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51. 发明申请

US20090023684A1 FLUID FOR PERITONEAL DIALYSIS 审中-公开
标题翻译：流体用于透析
公开(公告)号：US20090023684A1
公开(公告)日：2009-01-22
申请号：US11912279
申请日：2006-04-13
申请人： Hitomi Ohta , Toshiharu Hanaya , Shigeharu Fukuda , Yoshikatsu Miwa , Toshio Miyake
发明人： Hitomi Ohta , Toshiharu Hanaya , Shigeharu Fukuda , Yoshikatsu Miwa , Toshio Miyake
IPC分类号： A61K31/715
CPC分类号： A61K31/716 , A61K31/702 , A61K31/7048 , A61M1/287 , A61K2300/00
摘要： The present invention has an object to provide a fluid for peritoneal dialysis with satisfactory body fluid removability, high biocompatibility, and improved storage stability, and the object is attained by a fluid for peritoneal dialysis containing one or more saccharides selected from cyclonigerosylnigerose, cyclomaltosylmaltose, and L-ascorbic acid 2-glucoside.
摘要翻译：本发明的目的是提供一种用于腹膜透析的流体，其具有令人满意的体液清除性，高生物相容性和改善的储存稳定性，并且目的是通过含有一种或多种选自旋风黑素糖， L-抗坏血酸2-葡萄糖苷。

52. 发明申请

US20070269387A1 Moisture-Retaining Agent Comprising Alpha-Glycosyl Glycyrrhizing As An Effective Ingredient And Use Thereof 审中-公开
标题翻译：包含α-糖基甘草酸的保湿剂作为有效成分及其用途
公开(公告)号：US20070269387A1
公开(公告)日：2007-11-22
申请号：US11660922
申请日：2005-08-17
申请人： Hiromi Tatsukawa , Toshio Miyake
发明人： Hiromi Tatsukawa , Toshio Miyake
IPC分类号： A61K31/7028 , A61K8/02 , A61P17/00
CPC分类号： A61Q19/02 , A61K8/63 , A61K31/704 , A61Q1/02 , A61Q1/06 , A61Q1/10 , A61Q5/02 , A61Q11/00 , A61Q17/04 , A61Q19/00 , A61Q19/08 , A61Q19/10
摘要： The present invention has objects to provide a humectant applicable to preparations for external dermal agents, which has a moisturizing activity without causing unfavorable sticky feeling, and to provide an external dermal agent incorporated with the humectant. These objects are solved by providing a humectant containing α-glycosyl glycyrrhizin as an-effective ingredient, which has a satisfactory feeling of use and preferable makeup finish, imparts a desired softness and tension to the skin, and has an improved humectancy without causing unfavorable sticky feeling; and by providing an external dermal agent incorporated with the humectant.
摘要翻译：本发明的目的是提供一种可用于外用皮肤试剂制剂的保湿剂，其具有不会引起不适感的粘稠感的保湿活性，并提供与保湿剂结合的外用皮肤剂。通过提供含有α-糖基甘草甜素的保湿剂作为有效成分来解决这些问题，其具有令人满意的使用感和优选的妆面，赋予皮肤所需的柔软和张力，并且具有改善的保湿性而不引起不利的粘性感觉; 并通过提供与保湿剂结合的外部皮肤试剂。

53. 发明申请

US20070232563A1 Method for Enhancing Biological Activity and/or Expanding Suitable Region for Biological Activity of Living Body Contacting with Aqueous Environment 审中-公开
标题翻译：增加生物活性和/或扩大与水体环境接触的活体生物活性适宜区域的方法
公开(公告)号：US20070232563A1
公开(公告)日：2007-10-04
申请号：US11596930
申请日：2004-11-16
申请人： Yukio Uchida , Kazuyuki Oku , Toshio Miyake
发明人： Yukio Uchida , Kazuyuki Oku , Toshio Miyake
IPC分类号： A61K31/7016 , A01G7/00 , A01K63/04 , A01N59/00 , C05F11/00 , A01N61/00 , A01N63/00
CPC分类号： C05F11/10 , A01K61/13 , A01K61/50 , A01K63/04 , A61K31/7016
摘要： The present invention has an object to provide a method for enhancing biological activity and/or expanding suitable region for biological activity of living bodies contacting with aqueous environment, and solves the above object by providing a method for enhancing biological activity and/or expanding suitable region for biological activity of living bodies contacting with aqueous environment by incorporating α,α-trehalose or a saccharide derivative thereof when allowing living bodies to contact with aqueous environment for biological activity of the living bodies contacting with the aqueous environment, and composition and agent for enhancing biological activity and/or expanding suitable region for biological activity of living bodies.
摘要翻译：本发明的目的是提供一种用于增强生物活性和/或扩大与水性环境接触的生物体的生物活性的合适区域的方法，并且通过提供增强生物活性和/或扩大适宜区域的方法来解决上述目的通过在与水性环境接触的情况下，通过引入α，α-海藻糖或其糖衍生物与水性环境接触的生物体的生物活性，与与水性环境接触的活体的生物活性，以及增强作用的组合物和试剂生物活性和/或扩大生物体生物活性的适宜区域。

54. 发明申请

US20070003502A1 Skin preparation for external use characterized by containing sugar derivative of alpha, alpha-trehalose 有权
标题翻译：外用皮肤制剂，其特征在于含有α，α-海藻糖的糖衍生物
公开(公告)号：US20070003502A1
公开(公告)日：2007-01-04
申请号：US10545166
申请日：2004-02-10
申请人： Fujimi Tanabe , Michio Kubota , Hiromi Tatsukawa , Shigeru Fukuda , Toshio Miyake
发明人： Fujimi Tanabe , Michio Kubota , Hiromi Tatsukawa , Shigeru Fukuda , Toshio Miyake
IPC分类号： A61K31/7048 , A61K31/704 , A61K31/7012 , A61K8/73
CPC分类号： A61Q19/02 , A61K8/0212 , A61K8/60 , A61K9/0014 , A61K31/702 , A61K31/716 , A61K45/06 , A61K47/26 , A61K2800/522 , A61Q1/02 , A61Q1/08 , A61Q1/10 , A61Q5/02 , A61Q5/12 , A61Q7/00 , A61Q11/00 , A61Q17/005 , A61Q17/04 , A61Q19/00 , A61Q19/08 , A61Q19/10 , A61K2300/00
摘要： The present invention has an object to provide an external dermatological formulation having satisfactory blood flow-promoting effect, antiinflammatory effect, antibacterial effect, moisturizing effect, whitening effect, UV-absorbing effect, UV-scattering effect, antioxidant effect, hair growing effect, hair nourishing effect, emusifying effect, astringent effect, wrinkle-reducing effect, cell-activating effect and/or transdermal absorption-promoting effect with a satisfactory safety and skin feeling; The object is solved by providing an external dermatological formulation comprising a saccharide derivative of α,α-trehalose and one or more members selected from substances having any one of blood flow-promoting effect, antiinflammatory effect, antibacterial effect, moisturizing effect, whitening effect, UV-absorbing effect, UV-scattering effect, antioxidant effect, hair growing efect, hair nourishing effect, emulsifying effect, astringent effect, wrinkle-reducing effect, cell-activating effect and transdermal absorption-promoting effect.
摘要翻译：本发明的目的是提供具有令人满意的血液促进作用，抗炎作用，抗菌作用，保湿效果，美白效果，紫外线吸收效果，紫外线散射效果，抗氧化作用，发丝效果，毛发滋养效果，呕吐效果，皱纹减轻效果，细胞活化作用和/或透皮吸收促进作用，具有令人满意的安全性和皮肤感觉; 通过提供包含α，α-海藻糖的糖衍生物和一种或多种选自具有血流促进作用，抗炎作用，抗菌作用，保湿作用，美白效果，任何一种的物质的外部皮肤病学制剂来解决该问题，紫外线吸收效果，紫外线散射效果，抗氧化作用，毛发生长效果，滋养滋养效果，乳化作用，收敛效果，皱纹减轻效果，细胞活化作用和透皮吸收促进作用。

55. 发明申请

US20060216792A1 Process for producing 2-0-alpha-d-glucopyranosyl-l-ascorbic acid 有权
标题翻译：制备2-0-α-d-吡喃葡萄糖基-1-抗坏血酸的方法
公开(公告)号：US20060216792A1
公开(公告)日：2006-09-28
申请号：US10523920
申请日：2003-07-07
申请人： Kazuhisa Mukai , Keiji Tsusaki , Michio Kubota , Shigeharu Fukuda , Toshio Miyake
发明人： Kazuhisa Mukai , Keiji Tsusaki , Michio Kubota , Shigeharu Fukuda , Toshio Miyake
IPC分类号： C12P19/44
CPC分类号： C12P19/60
摘要： The object of the present invention is to provide a method and a process for producing 2-O-α-glucopyranosyl-L-ascorbic acid where 5-O-α-glucopyranosyl-L-ascorbic acid and 6-O-α-glucopyranosyl-L-ascorbic acid are not formed or formed in such a small amount that the formation of these can nor be detected. The present invention solves the above object by providing a process for producing 2-O-α-glucopyranosyl-L-ascorbic acid comprising the steps of allowing α-isomaltosyl glucosaccharide-forming enzyme together with or without cyclomaltodextrin glucanotransferase (EC 2.4.1.19) to act on a solution comprising L-ascorbic acid and, an α-glucosyl saccharide to form 2-O-α-glucopyranosyl-L-ascorbic acid and collecting the formed 2-O-α-glucopyranosyl-L-ascorbic acid.
摘要翻译：本发明的目的是提供一种生产2-O-α-glucopyranosyl-L-抗坏血酸的方法和方法，其中5-O-α-吡喃葡萄糖基-L-抗坏血酸和6-O-α-吡喃葡萄糖基-L- L-抗坏血酸不是以这样的少量形成或形成，也可以不形成。本发明通过提供一种生产2-O-α-吡喃葡萄糖基-L-抗坏血酸的方法来解决上述目的，其包括以下步骤：将α-异麦芽糖基糖糖形成酶与或不与环糊精葡聚糖转移酶（EC 2.4.1.19）一起使用作用于包含L-抗坏血酸和α-葡糖基糖的溶液以形成2-O-α-吡喃葡萄糖基-L-抗坏血酸并收集形成的2-O-α-吡喃葡萄糖基-L-抗坏血酸。

56. 发明申请

US20060159834A1 Refined royal jelly 审中-公开
标题翻译：精制皇家果冻
公开(公告)号：US20060159834A1
公开(公告)日：2006-07-20
申请号：US10525157
申请日：2003-09-04
申请人： Takashi Shibuya , Shigeharu Fukuda , Toshio Miyake
发明人： Takashi Shibuya , Shigeharu Fukuda , Toshio Miyake
IPC分类号： A23K1/00
CPC分类号： A61K8/64 , A23G9/38 , A23K20/10 , A23K50/40 , A23L21/20 , A23L33/11 , A23L33/15 , A23V2002/00 , A61K8/988 , A61Q19/00 , A23V2200/304
摘要： The object of the present invention is to provide an allergen-reduced royal jelly, having less fear of causing allergic symptoms, obtained by reducing allergens and keeping the useful pharmacological actions of royal jelly, a process for producing the same, and its uses. The present invention solves the above object by providing an allergen-reduced royal jelly where the amount of water-soluble proteins is reduced to less than 50% (w/w) to the amount of total proteins; a process for producing the allergen-reduced royal jelly comprising the steps of separating a royal jelly into a precipitate and a supernatant comprising water-soluble proteins by adding water and centrifuging, collecting low molecular substances by eliminating high molecular substances comprising water-soluble proteins from the resulting supernatant using ultra-filtration or gel filtration chromatography, and mixing the resulting low molecular substances with the aforesaid precipitate; a composition comprising the allergen-reduced royal jelly; and the uses of the composition for foods, feeds, baits, pet foods, and cosmetics.
摘要翻译：本发明的目的是提供一种通过减少过敏原并保持蜂王浆的有用药理作用而获得的对过敏症状的恐惧较少的过敏原降低的蜂王浆，其制备方法及其用途。本发明通过提供一种致敏剂降低的蜂王浆来解决上述目的，其中水溶性蛋白质的量降低到总蛋白质量的少于50％（w / w）; 一种生产降解过敏原的蜂王浆的方法，包括以下步骤：将蜂王浆分离成沉淀物，通过加入水分和离心分离含有水溶性蛋白质的上清液，通过除去含有水溶性蛋白质的高分子物质来收集低分子物质所得上清液使用超滤或凝胶过滤层析，并将得到的低分子物质与上述沉淀物混合; 包含变应原降低的蜂王浆的组合物; 以及食品，饲料，饵料，宠物食品和化妆品组合物的用途。

57. 发明申请

US20060134197A1 Method of reducing unpleasant taste and/or unpleasant odor 审中-公开
标题翻译：减少不愉快味道和/或不愉快气味的方法
公开(公告)号：US20060134197A1
公开(公告)日：2006-06-22
申请号：US10540772
申请日：2003-12-24
申请人： Yukio Uchida , Kanou Takeuchi , Michio Kubota , Toshio Miyake
发明人： Yukio Uchida , Kanou Takeuchi , Michio Kubota , Toshio Miyake
IPC分类号： A61K9/20 , A23G3/00
CPC分类号： A23L27/33 , A23L5/27 , A23V2002/00 , A23V2200/16 , A23V2250/636
摘要： The present invention has objects to provide a method of lowering the unpleasant taste and/or smell of compositions, and an agent for lowering unpleasant taste and/or smell. The objects are solved by providing a method of lowering unpleasant taste and/or smell, comprising a step of incorporating an saccharide derivative of α,α-trehalose in compositions; a composition with lowered unpleasant taste and/or smell, obtainable by the method; and an agent for lowering unpleasant taste and/or smell, comprising an saccharide derivatives of α,α-trehalose as an effective ingredients.
摘要翻译：本发明的目的是提供降低组合物的不愉快味道和/或气味的方法，以及降低不愉快味道和/或气味的药剂。通过提供降低不愉快味道和/或气味的方法来解决目的，包括将α，α-海藻糖的糖衍生物掺入组合物中的步骤; 通过该方法获得的具有降低的不愉快味道和/或气味的组合物; 以及降低不愉快味道和/或气味的药剂，其包含α，α-海藻糖的糖衍生物作为有效成分。

58. 发明申请

US20060008791A1 Dehydrating agent and method for dehydrating moist article using the agent and dehydrated article obtained by the method 有权
标题翻译：使用该方法获得的试剂和脱水制品脱水剂和脱水湿物品的方法
公开(公告)号：US20060008791A1
公开(公告)日：2006-01-12
申请号：US10466438
申请日：2002-01-17
申请人： Michio Kubota , Tomoyuki Nishimoto , Hajime Aga , Shigeharu Fukuda , Toshio Miyake
发明人： Michio Kubota , Tomoyuki Nishimoto , Hajime Aga , Shigeharu Fukuda , Toshio Miyake
IPC分类号： A01N1/02 , B01J20/00
CPC分类号： B01J20/262 , A21D2/181 , A23C13/125 , A23L3/42 , A61K9/0014 , A61K47/26 , A61K47/40 , B01J20/22 , C07H3/06
摘要： The present invention has the object to dehydrate hydrous matters without denaturing or deteriorating them by using a dehydrating agent comprising an anhydrous cyclotetrasaccharide, and provides a dehydrating agent comprising the cyclotetrasaccharide; a method for dehydrating hydrous matters through a step of incorporating, contacting or coexisting the cyclotetrasaccharide into, with, or in the hydrous matters; and dehydrated products obtainable thereby.
摘要翻译：本发明的目的是通过使用包含无水环四糖的脱水剂使含水物脱水而不使其变性或变质，并提供包含环四糖的脱水剂; 通过将环四糖与含水物质结合，接触或共存的步骤脱水含水物质的方法; 和可得到的脱水产品。

59. 发明申请

US20050123671A1 Reduction inhibitory agent for active oxygen eliminating activity 审中-公开
标题翻译：还原抑制剂用于活性氧消除活性
公开(公告)号：US20050123671A1
公开(公告)日：2005-06-09
申请号：US10965739
申请日：2004-10-18
申请人： Kazuyuki Oku , Michio Kubota , Shigeharu Fukuda , Toshio Miyake
发明人： Kazuyuki Oku , Michio Kubota , Shigeharu Fukuda , Toshio Miyake
IPC分类号： A23L1/30 , A23B7/14 , A61K8/00 , A61K8/60 , A61K8/96 , A61K31/702 , A61K36/18 , A61P9/10 , A61P17/16 , A61P19/02 , A61P25/16 , A61P25/28 , A61P35/00 , A61Q11/00 , A61Q19/00 , A61Q19/02 , A61Q19/08 , A61Q19/10 , C07H3/06 , A61K31/715 , A23G3/00
CPC分类号： A61Q19/00 , A61K8/60 , A61K31/702 , A61K2800/522 , A61Q11/00 , A61Q19/02 , A61Q19/08 , A61Q19/10 , C07H3/06
摘要： A reduction inhibitory agent for active oxygen eliminating activity which comprises cyclotetrasaccharide i.e., cyclo{6}-α-D-glucopyranosyl-(1 3)-α-D-glucopyranosyl-(1 6)-α-D-glucopyranosyl-(1 3)-α-D-glucopyranosyl-(1), as an effective ingredient, a method for inhibiting the reduction of active oxygen eliminating activity which comprises incorporating either cyclotetrasaccharide or the reduction inhibitory agent into plant edible products and/or plant antioxidants, and a composition where the reduction of active oxygen eliminating activity of the plant edible products and/or plant antioxidants has been satisfactorily inhibited by the method.
摘要翻译：环状四糖，即环{6} -alpha-D-吡喃葡萄糖基 - （1,3）-α-D-吡喃葡萄糖基 - （1,6）-alpha-D-吡喃葡萄糖基 - （13）的活性氧消除活性的还原抑制剂）-alpha-D-吡喃葡萄糖基 - （1）作为有效成分，抑制活性氧消除活性降低的方法，其包括将环四糖或还原抑制剂掺入植物性食品和/或植物抗氧化剂中，以及植物性食品和/或植物抗氧化剂的活性氧消除活性降低已被该方法令人满意地抑制的组合物。

60. 发明授权

US06576446B2 Process for producing high 2-O-&agr;-D-glucopyranosyl-L-ascorbic acid 有权
标题翻译：生产高2-O-α-D-吡喃葡萄糖基-L-抗坏血酸的方法
公开(公告)号：US06576446B2
公开(公告)日：2003-06-10
申请号：US09875963
申请日：2001-06-08
申请人： Hiroshi Yamasaki , Koichi Nishi , Toshio Miyake
发明人： Hiroshi Yamasaki , Koichi Nishi , Toshio Miyake
IPC分类号： C12P1944
CPC分类号： C07H17/04
摘要： Disclosed is a process for producing a high &agr;G-AA content product, which comprises the steps of: contacting a solution as a material solution, containing &agr;G-AA, L-ascorbic acid, and a saccharide(s), with an anion exchange resin packed in a column to adsorb the &agr;G-AA and L-ascorbic acid on the anion exchanger; washing the anion exchanger with water to remove the saccharide(s) therefrom; feeding to the column an aqueous solution, as an eluent, of an acid and/or a salt with a concentration of less than 0.5 N to fractionate a fraction rich in 2-O-&agr;-D-glucopyranosyl-L-ascorbic acid and a fraction rich in L-ascorbic acid; and collecting the former fraction.
摘要翻译：公开了一种制备高αG-AA含量产物的方法，其包括以下步骤：使含有αG-AA，L-抗坏血酸和糖的溶液与阴离子交换树脂接触填充在柱中以吸附阴离子交换剂上的αG-AA和L-抗坏血酸; 用水洗涤阴离子交换剂以除去其中的糖类; 向柱中加入浓度小于0.5N的酸和/或盐的水溶液作为洗脱剂，以分级富含2-O-α-D-吡喃葡萄糖基-L-抗坏血酸的级分和级分富含L-抗坏血酸; 并收集前一部分。

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