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51. 发明授权

US08207218B2 DMAE as sole agent for the treatment of mild cognitive impairment 有权
标题翻译： DMAE作为治疗轻度认知障碍的唯一代理
公开(公告)号：US08207218B2
公开(公告)日：2012-06-26
申请号：US12447816
申请日：2007-10-31
申请人： Pierre Fabre , Christophe Przybylski , Bruno Dubois
发明人： Pierre Fabre , Christophe Przybylski , Bruno Dubois
IPC分类号： A61K31/13 , A61K31/4015
CPC分类号： A61K31/133
摘要： The present invention relates to the use, as sole active ingredient, of dimethylaminoethanol (DMAE) in free form or in the form of salts or of esters and also of hydrates and solvates thereof, for the manufacture of a medicament for use in the treatment of a non-dementia mild cognitive impairment characterized by an amnestic syndrome of hippocampal type.
摘要翻译：本发明涉及作为唯一活性成分的游离形式或盐或酯形式的二甲基氨基乙醇（DMAE）以及其水合物和溶剂合物的用途，用于制备用于治疗以痴呆症轻度认知障碍为特征的遗忘综合征海马型。

52. 发明申请

US20110071226A1 EMOLLIENT COMPOSITION 审中-公开
标题翻译：外在成分
公开(公告)号：US20110071226A1
公开(公告)日：2011-03-24
申请号：US12992808
申请日：2009-05-18
申请人： Pierre Fabre , Christophe Przybylski , Jean-François Cordoliani , Marion Kopec
发明人： Pierre Fabre , Christophe Przybylski , Jean-François Cordoliani , Marion Kopec
IPC分类号： A61K31/047 , A61K31/01 , A61P17/00
CPC分类号： A61K31/01 , A61K8/31 , A61K8/345 , A61K31/047 , A61Q19/007 , A61K2300/00
摘要： The invention relates to an emollient composition for topical use that comprises a combination of glycerol, Vaseline and liquid paraffin as an active principle, in the form of an oil-in-water or water-in-oil emulsion. The invention also relates to: the use thereof for preparing a drug for treating dry skin conditions associated with certain dermatoses such as atopic dermatitis, ichthyosis conditions and psoriasis; the use thereof for preparing a drug for treating small superficial burns; and the use thereof for preparing a drug for preventing and/or treating and/or reducing the frequency and intensity of eczema attacks observed in patients suffering from atopic dermatitis.
摘要翻译：本发明涉及用于局部使用的润肤剂组合物，其包含以水包油或油包水乳液形式的甘油，凡士林和液体石蜡作为活性成分的组合。本发明还涉及：其用于制备用于治疗与某些皮肤病如特应性皮炎，鱼鳞病和牛皮癣相关的干性皮肤病症的药物的用途; 其用于制备治疗小型表面烧伤的药物的用途; 以及其用于制备用于预防和/或治疗和/或降低患有特应性皮炎的患者观察到的湿疹袭击的频率和强度的药物的用途。

53. 发明授权

US07899620B2 Terrain avoidance method and system for an aircraft 有权
标题翻译：飞机的地形回避方法和系统
公开(公告)号：US07899620B2
公开(公告)日：2011-03-01
申请号：US11908786
申请日：2006-03-01
申请人： Christophe Jourdan , Pierre Fabre , Stephane Walter , Isabelle Lacaze
发明人： Christophe Jourdan , Pierre Fabre , Stephane Walter , Isabelle Lacaze
IPC分类号： G08G1/16
CPC分类号： G05D1/0646 , G01C5/005 , G08G5/045
摘要： A terrain avoidance method and system for an aircraft includes a collision alarm device and an auto-pilot device including a first determination unit for determining a climbing order with optimal slope for the aircraft, a checking unit for checking whether a first altitude gain at the relief, by applying the optimal slope climbing order, is sufficient for clearing said relief, a finding unit for finding if at least one heading variation value exists, for which the corresponding altitude gain is sufficient to clear the relief, and a switching and calculating unit for applying to the aircraft, if the first altitude gain is sufficient, an optimal slope climbing order with an order to maintain the current heading and, if the first altitude gain is insufficient, a particular climbing order sufficient to clear the relief, with a heading order which corresponds to the selected heading variation value.
摘要翻译：一种用于飞行器的地形回避方法和系统包括一个碰撞报警装置和一个自动导航装置，包括用于确定飞机具有最佳坡度的爬坡顺序的第一确定单元，用于检查浮雕处的第一高度增益的检查单元通过应用最佳坡度爬坡顺序，足以清除所述浮雕，找出单元，用于确定是否存在至少一个航向变化值，相应的高度增益足以使其消除浮力;以及切换和计算单元，用于如果第一高度增益足够，则适用于飞机，具有维持当前航向的最佳斜坡爬升顺序，如果第一高度增益不足，则具有足以清除浮雕的特定爬坡顺序其对应于所选择的航向变化值。

54. 发明授权

US06599540B1 Use of a Serenoa repens extract for the production of a medicament to treat prostate cancer 有权
标题翻译：使用Serenoa repens提取物生产用于治疗前列腺癌的药物
公开(公告)号：US06599540B1
公开(公告)日：2003-07-29
申请号：US09937676
申请日：2001-09-28
申请人： Pierre Fabre , Jean-Pierre Raynaud , Henri Cousse
发明人： Pierre Fabre , Jean-Pierre Raynaud , Henri Cousse
IPC分类号： A61K3578
CPC分类号： A61K36/889 , A61K2300/00
摘要： The invention relates to the use of a lipido-sterolic Serenoa repens extract for the production of a medicament which is administered in an isolated manner or in an associated manner, in a simultaneous, separated or staggered manner, with prostatectomy, radiotherapy and/or hormonotherapy in order to prevent and/or treat prostate cancer.
摘要翻译：本发明涉及使用脂质 - 甾体Serenoa repens提取物来生产药物，其以前列腺切除术，放射治疗和/或激素治疗以同时，分离或交错的方式以孤立的方式或以相关联的方式施用以预防和/或治疗前列腺癌。

55. 发明申请

US20030064078A1 Peptide fragment of respiratory syncytial virus protein G, immunogenic agent, pharmaceutical composition containing it and preparation method 失效
标题翻译：呼吸道合胞病毒蛋白G，免疫原性药物，含有药物组合物的肽片段及其制备方法
公开(公告)号：US20030064078A1
公开(公告)日：2003-04-03
申请号：US10091257
申请日：2002-03-05
申请人： PIERRE FABRE MEDICAMENT
发明人： Hans Binz , Thien Ngoc N'Guyen , Thierry Baussant , Michel Trudel
IPC分类号： C07H021/04 , C12P021/06 , C12N015/09 , A61K039/00 , A61K039/38 , A61K039/12 , A61K039/155
CPC分类号： A61K39/155 , A61K38/00 , A61K39/12 , A61K47/646 , A61K2039/55505 , A61K2039/55566 , A61K2039/6037 , A61K2039/6068 , A61K2039/6081 , C07K14/005 , C07K14/26 , C07K14/765 , C07K2319/00 , C07K2319/40 , C12N2760/18522 , C12N2760/18534
摘要： A polypeptide useful as an immunogen element and characterised in that it is carried on the peptide sequence between amino acid residues 130-230 of the G protein sequence of the human respiratory syncytial virus of sub-groups A and B, or of the bovine respiratory syncytial virus, or on a sequence at least 80% homologous thereto. An immunogenic agent or pharmaceutical composition containing said polypeptide, and a method for preparing same, are also disclosed.
摘要翻译：可用作免疫原元件的多肽，其特征在于其携带在亚组A和B之间的人呼吸道合胞病毒的G蛋白序列的氨基酸残基130-230或牛呼吸道合胞体之间的肽序列上或与至少80％同源的序列上。还公开了含有所述多肽的免疫原性试剂或药物组合物及其制备方法。

56. 发明授权

US4921172A Electrostatic sprayer device for spraying products in powder form 失效
标题翻译：用于喷雾粉末形式的静电喷雾装置
公开(公告)号：US4921172A
公开(公告)日：1990-05-01
申请号：US152552
申请日：1988-02-05
申请人： Daniel Belmain , Pierre Chabert , Roger Tholome , Pierre Fabre , Jean-Yves Correard , Michel Gondrand
发明人： Daniel Belmain , Pierre Chabert , Roger Tholome , Pierre Fabre , Jean-Yves Correard , Michel Gondrand
IPC分类号： B05B5/025 , B05B5/03 , B05B5/053
CPC分类号： B05B5/0535 , B05B5/032
摘要： An electrostatic sprayer device for spraying products in powder form comprises an air-powder mixture pipe with an ejector orifice at one end. It has a charging electrode adjacent this orifice and a counter-electrode coaxial with and to the rear of the charging electrode relative to the direction in which the mixture is ejected from the pipe. This counter-electrode is external to the pipe and substantially perpendicular to the axis of the pipe, with the result that an annular space is defined between the two electrodes and around the pipe. The electrodes have a potential difference applied between them to generate an electric field which attracts free ions towards the counter-electrode. A blower adjacent the counter-electrode discharges into the annular space formed between the two electrodes and around the pipe.
摘要翻译：用于喷射粉末形式的静电喷雾装置包括一端具有喷射孔的空气 - 粉末混合管。它具有与该孔口相邻的充电电极和与充电电极相对的方向相对于从管道喷出混合物的方向的相对电极。该对电极在管的外部并且基本上垂直于管的轴线，结果是在两个电极之间并且围绕管道限定了环形空间。电极在它们之间施加电位差以产生吸引离子的电场朝向对置电极。靠近对置电极的鼓风机排放到形成在两个电极之间的环形空间中并且围绕管道排出。

57. 发明授权

US4688443A Control device with two coupled control sticks 失效
标题翻译：控制装置带有两个耦合的控制棒
公开(公告)号：US4688443A
公开(公告)日：1987-08-25
申请号：US858047
申请日：1986-05-01
申请人： Pierre Fabre , Didier Negre
发明人： Pierre Fabre , Didier Negre
IPC分类号： B64C19/00 , B64C13/12 , B64C19/02 , G05G9/10
CPC分类号： B64C13/12 , Y10T74/20 , Y10T74/20201
摘要： In a device for controlling elements of a machine, comprising two control members of the joy stick type from one or other of which said elements may be controlled, these members being intended to be actuated by separate operators and each being mounted for tilting about at least one axis and connected to at least one sensor delivering an electric signal representative of the amplitude of tilt of the associated joy stick about said axis on each side of a neutral position, a signal processing system is provided receiving the signals from two sensors and delivering a single control reference addressed to said controlled elements of the machine.
摘要翻译：在用于控制机器的元件的装置中，包括来自所述元件中的一个或另一个的操纵杆型的两个控制构件，这些控制构件可以被控制，这些构件旨在由单独的操作者致动，并且每个操作件被安装成用于至少倾斜一个轴并且连接到至少一个传感器，其传递表示相关联的操纵杆在中立位置的每一侧上围绕所述轴线的倾斜幅度的电信号，接收来自两个传感器的信号并传送单一控制参考指向机器的所述受控元件。

58. 发明公开

US20240350657A1 SULFOMALEIMIDE-BASED LINKERS AND CORRESPONDING CONJUGATES 审中-公开
公开(公告)号：US20240350657A1
公开(公告)日：2024-10-24
申请号：US18622613
申请日：2024-03-29
申请人： PIERRE FABRE MEDICAMENT
发明人： Michel PEREZ , Frédéric MARION , Jean-François HAEUW , Cyrille DREYFUS
IPC分类号： A61K47/68 , A61K38/07 , A61K38/12 , A61K47/54 , A61P35/00
CPC分类号： A61K47/6889 , A61K38/07 , A61K38/12 , A61K47/545 , A61K47/68031 , A61K47/6809 , A61K47/6811 , A61K47/6849 , A61P35/00
摘要： The present invention relates to a linker of the following formula (I) or a salt thereof:

The present invention relates to a linker-drug conjugate of the following formula (II) or a salt thereof:

The present invention relates also to a binding unit-drug conjugate, such as an antibody-drug conjugate, of the following formula (III) or (IV) or a salt thereof:

as well as a pharmaceutical composition comprising such a binding unit-drug conjugate and its use in the treatment of cancer.

59. 发明公开

US20240277601A1 NOVEL COSMETIC COMPOSITION IN GRANULAR FORM 审中-公开
公开(公告)号：US20240277601A1
公开(公告)日：2024-08-22
申请号：US18026912
申请日：2021-09-30
申请人： PIERRE FABRE DERMO-COSMETIQUE
发明人： Laetitia LEMERCIER , Philippe TRANNOY
IPC分类号： A61K8/96 , A61K8/26 , A61K8/46 , A61K8/73 , A61K8/9794 , A61Q5/00 , A61Q5/02
CPC分类号： A61K8/965 , A61K8/26 , A61K8/466 , A61K8/73 , A61K8/9794 , A61Q5/006 , A61Q5/02 , A61K2800/48 , A61K2800/651
摘要： A cosmetic composition which is in dry form and suitable for being topically applied to the skin and/or keratin fibres, and which includes at least 50% by volume of disintegratable granules containing a mixture of at least one anionic surfactant, at least one absorbent agent and at least one thickening agent chosen from gums of plant, microbial and/or synthetic origin, the total amount of the thickening agent(s) in the composition being between 1 and 4% by weight relative to the total weight of the composition.

60. 发明公开

US20240238190A1 COSMETIC COMPOSITIONS COMPRISING A BARBARY FIG EXTRACT FOR MOISTURISING KERATIN FIBRES 审中-公开
公开(公告)号：US20240238190A1
公开(公告)日：2024-07-18
申请号：US18562079
申请日：2022-05-20
申请人： PIERRE FABRE DERMO-COSMETIQUE
发明人： Sylvie DAUNES-MARION , Cédric FRIBAULT , David BLACK , Stéphane POIGNY
IPC分类号： A61K8/9789 , A61Q5/00
CPC分类号： A61K8/9789 , A61Q5/002
摘要： The present invention relates to the use of a Barbary fig extract for tightening the scales of keratin fibres.

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