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51. 发明申请

US20070038288A1 Methods and apparatuses for repairing aneurysms 审中-公开
标题翻译：修复动脉瘤的方法和装置
公开(公告)号：US20070038288A1
公开(公告)日：2007-02-15
申请号：US10521063
申请日：2003-07-11
申请人： Whye-Kei Lye , Michael Reed , Mark Wholey
发明人： Whye-Kei Lye , Michael Reed , Mark Wholey
IPC分类号： A61F2/06 , A61F2/90
CPC分类号： A61F2/07 , A61F2/064 , A61F2/848 , A61F2/91 , A61F2/915 , A61F2002/067 , A61F2002/072 , A61F2002/075 , A61F2002/91533 , A61F2002/91575 , A61F2220/0008 , A61F2220/0016
摘要： Apparatuses, systems and methods are provided for repairing aneurysms in the vasculature of a patient. An aneurysm is repaired by positioning a tube or graft within the vasculature, extending through the region of the aneurysm to provide a blood flow conduit similar to the native vasculature. The tube is held in place within the vasculature by at least one expandable body having at least one microstructure. The microstructures are attached to the expandable body in a low profile fashion suitable for atraumatic introduction to the vasculature with the use of a catheter or other suitable device. Each microstructure has an end which is attached to the expandable body and a free end. Once the apparatus is positioned within the vasculature in the desired location, the one or more of the microstructures are deployed so that the free ends project radially outwardly. The free ends of the deployed microstructures then penetrate the blood vessel wall by continued expansion of the body for anchoring, reduction or migration or leakage and/or drug delivery.
摘要翻译：提供了用于修复患者脉管系统中的动脉瘤的装置，系统和方法。通过将管或移植物定位在脉管系统内，延伸穿过动脉瘤的区域来修复动脉瘤，以提供类似于本地脉管系统的血流导管。通过具有至少一个微结构的至少一个可膨胀体将管保持在脉管系统内的适当位置。微结构以适于使用导管或其它合适的装置对脉管系统进行无损伤引入的低调方式附着到可膨胀体上。每个微结构具有连接到可膨胀体的端部和自由端。一旦将装置定位在期望位置的脉管系统内，则一个或多个微结构被展开，使得自由端径向向外突出。部署的微结构的自由端然后通过身体的持续膨胀而穿过血管壁，用于锚固，减少或迁移或渗漏和/或药物递送。

52. 发明申请

US20070038085A1 Navigation among multiple breast ultrasound volumes 有权
标题翻译：导航多个乳房超声体积
公开(公告)号：US20070038085A1
公开(公告)日：2007-02-15
申请号：US11439093
申请日：2006-05-23
申请人： Wei Zhang , Jiayu Chen , Thomas Neff , Michael Reed , Jeanine Rader
发明人： Wei Zhang , Jiayu Chen , Thomas Neff , Michael Reed , Jeanine Rader
IPC分类号： A61B8/00
CPC分类号： A61B8/0825 , A61B6/463 , A61B6/502 , A61B6/5247 , A61B6/563 , A61B8/13 , A61B8/406 , A61B8/4281 , A61B8/4405 , A61B8/462 , A61B8/463 , A61B8/465 , A61B8/466 , A61B8/467 , A61B8/469 , A61B8/483 , A61B8/5238 , A61B8/565
摘要： Navigation among breast ultrasound volumes derived from different volumetric ultrasonic scans of a same breast is described. On a display of a breast ultrasound workstation, a first image derived from a first ultrasonic volume is displayed. A user selection of a source region of interest (ROI) in the first image is received. A destination ROI within a second ultrasonic volume is identified that at least roughly corresponds to a same locality of tissue in the breast as the source ROI. A second image derived from the second ultrasonic volume and including the destination ROI is displayed, the destination ROI being highlighted.
摘要翻译：描述从相同乳房的不同体积超声波扫描得到的乳房超声体积之间的导航。在乳房超声工作站的显示器上，显示从第一超声波体积得到的第一图像。接收第一图像中的感兴趣的源区域（ROI）的用户选择。识别出在第二超声波体积内的目的地ROI至少大致对应于乳房中与源ROI相同的局部区域。显示从第二超声波体积导出并包括目的地ROI的第二图像，目的地ROI被突出显示。

53. 发明申请

US20060271169A1 Stent with nanoporous surface 审中-公开
标题翻译：支架纳米孔表面
公开(公告)号：US20060271169A1
公开(公告)日：2006-11-30
申请号：US11432281
申请日：2006-05-11
申请人： Whye-Kei Lye , Kareen Looi , Michael Reed
发明人： Whye-Kei Lye , Kareen Looi , Michael Reed
IPC分类号： A61F2/82 , A61F2/28
CPC分类号： A61L31/146 , A61F2/86 , A61L31/082 , A61L31/16 , A61L2300/41 , A61L2300/416 , Y10S623/901 , Y10T428/12458
摘要： Methods for fabricating a medical device having at least one porous layer include providing a medical device having at least one alloy and removing at least one component of the alloy to form the porous layer. Although methods may be used to make stent devices with porous layers, any other suitable medical device may be made having one or more porous layers. An alloy may include any suitable combination of metals and sometimes a combination of metal and non-metal. In some embodiments, one or more of the most electrochemically active component(s) of an alloy are removed by the dissolving (or “dealloying”) process, to leave a porous matrix behind. The porous matrix layer may then be infused with one or more therapeutic agents for enhancing treatment of a patient.
摘要翻译：制造具有至少一个多孔层的医疗装置的方法包括提供具有至少一种合金的医疗装置，并除去合金的至少一种成分以形成多孔层。虽然可以使用方法来制备具有多孔层的支架装置，但是可以制造具有一个或多个多孔层的任何其它合适的医疗装置。合金可以包括任何合适的金属组合，有时是金属和非金属的组合。在一些实施方案中，通过溶解（或“脱模”）方法除去合金中最大的电化学活性组分中的一种或多种，以留下多孔基体。然后可以用一种或多种用于增强患者治疗的治疗剂注入多孔基质层。

54. 发明申请

US20060193890A1 Method for loading nanoporous layers with therapeutic agent 有权
标题翻译：用治疗剂负载纳米多孔层的方法
公开(公告)号：US20060193890A1
公开(公告)日：2006-08-31
申请号：US11352436
申请日：2006-02-10
申请人： Gary Owens , Brian Wamhoff , Matthew Hudson , Whye-Kei Lye , Joshua Spradlin , Michael Reed , Kareen Looi
发明人： Gary Owens , Brian Wamhoff , Matthew Hudson , Whye-Kei Lye , Joshua Spradlin , Michael Reed , Kareen Looi
IPC分类号： A61K6/083 , B05D3/02
CPC分类号： A61L31/022 , A61F2/07 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2210/0076 , A61F2250/0067 , A61L31/10 , A61L31/146 , A61L31/16 , A61L31/18 , A61L2300/606 , A61L2400/12 , A61N1/05
摘要： The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy. In some embodiments, a porous layer is adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. One embodiment of the invention relates to medical devices, including vascular stents, having at least one porous layer adapted to resist stenosis or cellular proliferation without requiring elution of therapeutic agents. The invention also includes methods, devices, and specifications for loading of drugs and other therapeutic agents into nanoporous coatings.
摘要翻译：本发明一般涉及具有治疗洗脱组分的医疗装置及其制备方法。更具体地，本发明涉及具有至少一个多孔层的可植入医疗装置，以及用于制造这种装置的方法，以及用治疗剂加载这些装置。将混合物或合金放置在医疗装置的表面上，然后通常除去混合物或合金的一种组分，而不会通常除去混合物或合金的其它组分。在一些实施例中，多孔层适于粘合非金属涂层，包括药物洗脱的聚合物涂层。多孔层可以具有无规孔结构或定向或定向颗粒多孔结构。本发明的一个实施方案涉及包括血管支架的医疗装置，其具有适于抵抗狭窄或细胞增殖的至少一个多孔层，而不需要洗脱治疗剂。本发明还包括将药物和其它治疗剂装载到纳米多孔涂层中的方法，装置和规格。

55. 发明申请

US20060094696A1 Oestrogen derivatives as inhibitors of steroid sulphatase 失效
标题翻译：雌激素衍生物作为类固醇硫酸酯酶的抑制剂
公开(公告)号：US20060094696A1
公开(公告)日：2006-05-04
申请号：US11233945
申请日：2005-09-23
申请人： Mathew Leese , Alan Purohit , Michael Reed , Simon Newman , Surinder Chander , Fabrice Jourdan , Barry Potter
发明人： Mathew Leese , Alan Purohit , Michael Reed , Simon Newman , Surinder Chander , Fabrice Jourdan , Barry Potter
IPC分类号： A61K31/66 , C07J51/00 , A61K31/56
CPC分类号： C07J43/00 , C07J41/00
摘要： The present invention provides a compound comprising a steroidal ring system and an optional group R1 selected from any one of —OH, a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; wherein the D ring of the steroidal ring system is substituted by a group R2 of the formula -L-R3, wherein L is an optional linker group and R3 is selected from groups which are or which comprise one of a nitrite group, an alcohol, an ester, an ether, an amine and an alkene, provided that when R3 is or comprises an alcohol, L is present; and wherein the A ring of the steroidal ring system is substituted at position 2 or 4 with a group R4, wherein R4 is a hydrocarbyl group.
摘要翻译：本发明提供了包含选自-OH，氨基磺酸酯基，膦酸酯基，硫代膦酸酯基，磺酸酯基或磺酰胺中的任何一种的甾体环系和任选的基团R 1的化合物组; 其中所述甾体环体系的D环被式-LR 3 SO 2的基团R 2取代，其中L是任选的连接基团，R 3 选自亚硝酸根基团，醇类，酯类，醚类，胺类和烯烃中的一种或其中之一的基团，条件是当R 3是或包含一个或多个酒精，L存在; 并且其中所述甾族环系统的A环在位置2或4被基团R 4取代，其中R 4为烃基。

56. 发明申请

US20060074060A1 Compound 失效
标题翻译：复合
公开(公告)号：US20060074060A1
公开(公告)日：2006-04-06
申请号：US11234868
申请日：2005-09-23
申请人： Nigel Vicker , Harshani Lawrence , Gillian Allan , Christian Bubert , Delphine Sophie Fischer , Alan Purohit , Michael Reed , Barry Victor Potter
发明人： Nigel Vicker , Harshani Lawrence , Gillian Allan , Christian Bubert , Delphine Sophie Fischer , Alan Purohit , Michael Reed , Barry Victor Potter
IPC分类号： A61K31/58 , C07J71/00
CPC分类号： C07J71/00 , C07J41/00
摘要： There is provided a compound of Formula (I) wherein (I) R2 is selected from (i) an alkyloxyalkyl group (ii) a nitrile group, and wherein R2 is capable of forming a hydrogen bond (iii) alkylaryl group, wherein the aryl group is substituted by other than a C1-10 group (iv) alkenylaryl group wherein the aryl group is substituted (v) alkylheteroaryl group, wherein when heteroaryl group comprises only C and N in the ring, the aryl group is substituted by other than a methyl group (vi) alkenylheteroaryl group, (vii) ═N—O-alkyl or ═N—O—H group (viii) branched alkenyl (ix) alkyl-alcohol group (x) amide or alkylamide wherein (a) the alkyl of the alkylamide is —CH2— or —Ch2Ch2—, (b) the amide is di-substituted and/or (c) the amide is substituted with at least one of alkyl heterocycle group, alkenyl heterocycle group, alkylheteroaryl group, alkenylheteroaryl group, heteroaryl group, alkylamine group, alkyloxyalkyl group, alkylaryl group, straight or branched alkyl group, (xi) —CHO so that R1 together with R3 provide the enol tautomer (a); OR R2 together with R3 form (xii) a pyrazole wherein (a) R4 is ═N—O-alkyl or ═N—O—H group, (b) the pyrazole is substituted with one of alkyl-OH group, alkyl ester group, alkyloxyalkyl group, branched alkyl group, and an amide and/or (c) the 2 position is substituted with a group selected from —OH and —O-hydrocarbyl (xiii) a heteroaryl ring to provide a compound of the formula (b); (II) R2 is selected from groups capable of forming a hydrogen bond, a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group and a sulphonamide group; and (III) R3 is selected from —OH, ═O, or a C(═O)—mimetic.
摘要翻译：提供式（I）化合物，其中（I）R 2选自（ⅰ）烷氧基烷基（ⅱ）腈基，其中R2能够形成氢键（ⅲ）烷基芳基，其中芳基基团被取代的芳基（ⅴ）烷基杂芳基以外的C 1-10基团（ⅳ）链烯基芳基取代，其中当杂芳基仅在环中仅包含C和N时，芳基被除了甲基（vi）烯基杂芳基，（vii）-NO-烷基或-NOH基（viii）支链烯基（ix）烷基 - 醇基（x）酰胺或烷基酰胺，其中（a）烷基酰胺的烷基是-CH2- 或-C 2 -C 12 - ，（b）酰胺是二取代的和/或（c）酰胺被烷基杂环基，烯基杂环基，烷基杂芳基，烯基杂芳基，杂芳基，烷基胺基，烷氧基烷基中的至少一个基团，烷基芳基，直链或支链烷基，（xi）-CHO，使得R1起始与R3提供烯醇互变异构体（a）; OR 2与R 3一起形成（xii）吡唑，其中（a）R4是-NO-烷基或-NOH基，（b）吡唑被烷基-OH基，烷基酯基，烷氧基烷基，支链烷基基团和酰胺和/或（c）2位被选自-OH和-O-烃基（xiii）杂芳基环的基团取代，以提供式（b）的化合物; （II）R2选自能够形成氢键的基团，氨基磺酸酯基，膦酸酯基，硫代膦酸酯基，磺酸酯基和磺酰胺基; 和（III）R 3选自-OH，-O或C（-O） - 模仿物。

57. 发明申请

US20050277144A1 Compounds and methods for fluorescent labeling 有权
公开(公告)号：US20050277144A1
公开(公告)日：2005-12-15
申请号：US11127040
申请日：2005-05-10
申请人： Eugeny Lukhtanov , Alexei Vorobiev , Michael Reed , Nicolaas Vermeulen
发明人： Eugeny Lukhtanov , Alexei Vorobiev , Michael Reed , Nicolaas Vermeulen
IPC分类号： C09B11/08 , C09B19/00 , C09B57/02 , C09B57/14 , G01N33/533 , C12Q1/68 , C07D311/78 , C07K14/47
CPC分类号： C09B57/14 , C09B11/08 , C09B19/00 , C09B57/02 , G01N33/533
摘要： Dye reagents useful in labeling biological materials are provided along with methods for their use.

58. 发明申请

US20050149392A1 Using a customer's purchasing intent in recommending alternative items for purchase in a physical store 审中-公开
标题翻译：使用客户的购买意向推荐在实体商店购买的替代物品
公开(公告)号：US20050149392A1
公开(公告)日：2005-07-07
申请号：US10750151
申请日：2003-12-31
申请人： Kevin Gold , Michael Reed , Frank Vandervort , Todd Walter
发明人： Kevin Gold , Michael Reed , Frank Vandervort , Todd Walter
IPC分类号： G06F17/60
CPC分类号： G06Q30/0252 , G06Q30/0254 , G06Q30/0255 , G06Q30/0267 , G06Q30/0271 , G07G1/0036
摘要： A merchant who operates a physical store is able to communicate a message to a customer who is carrying one or more items for purchase. While the customer is moving through the store, the merchant uses electronic means to gather data identifying at least one of the items carried by the customer. A computer-implemented program applied to the data analyzes the data and identifies at least one alternative item that the customer might want to buy. The program then prepares a message about the alternative item and delivers the message to the customer while the customer is still in the store.
摘要翻译：经营实体商店的商家能够向携带一个或多个物品进行购买的客户传达消息。当客户正在通过商店移动时，商家使用电子方式来收集识别客户携带的至少一个项目的数据。应用于数据的计算机实现的程序分析数据并识别客户可能想要购买的至少一个备选项目。该程序然后准备关于备选项目的消息，并且在客户仍然在商店中时将消息传递给客户。

59. 发明申请

US20050135306A1 Discovery and connection management with mobile systems manager 审中-公开
标题翻译：使用移动系统管理器进行发现和连接管理
公开(公告)号：US20050135306A1
公开(公告)日：2005-06-23
申请号：US11005761
申请日：2004-12-06
申请人： Christopher McAllen , Christopher Dern , Gregory Borges , Michael Reed , Richard Batch
发明人： Christopher McAllen , Christopher Dern , Gregory Borges , Michael Reed , Richard Batch
IPC分类号： G06F12/00 , G06F17/30 , G06F19/00 , H04L12/24 , H04L12/28 , H04L12/56 , H04L29/06 , H04L29/08 , H04W12/02 , H04W52/02 , H04W68/00 , H04Q7/00
CPC分类号： H04W68/00 , G16H40/20 , H04L29/06 , H04L63/0428 , H04L63/08 , H04L63/083 , H04L67/12 , H04L67/14 , H04L67/24 , H04L69/329 , H04W12/0017 , H04W12/06 , H04W40/246 , H04W52/0216 , H04W52/0219 , H04W76/10 , Y02D70/142 , Y02D70/144 , Y02D70/166 , Y02D70/26
摘要： The present invention provides for a system and method of discovering whether a medical device is connected to a network, establishing secure communications between and a server and the medical device, and communicating with the medical device. Also disclosed is a method of encryption to ensure secure communications within the network between a server and medical devices connected to the network. The invention also includes a system and method for determining the location of medical devices within an institution. Also disclosed is a mobile server functioning as a mobile systems manager.
摘要翻译：本发明提供一种发现医疗设备是否连接到网络，建立服务器与医疗设备之间的安全通信以及与医疗设备通信的系统和方法。还公开了一种加密方法，以确保服务器与连接到网络的医疗设备之间网络内的安全通信。本发明还包括用于确定机构内的医疗设备的位置的系统和方法。还公开了用作移动系统管理器的移动服务器。

60. 发明申请

US20050014776A1 Steroidal compounds for inhibiting steroid sulphatase 有权
标题翻译：用于抑制类固醇硫酸酶的甾体化合物
公开(公告)号：US20050014776A1
公开(公告)日：2005-01-20
申请号：US10825758
申请日：2004-04-16
申请人： Barry Potter , Michael Reed , Lok Woo
发明人： Barry Potter , Michael Reed , Lok Woo
IPC分类号： A61K45/00 , A61K31/58 , A61P15/00 , A61P25/28 , A61P29/00 , A61P35/00 , A61P37/02 , A61P43/00 , C07J1/00 , C07J63/00 , C07J73/00 , A61K31/50
CPC分类号： C07J1/0051 , C07J63/00 , C07J63/008
摘要： There is provided a compound having Formula (I) wherein G is H or a substituent, and wherein R1 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group, capable of inhibiting steroid sulphatase.
摘要翻译：提供了具有式（I）的化合物，其中G是H或取代基，其中R 1是氨基磺酸酯基，膦酸酯基，硫代膦酸酯基，磺酸酯基或磺酰胺基中的任何一种，能够抑制类固醇硫酸酶。

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