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51. 依法登记的发明

USH949H Device for measuring ionic activity 失效
标题翻译：用于测量离子活性的装置
公开(公告)号：USH949H
公开(公告)日：1991-08-06
申请号：US321979
申请日：1989-03-10
申请人： Kimiko Ishizuka , Osamu Seshimoto
发明人： Kimiko Ishizuka , Osamu Seshimoto
IPC分类号： G01N27/28 , G01N27/30
CPC分类号： G01N27/307
摘要： A device for measuring the activity of carbonate ions and hydrogen ions comprises a carbonate ion selective electrode pair and a hydrogen ion selective electrode pair. Each ion selective electrode comprises a metal layer, metal halide layer and ion selective layer superposed in this order. A porous bridge is disposed so as to achieve a liquid junction between the ion selective electrodes of each electrode pair.

52. 依法登记的发明

USH745H Ion-selective electrode for measuring carbonate concentration 失效
标题翻译：用于测量碳酸盐浓度的离子选择性电极
公开(公告)号：USH745H
公开(公告)日：1990-02-06
申请号：US169288
申请日：1988-03-17
申请人： Kimiko Ishizuka , Osamu Seshimoto
发明人： Kimiko Ishizuka , Osamu Seshimoto
IPC分类号： G01N27/28 , G01N27/333
CPC分类号： G01N27/3335
摘要： An ion-selective electrode for measuring carbonate concentration comprising a conductive metal layer, a halide of said conductive metal layer, a carbonate ion-selective layer containing ion carrier, and a buffer layer containing a hydrophilic polymer binder and a buffer laminated in this order on an electrically insulating support, and a pair of the above electrodes.It is characterized by not having the electrolyte layer containing hydrophilic polymer binder, having the possibility of degradation of the electrolyte layer by the absorption of moisture being extremely little, and having a good stability in the course of time. In the electrode of the invention, the ion-selective layer comprised of hydrophobic organic material is directly laminated on the metal halide layer, the adhesive strength between the metal halide layer and the ion-selective layer is sufficient, the strength of the ion-selective layer is sufficiently great, and which is stable. The electrode of the invention has a sufficient buffering ability, and it requires neither operation of preliminary measurement of the pH value of aqueous liquid sample nor fixation of the pH value by adding a pH buffer to sample. Moreover, the adverse affect (measuring error) by the interfering substance such as salicylate, p-aminosilicylate or gentisate is eliminated or remarkably reduced.

53. 发明授权

US4877582A Chemical sensor device with field effect transistor 失效
标题翻译：具有场效应晶体管的化学传感器
公开(公告)号：US4877582A
公开(公告)日：1989-10-31
申请号：US87508
申请日：1987-08-20
申请人： Shohei Oda , Osamu Seshimoto , Tohru Sueyoshi , Hiroyuki Amano
发明人： Shohei Oda , Osamu Seshimoto , Tohru Sueyoshi , Hiroyuki Amano
IPC分类号： G01N27/00 , G01N27/28 , G01N27/414
CPC分类号： G01N27/414 , Y10S436/806
摘要： A chemical sensor having a field-effect transistor as an electronic transducer and used for the analysis of specific constituents in a liquid, the chemical sensor comprising means which permits an externally supplied sample solution to reach a chemical receptor of said chemical sensor but substantially prevents external light from reaching said field effect transistor.
摘要翻译：一种具有场效应晶体管作为电子换能器并用于分析液体中特定成分的化学传感器，该化学传感器包括允许外部供应的样品溶液达到所述化学传感器的化学受体但基本上防止外部光到达所述场效应晶体管。

54. 发明授权

US4655899A Probe assembly for an apparatus for measuring ionic activity 失效
标题翻译：用于测量离子活性的装置的探针组件
公开(公告)号：US4655899A
公开(公告)日：1987-04-07
申请号：US703396
申请日：1985-02-20
申请人： Yoshio Saito , Osamu Seshimoto
发明人： Yoshio Saito , Osamu Seshimoto
IPC分类号： G01N27/28 , G01N27/30 , G01N27/416 , G01N27/46
CPC分类号： G01N27/307
摘要： A probe assembly has at least two pairs of probes and a relay for switchably connecting any one pair of the probes to a single electric impedance lowering means. When the pairs of probes are brought into contact with terminals of at least two pairs of ion-selective electrodes of an ionic activity device, the potential difference generated between each pair of said electrodes is successively transferred to a measuring means by way of the electric impedance lowering means.
摘要翻译：探针组件具有至少两对探针和用于将任何一对探针可切换地连接到单个电阻抗降低装置的继电器。当成对的探针与离子活性器件的至少两对离子选择性电极的端子接触时，在每对所述电极之间产生的电位差通过电阻抗连续转移到测量装置降低手段。

55. 发明授权

US4613421A Apparatus for measuring ionic activity 失效
标题翻译：用于测量离子活性的装置
公开(公告)号：US4613421A
公开(公告)日：1986-09-23
申请号：US694221
申请日：1985-01-24
申请人： Osamu Seshimoto , Teruaki Koizumi , Yoshio Saito , Akira Yamaguchi
发明人： Osamu Seshimoto , Teruaki Koizumi , Yoshio Saito , Akira Yamaguchi
IPC分类号： G01N27/28 , G01N35/00
CPC分类号： G01N35/00029 , G01N2035/00138 , G01N2035/00376
摘要： An apparatus for measuring ionic activity is comprised of a rotatable turret and at least one pair of vertically movable probes. The turret intermittently conveys slide-type ionic activity measuring devices, one by one, on each of which are spots of reference and sample solutions, to a measuring section where the probes come into contact with the measuring device so as to measure the potential difference corresponding to the difference in ionic activity of a specific ion between the reference and sample solutions. After measurement the turret further conveys the device to a discharging section where the device is automatically discharged.
摘要翻译：用于测量离子活性的装置包括可旋转转台和至少一对可垂直移动的探针。转台间隔地将滑动型离子活性测量装置一个接一个地传送到测量部分，其中探针与测量装置接触，以测量相应的电位差到参考和样品溶液之间的特定离子的离子活性的差异。测量后，转塔进一步将装置输送到装置自动排出的排放部分。

56. 发明授权

US4317123A Thermal recording material 失效
标题翻译：热敏记录材料
公开(公告)号：US4317123A
公开(公告)日：1982-02-23
申请号：US088233
申请日：1979-10-25
申请人： Tomizo Namiki , Osamu Seshimoto , Fumiaki Shinozaki , Akira Nahara , Tomoaki Ikeda
发明人： Tomizo Namiki , Osamu Seshimoto , Fumiaki Shinozaki , Akira Nahara , Tomoaki Ikeda
IPC分类号： B41M5/26 , G11B7/241 , G11B7/256 , G11B7/257 , G11C13/04 , G01D15/34 , B32B15/08 , G01D15/10
CPC分类号： G11B7/256 , G11B7/257 , G11B2007/24304 , G11B2007/24308 , G11B2007/2431 , G11B2007/24312 , G11B2007/24314 , G11B2007/24316 , G11B2007/25706 , G11B2007/25708 , G11B2007/2571 , G11B2007/25715 , G11B2007/25716 , G11B2007/25718 , G11B7/2535 , G11B7/2575 , G11B7/2578 , Y10S428/913 , Y10S430/162 , Y10T428/261 , Y10T428/265 , Y10T428/31663 , Y10T428/31699
摘要： A thermal recording material possessing high sensitivity which comprises a support having thereon in sequence a subbing layer, a recording layer and optionally, a protecting layer in which the subbing layer contains a composition comprising (A) 100 parts by weight of chlorinated polyolefin having a chlorine content of about 30% by weight or more and (B) 1 part to 100 parts by weight of aminoalkylalkoxysilane compound represented by the following general formula (I): ##STR1## wherein R.sup.1 represents an amino group or a H.sub.2 N--R.sup.5 --NH-- group; R.sup.2 and R.sup.5 each represents a polymethylene group having 1 to 2 carbon atoms or a straight or branched chain alkylene (alkanediyl) group having 3 to 5 carbon atoms, and may be the same or different; R.sup.3 represents a straight or branched chain alkyl group having 1 to 5 carbon atoms; m represents 2 or 3; R.sup.4 represents a straight or branched chain alkyl group having 1 to 5 carbon atoms or an R.sup.1 --R.sup.2 -- group; p represents 0 or 1, and m+p=3 using this composition the support and the recording layer are closely adhered to each other.
摘要翻译：具有高灵敏度的热敏记录材料包括其上依次具有底层，支撑层和任选地保护层的支撑体，其中底层含有组合物，其包含（A）100重量份具有氯的氯化聚烯烃含量为约30重量％以上，（B）1〜100重量份的由以下通式（I）表示的氨基烷基烷氧基硅烷化合物：其中R 1表示氨基或H 2 N-R 5 -NH-基团 R2和R5各自表示具有1至2个碳原子的多亚甲基或具有3至5个碳原子的直链或支链亚烷基（烷二基），并且可以相同或不同; R3表示碳原子数1〜5的直链或支链烷基; m表示2或3; R4表示碳原子数为1〜5的直链或支链烷基或R1-R2-基团; p表示0或1，m + p = 3，使用该组合物，载体和记录层彼此紧密粘合。

57. 发明申请

US20060205088A1 Agglutination Assay Method in Porous Medium Layer 审中-公开
标题翻译：多孔介质层中凝集测定法
公开(公告)号：US20060205088A1
公开(公告)日：2006-09-14
申请号：US11420147
申请日：2006-05-24
申请人： Kentaro Nakamura , Kazuya Kawasaki , Osamu Seshimoto , Masahito Nagata , Toru Tanaka
发明人： Kentaro Nakamura , Kazuya Kawasaki , Osamu Seshimoto , Masahito Nagata , Toru Tanaka
IPC分类号： G01N33/558
CPC分类号： G01N33/54346 , G01N33/525 , G01N33/587
摘要： An agglutination assay method for quantitatively determination of an analyte in an aqueous liquid sample using particles bearing an anti-analyte. The agglutination is conducted in the porous medium layer of the analysis element A speedy quantitative analysis of the analyte can be conveniently attained with high sensitivity. When the particle-labeled anti-analyte is contained in the porous medium layer, the anti-analyte can be stored with higher stability in the dry state A dry analysis element for enabling such analysis method is also provided.
摘要翻译：一种用于使用带有抗分析物的颗粒定量测定含水液体样品中的分析物的凝集测定方法。凝集在分析元件的多孔介质层中进行。分析物的快速定量分析可以方便地以高灵敏度获得。当颗粒标记的抗分析物包含在多孔介质层中时，抗分析物可以在干燥状态下以更高的稳定性储存。还提供了用于实现这种分析方法的干燥分析元件。

58. 发明授权

US07059480B2 Continuous blood filtration apparatus 失效
标题翻译：连续血液过滤装置
公开(公告)号：US07059480B2
公开(公告)日：2006-06-13
申请号：US10674445
申请日：2003-09-30
申请人： Osamu Seshimoto , Kenichiro Yazawa
发明人： Osamu Seshimoto , Kenichiro Yazawa
IPC分类号： B01F33/333
CPC分类号： B01L3/0275 , B01L2300/0681 , G01N33/491 , G01N35/10 , G01N2035/00475 , G01N2035/0441 , G01N2035/1053
摘要： This invention provides a continuous blood filtration apparatus capable of filtering a plurality of blood samples continuous by using blood filter units to prepare plasma or serum samples in a short period, which comprises, a conveyor conveying a plurality of blood reservoirs each of which contains a blood sample and in which a suction nozzle of a blood filter unit has been put, a manifold connected to a suction line, couples of a valve and a connector for connecting the manifold to the blood filter unit provided on the end of each branch of the manifold, and a mechanism of moving the blood reservoirs in vertical direction.
摘要翻译：本发明提供一种连续血液过滤装置，其能够通过使用血液过滤器单元在短时间内过滤多个血液样本以制备血浆或血清样品，其包括：输送器，其输送多个血液储存器，每个血液储存器包含血液样品，并且其中已经放置了血液过滤器单元的吸嘴，连接到吸入管路的歧管，将阀和连接器连接以将歧管连接到设置在歧管的每个分支端部上的血液过滤器单元，以及使血液储存器沿垂直方向移动的机构。

59. 发明申请

US20050186109A1 Multilayer analysis element 审中-公开
标题翻译：多层分析单元
公开(公告)号：US20050186109A1
公开(公告)日：2005-08-25
申请号：US11060775
申请日：2005-02-18
申请人： Kentaro Nakamura , Kazuya Kawasaki , Yoshiki Sakaino , Toshihisa Ito , Osamu Seshimoto
发明人： Kentaro Nakamura , Kazuya Kawasaki , Yoshiki Sakaino , Toshihisa Ito , Osamu Seshimoto
IPC分类号： G01N31/22
CPC分类号： G01N31/22
摘要： An object of the invention to provide a multilayer analysis element with small intra-lot and lot-to-lot differences that has high measurement accuracy and which is small in size. The present invention provides a multilayer analysis element for the analysis of a liquid sample, comprising a water impermeable planar support on one side of which at least one functional layer and at least one porous liquid sample spreading layer of non-fibrous porous film are integrally laminated in the mentioned order, wherein the arithmetic mean deviation of the profile (Ra) of a contact surface of the at least one functional layer that is in contact with said porous liquid sample spreading layer of said non-fibrous porous film is 1 μm or less and/or the ten-point height of irregularities (Rz) of said contact surface is 8 μm or less.
摘要翻译：本发明的目的是提供一种具有很高的测量精度并且尺寸小的多批次间差异小的多层分析元件。本发明提供了一种用于分析液体样品的多层分析元件，其包括不透水平面支撑体，其一侧上至少一个功能层和至少一个非纤维多孔膜的多孔液体样品铺展层整体层压其中与所述非纤维多孔膜的所述多孔液体样品扩散层接触的所述至少一个功能层的接触表面的轮廓（Ra）的算术平均偏差为1μm以下和/或所述接触表面的十点高度的不规则（Rz）为8μm或更小。

60. 发明申请

US20050084953A1 Immunoassay element 审中-公开
标题翻译：免疫测定元件
公开(公告)号：US20050084953A1
公开(公告)日：2005-04-21
申请号：US10961459
申请日：2004-10-07
申请人： Yoshiki Sakaino , Hitomi Ito , Toshihiro Mori , Osamu Seshimoto , Toshihisa Ito , Yoshikazu Amano
发明人： Yoshiki Sakaino , Hitomi Ito , Toshihiro Mori , Osamu Seshimoto , Toshihisa Ito , Yoshikazu Amano
IPC分类号： G01N33/543 , G01N33/53
CPC分类号： G01N33/54386 , G01N2333/924 , Y10S435/966 , Y10S435/969 , Y10S435/97 , Y10S436/807 , Y10S436/81
摘要： The immunoassay element for quantitatively analyzing an antigen by determining the change in enzymatic activity of an enzyme-labelled antigen or antibody caused by an immunological reaction. The immunoassay element comprises a substrate layer containing a non-diffusible substrate which forms a diffusible material in the presence of the labelling enzyme, and a reagent layer containing a fragmenting enzyme for further fragmenting the diffusible material into a lower molecular weight product. As the non-diffusible substrate, a substrate capable of reacting solely with the lebelling enzyme and incapable of reacting the fragmenting enzyme is utilized. When an endo-active glucosidase is used as the labelling enzyme, and an exo-active glucosidase is used the fragmenting enzyme in the reagent layer, the non-diffusible substrate of the substrate layer is preferred to be an endo type selectively reactive substrate, which means a substrate having a reactivity specific to endo-active glucosidase. Highly sensitive assay is realized with high accuracy and high reproducibility and good storage stability.
摘要翻译：用于通过确定由免疫反应引起的酶标记的抗原或抗体的酶活性的变化来定量分析抗原的免疫测定元件。免疫测定元件包括含有在标记酶存在下形成可扩散材料的不扩散基底的底物层和含有用于进一步将可扩散材料分解成较低分子量产物的碎裂酶的试剂层。作为非扩散性底物，可以使用能够仅与前体酶反应并且不能使片段化酶反应的底物。当使用内源活性葡糖苷酶作为标记酶，并且使用外源活性葡糖苷酶时，试剂层中的断裂酶，底物层的非扩散性基质优选为内型选择性反应性底物，其中是指具有对内源性葡糖苷酶特异性的反应性的底物。高精度，高重现性和良好的储存稳定性实现了高灵敏度测定。

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