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51. 发明授权

US06261271B1 Anti-infective and antithrombogenic medical articles and method for their preparation 失效
标题翻译：抗感染和抗血栓形成的医疗用品及其制备方法
公开(公告)号：US06261271B1
公开(公告)日：2001-07-17
申请号：US09006677
申请日：1998-01-13
申请人： Donald D. Solomon , M. Parke Byron
发明人： Donald D. Solomon , M. Parke Byron
IPC分类号： A61M532
CPC分类号： A61L29/085 , A61L27/34 , A61L27/54 , A61L29/06 , A61L29/16 , A61L31/10 , A61L2300/104 , A61L2300/206 , A61L2300/404 , A61L2300/406 , A61L2300/42 , A61L2300/45 , A61M2025/0056 , C08L75/00
摘要： An anti-infective medical article has chlorhexidine bulk distributed throughout a polyurethane base layer and may have a coating layer on the base layer. The coating layer may be chlorhexidine permeated into the surface or it may be an antibiotic, antithrombogenic agent or a polymeric surface layer laminated onto the base layer. The invention includes a method for preparing the article wherein a homogeneous melt of polymer and chlorhexidine is prepared by twin screw compounding and the melt is extruded to give a medical article having bulk distributed chlorhexidine.
摘要翻译：抗感染性医疗用品具有遍及整个聚氨酯基层的氯己定，并且可以在基层上具有涂层。涂层可以是氯己定渗透到表面中，或者它可以是层压到基底层上的抗生素，抗血栓形成剂或聚合物表面层。本发明包括一种制备该制品的方法，其中通过双螺杆混合制备聚合物和氯己定的均匀熔体，并将该熔体挤出以得到具有体积分布的氯己定的医用制品。

52. 发明授权

US5855575A Method and apparatus for providing a sterility seal in a medicinal storage bottle 失效
标题翻译：用于在药物储存瓶中提供无菌密封的方法和装置
公开(公告)号：US5855575A
公开(公告)日：1999-01-05
申请号：US754824
申请日：1996-11-21
申请人： Donald D. Solomon , Jean-Claude Thibault
发明人： Donald D. Solomon , Jean-Claude Thibault
IPC分类号： B65B7/28 , A61J1/00 , A61J1/14 , A61J1/20 , B65D41/02 , B65D53/06 , A61B19/00
CPC分类号： A61J1/2089 , A61J1/1412 , A61J1/18 , A61J1/1468 , A61J1/201 , Y10S604/905 , Y10T29/49885 , Y10T29/49982
摘要： A bottle having a sterility seal and a method for producing same are disclosed. The bottle, which can be configured to retain a medicament in powder or tablet form, features a protective cap configured to engage a transfer assembly associated with the bottle. The cap includes one or more raised ridges on an interior surface engageable with a portion of the transfer assembly. A band or layer configuration of a sealing material such as silicone is applied to the transfer assembly prior to insertion of the cap thereover. As the cap comes into surface contact with the sealing material, the ridges cause the material to "roll up" into a toroidal O-ring configuration, thereby forming a seal between the cap and the bottle adapted to the dimensional variations of those components. The seal, which is resilient, is able to withstand harsh handling treatment and pressure or temperature variations without separation from the cap or bottle, thereby providing a hermetic seal isolating the transfer assembly and, hence, the medicament from the outside environment.
摘要翻译：公开了一种具有无菌密封的瓶子及其制造方法。可以构造成保持粉末或片剂形式的药物的瓶具有构造成接合与瓶相关联的转运组件的保护帽。所述盖包括在内表面上与所述转移组件的一部分可接合的一个或多个凸脊。在其上插入盖之前，将诸如硅树脂的密封材料的带或层构造施加到转移组件。当盖与密封材料进行表面接触时，脊使材料“卷起”成环形O形环构型，从而在适合于这些部件的尺寸变化的帽和瓶之间形成密封。具有弹性的密封件能够承受恶劣的处理处理和压力或温度变化，而不会与盖或瓶分离，从而提供将转印组件以及因此从外部环境分离的气密密封。

53. 发明授权

US5352754A High impact polyurethane 失效
标题翻译：高抗冲聚氨酯
公开(公告)号：US5352754A
公开(公告)日：1994-10-04
申请号：US966234
申请日：1992-10-26
申请人： Delmer R. Rhodes , James M. Lambert , Donald D. Solomon
发明人： Delmer R. Rhodes , James M. Lambert , Donald D. Solomon
IPC分类号： C08G18/32 , C08G18/65 , C08G18/73 , C08G18/75 , C08G18/18
CPC分类号： C08G18/3206 , C08G18/3275 , C08G18/6535 , C08G18/73 , C08G18/758
摘要： A non-yellowing, impact resistant high hard segment polyurethane made from a non-aromatic diisocyanate, a diol chain extender and an aminodiol chain extender may also contain up to five percent by weight of a macroglycol. A catalyst free method to prepare the polyurethane is a feature of the invention.
摘要翻译：由非芳族二异氰酸酯，二醇增链剂和氨基二醇扩链剂制成的非黄变，耐冲击的高硬链段聚氨酯也可含有高达5重量％的大分子二糖。制备聚氨酯的无催化剂方法是本发明的特征。

54. 发明授权

US5077372A Amine rich fluorinated polyurethaneureas and their use in a method to immobilize an antithrombogenic agent on a device surface 失效
标题翻译：富胺氟化聚氨酯脲及其在将抗血栓形成剂固定在器械表面上的方法中的用途
公开(公告)号：US5077372A
公开(公告)日：1991-12-31
申请号：US672245
申请日：1991-03-20
申请人： Can B. Hu , Donald D. Solomon
发明人： Can B. Hu , Donald D. Solomon
IPC分类号： A61L33/00 , C08G18/12 , C08G18/50
CPC分类号： C08G18/5015 , A61L33/0029 , C08G18/12 , Y10T428/31551
摘要： A thermoplastic polyurethaneurea having free amino groups is the reaction product of a diisocyanate, a fluorinated polyol, a non-fluorinated polyol and a polyamine. The invention includes a shaped polymeric support structure having the thermoplastic polyurethaneurea coated thereon and a medical article comprising the coated support and heparin covalently bonded to the free amino groups of the coated support. In another aspect of the invention, a method for preparing the heparinized medical article is provided.
摘要翻译：具有游离氨基的热塑性聚氨酯脲是二异氰酸酯，氟化多元醇，非氟化多元醇和多胺的反应产物。本发明包括具有涂覆在其上的热塑性聚氨酯脲的成形聚合物支撑结构和包含共价结合到涂覆的载体的游离氨基的涂覆的载体和肝素的医疗制品。在本发明的另一方面，提供了一种制备肝素化医疗用品的方法。

55. 发明授权

US5064415A Catheter obturator with automatic feed and control 失效
标题翻译：导管闭塞器具有自动进料和控制
公开(公告)号：US5064415A
公开(公告)日：1991-11-12
申请号：US568923
申请日：1990-08-17
申请人： Anthony J. Walder , Donald D. Solomon
发明人： Anthony J. Walder , Donald D. Solomon
IPC分类号： A61M25/00 , A61M25/01
CPC分类号： A61M25/0113 , A61M25/0017
摘要： An obturator is provided which allows for placing and withdrawing of a single catheter obturator over an extended period of time so as to allow spaced intervals of use, and non-use of a catheter while in place in the patient's skin, while at the same time doing away with cumbersome, costly and time consuming administration and maintenance of saline and heparin locks. The device feeds the obturator in place for occluding the catheter lumen, when no fluids are being administered to the patient, and then may be retracted to a position allowing fluid feed through a supply tube connection to the catheter. The device includes a coating on the obturator rod which swells in contact with aqueous fluids to seal completely the catheter lumen which coating includes heparin to prevent clotting. Moreover, the entire internal functioning arrangement remains sterile during the entire period of use, thus avoiding infection.
摘要翻译：提供了一种闭孔器，其允许在延长的时间段内放置和取出单个导管闭塞器，以允许间隔的使用间隔，并且在同时在患者皮肤中的适当位置时不使用导管消除麻醉，昂贵和耗时的盐水和肝素锁的管理和维护。当没有向患者施用流体时，该装置将闭塞器馈送到适当位置以封闭导管腔，然后可以缩回至允许流体通过与导管连接的供应管的位置。该装置包括在封闭杆上的涂层，其与水性流体接触膨胀以完全密封导管腔，该涂层包括肝素以防止凝血。此外，整个内部功能安排在整个使用期间保持不育，从而避免感染。

56. 发明授权

US5061738A Blood compatible, lubricious article and composition and method therefor 失效
标题翻译：血液兼容，润滑物品及其组成及方法
公开(公告)号：US5061738A
公开(公告)日：1991-10-29
申请号：US639848
申请日：1991-01-11
申请人： Donald D. Solomon , Robert A. Taller , Victor A. Williamitis
发明人： Donald D. Solomon , Robert A. Taller , Victor A. Williamitis
IPC分类号： A61L29/08 , A61L33/00 , C08L83/04
CPC分类号： C08L83/04 , A61L29/085 , A61L33/0017 , A61L33/0029 , A61L33/0047 , A61L2400/10 , Y10S514/822 , Y10S514/953
摘要： A leach resistant composition includes a quaternary ammonium complex of heparin and a silicone. A method for applying a coating of the composition to a surface of a medical article is within the purview of the present invention. Medical articles having surfaces which are both lubricious and antithrombogenic, are produced in accordance with the method hereof.
摘要翻译：耐浸剂组合物包括肝素和硅氧烷的季铵络合物。将组合物的涂层施加到医疗用品的表面的方法在本发明的范围内。具有光滑和抗血栓形成的表面的医疗制品根据本发明的方法生产。

57. 发明授权

US4865870A Method for rendering a substrate surface antithrombogenic 失效
标题翻译：使底物表面抗血栓形成的方法
公开(公告)号：US4865870A
公开(公告)日：1989-09-12
申请号：US215974
申请日：1988-07-07
申请人： Can B. Hu , Donald D. Solomon , Nancy L. Shields
发明人： Can B. Hu , Donald D. Solomon , Nancy L. Shields
IPC分类号： A61L33/10 , A61L33/00
CPC分类号： A61L33/0017
摘要： A method for heparinizing a substrate includes applying a coating of ammonium salt to a substrate by steeping the substrate in a solution of the salt at an alkaline pH and contacting the coated substrate with a solution of a salt of heparin.

58. 发明授权

US4786556A Polymeric articles having enhanced antithrombogenic activity 失效
标题翻译：具有增强的抗血栓形成活性的聚合物制品
公开(公告)号：US4786556A
公开(公告)日：1988-11-22
申请号：US77468
申请日：1987-07-24
申请人： Can B. Hu , Donald D. Solomon
发明人： Can B. Hu , Donald D. Solomon
IPC分类号： A61L33/00 , B32B27/08 , B32B27/36
CPC分类号： A61L33/0047 , A61L33/0029 , A61L33/0094 , Y10S514/822 , Y10T428/31507 , Y10T428/3154 , Y10T428/31544 , Y10T428/31562 , Y10T428/31565 , Y10T428/31587 , Y10T428/31598 , Y10T428/31663 , Y10T428/31721 , Y10T428/31725
摘要： Plastic articles having enhanced antithrombogenic activity due to the presence or hydrophobic materials attached to amine compounds bonded on the surface of the plastic which repel bonded antithrombogenic agents outwardly from the plastic surface, making them more readily available to the blood for subsequent thrombus inhibition.
摘要翻译：塑料制品具有增强的抗血栓形成活性，这是由于粘附在塑料表面上的胺化合物的存在或疏水性材料的存在或疏水性材料，其从塑料表面向外排斥结合的抗血栓形成剂，使得它们更容易获得血液用于随后的血栓抑制。

59. 发明授权

US4676975A Thermoplastic polyurethane anticoagulant alloy coating 失效
公开(公告)号：US4676975A
公开(公告)日：1987-06-30
申请号：US679160
申请日：1984-12-07
申请人： Charles W. McGary , Donald D. Solomon
发明人： Charles W. McGary , Donald D. Solomon
IPC分类号： C08G18/00 , A61L27/54 , A61L29/16 , A61L33/00 , A61L33/10 , C08K5/00 , C08L5/00 , C08L75/00 , C08L75/04 , C09D175/04 , C08L5/10 , A61K31/75
CPC分类号： A61L33/0029 , A61L27/54 , A61L29/16 , C09D175/04 , A61L2300/22 , A61L2300/232 , A61L2300/236 , A61L2300/42 , Y10S128/22 , Y10S514/822 , Y10S514/929
摘要： An antithrombogenic thermoplastic polyurethane product and process for preparing the same which comprises a substrate and at least one layer of a polyurethane alloy complex comprising a thermoplastic polyurethane and completely dispersed therein a preformed complex of an antithrombogenic material ionically bonded with a quaternary ammonium compound.

60. 发明授权

US06200338B1 Enhanced radiopacity of peripheral and central catheter tubing 有权
标题翻译：外周和中央导管管的射线不透性增强
公开(公告)号：US06200338B1
公开(公告)日：2001-03-13
申请号：US09224443
申请日：1998-12-31
申请人： Donald D. Solomon , Fidelis C. Onwumere
发明人： Donald D. Solomon , Fidelis C. Onwumere
IPC分类号： A61F204
CPC分类号： C08G18/381 , A61L27/18 , A61L29/06 , A61L31/06 , A61L31/18 , Y10T428/139 , C08L75/04
摘要： A medical implant, tubing and method to provide enhanced X-ray detection intensity in catheters, stents, vascular grafts or other tubular implants. In one aspect the medical implant includes a visually transparent radiopaque polymer and a filler material having a radiopaque component.
摘要翻译：用于在导管，支架，血管移植物或其他管状植入物中提供增强的X射线检测强度的医疗植入物，管道和方法。在一个方面，医学植入物包括视觉上透明的不透射线聚合物和具有不透射线组分的填充材料。

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