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51. 发明申请

US20110020861A1 METHOD FOR THE REAL-TIME DETECTION OF MICROORGANISMS IN A LIQUID CULTURE MEDIUM BY AGGLUTINATION 审中-公开
标题翻译：通过AGGLUTINATION实时检测液体培养基中的微生物的方法
公开(公告)号：US20110020861A1
公开(公告)日：2011-01-27
申请号：US12918159
申请日：2009-03-12
申请人： Bruno Colin , David Mosticone , Jean-Claude Raymond , Thierry Sofia , Antoine Vimont
发明人： Bruno Colin , David Mosticone , Jean-Claude Raymond , Thierry Sofia , Antoine Vimont
IPC分类号： C12Q1/06 , C12Q1/04 , C12M1/34
CPC分类号： G01N33/569 , C12Q1/04 , G01N33/5304
摘要： A method for detecting at least one microorganism that may be present in a sample, comprising the steps of:a) bringing into contact, in a container: a culture medium that enables the growth and/or detection of microorganisms, said sample and a sensitized solid support;b) subjecting the whole to a temperature that promotes the growth and/or detection of microorganisms; andc) observing, in real time, the appearance of an agglutination indicating the presence of the microorganism(s) or confirming said presence when said microorganisms are detected in said culture medium, when step b) has been completed, anda method for detecting and identifying at least one target microorganism that may be present in a sample.
摘要翻译：一种用于检测可能存在于样品中的至少一种微生物的方法，包括以下步骤：a）在容器中接触：使微生物生长和/或检测的培养基，所述样品和敏化的坚实的支持 b）使整体处于促进微生物生长和/或检测的温度; 以及c）当步骤b）已经完成时，实时地观察表明微生物存在的凝集物的出现或者在所述培养基中检测到所述微生物时确认存在的情况，以及检测方法并鉴定可能存在于样品中的至少一种靶微生物。

52. 发明申请

US20100168805A1 Oral Prosthesis System Including an Electrostimulation Device Associated with a Wireless Transmission-Reception Device 审中-公开
标题翻译：包括与无线发射 - 接收设备相关联的电刺激装置的口腔假体系统
公开(公告)号：US20100168805A1
公开(公告)日：2010-07-01
申请号：US12594689
申请日：2008-04-04
申请人： Bruno Colin , Yohan Payan
发明人： Bruno Colin , Yohan Payan
IPC分类号： A61N1/36 , A61N1/08
CPC分类号： A61B5/682 , A61F9/08 , A61N1/36007 , A61N1/36014 , A61N1/36103 , A61N1/36167 , G06F1/3203
摘要： An oral prosthesis system comprising an electrical tongue stimulation unit associated with a wireless transceiver device and comprising two microcontrollers, the first microcontroller dedicated to transmit and receive operations, and the second microcontroller dedicated to the control of an electrical stimulation array.
摘要翻译：一种口腔假体系统，包括与无线收发器设备相关联的电舌刺激单元，并且包括两个微控制器，专用于发送和接收操作的第一微控制器，以及专用于控制电刺激阵列的第二微控制器。

53. 发明授权

US07741129B2 Method for treating magnetic particles and biological analysis device using magnets 失效
标题翻译：使用磁铁处理磁性颗粒的方法和生物分析装置
公开(公告)号：US07741129B2
公开(公告)日：2010-06-22
申请号：US12102830
申请日：2008-04-14
申请人： Bruno Colin
发明人： Bruno Colin
IPC分类号： G01N33/553
CPC分类号： B03C1/288 , B03C1/035 , G01N35/0098
摘要： A method for treating magnetic particles present in a solution in a container by redispersion, rinsing or displacement, the particles having novel characteristics under the effect of a specific magnet and being associated or not with biological entities. The magnetic particles undergo at least one low-intensity magnetization where they are disposed in filaments oriented according to the north-south axis of the magnet; the magnetization source and/or container is/are displaced while the magnetic effect is maintained on the magnetic particles; the magnetization source and/or container is/are displaced or the magnetization is stopped, in order to suppress the magnetic field on the magnetic particles. Preferably, the invention can be used in the field of biology.
摘要翻译：用于通过再分散，漂洗或置换来处理存在于容器中的溶液中的磁性颗粒的方法，所述颗粒在特定磁体的作用下具有新特性并且与生物实体相关联。磁性颗粒经历至少一个低强度磁化，其中它们设置在根据磁体的南北轴线取向的长丝中; 当磁效应保持在磁性颗粒上时，磁化源和/或容器被移位; 磁化源和/或容器被移位或磁化被停止，以便抑制磁性颗粒上的磁场。优选地，本发明可以用于生物学领域。

54. 发明授权

US07691600B2 Method for detecting and/or identifying bacteria present in a sample 有权
标题翻译：用于检测和/或鉴定样品中存在的细菌的方法
公开(公告)号：US07691600B2
公开(公告)日：2010-04-06
申请号：US10551989
申请日：2004-04-02
申请人： Josep Vicent Mercader Badia , Bruno Colin , Vincent Atrache
发明人： Josep Vicent Mercader Badia , Bruno Colin , Vincent Atrache
IPC分类号： G01N27/447
CPC分类号： C12Q1/04 , B01L3/502 , B01L2300/0636 , B01L2300/0663 , B01L2300/0832 , B01L2300/18 , B01L2400/0442 , Y10S436/809
摘要： The present invention relates to a method for detecting and/or identifying bacteria present in a liquid or solid sample, characterized in that: a. the sample that may contain said bacteria is placed in a liquid culture medium, in a first container, b. a second container comprising at least one system for detecting said bacteria is provided, c. a means of transfer between the first container and the second container is provided, d. a temperature T1 is applied inside the second container, then e. a temperature T2 is applied inside the second container, f. the temperature T1 is higher than the temperature T2 such that a defined volume of culture medium is transferred from the first container to the second container, g. the presence or absence of bacteria is determined and/or the bacteria are identified within the detection system.
摘要翻译：本发明涉及一种用于检测和/或识别存在于液体或固体样品中的细菌的方法，其特征在于：a。将含有所述细菌的样品置于第一容器中的液体培养基中，b。提供了包含至少一个用于检测所述细菌的系统的第二容器，c。提供了在第一容器和第二容器之间的转移装置，d。在第二容器内施加温度T1，在第二容器内施加温度T2，f。温度T1高于温度T2，使得将限定体积的培养基从第一容器转移到第二容器，g。确定细菌的存在或不存在和/或在检测系统内识别细菌。

55. 发明申请

US20080257825A1 METHOD FOR TREATING MAGNETIC PARTICLES AND BIOLOGICAL ANALYSIS DEVICE USING MAGNETS 失效
标题翻译：使用磁铁处理磁性粒子和生物分析装置的方法
公开(公告)号：US20080257825A1
公开(公告)日：2008-10-23
申请号：US12102830
申请日：2008-04-14
申请人： Bruno Colin
发明人： Bruno Colin
IPC分类号： B03C1/24
CPC分类号： B03C1/288 , B03C1/035 , G01N35/0098
摘要： A method for treating magnetic particles present in a solution in a container by redispersion, rinsing or displacement, the particles having novel characteristics under the effect of a specific magnet and being associated or not with biological entities. The magnetic particles undergo at least one low-intensity magnetisation where they are disposed in filaments oriented according to the north-south axis of the magnet; the magnetisation source and/or container is/are displaced while the magnetic effect is maintained on the magnetic particles; the magnetisation source and/or container is/are displaced or the magnetisation is stopped, in order to suppress the magnetic field on the magnetic particles. Preferably, the invention can be used in the field of biology.
摘要翻译：用于通过再分散，漂洗或置换来处理存在于容器中的溶液中的磁性颗粒的方法，所述颗粒在特定磁体的作用下具有新特性并且与生物实体相关联。磁性颗粒经历至少一个低强度磁化，其中它们被布置在根据磁体的南北轴线取向的长丝中; 当磁效应保持在磁性颗粒上时，磁化源和/或容器被移位; 磁化源和/或容器被移位或磁化停止，以便抑制磁性颗粒上的磁场。优选地，本发明可以用于生物学领域。

56. 外观设计

USD553254S1 Specimen container 有权
标题翻译：标本容器
公开(公告)号：USD553254S1
公开(公告)日：2007-10-16
申请号：US29238063
申请日：2005-09-09
申请人： Bruno Colin , Sylvain Baeyaert , Chris Ronsick , Mark Wilson
设计人： Bruno Colin , Sylvain Baeyaert , Chris Ronsick , Mark Wilson

57. 发明申请

US20070172886A1 Reaction module for biological analysis 审中-公开
标题翻译：反应模块用于生物分析
公开(公告)号：US20070172886A1
公开(公告)日：2007-07-26
申请号：US10553440
申请日：2004-05-06
申请人： Bruno Colin , Frederic Paulhet
发明人： Bruno Colin , Frederic Paulhet
IPC分类号： G01N33/53 , C12M3/00
CPC分类号： G01N33/52 , B01L3/5085 , B01L2200/0642 , B01L2200/143 , B01L2300/028 , G01N21/78 , G01N21/8483 , G01N2021/7759
摘要： The present invention relates to a reaction module for biological analysis comprising the injection of biological fluid and/or of reagent allowing a determined biological reaction comprising at least one means for controlling the quantity of biological fluid and/or of reagent injected.
摘要翻译：本发明涉及用于生物分析的反应模块，其包括注入生物流体和/或试剂，其允许包含至少一种用于控制生物流体和/或试剂注入量的装置的确定的生物反应。

58. 发明申请

US20070102393A1 Specimen enclosure apparatus and containers and closure devices for the same 审中-公开
标题翻译：样品外壳装置和容器以及封闭装置相同
公开(公告)号：US20070102393A1
公开(公告)日：2007-05-10
申请号：US11523306
申请日：2006-09-19
申请人： Bruno Colin , Sylvain Baeyaert , Chris Ronsick , Mark Wilson , Ron Robinson
发明人： Bruno Colin , Sylvain Baeyaert , Chris Ronsick , Mark Wilson , Ron Robinson
IPC分类号： B65D51/00 , B65D39/00
CPC分类号： B65D51/241 , B01L3/50825 , B01L2300/042 , B01L2300/048 , B01L2300/049 , B65D39/0005 , B65D41/16 , B65D45/322
摘要： Embodiments of the present invention include a specimen enclosure apparatus. The specimen enclosure apparatus includes a container having a cavity configured to receive the specimen and an opening extending through a neck of the container to the cavity. An internal flange is positioned intermediate the neck of the container. The specimen enclosure apparatus further includes a closure device configured to be received in the opening. The closure device has a flange seal portion configured to contact the internal flange to form a flange seal proximate the cavity and further has a radial travel limiter integrally formed with the closure device that is configured to contact the container in the opening to limit radial movement of the flange seal portion relative to the internal flange. Containers and closure devices are also provided.
摘要翻译：本发明的实施例包括一个样本封闭装置。样本封闭装置包括容器，该容器具有构造成容纳样本的空腔和延伸穿过容器的颈部到空腔的开口。内部法兰定位在容器颈部的中间。样品外壳设备还包括被配置为容纳在开口中的封闭装置。闭合装置具有法兰密封部分，其被构造成接触内部凸缘以形成靠近空腔的凸缘密封件，并且还具有与封闭装置一体形成的径向移动限制器，其构造成在开口中接触容器以限制径向运动凸缘密封部分相对于内部凸缘。还提供容器和封闭装置。

59. 发明授权

US06429007B1 Nucleic acid amplification reaction station for disposable test devices 有权
标题翻译：一次性试验装置的核酸扩增反应站
公开(公告)号：US06429007B1
公开(公告)日：2002-08-06
申请号：US09420140
申请日：1999-10-18
申请人： Bryan W. Kluttz , Geoff A. McKinley , Fabio Gennari , Michel Guy , Christopher Cotter , Luigi Catanzariti , Louis Graziano , Bruno Colin , Cecile Jaravel , Jacques Dachaud
发明人： Bryan W. Kluttz , Geoff A. McKinley , Fabio Gennari , Michel Guy , Christopher Cotter , Luigi Catanzariti , Louis Graziano , Bruno Colin , Cecile Jaravel , Jacques Dachaud
IPC分类号： C12M136
CPC分类号： C12Q1/6848 , B01L3/502 , B01L7/52 , B01L7/525 , B01L2200/026 , B01L2200/16 , B01L2300/044 , B01L2300/0809 , B01L2300/0825 , B01L2300/0861 , B01L2300/087 , B01L2300/1822 , B01L2400/0487 , B01L2400/049 , B01L2400/0633 , B01L2400/0644 , B01L2400/0655 , G01N35/026 , G01N2035/0436
摘要： An instrument for conducting nucleic acid amplification reactions in a disposable test device. The test device includes a first reaction chamber containing a first nucleic acid amplification reagent (e.g., primers and nucleotides) and a second reaction chamber either containing, or in fluid communication, with a second nucleic acid amplification reagent (e.g., an amplification enzyme such as RT). The instrument includes a support structure receiving the test device. A temperature control system maintains the first reaction chamber at a first elevated temperature but simultaneously maintains the second nucleic acid amplification reagent at a second temperature lower than the first temperature so as to preserve the second nucleic acid amplification reagent. An actuator operates on a fluid conduit in the test device to place the first and second reaction chambers in fluid communication with each other after a reaction has occurred in the first reaction chamber at the first temperature. A pneumatic system is also provided that assists in fluid transfer of a reaction solution from the first chamber to the second chamber.
摘要翻译：用于在一次性测试装置中进行核酸扩增反应的仪器。测试装置包括含有第一核酸扩增试剂（例如引物和核苷酸）的第一反应室和含有或与第二核酸扩增试剂（例如，扩增酶如 RT）。仪器包括接收测试装置的支撑结构。温度控制系统将第一反应室保持在第一升高温度，同时将第二核酸扩增试剂保持在低于第一温度的第二温度，以便保留第二核酸扩增试剂。致动器在测试装置中的流体导管上操作，以在第一温度下在第一反应室中发生反应之后使第一和第二反应室彼此流体连通。还提供了一种有助于将反应溶液从第一室流体转移到第二室的气动系统。

60. 发明授权

US06410275B1 Disposable test devices for performing nucleic acid amplification reactions 有权
标题翻译：用于进行核酸扩增反应的一次性测试装置
公开(公告)号：US06410275B1
公开(公告)日：2002-06-25
申请号：US09420139
申请日：1999-10-18
申请人： Bryan Kluttz , Lawrence Burg , Garry Tegeler , Louis Graziano , Christopher Cotter , Michel Guy , James Greer , Geoff McKinley , Luigi Catanzariti , Robert Glassfold , James Clement Bishop , Bruno Colin , Cécile Paris , Thomas Wang , Michael Morin
发明人： Bryan Kluttz , Lawrence Burg , Garry Tegeler , Louis Graziano , Christopher Cotter , Michel Guy , James Greer , Geoff McKinley , Luigi Catanzariti , Robert Glassfold , James Clement Bishop , Bruno Colin , Cécile Paris , Thomas Wang , Michael Morin
IPC分类号： C12P1934
CPC分类号： B01L7/52 , B01L3/502 , B01L2200/026 , B01L2300/0825 , B01L2300/0861 , B01L2400/049 , B01L2400/0644 , B01L2400/0655 , G01N2035/00366
摘要： A unit dose test device for a nucleic acid amplification reaction has the form of a elongate disposable test strip. The test strip includes a dual-chamber reaction vessel pre-loaded with nucleic acid amplification reaction reagents, and a plurality of wells for processing a reaction occurring in the reaction vessel.
摘要翻译：用于核酸扩增反应的单位剂量测试装置具有细长的一次性测试条的形式。测试条包括预装有核酸扩增反应试剂的双室反应容器和用于处理在反应容器中发生的反应的多个孔。

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