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1. 发明授权

US08686350B2 Multiple ion injection in mass spectrometry 有权
标题翻译：多重离子注入质谱法
公开(公告)号：US08686350B2
公开(公告)日：2014-04-01
申请号：US13853603
申请日：2013-03-29
申请人： Alexander A. Makarov , Oliver Lange , Stevan R. Horning
发明人： Alexander A. Makarov , Oliver Lange , Stevan R. Horning
IPC分类号： H01J49/00
CPC分类号： H01J49/0009 , H01J49/0031 , H01J49/004 , H01J49/14 , H01J49/4265
摘要： This invention relates to mass spectrometry that includes ion trapping in at least one of the stages of mass analysis. In particular, although not exclusively, this invention relates to tandem mass spectrometry where precursor ions and fragment ions are analyzed. A method of mass spectrometry is provided comprising the sequential steps of: accumulating in an ion store a sample of one type of ions to be analyzed; accumulating in the ion store a sample of another type of ions to be analyzed; and mass analyzing the combined samples of the ions; wherein the method comprises accumulating the sample of the one type of ions and/or the sample of another type of ions to achieve a target number of ions based on the results of a previous measurement of the respective type of ions.
摘要翻译：本发明涉及在质谱分析的至少一个阶段中包括离子捕获的质谱。具体地说，尽管并非排他地，本发明涉及分析前体离子和碎片离子的串联质谱法。提供了一种质谱法，其包括以下顺序步骤：在离子存储中积聚待分析的一种类型离子的样品; 在离子存储中积聚待分析的另一种类型的离子的样品; 并对离子的组合样品进行质量分析; 其中所述方法包括基于先前测量各种类型离子的结果累积一种类型离子的样品和/或另一类型离子的样品以实现目标数目的离子。

2. 发明授权

US08410424B2 Multiple ion injection in mass spectrometry 有权
标题翻译：多重离子注入质谱法
公开(公告)号：US08410424B2
公开(公告)日：2013-04-02
申请号：US13008790
申请日：2011-01-18
申请人： Alexander A. Makarov , Oliver Lange , Stevan R. Horning
发明人： Alexander A. Makarov , Oliver Lange , Stevan R. Horning
IPC分类号： B01D59/44
CPC分类号： H01J49/0009 , H01J49/0031 , H01J49/004 , H01J49/14 , H01J49/4265
摘要： This invention relates to mass spectrometry that includes ion trapping in at least one of the stages of mass analysis. In particular, although not exclusively, this invention relates to tandem mass spectrometry where precursor ions and fragment ions are analysed. A method of mass spectrometry is provided comprising the sequential steps of: accumulating in an ion store a sample of one type of ions to be analysed; accumulating in the ion store a sample of another type of ions to be analysed; and mass analysing the combined samples of the ions; wherein the method comprises accumulating the sample of the one type of ions and/or the sample of another type of ions to achieve a target number of ions based on the results of a previous measurement of the respective type of ions.
摘要翻译：本发明涉及在质谱分析的至少一个阶段中包括离子捕获的质谱。具体地说，尽管并非排他地，本发明涉及分析前体离子和碎片离子的串联质谱法。提供了一种质谱法，其包括以下顺序步骤：在离子存储中积聚待分析的一种类型离子的样品; 在离子存储中积聚待分析的另一种类型的离子的样品; 并对离子的组合样品进行质量分析; 其中所述方法包括基于先前测量各种类型离子的结果累积一种类型离子的样品和/或另一类型离子的样品以实现目标数目的离子。

3. 发明授权

US08716654B2 Electrostatic trap 有权
标题翻译：静电诱捕器
公开(公告)号：US08716654B2
公开(公告)日：2014-05-06
申请号：US13737771
申请日：2013-01-09
申请人： Alexander A. Makarov , Eduard V. Denisov , Gerhard Jung , Wilko Balschun , Stevan R. Horning
发明人： Alexander A. Makarov , Eduard V. Denisov , Gerhard Jung , Wilko Balschun , Stevan R. Horning
IPC分类号： H01J49/26
CPC分类号： H01J49/4245 , H01J49/0027 , H01J49/02 , H01J49/282 , H01J49/406 , H01J49/425
摘要： An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U′ (r, Φ, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U′(r, Φ, z) is the result of a perturbation W to an ideal field U(r, Φ, z) which, for example, is hypologarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, Φ, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2 π radians over an ion detection period Tm.
摘要翻译：公开了诸如轨道捕获器的静电捕获器，具有电极结构。产生U'（r，Φ，z）形式的静电捕获场，以捕获陷阱内的离子，使它们经历同步振荡。捕获场U'（r，Φ，z）是对于理想场U（r，Φ，z）的扰动W的结果，其在轨道捕获的情况下例如是对数的。扰动W可以以各种方式引入，例如通过使陷波器的几何形状变形，使得其不再遵循理想场U（r，Φ，z）的等电位，或者通过添加失真场（电或磁性）。扰动的幅度使得至少一些捕获的离子具有大于零但小于2的绝对相位扩展; 弧度超过离子检测周期Tm。

4. 发明授权

US08692189B2 Parallel mass analysis 有权
标题翻译：平行质量分析
公开(公告)号：US08692189B2
公开(公告)日：2014-04-08
申请号：US13970310
申请日：2013-08-19
申请人： Alexander A. Makarov , Stevan R. Horning
发明人： Alexander A. Makarov , Stevan R. Horning
IPC分类号： H01J49/26 , H01J27/02
CPC分类号： H01J49/009 , H01J49/425
摘要： A system and method of mass spectrometry is provided. Ions from an ion source are stored in a first ion storage device and in a second ion storage device. Ions are ejected from the first ion storage device to a first mass analysis device during a first ejection time period, for analysis during a first analysis time period. Ions are ejected from the second ion storage device to a second mass analysis device during a second ejection time period. The ion storage devices are connected in series such that an ion transport aperture of the first ion storage device is in communication with an ion transport aperture of the second ion storage device. The first analysis time period and the second ejection time period at least partly overlap.
摘要翻译：提供了一种质谱系统和方法。来自离子源的离子存储在第一离子存储装置和第二离子存储装置中。在第一喷射时间段期间，离子从第一离子存储装置喷射到第一质量分析装置，以在第一分析时间段期间进行分析。在第二喷射时间段期间，离子从第二离子存储装置喷射到第二质量分析装置。离子存储装置串联连接，使得第一离子存储装置的离子传送孔与第二离子存储装置的离子传送孔连通。第一分析时间段和第二喷射时间段至少部分重叠。

5. 发明申请

US20140224995A1 Ion Detection 有权
标题翻译：离子检测
公开(公告)号：US20140224995A1
公开(公告)日：2014-08-14
申请号：US14117302
申请日：2012-05-14
申请人： Alexander Kholomeev , Alexander A. Makarov
发明人： Alexander Kholomeev , Alexander A. Makarov
IPC分类号： H01J49/02 , H01J49/00
CPC分类号： H01J49/025 , H01J49/0031 , H01J49/022 , H01J49/425
摘要： A mass analyser in which ions form packets that oscillate with a period has an ion detector comprising: a detection arrangement; and compensation circuitry. The detection arrangement may comprise: a plurality of detection electrodes detecting image current signals from ions in the mass analyser; and a preamplifier, providing an output based on the image current signals. The compensation circuitry provides a compensation signal to a respective compensatory part of the detection arrangement, based on one or more of the image current signals. A capacitance between each of the compensatory parts of the detection arrangement and a signal-carrying part of the detection arrangement affects the signal-to-noise ratio of the preamplifier output. A generator may provide a trapping field defining an ion trapping volume and a shielding conductor may be positioned between two detection electrodes, with a controller applying a voltage to the shielding conductor based on a detected image current.
摘要翻译：其中离子形成具有一段时间振荡的分组的质量分析器具有离子检测器，其包括：检测装置; 和补偿电路。检测装置可以包括：多个检测电极，用于检测质量分析器中离子的图像电流信号; 和前置放大器，基于图像电流信号提供输出。补偿电路基于一个或多个图像电流信号向检测装置的相应的补偿部分提供补偿信号。检测装置的每个补偿部分和检测装置的信号承载部分之间的电容影响前置放大器输出的信噪比。发生器可以提供限定离子捕获体积的捕获场，并且屏蔽导体可以位于两个检测电极之间，其中控制器基于检测到的图像电流向屏蔽导体施加电压。

6. 发明申请

US20140191122A1 Mass Analyser 有权
标题翻译：质量分析仪
公开(公告)号：US20140191122A1
公开(公告)日：2014-07-10
申请号：US14117172
申请日：2012-05-14
申请人： Eduard V. Denisov , Alexander Kholomeev , Jan-Peter Hauschild , Alexander A. Makarov
发明人： Eduard V. Denisov , Alexander Kholomeev , Jan-Peter Hauschild , Alexander A. Makarov
IPC分类号： H01J49/26
CPC分类号： H01J49/26 , H01J49/425 , Y10T29/49117
摘要： A mass analyser comprises: an electrical field generator, providing a time-varying electric field for injection of ions to be analysed, excitation of ions to be analysed or both; first and second detection electrodes, each of which receives a respective voltage pickup due to the time-varying electric field and provides a respective detection signal based on a respective image current at the detection electrode; and a differential amplifier, providing an output based on the difference between the detection signal for the first detection electrode and the detection signal for the second detection electrode. It may also be provided that the electrical field generator comprises at least one field generating electrode without a spatially symmetrical counterpart and the capacitance between each field generating electrode and the first detection electrode is substantially the same as the capacitance between that field generating electrode and the second detection electrode.
摘要翻译：质量分析器包括：电场发生器，提供用于注入要分析的离子的时变电场，要分析的离子的激发或两者; 第一和第二检测电极，每个检测电极由于时变电场而接收相应的电压拾取器，并且基于检测电极处的各自的图像电流提供相应的检测信号; 以及差分放大器，基于第一检测电极的检测信号和第二检测电极的检测信号之间的差提供输出。还可以提供的是，电场发生器包括至少一个没有空间对称的场产生电极，并且每个场产生电极和第一检测电极之间的电容与该场产生电极和第二检测电极之间的电容基本相同检测电极。

7. 发明授权

US08735811B2 Multi-channel detection 有权
标题翻译：多通道检测
公开(公告)号：US08735811B2
公开(公告)日：2014-05-27
申请号：US13345329
申请日：2012-01-06
申请人： Alexander A. Makarov
发明人： Alexander A. Makarov
IPC分类号： H01J49/40
CPC分类号： H01J49/406 , H01J49/004 , H01J49/025 , H01J49/061 , H01J49/408
摘要： A mass spectrometer and method of mass spectrometry wherein charged particles in a beam undergo multiple changes of direction. A detection arrangement detects a first portion of the charged particle beam, and provides a first output based upon the intensity of the detected first portion of the charged particle beam. The detection arrangement detects a second portion of the charged particle beam that has traveled a greater path length through the mass spectrometer than the first portion of the charged particle beam, and provides a second output based upon the detected second portion of the charged particle beam. A controller adjusts the parameters of the charged particle beam and/or the detection arrangement, based upon the first output of the detection arrangement, so as to adjust the second output of the detection arrangement.
摘要翻译：质谱仪和质谱法，其中光束中的带电粒子经历多个方向改变。检测装置检测带电粒子束的第一部分，并且基于所检测到的带电粒子束的第一部分的强度提供第一输出。检测装置检测带电粒子束的第二部分，该第二部分已经比通过质谱仪行进了比带电粒子束的第一部分更大的路径长度，并且基于检测到的带电粒子束的第二部分提供第二输出。控制器基于检测装置的第一输出来调整带电粒子束和/或检测装置的参数，以便调整检测装置的第二输出。

8. 发明授权

US08642973B2 Detection apparatus for detecting charged particles, methods for detecting charged particles and mass spectrometer 有权
标题翻译：用于检测带电粒子的检测装置，用于检测带电粒子的方法和质谱仪
公开(公告)号：US08642973B2
公开(公告)日：2014-02-04
申请号：US12909720
申请日：2010-10-21
申请人： Anastassios Giannakopulos , Alexander A. Makarov
发明人： Anastassios Giannakopulos , Alexander A. Makarov
IPC分类号： H01J37/244 , H01J49/02
CPC分类号： H01J37/244 , H01J49/025 , H01J2237/2444
摘要： Embodiments of the invention provide a detection apparatus for detecting charged particles having a charged particle detector for receiving and detecting either incoming charged particles or secondary charged particles generated from the incoming charged particles, a photon generator for generating photons in response to receiving at least some of the same incoming charged particles or secondary charged particles generated from the incoming charged particles as are received and detected by the charged particle detector, and a photon detector for detecting photons generated by the photon generator.
摘要翻译：本发明的实施例提供了一种检测装置，用于检测具有带电粒子检测器的带电粒子的检测装置，用于接收和检测从进入的带电粒子产生的输入带电粒子或二次带电粒子;光子发生器，用于响应于接收至少一些由带电粒子检测器接收和检测从进入的带电粒子产生的相同的进入带电粒子或二次带电粒子，以及用于检测由光子发生器产生的光子的光子检测器。

9. 发明授权

US08642949B2 Efficient atmospheric pressure interface for mass spectrometers and method 有权
标题翻译：用于质谱仪和方法的高效大气压力界面
公开(公告)号：US08642949B2
公开(公告)日：2014-02-04
申请号：US13413568
申请日：2012-03-06
申请人： Alexander A. Makarov , Reinhold Pesch , Robert Malek , Viacheslav Kozlovskiy
发明人： Alexander A. Makarov , Reinhold Pesch , Robert Malek , Viacheslav Kozlovskiy
IPC分类号： H01J37/301 , H01J49/04 , H01J49/24 , H01J3/18
CPC分类号： H01J49/062 , H01J3/14
摘要： An ion transfer arrangement for transporting ions between higher and lower pressure regions of the mass spectrometer comprises an ion transfer conduit 60. The conduit 60 has an inlet opening towards a relatively high pressure chamber 40 and an outlet 70 opening towards a relatively low pressure chamber. The conduit 60 also has at least one side wall surrounding an ion transfer channel 115. The side wall includes a plurality of apertures 140 formed in the longitudinal direction of the side wall so as to permit a flow of gas from within the ion transfer channel 115 to a lower pressure region outside of the side wall of the conduit 60.
摘要翻译：用于在质谱仪的较高和较低压力区域之间输送离子的离子传递装置包括离子传递管道60.导管60具有朝向较高压力室40的入口开口和朝向较低压力室开口的出口70。导管60还具有围绕离子传递通道115的至少一个侧壁。侧壁包括在侧壁的纵向方向上形成的多个孔140，以允许来自离子传递通道115内的气体流到导管60的侧壁外侧的较低压力区域。

10. 发明申请

US20130268212A1 Data Acquisition System and Method for Mass Spectrometry 审中-公开
标题翻译：数据采集系统和质谱法
公开(公告)号：US20130268212A1
公开(公告)日：2013-10-10
申请号：US13994312
申请日：2011-12-15
申请人： Alexander A. Makarov , Anastassios Giannakopulos , Matthias Biel
发明人： Alexander A. Makarov , Anastassios Giannakopulos , Matthias Biel
IPC分类号： H01J49/02
CPC分类号： H01J49/025 , H01J49/0036
摘要： The invention provides a data acquisition system and method for detecting ions in a mass spectrometer, comprising: a detection system for detecting ions comprising two or more detectors for outputting two or more detection signals in separate channels in response to ions arriving at the detection system; and a data processing system for receiving and processing the detection signals in separate channels of the data processing system and for merging the processed detection signals to construct a mass spectrum; wherein the processing in separate channels comprises removing noise from the detection signals by applying a threshold to the detection signals. The detection signals are preferably produced in response to the same ions, the signals being shifted in time relative to each other. The invention is suitable for a TOF mass spectrometer.
摘要翻译：本发明提供了一种用于检测质谱仪中的离子的数据采集系统和方法，包括：用于检测包括两个或更多个检测器的离子的检测系统，用于响应于到达检测系统的离子在单独的通道中输出两个或更多个检测信号; 以及数据处理系统，用于在数据处理系统的单独信道中接收和处理检测信号，并且用于合并处理的检测信号以构建质谱; 其中在单独信道中的处理包括通过对检测信号应用阈值来从检测信号中去除噪声。优选地，响应于相同的离子产生检测信号，信号在时间上相对于彼此移动。本发明适用于TOF质谱仪。

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