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51. 发明授权

US08337775B2 Apparatus for precise transfer and manipulation of fluids by centrifugal and or capillary forces 有权
标题翻译：用于通过离心和/或毛细作用力精确地转移和操纵流体的装置
公开(公告)号：US08337775B2
公开(公告)日：2012-12-25
申请号：US12205965
申请日：2008-09-08
申请人： Michael J. Pugia , Gert Blankenstein , Ralf-Peter Peters , Holger Bartos
发明人： Michael J. Pugia , Gert Blankenstein , Ralf-Peter Peters , Holger Bartos
IPC分类号： G01N33/00
CPC分类号： B01L3/5025 , B01L3/5027 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L2200/0605 , B01L2200/10 , B01L2300/0645 , B01L2300/0861 , B01L2300/165 , B01L2400/0406 , B01L2400/06 , B01L2400/0688 , F04B19/006 , Y10T436/2575
摘要： A micro-liter liquid sample, particularly a biological sample, is analyzed in a device employing centrifugal and capillary forces. The sample is moved through one or more sample wells arrayed within a small flat chip via interconnecting capillary passageways. The passageways may be either hydrophobic or hydrophilic and may include hydrophobic or hydrophilic capillary stops.
摘要翻译：在使用离心和毛细管力的装置中分析微升液体样品，特别是生物样品。通过互连的毛细管通道将样品移动通过一个或多个排列在小扁平芯片内的样品阱。通道可以是疏水的或亲水的，并且可以包括疏水或亲水的毛细管停止。

52. 发明授权

US08263414B2 Dispensing of a diagnostic liquid onto a diagnostic reagent 有权
标题翻译：将诊断液体分配到诊断试剂上
公开(公告)号：US08263414B2
公开(公告)日：2012-09-11
申请号：US11135928
申请日：2005-05-23
申请人： Michael J. Pugia , James A. Profitt , Lloyd S. Schulman , Chris T. Zimmerle , Hai-Hang Kuo
发明人： Michael J. Pugia , James A. Profitt , Lloyd S. Schulman , Chris T. Zimmerle , Hai-Hang Kuo
IPC分类号： G01N1/10
CPC分类号： B01L3/0268 , B01J2219/0036 , B01J2219/00378 , B01J2219/00385 , B01J2219/00527 , B01J2219/00545 , B01J2219/00641 , B01J2219/00725 , B01J2219/0074 , B01L2400/0487 , G01N33/52 , G01N35/1016 , G01N2035/00158 , Y10T436/144444 , Y10T436/2575
摘要： Biological fluid samples are deposited by methods that produce a uniform layer of the sample over a reagent-containing surface. In one embodiment, a nozzle having multiple openings is used to deposit a sample over the reagent-containing surface simultaneously. In an alternative embodiment, single droplets of the sample are deposited in a pattern on the surface, preferably in a sequence of parallel lines. The reaction between the biological sample and the reagents is read from a spectrographic image of the reagent-containing surface obtained by optical methods.
摘要翻译：通过在含试剂的表面上产生均匀的样品层的方法沉积生物流体样品。在一个实施例中，使用具有多个开口的喷嘴同时将试样沉积在含有试剂的表面上。在替代实施例中，样品的单个液滴以图案沉积在表面上，优选地以一系列平行线沉积。从通过光学方法获得的含有试剂的表面的光谱图像中读取生物样品和试剂之间的反应。

53. 发明申请

US20120115174A1 URINARY TRYPSIN INHIBITORS AS DIAGNOSTIC AID FOR INTERSTITIAL CYSTITIS 审中-公开
标题翻译：尿激酶抑制剂作为间质细胞诊断辅助药物
公开(公告)号：US20120115174A1
公开(公告)日：2012-05-10
申请号：US13384013
申请日：2010-07-12
申请人： Michael J. Pugia
发明人： Michael J. Pugia
IPC分类号： G01N33/569 , C12Q1/04 , C12M1/34
CPC分类号： C12Q1/6883 , C12Q1/6841 , C12Q2600/158 , G01N33/558 , G01N2800/34
摘要： A method aiding the diagnosis of interstitial cystitis involving the combination of an infection marker and an inflammation marker. More specifically, the method includes correlating the presence of urinary trypsin inhibitors in urine with the absence of traditional infection markers in urine to aid in the diagnosis of interstitial cystitis. The method provides for a differential diagnosis between kidney disease, infection and chronic inflammation with a noninvasive urine test. Assay devices and kits, as well as analyzers and systems are also described that utilize the methodology.
摘要翻译：一种辅助诊断间质性膀胱炎的方法，涉及感染标记物和炎症标记物的组合。更具体地，该方法包括将尿中的尿胰蛋白酶抑制剂的存在与尿中不存在传统感染标记物相关联以帮助诊断间质性膀胱炎。该方法提供肾脏疾病，感染和慢性炎症与非侵入性尿液检测之间的鉴别诊断。还使用方法学来描述测定装置和试剂盒以及分析仪和系统。

54. 发明申请

US20110301089A1 ADIPONECTIN RECEPTOR FRAGMENTS AND METHODS OF USE 有权
标题翻译： ADIPONECTIN受体片段和使用方法
公开(公告)号：US20110301089A1
公开(公告)日：2011-12-08
申请号：US13211558
申请日：2011-08-17
申请人： Michael J. Pugia , Rui Ma
发明人： Michael J. Pugia , Rui Ma
IPC分类号： A61K38/17 , A61P9/00
CPC分类号： C07K14/72 , A61K38/00
摘要： Methods are disclosed of treating diabetes, abnormal adipocyte activity, and insulin resistance using C-terminal fragments of adiponectin receptor R1. Methods of causing the secretion of insulin in healthy and diabetic patients using C-terminal fragments of adiponectin receptor R1 are also disclosed. In addition, methods are disclosed of increasing the insulin levels in healthy patients using C-terminal fragments of adiponectin receptor R1. In addition, methods of treating abnormal adipocyte activity, treating metabolic syndrome, causing insulin secretion, increasing insulin levels, inhibiting insulin degradation enzyme, treating Alzheimer's disease, treating cardiovascular disease associated with adiponectin levels, inhibiting ADAM-17 enzyme, treating a condition associated with TNF-alpha, and treating a condition associated with HER2-neu are disclosed. Compositions, dosage forms, and kits are also disclosed.
摘要翻译：公开了使用脂联素受体R1的C末端片段治疗糖尿病，异常脂肪细胞活性和胰岛素抵抗的方法。还公开了使用脂联素受体R1的C末端片段在健康和糖尿病患者中分泌胰岛素的方法。此外，公开了使用脂联素受体R1的C末端片段增加健康患者的胰岛素水平的方法。另外，处理异常脂肪细胞活性，治疗代谢综合征，引起胰岛素分泌，增加胰岛素水平，抑制胰岛素降解酶，治疗阿尔茨海默氏病，治疗与脂联素水平相关的心血管疾病，抑制ADAM-17酶，治疗与公开了TNF-α和治疗与HER2-neu相关的病症。还公开了组合物，剂型和试剂盒。

55. 发明授权

US08017573B2 Adiponectin receptor fragments and methods of use 有权
标题翻译：脂联素受体片段和使用方法
公开(公告)号：US08017573B2
公开(公告)日：2011-09-13
申请号：US12169983
申请日：2008-07-09
申请人： Michael J. Pugia , Rui Ma
发明人： Michael J. Pugia , Rui Ma
IPC分类号： A61K38/17
CPC分类号： C07K14/72 , A61K38/00
摘要： Methods are disclosed of treating diabetes, abnormal adipocyte activity, and insulin resistance using C-terminal fragments of adiponectin receptor R1. Methods of causing the secretion of insulin in healthy and diabetic patients using C-terminal fragments of adiponectin receptor R1 are also disclosed. In addition, methods are disclosed of increasing the insulin levels in healthy patients using C-terminal fragments of adiponectin receptor R1. In addition, methods of treating abnormal adipocyte activity, treating metabolic syndrome, causing insulin secretion, increasing insulin levels, inhibiting insulin degradation enzyme, treating Alzheimer's disease, treating cardiovascular disease associated with adiponectin levels, inhibiting ADAM-17 enzyme, treating a condition associated with TNF-alpha, and treating a condition associated with HER2-neu are disclosed. Compositions, dosage forms, and kits are also disclosed.
摘要翻译：公开了使用脂联素受体R1的C末端片段治疗糖尿病，异常脂肪细胞活性和胰岛素抵抗的方法。还公开了使用脂联素受体R1的C末端片段在健康和糖尿病患者中分泌胰岛素的方法。此外，公开了使用脂联素受体R1的C末端片段增加健康患者的胰岛素水平的方法。另外，处理异常脂肪细胞活性，治疗代谢综合征，引起胰岛素分泌，增加胰岛素水平，抑制胰岛素降解酶，治疗阿尔茨海默氏病，治疗与脂联素水平相关的心血管疾病，抑制ADAM-17酶，治疗与公开了TNF-α和治疗与HER2-neu相关的病症。还公开了组合物，剂型和试剂盒。

56. 发明申请

US20100184110A1 PREDICTIVE DIAGNOSTICS FOR KIDNEY DISEASE 审中-公开
标题翻译： KIDNEY病的预测诊断
公开(公告)号：US20100184110A1
公开(公告)日：2010-07-22
申请号：US12602904
申请日：2008-06-04
申请人： Michael J. Pugia
发明人： Michael J. Pugia
IPC分类号： C12Q1/37 , C12Q1/02
CPC分类号： G01N33/5091 , G01N2333/8114 , G01N2333/976 , G01N2800/347
摘要： The present invention relates to markers for kidney disease.
摘要翻译：本发明涉及肾脏疾病的标志物。

57. 发明授权

US07713474B2 Liquid permeable composition in dry reagent devices 有权
标题翻译：干燥试剂装置中的透液性组合物
公开(公告)号：US07713474B2
公开(公告)日：2010-05-11
申请号：US10966858
申请日：2004-10-14
申请人： Lloyd S. Schulman , Michael J. Pugia , Spencer Lin , Karlheinz Hildenbrand
发明人： Lloyd S. Schulman , Michael J. Pugia , Spencer Lin , Karlheinz Hildenbrand
IPC分类号： G01N31/22 , G01N31/00
CPC分类号： G01N33/54393 , G01N33/525
摘要： A device for detecting an analyte in a fluid sample includes a liquid permeable composition for making a physical separation between compositions of the sample or for reacting with components. The liquid permeable composition has adhesive properties and can be used to make a multi-layered test strip or the composition can be used in the sample wells of microfluidic devices.
摘要翻译：用于检测流体样品中的分析物的装置包括用于在样品组合物之间进行物理分离或与组分反应的液体可渗透组合物。液体可渗透组合物具有粘合性能，并且可用于制备多层测试条，或者该组合物可用于微流体装置的样品孔中。

58. 发明申请

US20100093109A1 PIEZO DISPENSING OF A DIAGNOSTIC LIQUID INTO MICROFLUIDIC DEVICES 有权
标题翻译：诊断液中PIEZO分配到微流体装置中
公开(公告)号：US20100093109A1
公开(公告)日：2010-04-15
申请号：US12598141
申请日：2008-03-14
申请人： Michael J. Pugia , James A. Profitt
发明人： Michael J. Pugia , James A. Profitt
IPC分类号： G01N33/544
CPC分类号： B01L3/502738 , B01L3/0268 , B01L3/50273 , B01L2200/0621 , B01L2300/0636 , B01L2300/0825 , B01L2400/0406 , B01L2400/0688 , B01L2400/086 , Y10T436/118339
摘要： Assays in which samples of biological fluids are dispensed into the inlet port of a microfluidic device are improved in the accuracy and repeatability by dispensing the biological sample and/or associated liquids in small droplets and at timed intervals to control the operation of the microfluidic device.
摘要翻译：通过以小液滴和定时的间隔分配生物样品和/或相关液体来控制微流体装置的操作，通过将生物流体的样品分配到微流体装置的入口端口的分析物的精度和重复性得到改善。

59. 发明授权

US07459127B2 Method and apparatus for precise transfer and manipulation of fluids by centrifugal and/or capillary forces 有权
标题翻译：用于通过离心和/或毛细管力精确地转移和操纵流体的方法和装置
公开(公告)号：US07459127B2
公开(公告)日：2008-12-02
申请号：US10082415
申请日：2002-02-26
申请人： Michael J. Pugia , Gert Blankenstein , Ralf-Peter Peters , Holger Bartos
发明人： Michael J. Pugia , Gert Blankenstein , Ralf-Peter Peters , Holger Bartos
IPC分类号： G01N33/00
CPC分类号： B01L3/5025 , B01L3/5027 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L2200/0605 , B01L2200/10 , B01L2300/0645 , B01L2300/0861 , B01L2300/165 , B01L2400/0406 , B01L2400/06 , B01L2400/0688 , F04B19/006 , Y10T436/2575
摘要： A micro-liter liquid sample, particularly a biological sample, is analyzed in a device employing centrifugal and capillary forces. The sample is moved through one or more sample wells arrayed within a small flat chip via interconnecting capillary passageways. The passageways may be either hydrophobic or hydrophilic and may include hydrophobic or hydrophilic capillary stops.
摘要翻译：在使用离心和毛细管力的装置中分析微升液体样品，特别是生物样品。通过互连的毛细管通道将样品移动通过一个或多个排列在小扁平芯片内的样品阱。通道可以是疏水的或亲水的，并且可以包括疏水或亲水的毛细管停止。

60. 发明授权

US07435381B2 Packaging of microfluidic devices 有权
标题翻译：包装微流体装置
公开(公告)号：US07435381B2
公开(公告)日：2008-10-14
申请号：US10447969
申请日：2003-05-29
申请人： Michael J. Pugia , James A. Profitt , Ronald G. Sommer , Sung-Kwon Jung
发明人： Michael J. Pugia , James A. Profitt , Ronald G. Sommer , Sung-Kwon Jung
IPC分类号： G01N33/48
CPC分类号： B01L3/502707 , B01L2200/142 , B01L2200/16 , B01L2300/0672 , B01L2400/0406 , B01L2400/0677 , B01L2400/0683 , B29K2509/08
摘要： A microfluidic device containing liquid reagents having an extended shelf life contains the liquid reagents in micro-reservoirs that limit the escape of moisture to less than 10% over the shelf life of the device. The micro-reservoir preferably is made of polypropylene and covered with a metallized plastic film.
摘要翻译：包含具有延长的保存期限的液体试剂的微流体装置包含微储存器中的液体试剂，其在装置的保存期限内将水分逸出限制在小于10％。微型储存器优选由聚丙烯制成并用金属化塑料膜覆盖。

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