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51. 发明申请

US20100081941A1 CARDIOVASCULAR HEALTH STATION METHODS AND APPARATUS 审中-公开
标题翻译：心血管健康站方法和装置
公开(公告)号：US20100081941A1
公开(公告)日：2010-04-01
申请号：US11963681
申请日：2007-12-21
申请人： Morteza Naghavi , Robin Antony Owen , Albert Andrew Yen , Craig Jamieson , Haider Hassan , David Panthagani , Gary L. McQuilkin , Timothy O'Brien
发明人： Morteza Naghavi , Robin Antony Owen , Albert Andrew Yen , Craig Jamieson , Haider Hassan , David Panthagani , Gary L. McQuilkin , Timothy O'Brien
IPC分类号： A61B5/02
CPC分类号： A61B5/022 , A61B5/0066 , A61B5/015 , A61B5/02007 , A61B5/0261 , A61B5/0285 , A61B8/06
摘要： Methods and apparatus for improving measurements of cardiovascular health status in a given individual are provided. The comprehensive assessment of cardiovascular health includes at least two components: risk factor assessment based on epidemiologic studies and functional status of the individual. Structural studies of the individual can also be included in the comprehensive assessment of cardiovascular health. The invention aims to improve detection, treatment, devices, and administration of cardiovascular risk assessment.
摘要翻译：提供了用于改善给定个体心血管健康状况测量的方法和装置。心血管健康综合评估至少包括两个部分：基于流行病学研究的风险因素评估和个体功能状态。个人的结构研究也可以纳入心血管健康综合评估。本发明旨在改善心血管风险评估的检测，治疗，设备和管理。

52. 发明申请

US20090239912A1 CONCENTRATED, NON-FOAMING SOLUTION OF QUATERNARY AMMONIUM COMPOUNDS AND METHODS OF USE 审中-公开
标题翻译：浓缩的季铵盐化合物的非泡沫溶液及其使用方法
公开(公告)号：US20090239912A1
公开(公告)日：2009-09-24
申请号：US12475760
申请日：2009-06-01
申请人： CESAR COMPADRE , Philip Breen , Hamid Salari , E. Kim Fifer , Danny L. Lattin , Michael Slavik , Yanbin Li , Timothy O'Brien , Amy L. Waldroup , Thomas F. Berg
发明人： CESAR COMPADRE , Philip Breen , Hamid Salari , E. Kim Fifer , Danny L. Lattin , Michael Slavik , Yanbin Li , Timothy O'Brien , Amy L. Waldroup , Thomas F. Berg
IPC分类号： A01N43/40
CPC分类号： A23L3/3526 , A01N33/12 , A01N43/40 , A23B4/20 , A23B4/30 , A23B7/154 , A23B7/158 , A23L3/3544 , Y02A50/486 , A01N31/02 , A01N25/30 , A01N25/02 , A01N2300/00
摘要： A concentrated quaternary ammonium compound (QAC) solution comprising a QAC with a concentration from greater than about 10% by weight and at least one solubility enhancing agent, such as an alcohol, is disclosed. A diluted QAC solution is used to contact food products to prevent microbial growth on the food products from a broad spectrum of foodborne microbial contamination. A method of contacting the food products with the dilute QAC for an application time of at least 0.1 second is disclosed. The foods that can be treated by this method are meat and meat products, seafood, vegetables, fruit, dairy products, pet foods and snacks, and any other food that can be treated and still retain its appearance and texture. One of the treatment methods is spraying and misting the QAC solutions on the food products for an application time of at least 0.1 second to prevent broad spectrum foodborne microbial contamination.
摘要翻译：公开了包含浓度大于约10重量％的QAC和至少一种溶解度增强剂如醇的浓缩季铵化合物（QAC）溶液。稀释的QAC溶液用于接触食品，以防止食品中的微生物生长受到广泛的食源性微生物污染。公开了一种将食品与稀释的QAC接触至少0.1秒的施用时间的方法。可以通过这种方法处理的食物是肉类和肉制品，海鲜，蔬菜，水果，乳制品，宠物食品和小吃，以及任何其他可以处理，仍然保持其外观和质感的食物。其中一种处理方法是将食品中的QAC溶液喷雾和雾化至少0.1秒的施用时间，以防止广谱食源性微生物污染。

53. 发明申请

US20090035819A1 CA125 gene and its use for diagnostic and therapeutic interventions 有权
公开(公告)号：US20090035819A1
公开(公告)日：2009-02-05
申请号：US11975668
申请日：2007-10-19
申请人： Timothy O'Brien , John Beard , Lowell Underwood
发明人： Timothy O'Brien , John Beard , Lowell Underwood
IPC分类号： C12P21/06 , C07H21/00 , C07K16/18 , C12N5/00
CPC分类号： C07K14/705 , C07K16/3092
摘要： The CA125 gene has been cloned and multiple repeat sequences as well as the carboxy terminus have been identified. The CA125 molecule comprises three major domains: an extracellular amino terminal domain (Domain 1); a large multiple repeat domain (Domain 2); and a carboxy terminal domain (Domain 3) which includes a transmembrane anchor with a short cytoplasmic domain. The amino terminal domain is assembled by combining five genomic exons, four very short amino terminal sequences and one extraordinarily large exon. This domain is dominated by its capacity for O-glycosylation and its resultant richness in serine and threonine residues. Additionally, an amino terminal extension is present, which comprises four genomic exons. The amino acid composition of the amino terminal extension was found to be consistent with the amino acid composition of the amino terminal domain. The molecular structure is dominated by a repeat domain comprising 156 amino acid repeat units, which encompass the epitope binding sites. More than 60 repeat units have been identified, sequenced, and contiguously placed in the CA125 domain structure. The repeat units encompass an interactive disulfide bridged C-enclosure and the site of OC125 and M11 binding. The repeat sequences demonstrated 70-85% homology to each other. Expression of the repeats was demonstrated in E. coli. The CA125 molecule is anchored at its carboxy terminal through a transmembrane domain and a short cytoplasmic tail. The carboxy terminal also contains a proteolytic cleavage site approximately 50 amino acids upstream from the transmembrane domain, which allows for proteolytic cleavage and release of the CA125 molecule. Any one of the repeat domains has the potential for use as a new gold standard for detecting and monitoring the presence of the CA125 antigen. Further, the repeat domains or other domains, especially the c-terminal to the repeat domain also provide a basis for the development of a vaccine, which would be useful for the treatment of ovarian cancer and other carcinomas where CA125 is elevated.

54. 发明申请

US20070118045A1 Iontophoresis challenge for monitoring cardiovascular status 审中-公开
标题翻译：用于监测心血管状态的离子电渗疗法挑战
公开(公告)号：US20070118045A1
公开(公告)日：2007-05-24
申请号：US11585781
申请日：2006-10-23
申请人： Morteza Naghavi , Timothy O'Brien , Craig Jamieson , Mark Johnson
发明人： Morteza Naghavi , Timothy O'Brien , Craig Jamieson , Mark Johnson
IPC分类号： A61B5/00 , A61B6/00 , A61B5/02
CPC分类号： A61B5/01 , A61B5/02007
摘要： Methods and apparatus are provided for determining individual vascular responses by employing iontophoresis to deliver vasoactive compounds to local area and determining resultant changes in blood flow by measuring changes in skin temperature as a correlate of local blood flow. The invention further provides methods and apparatus for assessing vascular reactivity in individuals under ambulatory conditions and relating stress responses to vascular reactivity.
摘要翻译：提供了用于通过使用离子电渗法将血管活性化合物递送至局部区域并通过测量皮肤温度变化作为局部血流量的相关性来确定血流变化的方法和装置。本发明进一步提供了用于评估在动态条件下个体的血管反应性并将应激反应与血管反应性相关联的方法和装置。

55. 发明申请

US20070015907A1 Repeat sequences of the ca125 gene and their use for diagnostic and therapeutic interventions 有权
公开(公告)号：US20070015907A1
公开(公告)日：2007-01-18
申请号：US10475117
申请日：2002-04-12
申请人： Timothy O'Brien , John Beard , Lowell Underwood
发明人： Timothy O'Brien , John Beard , Lowell Underwood
IPC分类号： C07K14/705 , C07H21/04
CPC分类号： C07K14/47 , A61K38/00 , C12Q1/6886 , C12Q2600/158
摘要： The CA125 gene has been cloned and multiple repeat sequences as well as the carboxy terminus have been identified. The CA125 molecule comprises three major domains: an extracellular amino terminal domain (Domain 1); a large multiple repeat domain (Domain 2); and a carboxy terminal domain (Domain 3) which includes a transmembrane anchor with a short cytoplasmic domain. The amino terminal domain is assembled by combining five genomic exons, four very short amino terminal sequences and one extraordinarily large exon. This domain is dominated by its capacity for O-glycosylation and its resultant richness in serine and threonine residues. Additionally, an amino terminal extension is present, which comprises four genomic exons. The amino acid composition of the amino terminal extension was found to be consistent with the amino acid composition of the amino terminal domain. The molecular structure is dominated by a repeat domain comprising 156 amino acid repeat units, which encompass the epitope binding sites. More than 60 repeat units have been identified, sequenced, and contiguously placed in the CA125 domain structure. The repeat units encompass an interactive disulfide bridged C-enclosure and the site of OC125 and M11 binding. The repeat sequences demonstrated 70-85% homology to each other. Expression of the repeats was demonstrated in E. coli. The CA125 molecule is anchored at its carboxy terminal through a transmembrane domain and a short cytoplasmic tail. The carboxy terminal also contains a proteolytic cleavage site approximately 50 amino acids upstream from the transmembrane domain, which allows for proteolytic cleavage and release of the CA125 molecule. Any one of the repeat domains has the potential for use as a new gold standard for detecting and monitoring the presence of the CA125 antigen. Further, the repeat domains or other domains, especially the c-terminal to the repeat domain also provide a basis for the development of a vaccine, which would be useful for the treatment of ovarian cancer and other carcinomas where CA125 is elevated.

56. 发明申请

US20060263708A1 Imaging member 失效
公开(公告)号：US20060263708A1
公开(公告)日：2006-11-23
申请号：US11133979
申请日：2005-05-20
申请人： Jin Wu , Yuhua Tong , Jennifer Hwang , Liang-bih Lin , Andronique Ioannidis , Nancy Belknap , Timothy O'Brien , Anthony Uttaro
发明人： Jin Wu , Yuhua Tong , Jennifer Hwang , Liang-bih Lin , Andronique Ioannidis , Nancy Belknap , Timothy O'Brien , Anthony Uttaro
IPC分类号： G03G5/14
CPC分类号： G03G5/142 , G03G5/051 , G03G5/0514 , G03G5/0517 , G03G5/0525 , G03G5/144
摘要： Provided is an imaging member comprising a substrate, an undercoat layer (UCL), a charge generation layer, a charge transport layer, and an optional overcoat layer. The undercoat layer is formed from a single-phase UCL coating formulation comprising an organic titanate, a polymer containing active hydrogen, and an aminosilane. The UCL formulation has improved properties such as stability, processing convenience, and longer pot life etc. The UCL formulation can be used to manufacture an imaging member such as photoreceptor with improved properties such as stable, thick UCL coating, resistance to electrical failure, and PIDC independency on UCL thickness etc.

57. 发明授权

US07130983B1 System and method for reference count regeneration 有权
标题翻译：参考计数再生的系统和方法
公开(公告)号：US07130983B1
公开(公告)日：2006-10-31
申请号：US10738946
申请日：2003-12-17
申请人： George Franklin DeTar, Jr. , John Timothy O'Brien
发明人： George Franklin DeTar, Jr. , John Timothy O'Brien
IPC分类号： G06F12/06
CPC分类号： G06F3/0656 , G06F3/0617 , G06F3/0676 , G06F11/1441
摘要： In a disk-based data storage system, a controller configured to control a reference count regeneration operation, the controller includes a control register, an address register, a status register, a boundary register, and an embedded memory. The control register may be configured to set up and initiate program instructions that are executed by at least one processor. The address register may be configured as a cache address pointer and correspond to at least one of a sort output list pointer, a virtual track table input list pointer, a reference list pointer, a track number table pointer, and a reference count mis-compare list pointer. The status register may be configured to indicate status of a routine. The routine includes at least one of a radix sort, a reference list count, a combine counts, and a merger of the reference list count into the TNT to generate an updated TNT. The boundary register corresponds to a disk cache memory that may be configured to store at least one of a reference list, a reference list count length, and a mis-compare list. The embedded memory may be configured to perform at least one buffer operation in connection with the routine.
摘要翻译：在基于磁盘的数据存储系统中，控制器被配置为控制参考计数再生操作，所述控制器包括控制寄存器，地址寄存器，状态寄存器，边界寄存器和嵌入存储器。控制寄存器可以被配置为建立和启动由至少一个处理器执行的程序指令。地址寄存器可以被配置为高速缓存地址指针，并且对应于排序输出列表指针，虚拟轨道表输入列表指针，参考列表指针，轨道号表指针和参考计数误比较中的至少一个列表指针。状态寄存器可以被配置为指示例程的状态。例程包括基数排序，参考列表计数，组合计数和参考列表计数合并到TNT中以生成更新的TNT中的至少一个。边界寄存器对应于可被配置为存储参考列表，参考列表计数长度和误比较列表中的至少一个的磁盘高速缓存存储器。嵌入式存储器可以被配置为执行与该例程有关的至少一个缓冲器操作。

58. 发明申请

US20060051212A1 Coated turbine blade, turbine wheel with plurality of coated turbine blades, and process of coating turbine blade 审中-公开
标题翻译：涂覆的涡轮叶片，具有多个涂覆的涡轮叶片的涡轮机叶轮和涂覆涡轮叶片的工艺
公开(公告)号：US20060051212A1
公开(公告)日：2006-03-09
申请号：US10935087
申请日：2004-09-08
申请人： Timothy O'Brien , William Weidner , Robert Hundertmark
发明人： Timothy O'Brien , William Weidner , Robert Hundertmark
IPC分类号： F03B3/12
CPC分类号： F01D5/288 , F01D5/28 , F05D2230/90 , F05D2240/80 , F05D2300/611 , Y02T50/672
摘要： A turbine blade includes a platform having a top surface, a bottom surface, and a peripheral sidewall between the top and bottom surfaces. An airfoil protrudes from the top surface of the platform. A blade mount extends from the bottom surface of the platform for attaching the turbine blade to a turbine wheel. A corrosion resistant protective coating is applied on one or more of the airfoil, the top surface, the peripheral sidewall and the bottom surface of the platform.
摘要翻译：涡轮机叶片包括具有顶表面，底表面和在顶表面和底表面之间的周边侧壁的平台。机翼从平台的顶面突出。叶片安装架从平台的底表面延伸，用于将涡轮机叶片附接到涡轮机叶轮。将抗腐蚀保护涂层施加在平台的一个或多个翼面，顶面，周边侧壁和底面上。

59. 发明申请

US20050040071A1 Diode cutoff and safe packaging method for textile detonating cord 审中-公开
标题翻译：纺织品引爆线二极管截止和安全包装方法
公开(公告)号：US20050040071A1
公开(公告)日：2005-02-24
申请号：US10645369
申请日：2003-08-21
申请人： John O'Brien , Timothy O'Brien
发明人： John O'Brien , Timothy O'Brien
IPC分类号： F42B39/14 , F42B39/30 , B65D85/30
CPC分类号： F42B39/14 , F42B39/30 , F42D1/042 , H01L2924/01005 , H01L2924/01006
摘要： A block molded from a polymeric material has a through passageway to contain a percussive shock wave. Angularly related channels communicate with the containment passageway for receiving arcuate segments of detonation cord. Alignment of a plurality of blocks provides a convenient packaging setup for the cord. A percussive signal traveling along the cord can be short-circuited in the packaging setup. A diode version of the block can react to the signal in a given direction of travel.
摘要翻译：由聚合材料模制的块具有通过通道以容纳冲击波。角度相关的通道与容纳通道连通，用于接收引爆线的弧形段。多个块的对准提供了用于绳索的方便的包装设置。沿着绳索行进的撞击信号可能在包装设置中短路。块的二极管版本可以在给定的行进方向上对信号做出反应。

60. 发明授权

US09950016B2 Cell secreted proteins for the treatment of myocardial infarction 有权
公开(公告)号：US09950016B2
公开(公告)日：2018-04-24
申请号：US14127991
申请日：2012-06-25
申请人： Timothy O'Brien , Frank Barry , Claire Kavanagh
发明人： Timothy O'Brien , Frank Barry , Claire Kavanagh
IPC分类号： A01N63/00 , A61K35/545 , A61K38/19 , A61K38/17 , A61K38/18 , A61K38/39 , A61K35/28 , A61K35/44 , A61K38/21 , A61K38/36 , A61L15/44 , A61L27/28 , A61L27/38 , A61L27/54 , A61L29/08 , A61L29/16
CPC分类号： A61K35/545 , A61K35/28 , A61K35/44 , A61K38/1709 , A61K38/1735 , A61K38/177 , A61K38/179 , A61K38/1891 , A61K38/19 , A61K38/195 , A61K38/217 , A61K38/363 , A61K38/39 , A61L15/44 , A61L27/28 , A61L27/3804 , A61L27/54 , A61L29/08 , A61L29/16
摘要： The present invention relates to the use of secreted proteins from mesenchymal stem cells and other cells for the treatment of myocardial infarction. In particular, the invention provides compositions and methods based on secreted proteins from mesenchymal stem cells and the genes encoding them.

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