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51. 发明授权

US5608039A Single chain B3 antibody fusion proteins and their uses 失效
标题翻译：单链B3抗体融合蛋白及其用途
公开(公告)号：US5608039A
公开(公告)日：1997-03-04
申请号：US331398
申请日：1994-10-28
申请人： Ira Pastan , Mark Willingham , David Fitzgerald , Ulrich Brinkmann , Lee Pai
发明人： Ira Pastan , Mark Willingham , David Fitzgerald , Ulrich Brinkmann , Lee Pai
IPC分类号： A61K38/00 , A61K47/48 , A61P35/00 , C07K14/21 , C07K16/18 , C07K16/30 , C07K16/34 , C07K19/00 , G01N33/574 , C12N15/62 , A61K39/00 , A61K51/10 , C07K16/28
CPC分类号： A61K47/48569 , C07K14/21 , C07K16/18 , C07K16/30 , C07K16/34 , C07K19/00 , G01N33/57419 , G01N33/57446 , G01N33/57449 , G01N33/57492 , A61K38/00 , C07K2317/24 , C07K2317/56 , C07K2317/622 , C07K2319/00 , Y10S530/866 , Y10S530/867
摘要： This invention provides for recombinant single chain antibodies capable of specifically binding to a Lewis.sup.Y -related carbohydrate antigen and fusion proteins comprising these antibodies. More particularly, the invention provides for single chain Fv regions of the monoclonal antibody B3. The invention also provides for a method of improving the binding affinity of antibodies lacking a serine at position 95 of the V.sub.H region that involves mutating position 95 to a serine.
摘要翻译：本发明提供能够特异性结合LewisY相关糖类抗原的重组单链抗体和包含这些抗体的融合蛋白。更具体地，本发明提供单克隆抗体B3的单链Fv区。本发明还提供了一种方法，其将VH区域的95位缺失丝氨酸的抗体与包含突变位置95的丝氨酸相结合。

52. 发明授权

US5336602A Expression enhancer and use thereof to increase the yield in the expression of recombinant genes 失效
标题翻译：表达增强子及其用于增加重组基因表达的产量
公开(公告)号：US5336602A
公开(公告)日：1994-08-09
申请号：US7405
申请日：1993-01-22
申请人： Ulrich Brinkmann , Ralf Mattes , Peter Buckel
发明人： Ulrich Brinkmann , Ralf Mattes , Peter Buckel
IPC分类号： C07H21/04 , C12N9/64 , C12N9/72 , C12N15/09 , C12N15/49 , C12N15/58 , C12N15/67 , C12N15/70 , C12P21/00 , C12R1/19 , C12P21/02
CPC分类号： C12N9/6456 , C12N15/67 , C12N15/70
摘要： An expression enhancer has a DNA sequence which is capable of forming a t-RNA clover-leaf structure after transcription and hybridizes in that region of the DNA which, after transcription, forms the anticodon loop in the clover-leaf structure with an oligonucleotide with the sequence 5'-GACTTAGAAGGTCGTT-3' or its complementary sequence (5'-AACGACCTTCTAAGTC-3'). It can be used to increase the yield in the expression of a recombinant gene by transformation of suitable host cells with an expression vector containing the recombinant gene, whereby it is likewise introduced into the host cells in a form capable of expression and expressed.
摘要翻译：表达增强子具有能够在转录后形成t-RNA三叶草叶结构的DNA序列，并在DNA区域中杂交，转录后，在三叶草叶结构中形成反密码子环，其中寡核苷酸与序列5'-GACTTAGAAGGTCGTT-3'或其互补序列（5'-AACGACCTTCTAAGTC-3'）。可以通过用含有重组基因的表达载体转化合适的宿主细胞来增加重组基因表达的产量，由此同样以能够表达和表达的形式将其引入宿主细胞中。

53. 发明授权

US4584632A Mirror or mirrored cabinet 失效
标题翻译：镜面或镜面柜
公开(公告)号：US4584632A
公开(公告)日：1986-04-22
申请号：US634950
申请日：1984-07-27
申请人： Ulrich Brinkmann
发明人： Ulrich Brinkmann
IPC分类号： A47B67/00 , F21S2/00 , F21S8/00 , F21V33/00 , H01R33/00
CPC分类号： F21V33/004 , A47B67/005 , F21S2/00 , F21S8/00
摘要： In a mirror or mirrored cabinet with at least one lamp mounted at the side, wherein the mirror or mirrored cabinet is suspended from an assembly rail that can be secured toward the wall and wherein a lamp mount, which supports the lamps, is secured to and can be released from the front of the assembly rail.
摘要翻译：在具有安装在侧面的至少一个灯的镜子或镜面柜中，其中反射镜或镜面柜从可以朝向壁固定的组装轨道悬挂，并且其中支撑灯的灯座被固定到可以从组装轨道的前面释放。

54. 发明授权

US09890204B2 Trivalent, bispecific antibodies 有权
公开(公告)号：US09890204B2
公开(公告)日：2018-02-13
申请号：US13568224
申请日：2012-08-07
申请人： Ulrich Brinkmann , Rebecca Croasdale , Eike Hoffmann , Christian Klein , Ekkehard Moessner , Juergen Michael Schanzer , Claudio Sustmann , Pablo Umana
发明人： Ulrich Brinkmann , Rebecca Croasdale , Eike Hoffmann , Christian Klein , Ekkehard Moessner , Juergen Michael Schanzer , Claudio Sustmann , Pablo Umana
IPC分类号： C07K16/00 , C07K16/28 , C07K16/32
CPC分类号： C07K16/00 , C07K16/2863 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/00
摘要： The present invention relates to trivalent, bispecific antibodies, methods for their production, pharmaceutical compositions containing the antibodies, and uses thereof.

55. 发明授权

US08907069B2 Complex of bi-specific antibody and digoxigenin conjugated to a therapeutic or diagnostic agent 有权
标题翻译：缀合于治疗或诊断剂的双特异性抗体和地高辛的复合物
公开(公告)号：US08907069B2
公开(公告)日：2014-12-09
申请号：US13382502
申请日：2010-07-05
申请人： Ulrich Brinkmann , Rebecca Croasdale , Wilma Dormeyer , Guy Georges , Alexander Haas , Eike Hoffmann , Silke Metz , Olaf Mundigl , Werner Scheuer , Jan Olaf Stracke
发明人： Ulrich Brinkmann , Rebecca Croasdale , Wilma Dormeyer , Guy Georges , Alexander Haas , Eike Hoffmann , Silke Metz , Olaf Mundigl , Werner Scheuer , Jan Olaf Stracke
IPC分类号： C07K16/46 , A61K51/10 , A61K49/00 , A61K47/48 , C07K16/28 , B82Y5/00 , C12N15/113 , A61K39/395 , C07K16/16 , C07K16/44 , C07K16/32 , C12N15/11 , A61K31/704 , A61K39/00
CPC分类号： C07K16/44 , A61K31/704 , A61K39/39533 , A61K47/6879 , A61K47/6897 , A61K49/0045 , A61K49/0058 , A61K2039/505 , B82Y5/00 , C07K16/16 , C07K16/2803 , C07K16/2863 , C07K16/2896 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C12N15/111 , C12N15/1138 , C12N2310/14 , C12N2310/3513 , C12N2320/32 , A61K2300/00
摘要： The present invention relates to complexes of a) bi-specific antibodies and antibody fragments against a target protein and b) a digoxigenin conjugated to a therapeutic or diagnostic agent, methods for their production, their use as a delivery platform for therapeutic or diagnostic agents, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译：本发明涉及a）针对靶蛋白的双特异性抗体和抗体片段的复合物，和b）与治疗或诊断试剂缀合的地高辛，其生产方法，它们作为治疗或诊断试剂的递送平台的用途，含有所述抗体的药物组合物及其用途。

56. 发明申请

US20140065151A1 ANTIBODIES AGAINST HUMAN ANGIOPOIETIN 2 审中-公开
标题翻译：抗体人类抗体2
公开(公告)号：US20140065151A1
公开(公告)日：2014-03-06
申请号：US13548244
申请日：2012-07-13
申请人： Ulrich Brinkmann , Remko Albert Griep , Klaus Kaluza , Anita Kavlie , Christian Klein , Joerg Thomas Regula , Werner Scheuer
发明人： Ulrich Brinkmann , Remko Albert Griep , Klaus Kaluza , Anita Kavlie , Christian Klein , Joerg Thomas Regula , Werner Scheuer
IPC分类号： C07K16/22
CPC分类号： C07K16/22 , A61K39/00 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N15/85
摘要： The present invention relates to a method of treating a disease or disorder in a patient comprising administering, to a patient in need of such treatment, an antibody which binds specifically to human angiopoietin-2 (ANG-2). The present invention also relates to a method for preventing metastasis in a patient suffering from primary cancer comprising administering, to a patient in need of such preventative treatment, an antibody which binds specifically to human angiopoietin-2 (ANG-2).
摘要翻译：本发明涉及治疗患者疾病或病症的方法，包括向需要这种治疗的患者施用特异性结合人血管生成素-2（ANG-2）的抗体。本发明还涉及一种用于预防患有原发性癌症的患者转移的方法，包括向需要这种预防性治疗的患者施用特异性结合人血管生成素-2（ANG-2）的抗体。

57. 发明授权

US08399626B2 Antibodies against human angiopoietin 2 有权
公开(公告)号：US08399626B2
公开(公告)日：2013-03-19
申请号：US13358831
申请日：2012-01-26
申请人： Ulrich Brinkmann , Remko Albert Griep , Klaus Kaluza , Anita Kavlie , Christian Klein , Joerg Thomas Regula , Werner Scheuer
发明人： Ulrich Brinkmann , Remko Albert Griep , Klaus Kaluza , Anita Kavlie , Christian Klein , Joerg Thomas Regula , Werner Scheuer
IPC分类号： C07K16/46 , C07K16/28
CPC分类号： C07K16/22 , A61K39/00 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N15/85
摘要： The present invention relates to antibodies against human Angiopoietin 2 (anti-ANG-2 antibodies), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.

58. 发明申请

US20120282280A1 BI-SPECIFIC DIGOXIGENIN BINDING ANTIBODIES 有权
标题翻译：双特异性抗体结合抗体
公开(公告)号：US20120282280A1
公开(公告)日：2012-11-08
申请号：US13382505
申请日：2010-06-30
申请人： Birgit Bramlage , Ulrich Brinkmann , Rebecca Croasdale , Simone Dill , Wilma Dormeyer , Guy Georges , Michael Grote , Alexander Haas , Eike Hoffman , Ludger Markus Ickenstein , Kerstin Jahn-Hofman , Matthias John , Silke Metz , Olaf Mundigl , Werner Scheuer , Jan Olaf Stracke
发明人： Birgit Bramlage , Ulrich Brinkmann , Rebecca Croasdale , Simone Dill , Wilma Dormeyer , Guy Georges , Michael Grote , Alexander Haas , Eike Hoffman , Ludger Markus Ickenstein , Kerstin Jahn-Hofman , Matthias John , Silke Metz , Olaf Mundigl , Werner Scheuer , Jan Olaf Stracke
IPC分类号： A61K39/44 , C07K16/30 , A61P35/00 , G01N21/64
CPC分类号： C07K16/44 , A61K31/704 , A61K39/39533 , A61K47/6879 , A61K47/6897 , A61K49/0045 , A61K49/0058 , A61K2039/505 , B82Y5/00 , C07K16/16 , C07K16/2803 , C07K16/2863 , C07K16/2896 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C12N15/111 , C12N15/1138 , C12N2310/14 , C12N2310/3513 , C12N2320/32 , A61K2300/00
摘要： This invention relates to bispecific antibodies and antibody fragments against a target protein and a hapten, wherein the hapten is PEG or biotin, most preferably digoxigenin, methods for their production, their use as a delivery platform for therapeutic or diagnostic agents, pharmaceutical 5 compositions containing said antibodies, and uses thereof.
摘要翻译：本发明涉及针对靶蛋白和半抗原的双特异性抗体和抗体片段，其中半抗原是PEG或生物素，最优选地高辛，其制备方法，它们作为治疗或诊断剂的递送平台的用途，含有所述抗体及其用途。

59. 发明授权

US08039211B2 Polymorphisms in the human gene for the multidrug resistance-associated protein 1 (MRP-1) and their use in diagnostic and therapeutic applications 有权
标题翻译：多药耐药相关蛋白1（MRP-1）的人类基因多态性及其在诊断和治疗应用中的应用
公开(公告)号：US08039211B2
公开(公告)日：2011-10-18
申请号：US11901238
申请日：2007-09-13
申请人： Ulrich Brinkmann , Sven Hoffmeyer , Esther Mornhinweg
发明人： Ulrich Brinkmann , Sven Hoffmeyer , Esther Mornhinweg
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6883 , C07K14/47 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , G01N33/6893 , G01N2333/705 , G01N2500/04 , G01N2800/44
摘要： The present invention relates to a polymorphic MRP-1 polynucleotide. Moreover, the invention relates to genes or vectors comprising the polynucleotides of the invention and to a host cell genetically engineered with the polynucleotide or gene of the invention. Further, the invention relates to methods for producing molecular variant polypeptides or fragments thereof, methods for producing cells capable of expressing a molecular variant polypeptide and to a polypeptide or fragment thereof encoded by the polynucleotide or the gene of the invention or which is obtainable by the method or from the cells produced by the method of the invention. Furthermore, the invention relates to an antibody which binds specifically the polypeptide of the invention. Moreover, the invention relates to a transgenic non-human animal. The invention also relates to a solid support comprising one or a plurality of the above mentioned polynucleotides, genes, vectors, polypeptides, antibodies or host cells. Furthermore, methods of identifying a polymorphism, identifying and obtaining a pro-drug or drug or an inhibitor are also encompassed by the present invention. In addition, the invention relates to methods for producing of a pharmaceutical composition and to methods of diagnosing a disease. Further, the invention relates to a method of detection of the polynucleotide of the invention. Furthermore, comprised by the present invention are a diagnostic and a pharmaceutical composition. Even more, the invention relates to uses of the polynucleotides, genes, vectors, polypeptides or antibodies of the invention. Finally, the invention relates to a diagnostic kit.
摘要翻译：本发明涉及多形性MRP-1多核苷酸。此外，本发明涉及包含本发明的多核苷酸的基因或载体，并涉及用本发明的多核苷酸或基因进行遗传工程改造的宿主细胞。此外，本发明涉及用于产生分子变体多肽或其片段的方法，用于产生能够表达分子变体多肽的细胞的方法及其由本发明的多核苷酸或基因编码的多肽或其片段，或可由方法或由本发明方法生产的细胞。此外，本发明涉及特异性结合本发明多肽的抗体。此外，本发明涉及转基因非人动物。本发明还涉及包含一种或多种上述多核苷酸，基因，载体，多肽，抗体或宿主细胞的固体支持物。此外，鉴定多态性，鉴定和获得前药或药物或抑制剂的方法也包括在本发明中。此外，本发明涉及制备药物组合物的方法和诊断疾病的方法。此外，本发明涉及本发明的多核苷酸的检测方法。此外，本发明包括诊断和药物组合物。更进一步地，本发明涉及本发明的多核苷酸，基因，载体，多肽或抗体的用途。最后，本发明涉及诊断试剂盒。

60. 发明授权

US08039105B2 Amorphous submicron particles 有权
标题翻译：无定形亚微米颗粒
公开(公告)号：US08039105B2
公开(公告)日：2011-10-18
申请号：US12840816
申请日：2010-07-21
申请人： Karl Meier , Ulrich Brinkmann , Christian Panz , Doris Misselich , Christian Goetz
发明人： Karl Meier , Ulrich Brinkmann , Christian Panz , Doris Misselich , Christian Goetz
IPC分类号： B32B5/66
CPC分类号： B02C19/06 , B02C19/068 , Y10T428/259 , Y10T428/29 , Y10T428/2982
摘要： A process for milling amorphous solids using a milling apparatus can result in particles having a median particle diameter d50 of
摘要翻译：使用研磨装置研磨无定形固体的方法可导致中值粒径d50 <1.5μm的颗粒。该方法包括：使用选自气体，蒸气，蒸汽，含蒸汽的气体及其混合物的操作介质在研磨阶段操作研磨机，以及在实际操作之前在加热阶段加热研磨室其中操作介质使得研磨室，轧机出口或两者中的温度高于操作介质的露点。

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