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51. 发明授权

US06687745B1 System and method for delivering a graphical user interface of remote applications over a thin bandwidth connection 有权
标题翻译：通过薄带宽连接传送远程应用程序的图形用户界面的系统和方法
公开(公告)号：US06687745B1
公开(公告)日：2004-02-03
申请号：US09599382
申请日：2000-06-22
申请人： Louis M. Franco , Frank Leon Rose , Philip S. J. Brittan , Mark Cunningham , Alex Bulkin , Mat Baskin , Greg Blonder
发明人： Louis M. Franco , Frank Leon Rose , Philip S. J. Brittan , Mark Cunningham , Alex Bulkin , Mat Baskin , Greg Blonder
IPC分类号： G06F1516
CPC分类号： H04L67/42 , G06F8/60 , G06F9/54 , H04L29/06 , H04L51/06 , H04L67/025 , H04L67/14 , H04L67/34 , H04L67/36 , H04L69/329
摘要： A method and system are disclosed for delivering interactive links for presenting applications and second information at a client computer from remote sources in a network-configured computer processing system. In one embodiment, the method includes retrieving over a first communication connection, in response to a request of a client computer, informational content having computer program code embedded therein, and executing the embedded computer program code for establishing a second communication connection to an application server. The method further includes retrieving over the second communication connection first information including presentational information for presenting the application and the second information. The method also includes presenting the application and the second information based upon the presentational information, and storing on the client computer an interactive link for selectively re-establishing the second communication connection to the application server for retrieving the first information and presenting the application and the second information on an as-needed basis. Preferably, the storing of the interactive link includes downloading a graphical representation of the interactive link and storing a file containing information representing an operating environment of the client computer and a network address of the application server.
摘要翻译：公开了一种方法和系统，用于在网络配置的计算机处理系统中从远程源提供用于在客户端计算机上呈现应用和第二信息的交互式链接。在一个实施例中，该方法包括响应于客户端计算机的请求检索第一通信连接，其中嵌入有计算机程序代码的信息内容，以及执行用于建立到应用服务器的第二通信连接的嵌入式计算机程序代码。该方法还包括通过第二通信连接检索第一信息，包括用于呈现应用程序的显示信息和第二信息。该方法还包括基于该展示信息呈现应用程序和第二信息，并在客户端计算机上存储交互式链接，用于选择性地重新建立到应用服务器的第二通信连接，用于检索第一信息并呈现应用程序和根据需要提供第二个信息。优选地，交互式链接的存储包括下载交互式链接的图形表示，并且存储包含表示客户端计算机的操作环境的信息的文件和应用服务器的网络地址。

52. 发明授权

US06458565B1 Method for producing a heterologous secreted protein from chinese hamster ovary cells grown on microcarriers 失效
标题翻译：从微载体上生长的中国仓鼠卵巢细胞产生异源分泌蛋白的方法
公开(公告)号：US06458565B1
公开(公告)日：2002-10-01
申请号：US09654353
申请日：2000-09-01
申请人： Mark Cunningham , Tom Iley
发明人： Mark Cunningham , Tom Iley
IPC分类号： C12P2104
CPC分类号： C12N5/0075 , C07K14/7156 , C12N2500/25 , C12N2500/90 , C12N2510/02 , C12N2531/00
摘要： The present invention relates to a method for producing a heterologous secreted protein from transformed CHO cells grown on microcarriers in a serum-free cell culture medium. This method avoids a production lag phase when switching from a serum-containing to a serum-free environment, a problem observed in the mammalian adherent cell culture production of secreted proteins.
摘要翻译：本发明涉及在无血清细胞培养基中在微载体上生长的转化CHO细胞产生异源分泌蛋白的方法。这种方法避免了从含血清转化为无血清环境时的生产滞后期，这是在分泌蛋白质的哺乳动物贴壁细胞培养产生中观察到的问题。

53. 发明授权

US06372207B1 IFNAR2/IFN complex 有权
标题翻译： IFNAR2 / IFN复合物
公开(公告)号：US06372207B1
公开(公告)日：2002-04-16
申请号：US09215212
申请日：1998-12-18
申请人： Mark Tepper , Mark Cunningham , David Sherris , Nabil El Tayar , Sean McKenna
发明人： Mark Tepper , Mark Cunningham , David Sherris , Nabil El Tayar , Sean McKenna
IPC分类号： A61K3821
CPC分类号： A61K38/21 , C07K14/56 , C07K14/565 , C07K14/715 , C07K2319/00
摘要： The in vivo effect of Type I interferon (IFN) can be prolonged by administering the interferon in the form of a complex with an IFN binding chain of the human interferon &agr;/&bgr; receptor (IFNAR). Such a complex also improves the stability of the IFN and enhances the potency of the IFN. The complex may be a non-covalent complex or one in which the IFN and the IFNAR are bound by a covalent bond or a peptide. When bound by a peptide bond in the form of a fusion protein, the IFN may be separated from the IFNAR by means of a peptide linker. Such a fusion protein may be produced by recombinant DNA technology. Storing IFN in the form of such a complex improves the storage life of the IFN and permits storage under milder conditions than would otherwise be possible.
摘要翻译： I型干扰素（IFN）的体内效应可以通过以与人类干扰素α/β受体（IFNAR）的IFN结合链的复合物的形式施用干扰素来延长。这样的复合物还可以改善IFN的稳定性并提高IFN的效力。复合物可以是非共价复合物或其中IFN和IFNAR通过共价键或肽结合的复合物。当以融合蛋白形式的肽键结合时，IFN可以通过肽接头与IFNAR分离。这种融合蛋白可以通过重组DNA技术产生。以这种复合物的形式存储IFN可改善IFN的储存期，并允许在比其它条件下更温和的条件下储存。

54. 发明授权

US08618264B2 Anti-CD147 antibodies, methods and uses 失效
标题翻译：抗CD147抗体，方法和用途
公开(公告)号：US08618264B2
公开(公告)日：2013-12-31
申请号：US13062702
申请日：2009-08-19
申请人： Mark Cunningham , Bethany Swencki-Underwood , Yi Tang , Li Yan
发明人： Mark Cunningham , Bethany Swencki-Underwood , Yi Tang , Li Yan
IPC分类号： C07K16/30
CPC分类号： C07K16/2803 , A61K2039/505 , A61K2039/507 , C07K14/70503 , C07K2317/34 , C07K2317/56 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C07K2319/32
摘要： The present invention provides antibodies immunospecific for human CD147 capable of blocking bioactivity of CD147 associated with malignant disease such as the stimulation of MMPs from fibroblast cells by tumor cells, the release of VEGF, and the promotion of angiogenesis. The antibodies of the present invention of are useful in treating malignant disease and those diseases in which CD147 activity is plays a pathogenic role, such as diseases of the eye, lung, and cardiovascular system.
摘要翻译：本发明提供能够阻断与恶性疾病相关的CD147的生物活性的人CD147的抗体，例如肿瘤细胞刺激来自成纤维细胞的MMPs，VEGF的释放和促进血管发生。本发明的抗体可用于治疗恶性疾病和其中CD147活性发挥致病作用的疾病，例如眼睛，肺和心血管系统的疾病。

55. 发明授权

US07807471B2 IL-23p40 specific immunoglobulin derived proteins, compositions, epitopes, methods and uses 有权
标题翻译： IL-23p40特异性免疫球蛋白衍生的蛋白质，组合物，表位，方法和用途
公开(公告)号：US07807471B2
公开(公告)日：2010-10-05
申请号：US11768582
申请日：2007-06-26
申请人： Jacqueline Benson , Mark Cunningham , Jeffrey (Sinquan) Luo
发明人： Jacqueline Benson , Mark Cunningham , Jeffrey (Sinquan) Luo
IPC分类号： G01N33/00 , G01N33/50 , C12P21/06 , C12P21/00
CPC分类号： C07K16/244 , C07K2317/34 , G01N33/6869
摘要： An anti-IL-23 specific human Ig derived protein, isolated nucleic acids that encode at least one anti-IL-23 Ig derived protein, vectors, host cells, transgenic animals or plants, and methods of making and using thereof are useful as therapeutic and diagnostic compositions, methods and devices. The anti-IL-23 Ig derived protein preferably binds to one or more of the Seg 1, Seg 2, and Seg 3 epitopes of the p40 subunit of IL-23.
摘要翻译：编码至少一种抗IL-23Ig衍生蛋白，载体，宿主细胞，转基因动物或植物的抗IL-23特异性人Ig衍生蛋白，分离的核酸及其制备和使用方法可用作治疗和诊断组合物，方法和装置。抗IL-23Ig衍生的蛋白质优选与IL-23的p40亚基的Seg1，Seg2和Seg3表位的一个或多个表位结合。

56. 发明授权

US07502838B2 System and method for delivering remotely stored applications and information 有权
标题翻译：提供远程存储的应用程序和信息的系统和方法
公开(公告)号：US07502838B2
公开(公告)日：2009-03-10
申请号：US10720728
申请日：2003-11-24
申请人： Louis M. Franco , Frank Leon Rose , Philip S. J. Brittan , Mark Cunningham , Alex Bulkin , Mat Baskin , Greg Blonder
发明人： Louis M. Franco , Frank Leon Rose , Philip S. J. Brittan , Mark Cunningham , Alex Bulkin , Mat Baskin , Greg Blonder
IPC分类号： G06F15/16
CPC分类号： H04L67/42 , G06F8/60 , G06F9/54 , H04L29/06 , H04L51/06 , H04L67/025 , H04L67/14 , H04L67/34 , H04L67/36 , H04L69/329
摘要： A method and system are disclosed for delivering interactive links for presenting applications and second information at a client computer from remote sources in a network-configured computer processing system. In one embodiment, the method includes retrieving over a first communication connection, in response to a request of a client computer, informational content having computer program code embedded therein, and executing the embedded computer program code for establishing a second communication connection to an application server. The method further includes retrieving over the second communication connection first information including presentational information for presenting the application and the second information. The method also includes presenting the application and the second information based upon the presentational information, and storing on the client computer an interactive link for selectively re-establishing the second communication connection to the application server for retrieving the first information and presenting the application and the second information on an as-needed basis. Preferably, the storing of the interactive link includes downloading a graphical representation of the interactive link and storing a file containing information representing an operating environment of the client computer and a network address of the application server.
摘要翻译：公开了一种方法和系统，用于在网络配置的计算机处理系统中从远程源提供用于在客户端计算机上呈现应用和第二信息的交互式链接。在一个实施例中，该方法包括响应于客户端计算机的请求检索第一通信连接，其中嵌入有计算机程序代码的信息内容，以及执行用于建立到应用服务器的第二通信连接的嵌入式计算机程序代码。该方法还包括通过第二通信连接检索第一信息，包括用于呈现应用程序的显示信息和第二信息。该方法还包括基于该展示信息呈现应用程序和第二信息，并在客户端计算机上存储交互式链接，用于选择性地重新建立到应用服务器的第二通信连接，用于检索第一信息并呈现应用程序和根据需要提供第二个信息。优选地，交互式链接的存储包括下载交互式链接的图形表示，并且存储包含表示客户端计算机的操作环境的信息的文件和应用服务器的网络地址。

57. 发明申请

US20050137385A1 IL-23p40 specific immunoglobulin derived proteins, compositions, methods and uses 有权
标题翻译： IL-23p40特异性免疫球蛋白衍生的蛋白质，组合物，方法和用途
公开(公告)号：US20050137385A1
公开(公告)日：2005-06-23
申请号：US10840789
申请日：2004-05-06
申请人： Jacqueline Benson , Mark Cunningham
发明人： Jacqueline Benson , Mark Cunningham
IPC分类号： C07H21/04 , C07K16/24 , C12N20060101 , C12N5/06 , C12N5/16
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/74 , C07K2317/76
摘要： Novel anti-IL-23p40 specific human Ig derived proteins, including, without limitation, antibodies, fusion proteins, and mimetibodies, isolated nucleic acids that encode the anti-IL-23p40 Ig derived proteins, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, are useful for therapeutic compositions, methods and devices. Preferably, the anti-IL-23p40 specific human Ig derived proteins do not bind the p40 subunit of IL-12 and, thus, do not neutralize IL-12-related activity.
摘要翻译：新型抗IL-23p40特异性人Ig衍生蛋白，包括但不限于抗体，融合蛋白和模拟抗体，编码抗IL-23p40Ig衍生蛋白质的分离的核酸，载体，宿主细胞，转基因动物或植物，及其制备和使用方法可用于治疗组合物，方法和装置。优选地，抗IL-23p40特异性人Ig衍生的蛋白质不结合IL-12的p40亚基，因此不中和IL-12相关活性。

58. 发明授权

US08626829B2 System and method for delivering remotely stored applications and information 有权
标题翻译：提供远程存储的应用程序和信息的系统和方法
公开(公告)号：US08626829B2
公开(公告)日：2014-01-07
申请号：US13606197
申请日：2012-09-07
申请人： Louis M. Franco , Frank Leon Rose , Philip S. J. Brittan , Mark Cunningham , Alex Bulkin , Mat Baskin , Greg Blonder
发明人： Louis M. Franco , Frank Leon Rose , Philip S. J. Brittan , Mark Cunningham , Alex Bulkin , Mat Baskin , Greg Blonder
IPC分类号： G06F15/16
CPC分类号： H04L67/42 , G06F8/60 , G06F9/54 , H04L29/06 , H04L51/06 , H04L67/025 , H04L67/14 , H04L67/34 , H04L67/36 , H04L69/329
摘要： The computerized method and apparatus for mobile device interactivity includes hosting a network application on a server. The method and apparatus further includes receiving, at the network application on the server, an event message from a mobile application executing on a mobile device, the mobile application having executable code embedded therein for communicating with the network information for presenting a user interface for the network application on the mobile device, the event message reporting an action taken via the user interface. The method and apparatus further including executing application logic within the network application to generate data values based on the action reported in the event message and mobile device information and sending to the mobile device an update message with at least some of the generated data values and instructions for use by the executable code to present the data values within the user interface at the mobile device.
摘要翻译：用于移动设备交互的计算机化方法和装置包括在服务器上托管网络应用。该方法和装置还包括在服务器上的网络应用程序处接收来自在移动设备上执行的移动应用程序的事件消息，该移动应用程序具有嵌入其中的可执行代码，用于与网络信息进行通信，以呈现用于移动设备上的网络应用程序，事件消息报告通过用户界面执行的操作。所述方法和装置还包括在网络应用程序内执行应用逻辑，以基于在事件消息和移动设备信息中报告的动作来产生数据值，并向移动设备发送具有至少一些生成的数据值和指令的更新消息由可执行代码用于在移动设备处呈现用户界面内的数据值。

59. 发明授权

US08589483B2 System and method for delivering remotely stored applications and information 有权
公开(公告)号：US08589483B2
公开(公告)日：2013-11-19
申请号：US13606197
申请日：2012-09-07
申请人： Louis M. Franco , Frank Leon Rose , Philip S. J. Brittan , Mark Cunningham , Alex Bulkin , Mat Baskin , Greg Blonder
发明人： Louis M. Franco , Frank Leon Rose , Philip S. J. Brittan , Mark Cunningham , Alex Bulkin , Mat Baskin , Greg Blonder
IPC分类号： G06F15/16
摘要： The computerized method and apparatus for mobile device interactivity includes hosting a network application on a server. The method and apparatus further includes receiving, at the network application on the server, an event message from a mobile application executing on a mobile device, the mobile application having executable code embedded therein for communicating with the network information for presenting a user interface for the network application on the mobile device, the event message reporting an action taken via the user interface. The method and apparatus further including executing application logic within the network application to generate data values based on the action reported in the event message and mobile device information and sending to the mobile device an update message with at least some of the generated data values and instructions for use by the executable code to present the data values within the user interface at the mobile device.

60. 发明申请

US20130024499A1 SYSTEM AND METHOD FOR DELIVERING REMOTELY STORED APPLICATIONS AND INFORMATION 有权
标题翻译：用于传送远程存储应用程序和信息的系统和方法
公开(公告)号：US20130024499A1
公开(公告)日：2013-01-24
申请号：US13606197
申请日：2012-09-07
申请人： Louis M. Franco , Frank Leon Rose , Philip S. J. Brittan , Mark Cunningham , Alex Bulkin , Mat Baskin , Greg Blonder
发明人： Louis M. Franco , Frank Leon Rose , Philip S. J. Brittan , Mark Cunningham , Alex Bulkin , Mat Baskin , Greg Blonder
IPC分类号： G06F15/16
CPC分类号： H04L67/42 , G06F8/60 , G06F9/54 , H04L29/06 , H04L51/06 , H04L67/025 , H04L67/14 , H04L67/34 , H04L67/36 , H04L69/329
摘要： The computerized method and apparatus for mobile device interactivity includes hosting a network application on a server. The method and apparatus further includes receiving, at the application on the server, an event message from a mobile application executing on a mobile device, the application having executable code embedded therein for communicating with the network information for presenting a user interface for the network application on the mobile device, the event message reporting an action taken via the user interface. The method and apparatus further including executing application logic within the network application to generate data values based on the action reported in the event message and mobile device information and sending to the mobile device an update message with at least some of the generated data values and instructions for use by the executable code to present the data values within the user interface at the mobile device.
摘要翻译：用于移动设备交互的计算机化方法和装置包括在服务器上托管网络应用。所述方法和装置还包括在服务器上的应用程序处接收来自在移动设备上执行的移动应用程序的事件消息，所述应用程序具有嵌入其中的可执行代码，用于与网络信息进行通信，以呈现网络应用程序的用户界面在移动设备上，事件消息报告通过用户界面进行的动作。所述方法和装置还包括在网络应用程序内执行应用逻辑，以基于在事件消息和移动设备信息中报告的动作来产生数据值，并向移动设备发送具有至少一些生成的数据值和指令的更新消息由可执行代码用于在移动设备处呈现用户界面内的数据值。

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