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1. 发明授权

US06372207B1 IFNAR2/IFN complex 有权
标题翻译： IFNAR2 / IFN复合物
公开(公告)号：US06372207B1
公开(公告)日：2002-04-16
申请号：US09215212
申请日：1998-12-18
申请人： Mark Tepper , Mark Cunningham , David Sherris , Nabil El Tayar , Sean McKenna
发明人： Mark Tepper , Mark Cunningham , David Sherris , Nabil El Tayar , Sean McKenna
IPC分类号： A61K3821
CPC分类号： A61K38/21 , C07K14/56 , C07K14/565 , C07K14/715 , C07K2319/00
摘要： The in vivo effect of Type I interferon (IFN) can be prolonged by administering the interferon in the form of a complex with an IFN binding chain of the human interferon &agr;/&bgr; receptor (IFNAR). Such a complex also improves the stability of the IFN and enhances the potency of the IFN. The complex may be a non-covalent complex or one in which the IFN and the IFNAR are bound by a covalent bond or a peptide. When bound by a peptide bond in the form of a fusion protein, the IFN may be separated from the IFNAR by means of a peptide linker. Such a fusion protein may be produced by recombinant DNA technology. Storing IFN in the form of such a complex improves the storage life of the IFN and permits storage under milder conditions than would otherwise be possible.
摘要翻译： I型干扰素（IFN）的体内效应可以通过以与人类干扰素α/β受体（IFNAR）的IFN结合链的复合物的形式施用干扰素来延长。这样的复合物还可以改善IFN的稳定性并提高IFN的效力。复合物可以是非共价复合物或其中IFN和IFNAR通过共价键或肽结合的复合物。当以融合蛋白形式的肽键结合时，IFN可以通过肽接头与IFNAR分离。这种融合蛋白可以通过重组DNA技术产生。以这种复合物的形式存储IFN可改善IFN的储存期，并允许在比其它条件下更温和的条件下储存。

2. 发明授权

US06337316B1 Pharmaceutical compositions thereof, and methods of using same 失效
标题翻译：其药物组合物及其使用方法
公开(公告)号：US06337316B1
公开(公告)日：2002-01-08
申请号：US09460384
申请日：1999-12-13
申请人： Nabil El Tayar , Steven Blechner , Brad Jameson , Mark Tepper
发明人： Nabil El Tayar , Steven Blechner , Brad Jameson , Mark Tepper
IPC分类号： A61K3810
CPC分类号： C07K14/70521 , A61K38/00
摘要： The present invention relates to peptidomimetics capable of inhibiting CD28 and/or CTLA-4 interaction with CD80 (B7-1) and CD86 (B7-2) and having a core amino acid sequence, LeuMetTyrProProProTyrTyr, corresponding to residues 2 to 9 of SEQ ID NO:1. The present invention also relates to pharmaceutical compositions and a method of treating pathologies and disorders which are improved by inhibition of CD28 and/or CTLA-4 interaction with CD80 and CD86.
摘要翻译：本发明涉及能够抑制与CD80（B7-1）和CD86（B7-2）的CD28和/或CTLA-4相互作用并具有核苷酸序列LeuMetTyrProProProTyrTyr的肽模拟物，LeuMetTyrProProProTyrTyr对应于SEQ ID NO：2的残基2至9 NO：1。本发明还涉及通过抑制与CD80和CD86的CD28和/或CTLA-4相互作用而改善的药物组合物和治疗病症和病症的方法。

3. 发明授权

US07507707B2 Methods of inducing ovulation using a non-polypeptide camp level modulator 有权
标题翻译：使用非多肽血浆调节剂诱导排卵的方法
公开(公告)号：US07507707B2
公开(公告)日：2009-03-24
申请号：US10498639
申请日：2001-12-14
申请人： Stephen Palmer , Mark Tepper , Sean McKenna , Michael C. MacNamee , Aliza Eshkol
发明人： Stephen Palmer , Mark Tepper , Sean McKenna , Michael C. MacNamee , Aliza Eshkol
IPC分类号： A61K31/00
CPC分类号： A61K31/437 , A61K31/00 , A61K31/138 , A61K31/277 , A61K31/352 , A61K31/4196 , A61K31/44 , A61K31/4535 , A61K31/502 , A61K31/519 , A61K31/522 , A61K38/24 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to female host. In another aspect, the invention provides for specific administration of the phosphodiesterase inhibitor prior to the luteal phase of the host's ovulatory cycle. Preferred non-polypeptide cAMP level modulator include phosphodiesterase inhibitors, particularly inhibitors of phosphodiesterase 4 isoforms.
摘要翻译：本发明涉及在雌性宿主中诱导排卵的方法，包括向雌性宿主施用非多肽环状腺苷一磷酸（cAMP）水平调节剂。另一方面，本发明提供在宿主排卵周期的黄体期之前特异性施用磷酸二酯酶抑制剂。优选的非多肽cAMP水平调节剂包括磷酸二酯酶抑制剂，特别是磷酸二酯酶4同种型的抑制剂。

4. 发明申请

US20080293622A1 METHODS OF INDUCING OVULATION 有权
标题翻译：诱导卵泡的方法
公开(公告)号：US20080293622A1
公开(公告)日：2008-11-27
申请号：US12106882
申请日：2008-04-21
申请人： Stephen Palmer , Sean McKenna , Mark Tepper , Aliza Eshkol , Michael C. Macnamee
发明人： Stephen Palmer , Sean McKenna , Mark Tepper , Aliza Eshkol , Michael C. Macnamee
IPC分类号： A61K38/24 , A61K31/4196 , A61P15/00
CPC分类号： A61K38/24 , A61K31/275 , A61K31/44 , A61K31/501 , A61K31/519 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to the female host. In another aspect, the invention provides for specific administration of the phosphodiesterase inhibitor prior to the luteal phase of the host's ovulatory cycle. Preferred non-polypeptide cAMP level modulators include phosphodiesterase inhibitors, particularly inhibitors of phosphodiesterase 4 isoforms.
摘要翻译：本发明涉及在雌性宿主中诱导排卵的方法，包括向雌性宿主施用非多肽环状腺苷一磷酸（cAMP）水平调节剂。另一方面，本发明提供在宿主排卵周期的黄体期之前特异性施用磷酸二酯酶抑制剂。优选的非多肽cAMP水平调节剂包括磷酸二酯酶抑制剂，特别是磷酸二酯酶4同种型的抑制剂。

5. 发明授权

US07078236B2 Methods of inducing ovulation 失效
标题翻译：诱导排卵的方法
公开(公告)号：US07078236B2
公开(公告)日：2006-07-18
申请号：US11169183
申请日：2005-06-28
申请人： Stephen Palmer , Sean McKenna , Mark Tepper , Aliza Eshkol , Michael C. MacNamee
发明人： Stephen Palmer , Sean McKenna , Mark Tepper , Aliza Eshkol , Michael C. MacNamee
IPC分类号： A61K38/24 , C12N15/15
CPC分类号： A61K38/24 , A61K31/275 , A61K31/44 , A61K31/501 , A61K31/519 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to the female host. In another aspect, the invention provides for specific administration of the phosphodiesterase inhibitor prior to the luteal phase of the host's ovulatory cycle. Preferred non-polypeptide cAMP level modulators include phosphodiesterase inhibitors, particularly inhibitors of phosphodiesterase 4 isoforms.
摘要翻译：本发明涉及在雌性宿主中诱导排卵的方法，包括向雌性宿主施用非多肽环状腺苷一磷酸（cAMP）水平调节剂。另一方面，本发明提供在宿主排卵周期的黄体期之前特异性施用磷酸二酯酶抑制剂。优选的非多肽cAMP水平调节剂包括磷酸二酯酶抑制剂，特别是磷酸二酯酶4同种型的抑制剂。

6. 发明授权

US06953774B2 Methods of inducing ovulation 失效
标题翻译：诱导排卵的方法
公开(公告)号：US06953774B2
公开(公告)日：2005-10-11
申请号：US10014812
申请日：2001-12-14
申请人： Stephen Palmer , Sean McKenna , Mark Tepper , Aliza Eshkol , Michael C. MacNamee
发明人： Stephen Palmer , Sean McKenna , Mark Tepper , Aliza Eshkol , Michael C. MacNamee
IPC分类号： A61K31/00 , A61K31/137 , A61K38/24
CPC分类号： A61K38/24 , A61K31/275 , A61K31/44 , A61K31/501 , A61K31/519 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to the female host. In another aspect, the invention provides for specific administration of the phosphodiesterase inhibitor prior to the luteal phase of the host's ovulatory cycle. Preferred non-polypeptide cAMP level modulator include phosphodiesterase inhibitors, particularly inhibitors of phosphodiesterase type 4.
摘要翻译：本发明涉及在雌性宿主中诱导排卵的方法，包括向雌性宿主施用非多肽环状腺苷一磷酸（cAMP）水平调节剂。另一方面，本发明提供在宿主排卵周期的黄体期之前特异性施用磷酸二酯酶抑制剂。优选的非多肽cAMP水平调节剂包括磷酸二酯酶抑制剂，特别是4型磷酸二酯酶抑制剂。

7. 发明授权

US07364910B2 Methods of inducing ovulation 失效
标题翻译：诱导排卵的方法
公开(公告)号：US07364910B2
公开(公告)日：2008-04-29
申请号：US11456033
申请日：2006-07-06
申请人： Stephen Palmer , Sean McKenna , Mark Tepper , Aliza Eshkol , Michael C. MacNamee
发明人： Stephen Palmer , Sean McKenna , Mark Tepper , Aliza Eshkol , Michael C. MacNamee
IPC分类号： A61K38/24 , C12N15/15 , A61K38/00
CPC分类号： A61K38/24 , A61K31/275 , A61K31/44 , A61K31/501 , A61K31/519 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to the female host. In another aspect, the invention provides for specific administration of the phosphodiesterase inhibitor prior to the luteal phase of the host's ovulatory cycle. Preferred non-polypeptide cAMP level modulators include phosphodiesterase inhibitors, particularly inhibitors of phosphodiesterase 4 isoforms.
摘要翻译：本发明涉及在雌性宿主中诱导排卵的方法，包括向雌性宿主施用非多肽环状腺苷一磷酸（cAMP）水平调节剂。另一方面，本发明提供在宿主排卵周期的黄体期之前特异性施用磷酸二酯酶抑制剂。优选的非多肽cAMP水平调节剂包括磷酸二酯酶抑制剂，特别是磷酸二酯酶4同种型的抑制剂。

8. 发明申请

US20060293222A1 METHODS OF INDUCING OVULATION 失效
标题翻译：诱导卵泡的方法
公开(公告)号：US20060293222A1
公开(公告)日：2006-12-28
申请号：US11456033
申请日：2006-07-06
申请人： Stephen Palmer , Sean McKenna , Mark Tepper , Aliza Eshkol , Michael MacNamee
发明人： Stephen Palmer , Sean McKenna , Mark Tepper , Aliza Eshkol , Michael MacNamee
IPC分类号： A61K38/24
CPC分类号： A61K38/24 , A61K31/275 , A61K31/44 , A61K31/501 , A61K31/519 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to the female host. In another aspect, the invention provides for specific administration of the phosphodiesterase inhibitor prior to the luteal phase of the host's ovulatory cycle. Preferred non-polypeptide cAMP level modulators include phosphodiesterase inhibitors, particularly inhibitors of phosphodiesterase 4 isoforms.
摘要翻译：本发明涉及在雌性宿主中诱导排卵的方法，包括向雌性宿主施用非多肽环状腺苷一磷酸（cAMP）水平调节剂。另一方面，本发明提供在宿主排卵周期的黄体期之前特异性施用磷酸二酯酶抑制剂。优选的非多肽cAMP水平调节剂包括磷酸二酯酶抑制剂，特别是磷酸二酯酶4同种型的抑制剂。

9. 发明申请

US20060003925A1 Methods of inducing ovulation 失效
公开(公告)号：US20060003925A1
公开(公告)日：2006-01-05
申请号：US11169183
申请日：2005-06-28
申请人： Stephen Palmer , Sean McKenna , Mark Tepper , Aliza Eshkol , Michael MacNamee
发明人： Stephen Palmer , Sean McKenna , Mark Tepper , Aliza Eshkol , Michael MacNamee
IPC分类号： A61K38/24
CPC分类号： A61K38/24 , A61K31/275 , A61K31/44 , A61K31/501 , A61K31/519 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to the female host. In another aspect, the invention provides for specific administration of the phosphodiesterase inhibitor prior to the luteal phase of the host's ovulatory cycle. Preferred non-polypeptide cAMP level modulators include phosphodiesterase inhibitors, particularly inhibitors of phosphodiesterase 4 isoforms.

10. 发明授权

US07803760B2 Methods of inducing ovulation 有权
标题翻译：诱导排卵的方法
公开(公告)号：US07803760B2
公开(公告)日：2010-09-28
申请号：US12106882
申请日：2008-04-21
申请人： Stephen Palmer , Sean McKenna , Mark Tepper , Aliza Eshkol , Michael C. MacNamee
发明人： Stephen Palmer , Sean McKenna , Mark Tepper , Aliza Eshkol , Michael C. MacNamee
IPC分类号： A61K31/00 , A61K38/43 , A61K38/00
CPC分类号： A61K38/24 , A61K31/275 , A61K31/44 , A61K31/501 , A61K31/519 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to the female host. In another aspect, the invention provides for specific administration of the phosphodiesterase inhibitor prior to the luteal phase of the host's ovulatory cycle. Preferred non-polypeptide cAMP level modulators include phosphodiesterase inhibitors, particularly inhibitors of phosphodiesterase 4 isoforms.
摘要翻译：本发明涉及在雌性宿主中诱导排卵的方法，包括向雌性宿主施用非多肽环状腺苷一磷酸（cAMP）水平调节剂。另一方面，本发明提供在宿主排卵周期的黄体期之前特异性施用磷酸二酯酶抑制剂。优选的非多肽cAMP水平调节剂包括磷酸二酯酶抑制剂，特别是磷酸二酯酶4同种型的抑制剂。

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