专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08618264B2 Anti-CD147 antibodies, methods and uses 失效
标题翻译：抗CD147抗体，方法和用途
公开(公告)号：US08618264B2
公开(公告)日：2013-12-31
申请号：US13062702
申请日：2009-08-19
申请人： Mark Cunningham , Bethany Swencki-Underwood , Yi Tang , Li Yan
发明人： Mark Cunningham , Bethany Swencki-Underwood , Yi Tang , Li Yan
IPC分类号： C07K16/30
CPC分类号： C07K16/2803 , A61K2039/505 , A61K2039/507 , C07K14/70503 , C07K2317/34 , C07K2317/56 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C07K2319/32
摘要： The present invention provides antibodies immunospecific for human CD147 capable of blocking bioactivity of CD147 associated with malignant disease such as the stimulation of MMPs from fibroblast cells by tumor cells, the release of VEGF, and the promotion of angiogenesis. The antibodies of the present invention of are useful in treating malignant disease and those diseases in which CD147 activity is plays a pathogenic role, such as diseases of the eye, lung, and cardiovascular system.
摘要翻译：本发明提供能够阻断与恶性疾病相关的CD147的生物活性的人CD147的抗体，例如肿瘤细胞刺激来自成纤维细胞的MMPs，VEGF的释放和促进血管发生。本发明的抗体可用于治疗恶性疾病和其中CD147活性发挥致病作用的疾病，例如眼睛，肺和心血管系统的疾病。

2. 发明申请

US20110200627A1 ANTI-CD147 ANTIBODIES, METHODS AND USES 失效
标题翻译：抗CD147抗体，方法和用途
公开(公告)号：US20110200627A1
公开(公告)日：2011-08-18
申请号：US13062702
申请日：2009-08-19
申请人： Mark Cunningham , Bethany Swencki-Underwood , Yi Tang , Li Yan
发明人： Mark Cunningham , Bethany Swencki-Underwood , Yi Tang , Li Yan
IPC分类号： A61K39/00 , C07K16/42 , C07K16/00 , C12N5/09 , A61P35/00 , A61P37/04
CPC分类号： C07K16/2803 , A61K2039/505 , A61K2039/507 , C07K14/70503 , C07K2317/34 , C07K2317/56 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C07K2319/32
摘要： The present invention provides antibodies immunospecific for human CD 147 capable of blocking bioactivity of CD 147 associated with malignant disease such as the stimulation of MMPs from fibroblast cells by tumor cells, the release of VEGF, and the promotion of angiogenesis. The antibodies of the present invention of are useful in treating malignant disease and those diseases in which CD 147 activity is plays a pathogenic role, such as diseases of the eye, lung, and cardiovascular system.
摘要翻译：本发明提供能够阻断与恶性疾病相关的CD147的生物活性的人CD147的免疫特异性抗体，例如肿瘤细胞刺激来自成纤维细胞的MMPs，VEGF的释放和促进血管生成。本发明的抗体可用于治疗恶性疾病和其中CD147活性发挥致病作用的疾病，例如眼睛，肺和心血管系统的疾病。

3. 发明申请

US20050214302A1 Use of emmprin antagonists for the treatment of diseases associated with excessive angiogenesis 审中-公开
标题翻译：使用emmprin拮抗剂治疗与过度血管生成相关的疾病
公开(公告)号：US20050214302A1
公开(公告)日：2005-09-29
申请号：US10808699
申请日：2004-03-25
申请人： Marian Nakada , Li Yan , Yi Tang
发明人： Marian Nakada , Li Yan , Yi Tang
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2896 , A61K2039/505 , C07K2317/76
摘要： A method of using EMMPRIN antagonists to treat pathological processes associated with proliferative diseases, such as cancer, by specifically preventing or inhibiting the ability of new tissue to develop a blood supply. The invention more specifically relates to methods of treating such diseases by the use of EMMPRIN antagonists such as antibodies directed toward EMMPRIN, including specified portions or variants, specific for at least one EMMPRIN protein or fragment thereof, in an amount effective to inhibit angiogenesis.
摘要翻译：通过特异性预防或抑制新组织发展血液供应的能力，使用EMMPRIN拮抗剂治疗与增殖性疾病如癌症相关的病理过程的方法。本发明更具体地涉及通过使用有效抑制血管生成的量的EMMPRIN拮抗剂，例如针对EMMPRIN的抗体，包括对至少一种EMMPRIN蛋白或其片段特异性的特定部分或变体来治疗这些疾病的方法。

4. 发明申请

US20090028862A1 Emmprin antagonists and uses thereof 审中-公开
标题翻译： Emmprin拮抗剂及其用途
公开(公告)号：US20090028862A1
公开(公告)日：2009-01-29
申请号：US11664150
申请日：2005-09-29
申请人： Gregory M. Arndt , Mehnaaz Lomas , Marian T. Nakada , Laurent P. Rivory , Yi Tang , Li Yan
发明人： Gregory M. Arndt , Mehnaaz Lomas , Marian T. Nakada , Laurent P. Rivory , Yi Tang , Li Yan
IPC分类号： A61K39/395 , A61K31/7105 , A61K31/711 , A61K48/00 , A61P35/00
CPC分类号： C12N15/1138 , C07K16/2803 , C07K2317/76 , C12N2310/111 , C12N2310/12 , C12N2310/14
摘要： EMMPRIN (Extracellular Matrix Metalloproteinase Inducer) antagonists, such as antibodies, including specified portions or variants, siRNA, shRNA, antisense and DNAzymes, can be used to treat pathological processes associated with proliferative diseases, such as cancer, by specifically preventing or inhibiting the ability of proliferating tissue to develop a blood supply.
摘要翻译：通过特异性预防或抑制能力，EMMPRIN（细胞外基质金属蛋白酶诱导剂）拮抗剂，如包括特定部分或变体的siRNA，shRNA，反义和DNA酶等抗体可用于治疗与增殖性疾病如癌症相关的病理过程的增生组织以发展血液供应。

5. 发明申请

US20160260824A1 Bipolar Semiconductor Device Having a Charge-Balanced Inter-Trench Structure 有权
标题翻译：具有电荷平衡的沟槽间结构的双极半导体器件
公开(公告)号：US20160260824A1
公开(公告)日：2016-09-08
申请号：US14986150
申请日：2015-12-31
申请人： Florin Udrea , Alice Pei-Shan Hsieh , Gianluca Camuso , Chiu Ng , Yi Tang , Rajeev Krishna Vytla
发明人： Florin Udrea , Alice Pei-Shan Hsieh , Gianluca Camuso , Chiu Ng , Yi Tang , Rajeev Krishna Vytla
IPC分类号： H01L29/739 , H01L29/10 , H01L29/06
CPC分类号： H01L29/7397 , H01L29/0634 , H01L29/41708 , H01L29/7394
摘要： There are disclosed herein various implementations of a bipolar semiconductor device having a charge-balanced inter-trench structure. Such a device includes a drift region having a first conductivity type situated over an anode layer having a second conductivity type. The device also includes first and second control trenches extending through an inversion region having the second conductivity type into the drift region, each of the first and second control trenches being bordered by a cathode diffusion having the first conductivity type. In addition, the device includes an inter-trench structure situated in the drift region between the first and second control trenches. The inter-trench structure includes one or more first conductivity regions having the first conductivity type and one or more second conductivity region having the second conductivity type, the one or more first conductivity regions and the one or more second conductivity regions configured to substantially charge-balance the inter-trench structure.
摘要翻译：这里公开了具有电荷平衡的沟槽间结构的双极半导体器件的各种实施方式。这种器件包括位于具有第二导电类型的阳极层上的具有第一导电类型的漂移区。该器件还包括延伸穿过具有第二导电类型的反向区域到漂移区域中的第一和第二控制沟槽，第一和第二控制沟槽中的每一个都由具有第一导电类型的阴极扩散区界定。此外，该器件包括位于第一和第二控制沟槽之间的漂移区域中的沟槽间结构。沟槽间结构包括具有第一导电类型的一个或多个第一导电区域和具有第二导电类型的一个或多个第二导电区域，一个或多个第一导电区域和一个或多个第二导电区域，平衡沟槽间结构。

6. 发明授权

US08999690B2 Kits for analysis of biological samples 有权
标题翻译：用于生物样品分析的试剂盒
公开(公告)号：US08999690B2
公开(公告)日：2015-04-07
申请号：US13374994
申请日：2012-01-27
申请人： Zhenjun Diwu , Jianheng Zhang , Yi Tang , Xiang Guobing
发明人： Zhenjun Diwu , Jianheng Zhang , Yi Tang , Xiang Guobing
IPC分类号： C09B23/01 , C07D498/22 , C07D513/22 , G01N33/533 , C07D487/14 , C07D487/22 , C09B23/02
CPC分类号： C09B23/06 , C07D487/14 , C07D487/22 , C07D498/22 , C09B23/0066 , C09B23/02 , G01N33/52 , G01N33/533 , Y10T436/143333
摘要： Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.
摘要翻译：描述了在1位和3'-位之间分子内交联的化学反应性碳菁染料，它们的生物缀合物及其用途。 1,3'-交联的碳氰酸酯优于光谱相似的1,1'-交联或非交联染料的共轭物。本发明包括具有一个或多个苯并氮的衍生化合物。

7. 发明授权

US08951754B2 Methods and materials for making simvastatin and related compounds 有权
标题翻译：制备辛伐他汀及相关化合物的方法和材料
公开(公告)号：US08951754B2
公开(公告)日：2015-02-10
申请号：US13540188
申请日：2012-07-02
申请人： Yi Tang , Xinkai Xie
发明人： Yi Tang , Xinkai Xie
IPC分类号： C12P1/00 , C07K1/00 , C12P17/06 , C12N9/10 , C12P7/42 , C12P7/62
CPC分类号： C12P17/06 , C12N9/1025 , C12N9/1029 , C12P7/42 , C12P7/62
摘要： The invention disclosed herein relates to methods and materials for producing simvastatin and related compounds such as huvastatin.
摘要翻译：本文公开的本发明涉及用于生产辛伐他汀和相关化合物如胡伐他汀的方法和材料。

8. 发明授权

US08426618B2 Luminescence quenching compounds 有权
公开(公告)号：US08426618B2
公开(公告)日：2013-04-23
申请号：US13374728
申请日：2012-01-09
申请人： Zhenjun Diwu , Jianheng Zhang , Yi Tang
发明人： Zhenjun Diwu , Jianheng Zhang , Yi Tang
IPC分类号： C07D209/46 , C07D209/02
CPC分类号： C07D409/14 , C07D209/60 , C07D403/14 , C07D409/04 , C07D409/06 , C07D417/14 , C07D471/04 , C07H21/04 , C07J43/00 , G01N33/542 , G01N33/582
摘要： The quenching compounds of the invention are weakly luminescent cyanines that are substituted by one or more heteroaromatic quenching moieties. The quenching compounds of the invention exhibit little or no observable luminescence and efficiently quench a broad spectrum of luminescent compounds. The chemically reactive quenching compounds possess utility for labeling a wide variety of substances, including biomolecules. These labeled substances are highly useful for a variety of energy-transfer assays and applications.

9. 发明申请

US20120190038A1 LovD MUTANTS EXHIBITING IMPROVED PROPERTIES TOWARDS SIMVASTATIN SYNTHESIS 有权
标题翻译： LovD MUTANTS展示改进的SIMVASTATIN合成特性
公开(公告)号：US20120190038A1
公开(公告)日：2012-07-26
申请号：US13499356
申请日：2010-10-08
申请人： Yi Tang , Xue Gao , Xinkai Xie
发明人： Yi Tang , Xue Gao , Xinkai Xie
IPC分类号： C12P17/06 , C12N15/54 , C12N15/63 , C12Q1/68 , C12N1/15 , C12N1/19 , C12N9/96 , C12N9/10 , C12N1/21
CPC分类号： C12N9/1029 , C12P7/62 , C12P17/06
摘要： The invention disclosed herein relates to methods and materials for producing simvastatin and related compounds such as huvastatin. In particular, the disclosure teaches that variants of the LovD acyltransferase polypeptide can be engineered to exhibit properties that facilitate their use in the production of simvastatin and/or huvastatin. The materials and processes disclosed herein are designed so that fermentation facilities currently producing lovastatin can be converted to producing simvastatin and related compounds with minimal modifications.
摘要翻译：本文公开的本发明涉及用于生产辛伐他汀和相关化合物如胡伐他汀的方法和材料。特别地，本公开内容指出，LovD酰基转移酶多肽的变体可被工程化以显示有利于其用于生产辛伐他汀和/或胡伐他汀的性质。本文公开的材料和方法设计成使得目前生产洛伐他汀的发酵设备可以转化为以最少的修饰生产辛伐他汀和相关化合物。

10. 发明申请

US20110070593A1 Conjugates of biological substances 有权
公开(公告)号：US20110070593A1
公开(公告)日：2011-03-24
申请号：US12807268
申请日：2010-09-01
申请人： Zhenjun Diwu , Jianheng Zhang , Yi Tang , Xiang Guobing
发明人： Zhenjun Diwu , Jianheng Zhang , Yi Tang , Xiang Guobing
IPC分类号： G01N33/50 , G01N33/48 , G01N33/92 , G01N33/68
CPC分类号： C09B23/06 , C07D487/14 , C07D487/22 , C07D498/22 , C09B23/0066 , C09B23/02 , G01N33/52 , G01N33/533 , Y10T436/143333
摘要： Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式