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51. 发明授权

US08029709B2 Liquid core capsules and methods of synthesis thereof through interfacial polymerization 失效
标题翻译：液芯胶囊及其通过界面聚合合成的方法
公开(公告)号：US08029709B2
公开(公告)日：2011-10-04
申请号：US11263310
申请日：2005-10-31
申请人： Dan Wu , Charles Scott , Carlos Co , Chia-Chi Ho
发明人： Dan Wu , Charles Scott , Carlos Co , Chia-Chi Ho
IPC分类号： B01J13/02 , B32B5/00
CPC分类号： A61K9/5146 , A61K9/5192 , B01J13/16 , Y10T428/2982
摘要： A process for the encapsulation of liquid particles within nanometer thick polymer shells utilizes an interfacial free radical alternating copolymerization process. Encapsulating a liquid material includes providing a mixture comprising the liquid material to be encapsulated, a hydrophobic monomer in a non-polar solution and a hydrophilic monomer in a polar solution. The liquid material is compatible in either the polar solution or the non-polar solution. The polar solution and the non-polar solution are not miscible in each other. The mixture is homogenized to form an emulsion, and then polymerized by an initiator which initiates an interfacial free radical alternating copolymerization process. The copolymerization process is optimally constrained to proceed only at the hydrophobic and hydrophilic interface thus forming a polymer around the liquid material.
摘要翻译：液体颗粒在纳米厚聚合物壳体内的封装方法采用界面自由基交替共聚方法。包封液体材料包括提供包含待包封的液体材料，非极性溶液中的疏水性单体和极性溶液中的亲水性单体的混合物。液体材料在极性溶液或非极性溶液中是相容的。极性溶液和非极性溶液彼此不混溶。将混合物均化以形成乳液，然后通过引发界面自由基交替共聚方法的引发剂进行聚合。共聚过程被优化地限制在仅在疏水和亲水界面处进行，从而在液体材料周围形成聚合物。

52. 发明授权

US07989606B2 Phosphatase inhibitor protein-1 as a regulator of cardiac function 有权
标题翻译：磷酸酶抑制剂蛋白-1作为心脏功能的调节剂
公开(公告)号：US07989606B2
公开(公告)日：2011-08-02
申请号：US12162499
申请日：2007-02-09
申请人： Evangelia Kranias , Patricia Rodriguez , Bryan Mitton
发明人： Evangelia Kranias , Patricia Rodriguez , Bryan Mitton
IPC分类号： C07H21/02 , C12N15/12
CPC分类号： C07K14/4703 , A61K38/00
摘要： The present invention relates to novel nucleic acids which encode novel mutant forms of Inhibitor Protein-1 (1-1). In particular, the 1-1 mutant forms comprise altered phosphorylation sites of PKC-α. In addition, the present invention relates to methods of regulating cardiac contractility and function, and for treatment of cardio myopathy and heart failure, which employ the novel nucleic acids and polypeptides. Vectors comprising the novel nucleic acids, Antibodies to the novel proteins, and diagnostic and screening methods associated therewith, are also provided.
摘要翻译：本发明涉及编码新型突变型抑制蛋白-1（1-1）的新型核酸。特别地，1-1突变体形式包含PKC-α的改变的磷酸化位点。此外，本发明涉及调节心脏收缩力和功能以及使用新型核酸和多肽的治疗心脏肌病和心力衰竭的方法。还提供了包含新型核酸，新型蛋白质的抗体以及与其相关的诊断和筛选方法的载体。

53. 发明授权

US07753837B2 Power system for a heart actuation device 有权
标题翻译：用于心脏致动装置的动力系统
公开(公告)号：US07753837B2
公开(公告)日：2010-07-13
申请号：US11298423
申请日：2005-12-08
申请人： David Boyd Melvin
发明人： David Boyd Melvin
IPC分类号： A61M1/10
CPC分类号： A61M1/122 , A61M1/1003 , A61M1/1008 , A61M1/1049 , A61M1/1055 , A61M1/1068 , A61M1/1086 , A61M1/12 , A61M1/127 , A61M2205/33 , A61M2205/3303
摘要： Actuator mechanisms on the heart are of several types. In preferred embodiments, they are generally simple, durable, mechanical assemblies and are driven by power delivered from a remote location, generally outside the chest, by a variety of mechanisms. The invention teaches physical mechanisms (1) for transfer of cyclic power from outside the chest to the region of the heart for that purpose, either as translational or rotary motion. Also taught are electromechanical converting mechanisms suitable for delivering power to those transfer devices. The embodiments described herein for either transmission of energy from a site of generation to a conduit (2, 10, 22), and of conduits that then deliver energy to heart actuators, have contours and interfaces designed to promote a favorable biologic response similar to the pseudosynovial capsules that surround artificial joints. Further, design features are chosen to avoid both non-vented gas-filled chambers and static collections of tissue fluid.
摘要翻译：心脏上的致动器机制有几种类型。在优选实施例中，它们通常是简单，耐用的机械组件，并且通过各种机构从通常在胸部外部的远程位置递送的动力驱动。本发明教导了用于为了目的将循环功率从胸部外部转移到心脏区域的物理机制（1），作为平移或旋转运动。还教导了适于将功率传递给那些传送装置的机电转换机构。本文描述的用于将能量从发生位点传输到导管（2,10,22）的导管和然后将能量传递给心脏致动器的导管具有设计成促进类似于围绕人造关节的假性动脉胶囊。此外，选择设计特征以避免非排气的充气室和组织液的静态收集。

54. 再颁专利

USRE38773E1 High performance biodegradable materials from oriented starch derivatives 失效
标题翻译：来自定向淀粉衍生物的高性能可生物降解材料
公开(公告)号：USRE38773E1
公开(公告)日：2005-08-09
申请号：US10137675
申请日：2002-05-02
申请人： James E. Mark , Brooke Zhao Peterson , Burak Eman , Ivet Bahar , Andrzej Kloczkowski
发明人： James E. Mark , Brooke Zhao Peterson , Burak Eman , Ivet Bahar , Andrzej Kloczkowski
IPC分类号： B29C49/08 , B29C55/00 , B29D7/01 , C07G99/00 , D01F9/00 , D02J1/06 , D04H1/60 , D04H1/64 , C07G17/00
CPC分类号： D04H1/60 , B29C55/005 , B29D7/01 , B29K2003/00 , B29K2105/0061 , D01F9/00
摘要： The present invention involves the synthesis of a series of amylose (starch) derivatives with various degrees of substitution and amylose/amylopectin ratios. These chains are chemically crosslinked and then mechanically deformed (stretched) to produce a biodegradable and mechanically superior material. Specifically, the process consists of chemically modifying starch into starch derivatives such as starch ethers, starch esters and starch carbamates. The polymers have a percentage degree of substitution of from about 35% to about 95% (degree of substitution is from about 1.05 to about 2.85) and preferably have a percentage degree of substitution of from about 65% to about 90% (degree of substitution is from about 1.95 to about 2.70). The starch derivatives are crosslinked to obtain crosslinked chains and processed into sheets, films, fibers, threads or other articles as known in the art. After processing, the articles are swollen in a thermodynamically acceptable solvent or solvent mixture to a desired volume and deformed in a uniaxial or biaxial extension. The polymers materials are preferably stretched from about 1% to about 500% in the direction of stretching. Finally, the solvent is removed, yielding a homogeneous, highly-ordered material. The present invention improves the properties and the quality of sheets, films, fibers, threads or other articles with respect, for example, to mechanical strength. The materials are developed from starch, a natural renewable source which has low cost, high production levels and which replaces petroleum-based, synthetic polymers; the materials acquire high-strength, high-modulus, toughness and flexibility; and the materials exhibit structural and functional stability during processing, storage and use, yet are susceptible to biodegradation upon disposal.
摘要翻译：本发明涉及一系列具有不同取代度和直链淀粉/支链淀粉比例的直链淀粉（淀粉）衍生物的合成。这些链化学交联，然后机械变形（拉伸）以产生可生物降解和机械上优异的材料。具体来说，该方法包括将淀粉化学改性成淀粉衍生物如淀粉醚，淀粉酯和淀粉氨基甲酸酯。聚合物具有约35％至约95％的取代百分比（取代度为约1.05至约2.85），优选具有约65％至约90％的取代百分比（取代度为约1.95至约2.70）。将淀粉衍生物交联以获得交联链，并加工成如本领域已知的片，膜，纤维，线或其它制品。在加工之后，将物品在热力学上可接受的溶剂或溶剂混合物中溶胀至所需体积并在单轴或双轴延伸中变形。聚合物材料优选在拉伸方向上从约1％至约500％拉伸。最后，除去溶剂，得到均匀的高度有序的材料。本发明改进了例如机械强度的片材，薄膜，纤维，线或其他制品的性能和质量。该材料由淀粉，天然可再生能源开发，成本低，生产水平高，代替石油基合成聚合物; 该材料具有高强度，高模量，韧性和柔韧性; 并且该材料在加工，储存和使用期间表现出结构和功能稳定性，但在处理时易于生物降解。

55. 发明授权

US06912700B1 Method and system for non-linear state based satisfiability 失效
标题翻译：用于基于非线性状态的可满足性的方法和系统
公开(公告)号：US06912700B1
公开(公告)日：2005-06-28
申请号：US10164203
申请日：2002-06-06
申请人： John V. Franco , W. Mark VanFleet , John Schlipf , Michael R. Dransfield
发明人： John V. Franco , W. Mark VanFleet , John Schlipf , Michael R. Dransfield
IPC分类号： G06F7/60 , G06F17/10 , G06F17/11 , G06F17/50 , G06N5/04
CPC分类号： G06F17/11 , G06F17/504
摘要： A computerized method and system for solving non-linear Boolean equations is disclosed comprising at least partially solving a Boolean function; developing at least one inference regarding said Boolean function and saving said inference to a state machine; and accessing said inference from said state machine to develop at least one heuristic for determining whether said Boolean function is satisfiable.
摘要翻译：公开了一种用于求解非线性布尔方程的计算机化方法和系统，其包括至少部分地求解布尔函数; 开发关于所述布尔函数的至少一个推断并将所述推理保存到状态机; 以及从所述状态机访问所述推断以开发用于确定所述布尔函数是否可满足的至少一个启发式。

56. 发明申请

US20050067286A1 Microfabricated structures and processes for manufacturing same 审中-公开
公开(公告)号：US20050067286A1
公开(公告)日：2005-03-31
申请号：US10947557
申请日：2004-09-22
申请人： Chong Ahn , Krishnan Trichur , Sreeram Appasamy
发明人： Chong Ahn , Krishnan Trichur , Sreeram Appasamy
IPC分类号： C25D1/10
CPC分类号： B81C99/009 , B81B2203/033 , B81B2203/0361 , B81B2203/0376 , C25D1/10
摘要： Various techniques for the fabrication of highly accurate master molds with precisely defined microstructures for use in plastic replication using injection molding, hot embossing, or casting techniques are disclosed herein. Three different fabrication processes used for master mold fabrication are disclosed wherein one of the processes is a combination of the other two processes. In an embodiment of the first process, a two-step electroplating approach is used wherein one of the metals forms the microstructures and the second metal is used as a sacrificial support layer. Following electroplating, the exact height of the microstructures is defined using a chemical mechanical polishing process. In an embodiment of the second process, a modified electroforming process is used for master mold fabrication. The specific modifications include the use of Nickel-Iron (80:20) as a structural component of the master mold, and the use of a higher saccharin concentration in the electroplating bath to reduce tensile stress during plating and electroforming on the top as well as sides of the dummy substrate to prevent peel off of the electroform. The electroforming process is also well suited towards the fabrication of microstructures with non-rectangular cross sectional profiles. Also disclosed is an embodiment of a simple fabrication process using direct deposition of a curable liquid molding material combined with the electroforming process. Finally, an embodiment of a third fabrication process combines the meritorious features of the first two approaches and is used to fabricate a master mold using a combination of the two-step electroplating plus chemical mechanical polishing approach and the electroforming approach to fabricate highly accurate master molds with precisely defined microstructures. The microstructures are an integral part of the master mold and hence the master mold is more robust and well suited for high volume production of plastic MEMS devices through replication techniques such as injection molding.

57. 发明申请

US20040059180A1 Basal mounting cushion frame component to facilitate extrinsic heart wall actuation 审中-公开
标题翻译：基础安装坐垫框架组件，以促进外部心脏壁动作
公开(公告)号：US20040059180A1
公开(公告)日：2004-03-25
申请号：US10667877
申请日：2003-09-22
申请人： The University of Cincinnati
发明人： David Boyd Melvin
IPC分类号： A61N001/362
CPC分类号： A61F2/2481
摘要： An actuation system for assisting the operation of a natural heart that includes a dome structure configured for being coupled with a ventricular portion of the heart. The dome structure has at least one opening formed therein. The dome structure, proximate the opening, is configured to interface with at least one of an atrial chamber and a great vessel of the heart. A stabilizing element or an actuating element may be anchored to the dome structure for engaging a portion of the heart.
摘要翻译：一种用于辅助自然心脏的操作的致动系统，其包括构造成与心脏的心室部分联接的圆顶结构。圆顶结构具有形成在其中的至少一个开口。靠近开口的圆顶结构被配置成与心脏的心房和大容器中的至少一个相接合。稳定元件或致动元件可以锚定到穹顶结构以接合心脏的一部分。

58. 发明申请

US20040034271A1 Heart wall actuation system for the natural heart with shape limiting elements 失效
标题翻译：心墙致动系统为自然心脏与形状限制元素
公开(公告)号：US20040034271A1
公开(公告)日：2004-02-19
申请号：US10223271
申请日：2002-08-19
申请人： The University of Cincinnati , CardioEnergetics
发明人： David B. Melvin , Brad A. Klosterman , Alan J. Melvin
IPC分类号： A61N001/362
CPC分类号： A61F2/2481 , A61M1/1001 , A61M1/106 , A61M1/1068 , A61M1/12
摘要： An actuation system for assisting the operation of the natural heart includes an actuator element adapted to be positioned proximate a portion of a heart wall. The actuator element is operable for acting on the heart wall portion to effect a change in the shape of the heart. A shape-limiting element is configured for being positioned proximate a heart wall. The shape-limiting element is operable for flexing to assume a curvature no greater than a predetermined curvature when the heart wall is acted upon and maintaining that predetermined curvature to control the shape of the actuated heart.
摘要翻译：用于辅助自然心脏的操作的致动系统包括适于定位成靠近心壁的一部分的致动器元件。致动器元件可操作以作用在心脏壁部分上以实现心脏形状的改变。形状限制元件构造成用于定位在心壁附近。形状限制元件可操作用于当心壁作用并保持该预定曲率以控制致动心脏的形状时，弯曲成不大于预定曲率的曲率。

59. 发明授权

US6032076A Transintegumental power transformers with high permeability cores 失效
标题翻译：具有高磁导率核心的电力变压器
公开(公告)号：US6032076A
公开(公告)日：2000-02-29
申请号：US045432
申请日：1998-03-20
申请人： David Melvin , H. Thurman Henderson , Arthur J. Helmicki
发明人： David Melvin , H. Thurman Henderson , Arthur J. Helmicki
IPC分类号： A61F2/02 , A61N1/08 , A61N1/378 , A61N2/04 , A61N1/00
CPC分类号： A61N1/08 , A61F2250/0001 , A61N1/3787
摘要： Extra- to intra-corporeal power is provided by a transformer implanted at least partially within a defunctionalized intestinal pouch (or sack), such as an ileal pouch. The transformer includes a continuous loop magnetic core which is implanted within the pouch. The pouch itself includes a passageway permitting the secondary wiring to extend around the and through the magnetic core and through its central opening without entering the pouch providing intracorporeal current. Wire providing the primary windings extend from outside the body in through a stoma into the pouch and surround portions of the magnetic core within the pouch. Because of the use of a generally continuous loop magnetic core of high permeability, there is little or virtually no magnetic flux leakage. A solid circular core of a high permeability material may be used. In an alternate embodiment of the present invention the magnetic core can be divided into two separate portions, one implanted within the pouch and one implanted within the peritoneum adjacent the pouch so that the two core portions combine to form a generally continuous loop magnetic path, separated only by the intestinal wall of the pouch.
摘要翻译：通过植入至少部分在功能化的肠袋（或袋）（例如回肠袋）内的变压器来提供额外的体内功率。变压器包括植入袋内的连续环形磁芯。袋本身包括通道，允许二次布线围绕并通过磁芯延伸并穿过其中心开口而不进入提供体内电流的袋。提供初级绕组的线从身体外部通过造口延伸到袋中并且围绕袋内的磁芯的部分。由于使用高磁导率的通常连续的环形磁芯，因此几乎没有或几乎没有磁通泄漏。可以使用高磁导率材料的实心圆芯。在本发明的替代实施例中，磁芯可以分为两个分开的部分，一个植入在囊内，一个植入在邻近袋的腹膜内，使得两个核心部分组合形成大致连续的环路径，分离只能通过肠壁的肠壁。

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