20050149392A1
公开(公告)日：2005-07-07
申请号：US10750151
申请日：2003-12-31
申请人： Kevin Gold , Michael Reed , Frank Vandervort , Todd Walter
发明人： Kevin Gold , Michael Reed , Frank Vandervort , Todd Walter
IPC分类号： G06F17/60
CPC分类号： G06Q30/0252 , G06Q30/0254 , G06Q30/0255 , G06Q30/0267 , G06Q30/0271 , G07G1/0036
摘要： A merchant who operates a physical store is able to communicate a message to a customer who is carrying one or more items for purchase. While the customer is moving through the store, the merchant uses electronic means to gather data identifying at least one of the items carried by the customer. A computer-implemented program applied to the data analyzes the data and identifies at least one alternative item that the customer might want to buy. The program then prepares a message about the alternative item and delivers the message to the customer while the customer is still in the store.
摘要翻译：经营实体商店的商家能够向携带一个或多个物品进行购买的客户传达消息。当客户正在通过商店移动时，商家使用电子方式来收集识别客户携带的至少一个项目的数据。应用于数据的计算机实现的程序分析数据并识别客户可能想要购买的至少一个备选项目。该程序然后准备关于备选项目的消息，并且在客户仍然在商店中时将消息传递给客户。

56. 发明申请

US20050135306A1 Discovery and connection management with mobile systems manager 审中-公开
标题翻译：使用移动系统管理器进行发现和连接管理
公开(公告)号：US20050135306A1
公开(公告)日：2005-06-23
申请号：US11005761
申请日：2004-12-06
申请人： Christopher McAllen , Christopher Dern , Gregory Borges , Michael Reed , Richard Batch
发明人： Christopher McAllen , Christopher Dern , Gregory Borges , Michael Reed , Richard Batch
IPC分类号： G06F12/00 , G06F17/30 , G06F19/00 , H04L12/24 , H04L12/28 , H04L12/56 , H04L29/06 , H04L29/08 , H04W12/02 , H04W52/02 , H04W68/00 , H04Q7/00
CPC分类号： H04W68/00 , G16H40/20 , H04L29/06 , H04L63/0428 , H04L63/08 , H04L63/083 , H04L67/12 , H04L67/14 , H04L67/24 , H04L69/329 , H04W12/0017 , H04W12/06 , H04W40/246 , H04W52/0216 , H04W52/0219 , H04W76/10 , Y02D70/142 , Y02D70/144 , Y02D70/166 , Y02D70/26
摘要： The present invention provides for a system and method of discovering whether a medical device is connected to a network, establishing secure communications between and a server and the medical device, and communicating with the medical device. Also disclosed is a method of encryption to ensure secure communications within the network between a server and medical devices connected to the network. The invention also includes a system and method for determining the location of medical devices within an institution. Also disclosed is a mobile server functioning as a mobile systems manager.
摘要翻译：本发明提供一种发现医疗设备是否连接到网络，建立服务器与医疗设备之间的安全通信以及与医疗设备通信的系统和方法。还公开了一种加密方法，以确保服务器与连接到网络的医疗设备之间网络内的安全通信。本发明还包括用于确定机构内的医疗设备的位置的系统和方法。还公开了用作移动系统管理器的移动服务器。

57. 发明申请

US20050014776A1 Steroidal compounds for inhibiting steroid sulphatase 有权
标题翻译：用于抑制类固醇硫酸酶的甾体化合物
公开(公告)号：US20050014776A1
公开(公告)日：2005-01-20
申请号：US10825758
申请日：2004-04-16
申请人： Barry Potter , Michael Reed , Lok Woo
发明人： Barry Potter , Michael Reed , Lok Woo
IPC分类号： A61K45/00 , A61K31/58 , A61P15/00 , A61P25/28 , A61P29/00 , A61P35/00 , A61P37/02 , A61P43/00 , C07J1/00 , C07J63/00 , C07J73/00 , A61K31/50
CPC分类号： C07J1/0051 , C07J63/00 , C07J63/008
摘要： There is provided a compound having Formula (I) wherein G is H or a substituent, and wherein R1 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group, capable of inhibiting steroid sulphatase.
摘要翻译：提供了具有式（I）的化合物，其中G是H或取代基，其中R 1是氨基磺酸酯基，膦酸酯基，硫代膦酸酯基，磺酸酯基或磺酰胺基中的任何一种，能够抑制类固醇硫酸酶。

58. 发明申请

US20050008747A1 Method of forming a sugarless coating on chewing gum 审中-公开
标题翻译：在口香糖上形成无糖涂层的方法
公开(公告)号：US20050008747A1
公开(公告)日：2005-01-13
申请号：US10617905
申请日：2003-07-11
申请人： David Barkalow , Michael Reed , Robert Friedman , Elena Mirzoeva , Julius Zuehlke , Robert Yatka
发明人： David Barkalow , Michael Reed , Robert Friedman , Elena Mirzoeva , Julius Zuehlke , Robert Yatka
IPC分类号： A23G4/00 , A23G4/02 , A23G4/20 , A01K1/00
CPC分类号： A23G4/20 , A23G4/025
摘要： A method of forming a sugarless coating on chewing gum cores comprises: providing chewing gum cores; providing a coating syrup comprising one or more sugarless sweeteners; providing a dusting mix comprising about 20% to about 60% of a bulk sweetener selected from the group consisting of malitol, hydrogenated isomaltulose, lactitol, sorbitol and mixtures thereof and about 40% to about 80% filler; and applying a plurality of layers of the coating syrup and a plurality of layers of the dusting mix to the chewing gum cores to form a sugarless coating on the gum cores.
摘要翻译：在口香糖胶芯上形成无糖涂层的方法包括：提供口香糖芯; 提供包含一种或多种无糖甜味剂的包衣糖浆; 提供包含约20％至约60％的选自由麦芽糖醇，氢化异麦芽酮糖，乳糖醇，山梨糖醇及其混合物组成的组的约20％至约60％的粉末混合物和约40％至约80％的填料; 以及将多层所述涂覆糖浆和多层所述除尘混合物施加到所述口香糖芯上，以在所述胶芯芯上形成无糖涂层。

59. 发明授权

US06546399B1 Multimedia search system 失效
公开(公告)号：US06546399B1
公开(公告)日：2003-04-08
申请号：US08202985
申请日：1994-02-28
申请人： Michael Reed , Carol Greenhalgh , Ron Carlton , Dale Good , Carl Holzman , Harold Kester , Edwardo Munevar , Greg Bestick , Norman J. Bastin , Stanley D. Frank , Neil Holman , Ann Jensen , Gail B. Maatman , Derryl Rogers
发明人： Michael Reed , Carol Greenhalgh , Ron Carlton , Dale Good , Carl Holzman , Harold Kester , Edwardo Munevar , Greg Bestick , Norman J. Bastin , Stanley D. Frank , Neil Holman , Ann Jensen , Gail B. Maatman , Derryl Rogers
IPC分类号： G06F1730
CPC分类号： G06F17/30277 , G06F17/30637 , G11B27/105 , G11B27/34 , G11B2220/213 , G11B2220/2545 , Y10S707/99933 , Y10S707/99945 , Y10S707/99948 , Y10S715/978
摘要： A database search system that retrieves multimedia information in a flexible, user friendly system. The search system uses a multimedia database consisting of text, picture, audio and animated data. That database is searched through multiple graphical and textual entry paths. Those entry paths include an idea search, a title finder search, a topic tree search, a picture explorer search, a history timeline search, a world atlas search, a researcher's assistant search, and a feature articles search.

60. 发明授权

US5854204A A.beta. peptides that modulate .beta.-amyloid aggregation 失效
标题翻译：调节β-淀粉样蛋白聚集的β肽
公开(公告)号：US5854204A
公开(公告)日：1998-12-29
申请号：US612785
申请日：1996-03-14
申请人： Mark A. Findeis , Howard Benjamin , Marc B. Garnick , Malcolm L. Gefter , Arvind Hundal , Laura Kasman , Gary Musso , Ethan R. Signer , James Wakefield , Michael Reed , Susan Molineaux , William Kubasek , Joseph Chin , Jung-Ja Lee , Michael Kelley
发明人： Mark A. Findeis , Howard Benjamin , Marc B. Garnick , Malcolm L. Gefter , Arvind Hundal , Laura Kasman , Gary Musso , Ethan R. Signer , James Wakefield , Michael Reed , Susan Molineaux , William Kubasek , Joseph Chin , Jung-Ja Lee , Michael Kelley
IPC分类号： A61K39/02 , A61K31/00 , A61K38/00 , A61K51/00 , A61P25/00 , C07K7/06 , C07K14/47 , C07K14/435 , C07K7/08
CPC分类号： C07K14/4711 , A61K38/00
摘要： Compounds that modulate the aggregation of amyloidogenic proteins or peptides are disclosed. The modulators of the invention can promote amyloid aggregation or, more preferably, can inhibit natural amyloid aggregation. In a preferred embodiment, the compounds modulate the aggregation of natural .beta. amyloid peptides (.beta.-AP). In a preferred embodiment, the .beta. amyloid modulator compounds of the invention are comprised of an A.beta. aggregation core domain and a modifying group coupled thereto such that the compound alters the aggregation or inhibits the neurotoxicity of natural .beta. amyloid peptides when contacted with the peptides. Furthermore, the modulators are capable of altering natural .beta.-AP aggregation when the natural .beta.-APs are in a molar excess amount relative to the modulators. Pharmaceutical compositions comprising the compounds of the invention, and diagnostic and treatment methods for amyloidogenic diseases using the compounds of the invention, are also disclosed.
摘要翻译：公开了调节淀粉样蛋白形成蛋白或肽聚集的化合物。本发明的调节剂可以促进淀粉样蛋白聚集，更优选可以抑制天然淀粉样蛋白聚集。在优选的实施方案中，化合物调节天然β淀粉样蛋白肽（β-AP）的聚集。在优选的实施方案中，本发明的β淀粉样蛋白调节剂化合物由Aβ聚集核心结构域和与其偶联的修饰基团组成，使得当与肽接触时，该化合物改变聚集或抑制天然β淀粉样肽的神经毒性。此外，当天然β-APs相对于调节剂摩尔过量时，调节剂能够改变天然的β-AP聚集。还公开了包含本发明化合物的药物组合物，以及使用本发明化合物的淀粉样变性疾病的诊断和治疗方法。

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