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51. 发明申请

US20090036394A1 GRP 146 Receptor 审中-公开
标题翻译： GRP 146受体
公开(公告)号：US20090036394A1
公开(公告)日：2009-02-05
申请号：US12088051
申请日：2006-10-10
申请人： Johannes Grosse , Justin Powell , John Dixon , Rosemary Thresher , Kate Day
发明人： Johannes Grosse , Justin Powell , John Dixon , Rosemary Thresher , Kate Day
IPC分类号： A61K31/711 , G01N33/566 , G01N33/00 , A01K67/027 , C12Q1/68 , A01K67/00 , C12N15/12
CPC分类号： C07K14/705
摘要： We disclose GPR146 G-protein coupled receptor (GPCR) polypeptides comprising the amino acid sequence shown in SEQ ID NO. 3 or SEQ ID NO: 5, and homologues, variants and derivatives thereof. Nucleic acids capable of encoding GPR146 polypeptide are also disclosed, in particular, those comprising the nucleic acid sequences shown in SEQ ID No. 1A, SEQ ID No.1 B, SEQ ID No.2 or SEQ ID NO: 4. The GPR146 receptor is useful in the diagnosis and therapy of dyslipidaemias.
摘要翻译：我们公开了包含SEQ ID NO：1所示的氨基酸序列的GPR146G-蛋白偶联受体（GPCR）多肽。 3或SEQ ID NO：5，及其同源物，变体和衍生物。还公开了能够编码GPR146多肽的核酸，特别是包含SEQ ID No.1A，SEQ ID No.1B，SEQ ID No.2或SEQ ID NO：4所示的核酸序列的核酸.GPR146受体可用于血脂异常的诊断和治疗。

52. 发明申请

US20080165346A1 Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources 有权
公开(公告)号：US20080165346A1
公开(公告)日：2008-07-10
申请号：US11978168
申请日：2007-10-26
申请人： Paul Lundquist , Denis Zaccarin , Yves Lacroix , Stephen Turner , John Dixon
发明人： Paul Lundquist , Denis Zaccarin , Yves Lacroix , Stephen Turner , John Dixon
IPC分类号： G01N21/01 , G01N21/00 , G01J4/00
CPC分类号： G01J3/02 , G01J3/0224 , G01J3/10 , G01J3/14 , G01J3/2803 , G01N21/6445 , G01N21/6452 , G01N21/6456 , G01N21/648 , G01N2021/6417
摘要： Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains that direct excitation radiation to and emitted signals from such arrays and image the signals onto detector arrays, from which such signals may be subjected to additional processing.

53. 发明申请

US20080075863A1 TUNABLE DIELECTRIC COMPOSITIONS AND METHODS 审中-公开
标题翻译：电容式电介质组合物和方法
公开(公告)号：US20080075863A1
公开(公告)日：2008-03-27
申请号：US11834119
申请日：2007-08-06
申请人： Xiaorong Cai , Michael John Dixon , Mohanram Jayaram , Jeanne Marie Saldanha Singh
发明人： Xiaorong Cai , Michael John Dixon , Mohanram Jayaram , Jeanne Marie Saldanha Singh
IPC分类号： H01B3/20 , B05D3/02
CPC分类号： H05K1/162 , H05K3/0091 , H05K2201/0187 , H05K2201/0209 , H05K2203/013 , H05K2203/1476 , H05K2203/171
摘要： Methods of timing a printable dielectric layer, dielectric layers made by the method, and devices incorporating the dielectric layers. One such method includes printing a first dielectric composition and a second dielectric composition onto a substrate to provide a mixed composition. The first dielectric composition includes a first concentration of dispersed particles in a carrier fluid and the second dielectric composition includes a polymeric binder component. The mixed composition has a second concentration of particles.
摘要翻译：定时印刷电介质层的方法，通过该方法制成的电介质层和结合有电介质层的器件。一种这样的方法包括将第一电介质组合物和第二电介质组合物印刷到基底上以提供混合的组合物。第一电介质组合物包括在载体流体中的分散颗粒的第一浓度，第二电介质组合物包括聚合物粘合剂组分。混合组合物具有第二浓度的颗粒。

54. 发明申请

US20060270607A1 Pharmaceutical combinations 审中-公开
公开(公告)号：US20060270607A1
公开(公告)日：2006-11-30
申请号：US11441278
申请日：2006-05-25
申请人： John Dixon , Robert Humphries , Gavin Jarvis , Ian Kirk
发明人： John Dixon , Robert Humphries , Gavin Jarvis , Ian Kirk
IPC分类号： A61K38/05 , A61K31/7076 , A61K31/727 , A61K31/4743 , A61K31/60
CPC分类号： A61K31/397 , A61K31/7076 , A61K45/06 , A61K2300/00
摘要： The present invention provides novel pharmaceutical combinations and their use in anti-thrombotic therapy.

55. 发明申请

US20060242724A1 Receptor 审中-公开
标题翻译：受体
公开(公告)号：US20060242724A1
公开(公告)日：2006-10-26
申请号：US11385261
申请日：2006-03-20
申请人： Mark Carlton , John Dixon , Alan Hendrick , Sophie Messager , Dirk Zahn , Jennifer Horwood
发明人： Mark Carlton , John Dixon , Alan Hendrick , Sophie Messager , Dirk Zahn , Jennifer Horwood
IPC分类号： A01K67/027 , C12Q1/68 , G01N33/567 , C07H21/04 , C12P21/06 , C07K14/705
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0312 , A01K2267/0356 , A61K38/00 , C07K14/705 , C07K14/70571 , G01N33/57407 , G01N33/6893 , G01N33/6896 , G01N33/92 , G01N2500/00 , G01N2800/042 , G01N2800/046 , G01N2800/067 , G01N2800/28 , G01N2800/2821 , G01N2800/2835 , G01N2800/2842 , G01N2800/2857 , G01N2800/2864
摘要： The present invention relates to novel functions of a known receptor. In particular, the invention relates to the use of a sphingosylphosphorylcholine receptor and/or ligands thereof in the manipulation of the neuronal and limbic systems and diagnosis and treatment of pain.
摘要翻译：本发明涉及已知受体的新功能。特别地，本发明涉及鞘氨醇磷酰胆碱受体和/或其配体在神经元和边缘系统的操作中的用途以及疼痛的诊断和治疗。

56. 发明申请

US20060128910A1 Tandem tetramerisation-polymerisation of olefins 失效
标题翻译：烯烃的串联四聚化聚合
公开(公告)号：US20060128910A1
公开(公告)日：2006-06-15
申请号：US10538088
申请日：2003-12-19
申请人： Kevin Blann , Deon De Wet-Roos , John Dixon
发明人： Kevin Blann , Deon De Wet-Roos , John Dixon
IPC分类号： C08F4/44
CPC分类号： C07C2/36 , B01J31/128 , B01J31/14 , B01J31/143 , B01J31/1608 , B01J31/188 , B01J31/2295 , B01J2231/20 , B01J2531/46 , B01J2531/48 , B01J2531/62 , B01J2531/64 , B01J2531/66 , B01J2531/847 , C07C2531/14 , C07C2531/24 , C07C2531/34 , C07F11/005 , C08F4/65912 , C08F4/6592 , C08F4/65925 , C08F4/65927 , C08F10/00 , C08F110/02 , C08F210/16 , C08F2420/01 , C08F2420/02 , C07C11/02 , C07C11/107 , C08F4/63904 , C08F2500/02 , C08F2500/10 , C08F2500/08 , C08F210/14 , C08F4/69267 , C08F4/69146
摘要： The invention provides a process for polymerising olefins to branched polyolefins in the presence of a polymerisation catalyst and a cocatalyst, wherein the cocatalyst produces 1-octene in a selectivity greater than 30%.
摘要翻译：本发明提供了在聚合催化剂和助催化剂存在下将烯烃聚合成支链聚烯烃的方法，其中助催化剂以大于30％的选择性产生1-辛烯。

57. 发明授权

US5620348A Method of manufacturing electroluminescent lamps having surface designs and lamps produced thereby 失效
标题翻译：制造具有由此制造的表面设计和灯的电致发光灯的方法
公开(公告)号：US5620348A
公开(公告)日：1997-04-15
申请号：US439840
申请日：1995-05-12
申请人： Jose Santana , Harold Thorgersen , John Dixon , Andrew C. Ledesma
发明人： Jose Santana , Harold Thorgersen , John Dixon , Andrew C. Ledesma
IPC分类号： H05B33/02 , H05B33/10
CPC分类号： H05B33/02 , H05B33/10
摘要： The method and structure for providing surface designs to electroluminescent (EL) lamps involves two essential steps. First, a layer of transflective material is introduced to the EL lamp comprising a transparent substrate and front and back electrodes sandwiching an electroluminescent layer and an insulating layer. The layer of transflective material reflects incident ambient light and transmits light emitted by an energized electroluminescent layer. In the preferred embodiment of the invention, the layer of transflective material replaces the front electrode of the EL lamp. Second, a predetermined surface design is provided to the transparent substrate to enhance diffusion and fringing of both the reflected incident ambient light and the light emitted by the energized electroluminescent layer. This enhanced diffusion and fringing leads to a visually appealing appearance.
摘要翻译：用于向电致发光（EL）灯提供表面设计的方法和结构涉及两个基本步骤。首先，将一层半透反射材料引入到包括透明基板的EL灯和夹着电致发光层和绝缘层的前后电极。半透反射材料层反射入射的环境光并透过被激发的电致发光层发出的光。在本发明的优选实施例中，透反射材料层代替EL灯的前电极。其次，将预定的表面设计提供给透明基板，以增强反射的入射环境光和被激发的电致发光层发射的光的扩散和边缘。这种增强的扩散和边缘导致视觉吸引人的外观。

58. 发明授权

US5327825A Seamless holographic transfer 失效
标题翻译：无缝全息传输
公开(公告)号：US5327825A
公开(公告)日：1994-07-12
申请号：US60796
申请日：1993-05-12
申请人： Harry A. Parker , Joseph Allocco , John Dixon
发明人： Harry A. Parker , Joseph Allocco , John Dixon
IPC分类号： B23P15/24 , B29C59/00 , B44B5/00 , B44B5/02 , B31F1/07
CPC分类号： B44B5/028 , B23P15/24 , B29C59/002 , B44B5/009 , B29L2031/7224 , G03H1/028
摘要： A method of making a die and the die itself for establishing through embossing or micro-embossing a seamless pattern, preferably a holographic pattern, on a decorative medium such as a metallized film is provided. A cylindrical embossing or micro-embossing die is provided with a layer of an embossable material, preferably pure silver, a silver alloy or any other suitable embossable material. The cylindrical die is an integral member in which a pattern is recombined thereon by a step and repeat embossing or micro-embossing process as opposed an intricate lathe-type machine-turning operation, and can thus accept, carry and maintain complex patterns with the integrity required for producing a repeating holographic pattern.
摘要翻译：提供了一种制造模具和模具本身以通过压花或微压花来形成无缝图案（优选全息图案）的装置，例如金属化膜。圆柱形压花或微压纹模具设置有可压纹材料层，优选纯银，银合金或任何其它合适的可压纹材料。圆柱形模具是整体构件，其中通过步骤和重复压花或微压花工艺将图案重新结合在其上，而不是复杂的车床式机器翻转操作，因此可以接受，携带和保持具有完整性的复杂图案是产生重复全息图所需要的。

59. 发明授权

US4922022A Substituted 3,4-dihydroxy phenylethylamino compounds 失效
标题翻译：取代的3,4-二羟基苯基乙基氨基化合物
公开(公告)号：US4922022A
公开(公告)日：1990-05-01
申请号：US195722
申请日：1988-05-18
申请人： John Dixon , Brian Springthorpe , Francis Ince
发明人： John Dixon , Brian Springthorpe , Francis Ince
IPC分类号： C07C313/00 , C07C67/00 , C07C213/00 , C07C215/54 , C07C231/00 , C07C231/12
CPC分类号： C07C215/54
摘要： Novel compounds of the formula ##STR1## in which one of R.sub.30 and R.sub.40 represents a substituted phenylalkyl group,the other of R.sub.30 and R.sub.40 represents hydrogen or halogen, andR.sub.50 and R.sub.60 each independently represent hydrogen or alkyl; in addition R.sub.60 may represent a substituted alkyl chain interrupted by N.The compounds of the invention are useful for the treatment or prophylaxis of renal failure or cardiovascular disease.

60. 发明授权

US4914126A Aromatic amines 失效
标题翻译：芳香胺
公开(公告)号：US4914126A
公开(公告)日：1990-04-03
申请号：US102781
申请日：1987-09-23
申请人： John Dixon , Francis Ince
发明人： John Dixon , Francis Ince
IPC分类号： A61K31/135 , A61K31/38 , C07C20060101 , C07C317/04 , C07C323/25 , C07D20060101 , C07D333/20
CPC分类号： C07C323/25 , C07C323/00 , C07D333/20
摘要： ##STR1## Compounds of formula (I), in which Z represent O, S, SO
2 , CO, NR or a single bond, G represents a one or two ring, saturated or unsaturated carbocyclic or heterocyclic group optionally substituted by phenyl thrihalomethyl or at least groups selected from alkoxy C1 to 6 or halogen atoms, provided that when Z represents a single bond G does not represent phenyl, R represents hydrogen or alkyl C1-6, m and n each independently represent 2, 3 or 4, and q represents an integer from 1 to 3 inclusive, and pharmaceutically acceptable derivatives thereof. There are also described processes for producing the compounds and pharmaceutical, e.g. cardiac, compositions containing them.
摘要翻译：其中Z表示O，S，SO2，CO，NR或单键的式（I）化合物，G表示任选被苯基三卤代甲基取代的一个或两个环，饱和或不饱和的碳环或杂环基，至少选自烷氧基C1至6或卤原子的基团，条件是当Z表示单键时，G不表示苯基，R表示氢或C1-6烷基，m和n各自独立地表示2,3或4，且q 表示1〜3的整数，以及其药学上可接受的衍生物。还描述了用于生产化合物和药物的方法，例如。心脏，含有它们的组合物。

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