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51. 发明授权

US08692189B2 Parallel mass analysis 有权
标题翻译：平行质量分析
公开(公告)号：US08692189B2
公开(公告)日：2014-04-08
申请号：US13970310
申请日：2013-08-19
申请人： Alexander A. Makarov , Stevan R. Horning
发明人： Alexander A. Makarov , Stevan R. Horning
IPC分类号： H01J49/26 , H01J27/02
CPC分类号： H01J49/009 , H01J49/425
摘要： A system and method of mass spectrometry is provided. Ions from an ion source are stored in a first ion storage device and in a second ion storage device. Ions are ejected from the first ion storage device to a first mass analysis device during a first ejection time period, for analysis during a first analysis time period. Ions are ejected from the second ion storage device to a second mass analysis device during a second ejection time period. The ion storage devices are connected in series such that an ion transport aperture of the first ion storage device is in communication with an ion transport aperture of the second ion storage device. The first analysis time period and the second ejection time period at least partly overlap.
摘要翻译：提供了一种质谱系统和方法。来自离子源的离子存储在第一离子存储装置和第二离子存储装置中。在第一喷射时间段期间，离子从第一离子存储装置喷射到第一质量分析装置，以在第一分析时间段期间进行分析。在第二喷射时间段期间，离子从第二离子存储装置喷射到第二质量分析装置。离子存储装置串联连接，使得第一离子存储装置的离子传送孔与第二离子存储装置的离子传送孔连通。第一分析时间段和第二喷射时间段至少部分重叠。

52. 发明授权

US08658984B2 Charged particle analysers and methods of separating charged particles 有权
标题翻译：带电粒子分析仪和分离带电粒子的方法
公开(公告)号：US08658984B2
公开(公告)日：2014-02-25
申请号：US13375187
申请日：2010-05-27
申请人： Alexander A. Makarov , Anastassios Giannakopulos
发明人： Alexander A. Makarov , Anastassios Giannakopulos
IPC分类号： H01J3/16
CPC分类号： H01J49/40 , H01J49/406 , H01J49/4245
摘要： A method of separating charged particles using an analyzer is provided, the method comprising: causing a beam of charged particles to fly through the analyzer and undergo within the analyzer at least one full oscillation in the direction of an analyzer axis (z) of the analyzer whilst orbiting about the axis (z) along a main flight path; constraining the arcuate divergence of the beam as it flies through the analyzer; and separating the charged particles according to their flight time. An analyzer for performing the method is also provided. At least one arcuate focusing lens is preferably used to constrain the divergence, which may comprise a pair of opposed electrodes located either side of the beam. An array of arcuate focusing lenses may be used which are located at substantially the same z coordinate, the arcuate focusing lenses in the array being spaced apart in the arcuate direction and the array extending at least partially around the z axis, thereby constraining the arcuate divergence of the beam a plurality of times as it flies through the analyzer.
摘要翻译：提供了一种使用分析器分离带电粒子的方法，所述方法包括：使带电粒子束飞过分析器，并在分析器内沿分析器轴线（z）的方向进行至少一次全部振荡，同时沿着主飞行路径围绕轴线（z）绕行驶; 约束梁在其穿过分析器时的弓形发散; 并根据飞行时间分离带电粒子。还提供了用于执行该方法的分析器。优选地使用至少一个弧形聚焦透镜来限制发散，其可以包括位于光束的任一侧的一对相对的电极。可以使用位于基本上相同z坐标处的弧形聚焦透镜阵列，阵列中的弧形聚焦透镜在弧形方向上间隔开，并且阵列至少部分地围绕z轴延伸，从而约束弓形散度的光束多次通过分析仪。

53. 发明申请

US20130313424A1 Multireflection Time-of-flight Mass Spectrometer 有权
公开(公告)号：US20130313424A1
公开(公告)日：2013-11-28
申请号：US13957776
申请日：2013-08-02
申请人： Alexander A. MAKAROV , Dmitry E. GRINFELD , Mikhail A. MONASTYRSKIY
发明人： Alexander A. MAKAROV , Dmitry E. GRINFELD , Mikhail A. MONASTYRSKIY
IPC分类号： H01J49/40
CPC分类号： H01J49/406 , H01J49/061 , H01J49/405
摘要： A method of reflecting ions in a multireflection time of flight mass spectrometer is disclosed. The method includes guiding ions toward an ion mirror having multiple electrodes, and applying a voltage to the ion mirror electrodes to create an electric field that causes the mean trajectory of the ions to intersect a plane of symmetry of the ion mirror and to exit the ion mirror, wherein the ion are spatially focussed by the mirror to a first location and temporally focused to a second location different from the first location. Apparatus for carrying out the method is also disclosed.

54. 发明申请

US20130248702A1 Method of Mass Separating Ions and Mass Separator 有权
标题翻译：质量分离离子和质量分离器的方法
公开(公告)号：US20130248702A1
公开(公告)日：2013-09-26
申请号：US13989719
申请日：2011-11-24
申请人： Alexander A. Makarov
发明人： Alexander A. Makarov
IPC分类号： H01J49/40
CPC分类号： H01J49/40 , H01J49/406 , H01J49/4245
摘要： A method of separating ions according to their time of flight is provided comprising: a. providing an analyser comprising two opposing ion mirrors, each mirror comprising inner and outer field-defining electrode systems elongated along an analyser axis with the outer field-defining electrode system surrounding the inner field-defining electrode system and creating therebetween an analyser volume; b. injecting ions into the analyser volume or creating ions within the analyser volume so that they separate according to their time of flight as they travel along a main flight path whilst undergoing a plurality of axial oscillations in the direction of the analyser axis and a plurality of radial oscillations whilst orbiting about one or more inner field-defining electrodes; c. the plurality of axial oscillations and plurality of radial oscillations causing the separated ions to intercept an exit port after a predetermined number of orbits. Also provided is an analyser for performing the method, comprising: the two opposing ion mirrors which abut at a first plane, wherein the outer field-defining electrode system of one mirror comprises two sections, the sections abutting at a second plane, comprising a first section between the first plane and the second plane, and a second section adjacent the first section and wherein the first section has at least a portion which extends radially from the analyser axis a greater extent than an adjacent portion of the second section at the second plane.
摘要翻译：提供了根据其飞行时间分离离子的方法，包括：a。提供包括两个相对离子反射镜的分析器，每个反射镜包括沿着分析器轴线延伸的内部和外部场限定电极系统，外部场界限电极系统围绕内部场界定义电极系统并在其间产生分析器体积; b。将离子注入分析器体积中或在分析器体积内产生离子，使得当它们沿着主飞行路径行进时，它们根据其飞行时间分离，同时在分析器轴线的方向上经历多个轴向振荡，并且多个径向围绕一个或多个内场限定电极绕轨道运动的振荡; C。所述多个轴向振荡和多个径向振动导致分离的离子在预定数量的轨道之后拦截出口。还提供了一种用于执行该方法的分析器，包括：两个相对的离子反射镜，其在第一平面处邻接，其中一个反射镜的外场限定电极系统包括两个部分，所述部分邻接在第二平面，包括第一在第一平面和第二平面之间的部分，以及与第一部分相邻的第二部分，并且其中第一部分具有至少一个从分析器轴线径向延伸的部分比第二部分在第二平面处的相邻部分更大的范围。

55. 发明授权

US08529218B2 Vacuum pump having nested chambers associated with a mass spectrometer 有权
标题翻译：具有与质谱仪相关联的嵌套室的真空泵
公开(公告)号：US08529218B2
公开(公告)日：2013-09-10
申请号：US12527834
申请日：2008-02-21
申请人： Alexander A. Makarov
发明人： Alexander A. Makarov
IPC分类号： F04D29/40 , F04D19/04
CPC分类号： H01J49/24 , F04D19/042 , F04D19/048 , F04D29/083 , F04D29/601
摘要： A vacuum pump for the evacuation of one or a plurality of volumes is described. The vacuum pump has a plurality of pressure stages and at least two suction inlets. An outer suction inlet for a first pressure stage spatially encompasses an inner suction inlet for a second pressure stage such that the inner suction inlet seals only against pressure within the outer suction inlet, not against external pressure.
摘要翻译：描述用于排出一个或多个体积的真空泵。真空泵具有多个压力级和至少两个吸入口。用于第一压力级的外部吸入口空间地包围用于第二压力级的内部吸入口，使得内部吸入口仅抵抗外部吸入口内的压力而不受外部压力的影响。

56. 发明授权

US08207496B2 Multi-needle multi-parallel nanospray ionization source for mass spectrometry 有权
标题翻译：用于质谱的多针多平行纳米喷雾电离源
公开(公告)号：US08207496B2
公开(公告)日：2012-06-26
申请号：US12701011
申请日：2010-02-05
申请人： Alexander A. Makarov , Eloy R. Wouters
发明人： Alexander A. Makarov , Eloy R. Wouters
IPC分类号： H01J49/26 , H01J49/10 , H01J49/04 , H01B13/00
CPC分类号： H01J49/167 , H01J49/0018 , Y10T29/49423 , Y10T29/49433
摘要： An electrospray ion source for a mass spectrometer includes an electrode comprising at least a first plurality of protrusions protruding from a base, each protrusion of the at least a first plurality of protrusions having a respective tip; a conduit for delivering an analyte-bearing liquid to the electrode; and a voltage source, wherein, in operation of the electrospray ion source, the analyte-bearing liquid is caused to move, in the presence of a gas or air, from the base to each protrusion tip along a respective protrusion exterior so as to form a respective stream of charged particles emitted towards an ion inlet aperture of the mass spectrometer under application of voltage applied to the electrode from the voltage source.
摘要翻译：用于质谱仪的电喷雾离子源包括电极，其包括从基底突出的至少第一多个突起，所述至少第一多个突起的每个突起具有相应的末端; 用于将分析物承载液体输送到电极的导管; 以及电压源，其中，在电喷雾离子源的操作中，使有分析物的液体在气体或空气的存在下沿着相应的突起外部从基部移动到每个突起尖端，以形成在施加从电压源施加到电极的电压下，向质谱仪的离子入口孔发射的相应的带电粒子流。

57. 发明授权

US08093554B2 Multi-channel detection 有权
标题翻译：多通道检测
公开(公告)号：US08093554B2
公开(公告)日：2012-01-10
申请号：US12444838
申请日：2007-10-17
申请人： Alexander A. Makarov
发明人： Alexander A. Makarov
IPC分类号： H01J49/40
CPC分类号： H01J49/406 , H01J49/004 , H01J49/025 , H01J49/061 , H01J49/408
摘要： A mass spectrometer and method of mass spectrometry wherein charged particles in a beam undergo multiple changes of direction. A detection arrangement detects a first portion of the charged particle beam, and provides a first output based upon the intensity of the detected first portion of the charged particle beam. The detection arrangement detects a second portion of the charged particle beam that has travelled a greater path length through the mass spectrometer than the first portion of the charged particle beam, and provides a second output based upon the detected second portion of the charged particle beam. A controller adjusts the parameters of the charged particle beam and/or the detection arrangement, based upon the first output of the detection arrangement, so as to adjust the second output of the detection arrangement.
摘要翻译：质谱仪和质谱法，其中光束中的带电粒子经历多个方向改变。检测装置检测带电粒子束的第一部分，并且基于所检测到的带电粒子束的第一部分的强度提供第一输出。检测装置检测带电粒子束的第二部分，该第二部分已经比通过质谱仪行进了比带电粒子束的第一部分更大的路径长度，并且基于检测到的带电粒子束的第二部分提供第二输出。控制器基于检测装置的第一输出来调整带电粒子束和/或检测装置的参数，以便调整检测装置的第二输出。

58. 发明申请

US20110084205A1 Collision Cell 有权
标题翻译：碰撞细胞
公开(公告)号：US20110084205A1
公开(公告)日：2011-04-14
申请号：US12996226
申请日：2009-06-03
申请人： Alexander A. Makarov , Eduard V. Denisov , Wilko Balschun , Dirk Nolting , Jens Griep-Raming
发明人： Alexander A. Makarov , Eduard V. Denisov , Wilko Balschun , Dirk Nolting , Jens Griep-Raming
IPC分类号： H01J49/00 , H01J49/26
CPC分类号： H01J49/0422 , H01J49/0031 , H01J49/0045 , H01J49/0072 , H01J49/0081 , H01J49/0481 , H01J49/06 , H01J49/26 , H01J49/40
摘要： A method of operating a gas-filled collision cell in a mass spectrometer is provided. The collision cell has a longitudinal axis. Ions are caused to enter the collision cell. A trapping field is generated within the collision cell so as to trap the ions within a trapping volume of the collision cell, the trapping volume being defined by the trapping field and extending along the longitudinal axis. Trapped ions are processed in the collision cell and a DC potential gradient is provided, using an electrode arrangement, resulting in a non-zero electric field at all points along the axial length of the trapping volume so as to cause processed ions to exit the collision cell. The electric field along the axial length of the trapping volume has a standard deviation that is no greater than its mean value.
摘要翻译：提供了在质谱仪中操作充气碰撞池的方法。碰撞单元具有纵向轴线。导致离子进入碰撞池。在碰撞单元内产生捕获场，以便将离子捕获在碰撞池的捕获体积内，捕获体积由捕获场限定并沿着纵轴延伸。捕获的离子在碰撞单元中被处理，并且使用电极布置提供DC电位梯度，导致沿着捕获体积的轴向长度的所有点处的非零电场，从而使经处理的离子离开碰撞细胞。沿着捕集体积的轴向长度的电场具有不大于其平均值的标准偏差。

59. 发明申请

US20100314538A1 Parallel Mass Analysis 有权
标题翻译：平行质量分析
公开(公告)号：US20100314538A1
公开(公告)日：2010-12-16
申请号：US12521688
申请日：2007-12-27
申请人： Alexander A. Makarov , Stevan Horning
发明人： Alexander A. Makarov , Stevan Horning
IPC分类号： H01J49/26 , H01J49/02
CPC分类号： H01J49/009 , H01J49/425
摘要： A system and method of mass spectrometry is provided. Ions from an ion source are stored in a first ion storage device and in a second ion storage device. Ions are ejected from the first ion storage device to a first mass analysis device during a first ejection time period, for analysis during a first analysis time period. Ions are ejected from the second ion storage device to a second mass analysis device during a second ejection time period. The ion storage devices are connected in series such that an ion transport aperture of the first ion storage device is in communication with an ion transport aperture of the second ion storage device. The first analysis time period and the second ejection time period at least partly overlap.
摘要翻译：提供了一种质谱系统和方法。来自离子源的离子存储在第一离子存储装置和第二离子存储装置中。在第一喷射时间段期间，离子从第一离子存储装置喷射到第一质量分析装置，以在第一分析时间段期间进行分析。在第二喷射时间段期间，离子从第二离子存储装置喷射到第二质量分析装置。离子存储装置串联连接，使得第一离子存储装置的离子传送孔与第二离子存储装置的离子传送孔连通。第一分析时间段和第二喷射时间段至少部分重叠。

60. 发明申请

US20100098558A1 Vacuum Pump or Vacuum Apparatus with Vacuum Pump 有权
标题翻译：真空泵或真空泵真空设备
公开(公告)号：US20100098558A1
公开(公告)日：2010-04-22
申请号：US12527834
申请日：2008-02-21
申请人： Alexander A. Makarov
发明人： Alexander A. Makarov
IPC分类号： F04D19/04
CPC分类号： H01J49/24 , F04D19/042 , F04D19/048 , F04D29/083 , F04D29/601
摘要： The invention relates to a vacuum pump or vacuum apparatus having a vacuum pump for the evacuation of one or a plurality of volumes, the vacuum pump having a plurality of pressure stages and at least two suction inlets. According to the invention, an outer suction inlet for a first pressure stage spatially encompasses an inner suction inlet for a second pressure stage such that the inner suction inlet seals only against pressure within the outer suction inlet, not against external pressure.
摘要翻译：本发明涉及一种具有用于排空一个或多个体积的真空泵的真空泵或真空装置，真空泵具有多个压力级和至少两个吸入口。根据本发明，用于第一压力级的外部吸入口空间地包围用于第二压力级的内部吸入口，使得内部吸入口仅抵抗外部吸入口内的压力而不受外部压力的影响。

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