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1. 发明授权

US08092809B2 Pseudomonas exotoxin A-like chimeric immunogens 失效
标题翻译：假单胞菌外毒素A样嵌合免疫原
公开(公告)号：US08092809B2
公开(公告)日：2012-01-10
申请号：US11962007
申请日：2007-12-20
申请人： David FitzGerald
发明人： David FitzGerald
IPC分类号： A61K39/108
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/51 , C07K14/21 , C07K16/1063 , C07K2319/00 , C12N2740/16122
摘要： This invention provides Pseudomonas exotoxin A-like chimeric immunogens that include a non-native epitope in the Ib domain of Pseudomonas exotoxin. Methods of eliciting an immune response using these immunogens also are provided.
摘要翻译：本发明提供了假单胞菌外毒素A样嵌合免疫原，其包含假单胞菌外毒素的Ib结构域中的非天然表位。还提供了使用这些免疫原引发免疫应答的方法。

2. 发明申请

US20100323567A1 ADJUSTABLE FLEX WATERBOARD STRINGER 失效
标题翻译：可调节的FLEX WATERBOARD STRINGER
公开(公告)号：US20100323567A1
公开(公告)日：2010-12-23
申请号：US12490141
申请日：2009-06-23
申请人： DAVID FITZGERALD
发明人： DAVID FITZGERALD
IPC分类号： B63B35/79
CPC分类号： B63B35/7906
摘要： A waterboard with externally adjustable stiffness includes a stringer assembly having a rotatable beam to modulate the stiffness of the beam in a selected direction to impart a desired stiffness to the waterboard.
摘要翻译：具有外部可调节刚度的水板包括具有可旋转梁的纵梁组件，以在所选方向上调节梁的刚度以向水板赋予期望的刚度。

3. 发明授权

US07797172B2 Healthcare financial data and clinical information processing system 有权
标题翻译：医疗财务数据和临床信息处理系统
公开(公告)号：US07797172B2
公开(公告)日：2010-09-14
申请号：US10253223
申请日：2002-09-24
申请人： David Fitzgerald , Brian Lucas , Greg Long , David Hiebert Klassen, Sr. , John Hunter
发明人： David Fitzgerald , Brian Lucas , Greg Long , David Hiebert Klassen, Sr. , John Hunter
IPC分类号： G06Q40/00
CPC分类号： G06F19/328 , G06F19/00 , G06Q20/102 , G06Q40/02 , G06Q40/08 , G06Q50/22
摘要： A patient claim data processing system responds to and initiates clinical events and attains early accurate claim data during a patient healthcare encounter cycle to support prompt claim data validation and editing both for individual claim elements and for a completed claim to improve claim accuracy prior to claim submission to a payer. The system submits accurate claims to payers and receives remittance advice from payers and applies rules to the advice. A system processes financial data related to provision of healthcare to a patient in response to clinical events. The system includes an interface processor for receiving a message identifying an event and a related change in healthcare data concerning a patient and also includes a source of rules for determining characteristics associated with reimbursement for provision of an individual service to a patient. A rules processor initiates application of a rule derived from the rules source to process financial data concerning provision of the individual service to the patient in response to receiving the message identifying the event. A result processor initiates an action in response to a result derived by the application of the rule to process the financial data. The rules processor also validates the financial data complies with the rule.
摘要翻译：患者索赔数据处理系统响应并启动临床事件，并在患者医疗保健相关周期期间获得早期准确的索赔数据，以支持针对个人索赔要素的即时索赔数据验证和编辑，以及完成的索赔，以在索赔提交之前提高索赔准确性付款人系统向付款人提交准确的索赔，并从付款人那里收到汇款通知，并对建议采用规则。系统响应于临床事件处理与向患者提供医疗保健有关的财务数据。该系统包括接口处理器，用于接收标识事件的消息和关于患者的医疗保健数据的相关变化，并且还包括用于确定与向患者提供个体服务的报销相关联的特征的规则来源。响应于接收到标识事件的消息，规则处理器启动从规则源导出的规则的应用以处理关于向患者提供单独服务的财务数据。结果处理器响应于应用规则导出的结果来处理财务数据而发起操作。规则处理器还验证财务数据符合规则。

4. 发明申请

US20100215656A1 DELETIONS IN DOMAIN II OF PSEUDOMONAS EXOTOXIN A THAT REMOVE IMMUNOGENIC EPITOPES 有权
标题翻译：去除免疫原性外周血单核细胞的二核苷酸
公开(公告)号：US20100215656A1
公开(公告)日：2010-08-26
申请号：US12676203
申请日：2008-09-04
申请人： Ira H. Pastan , John Weldon , David FitzGerald
发明人： Ira H. Pastan , John Weldon , David FitzGerald
IPC分类号： A61K39/395 , C07K14/21 , C07K16/12 , C07H21/04 , A61P35/00
CPC分类号： C07K14/21 , A61K38/00 , C07K2319/30
摘要： The invention provides mutated, cytotoxic forms of Pseudomonas exotoxin A (PE) comprising a furin cleavage sequence conjugated or fused directly to residues 395-613 of PE or variants of that sequence. These minimal forms of PE are smaller than previous cytotoxic forms of PE, reduce non-specific toxicity, and reduce immunogenicity due to domain II or domain Ib of PE. The invention further provides nucleic acids encoding said PEs, chimeric molecules containing them, and methods of use thereof.
摘要翻译：本发明提供了突变的细胞毒性形式的假单胞菌外毒素A（PE），其包含与PE的残基395-613或该序列的变体直接缀合或融合的弗林蛋白酶切割序列。 PE的这些最小形式小于PE的先前细胞毒性形式，降低非特异性毒性，并降低由于PE的结构域II或结构域Ib引起的免疫原性。本发明还提供编码所述PE的核酸，含有它们的嵌合分子及其使用方法。

5. 发明申请

US20060249928A1 Snow recreation device 审中-公开
标题翻译：雪娱乐设备
公开(公告)号：US20060249928A1
公开(公告)日：2006-11-09
申请号：US11485498
申请日：2006-07-11
申请人： David Fitzgerald , Matthew Zilinskas , Terry Sanchez
发明人： David Fitzgerald , Matthew Zilinskas , Terry Sanchez
IPC分类号： A63C5/06
CPC分类号： B62B15/00 , B62B13/125 , B62B2501/065
摘要： A snow recreation device is provided. The device is defined by a convex bottom surface that includes tracking and steering ridges. In some embodiments, the device includes raised handles configured to position a rider's grip above the bottom surface of the device.
摘要翻译：提供雪地娱乐装置。该装置由包括跟踪和转向脊的凸底面限定。在一些实施例中，该装置包括构造成将骑手的把手定位在装置的底表面上方的提升手柄。

6. 发明申请

US20060152838A1 Magneto-resistive head resistance sensor 有权
标题翻译：磁阻电阻传感器
公开(公告)号：US20060152838A1
公开(公告)日：2006-07-13
申请号：US11034997
申请日：2005-01-13
申请人： David Fitzgerald , Jeffrey Gleason , James Howley , Scott O'Brien , Michael Straub
发明人： David Fitzgerald , Jeffrey Gleason , James Howley , Scott O'Brien , Michael Straub
IPC分类号： G11B5/09
CPC分类号： G11B5/02 , G11B2005/001 , G11B2005/0018
摘要： A recording system employing a magneto-resistive (MR) element senses a resistance value of the MR element and generates one or more MR resistance (MRR) signal values based on the sensed MR element resistance value. The MRR signal values might be, for example, current or voltage values proportional or inversely proportional to the MR element resistance value. The MRR signal values might be employed to control one or more of: i) a unity gain bandwidth of a bias loop for the MR element, ii) an MR read head preamplifier low corner frequency, and iii) a slew rate across the MR element.
摘要翻译：使用磁阻（MR）元件的记录系统感测MR元件的电阻值，并且基于感测的MR元件电阻值产生一个或多个MR电阻（MRR）信号值。 MRR信号值可以是例如与MR元件电阻值成比例或成反比的电流值或电压值。可以采用MRR信号值来控制以下各项中的一个或多个：i）用于MR元件的偏置环路的单位增益带宽，ii）MR读取头前置放大器低转角频率，以及iii）横跨MR元件的转换速率。

7. 外观设计

USD457047S1 Ruler with letter opener and magnifier 失效
标题翻译：标尺与信号开关和放大镜
公开(公告)号：USD457047S1
公开(公告)日：2002-05-14
申请号：US29135992
申请日：2001-01-22
申请人： David FitzGerald
设计人： David FitzGerald

8. 发明授权

US5608039A Single chain B3 antibody fusion proteins and their uses 失效
标题翻译：单链B3抗体融合蛋白及其用途
公开(公告)号：US5608039A
公开(公告)日：1997-03-04
申请号：US331398
申请日：1994-10-28
申请人： Ira Pastan , Mark Willingham , David Fitzgerald , Ulrich Brinkmann , Lee Pai
发明人： Ira Pastan , Mark Willingham , David Fitzgerald , Ulrich Brinkmann , Lee Pai
IPC分类号： A61K38/00 , A61K47/48 , A61P35/00 , C07K14/21 , C07K16/18 , C07K16/30 , C07K16/34 , C07K19/00 , G01N33/574 , C12N15/62 , A61K39/00 , A61K51/10 , C07K16/28
CPC分类号： A61K47/48569 , C07K14/21 , C07K16/18 , C07K16/30 , C07K16/34 , C07K19/00 , G01N33/57419 , G01N33/57446 , G01N33/57449 , G01N33/57492 , A61K38/00 , C07K2317/24 , C07K2317/56 , C07K2317/622 , C07K2319/00 , Y10S530/866 , Y10S530/867
摘要： This invention provides for recombinant single chain antibodies capable of specifically binding to a Lewis.sup.Y -related carbohydrate antigen and fusion proteins comprising these antibodies. More particularly, the invention provides for single chain Fv regions of the monoclonal antibody B3. The invention also provides for a method of improving the binding affinity of antibodies lacking a serine at position 95 of the V.sub.H region that involves mutating position 95 to a serine.
摘要翻译：本发明提供能够特异性结合LewisY相关糖类抗原的重组单链抗体和包含这些抗体的融合蛋白。更具体地，本发明提供单克隆抗体B3的单链Fv区。本发明还提供了一种方法，其将VH区域的95位缺失丝氨酸的抗体与包含突变位置95的丝氨酸相结合。

9. 发明授权

US5512658A Pseudomonas exotoxins (PE) and conjugates thereof having lower animal toxicity with high cytocidal activity through substitution of positively charged amino acids 失效
标题翻译：通过取代带正电荷的氨基酸，具有较低动物毒性和高杀细胞活性的假单胞菌外毒素（PE）及其结合物
公开(公告)号：US5512658A
公开(公告)日：1996-04-30
申请号：US130322
申请日：1993-10-01
申请人： Ira Pastan , David Fitzgerald , Vijay K. Chaudhary
发明人： Ira Pastan , David Fitzgerald , Vijay K. Chaudhary
IPC分类号： A61K38/00 , A61K31/00 , A61K35/74 , A61K38/22 , A61K39/00 , A61K39/395 , A61P35/00 , A61P43/00 , C07K14/195 , C07K14/21 , C07K14/41 , C07K14/495 , C07K14/52 , C07K14/54 , C07K14/73 , C07K19/00 , C12N15/09 , C12N15/31 , C12P21/00 , C12P21/02 , C12R1/19 , C12R1/38 , A61K39/04
CPC分类号： C07K14/70514 , C07K14/21 , C07K14/495 , C07K14/5412 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/034 , C07K2319/55 , C07K2319/75 , Y10S435/875
摘要： Improved Pseudomonas exotoxins of low animal toxicity and high cytocidal activity are described. Substitution of positively charged amino acid residues with an amino acid residue without a positive charge provides markedly changed exotoxins. Conjugation of the new exotoxins with suitable targeting agents provides cytocidal specificity for killing desired cellular entities.
摘要翻译：描述了改进的低动物毒性和高杀细胞活性的假单胞菌外毒素。用没有正电荷的氨基酸残基取代带正电荷的氨基酸残基提供明显改变的外毒素。新的外毒素与合适的靶向剂的结合为杀死所需的细胞实体提供杀细菌特异性。

10. 发明授权

US5082927A Selectively cytotoxic IL-4-PE40 fusion protein 失效
标题翻译：选择性细胞毒性IL-4-PE40融合蛋白
公开(公告)号：US5082927A
公开(公告)日：1992-01-21
申请号：US351448
申请日：1989-05-12
申请人： Ira Pastan , David FitzGerald , Masato Ogata
发明人： Ira Pastan , David FitzGerald , Masato Ogata
IPC分类号： A61K38/00 , A61K39/00 , A61K47/48 , C07K14/21 , C07K14/495 , C07K14/55 , C07K16/28
CPC分类号： C07K14/495 , A61K47/48369 , A61K47/48484 , C07K14/21 , C07K14/55 , C07K16/2866 , C07K16/2896 , A61K38/00 , A61K39/00 , C07K2319/00 , C07K2319/55 , C07K2319/75 , Y10S530/82 , Y10S530/825
摘要： The present invention provides a chimeric protein IL4-PE40 which selectively kills IL4 receptor bearing cells. A mutant form of the protein is also provided.
摘要翻译：本发明提供了选择性地杀死携带IL4受体的细胞的嵌合蛋白IL4-PE40。还提供了蛋白质的突变体形式。

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