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41. 发明申请

US20090318309A1 Thermo-reversibly gelled colloidal suspensions and a process for making the same 审中-公开
标题翻译：热可逆胶凝胶体悬浮液及其制备方法
公开(公告)号：US20090318309A1
公开(公告)日：2009-12-24
申请号：US12386335
申请日：2009-04-16
申请人： Kyle William Kimble , Jeremy Paul Walker , Sanlord Abraham Asher
发明人： Kyle William Kimble , Jeremy Paul Walker , Sanlord Abraham Asher
IPC分类号： C40B40/14 , C40B40/04 , B01J13/00
CPC分类号： C40B40/14 , B01J13/0065
摘要： Disclosed is a thermoreversible synthesis of a new type of material made by embedding a colloidal population within a thermo-reversibly gelled polymer. The polymer may be a physically cross-linked PVA hydrogel. PVA hydrogels are non-toxic, biocompatible, mechanically robust, and elastic. The present invention TGCCA diffraction is similar to that of photo-polymerized PCCA. The present invention TGCCA can be irreversibly covalently cross-linked using glutaraldehyde. The cross-linked TGCCA can be made responsive to chemical stimuli by functionalizing the hydrogel hydroxyl groups. The diffraction of carboxyl or amine functionalized TGCCA was monitored as a function of the pH and determined diffraction wavelengths titrate with the pKa of the functional group. It was also demonstrated that TGCCA could be fabricated in arbitrarily large volumes and shapes. The present invention method fabricates inexpensive homogenously diffracting chemically modifiable TGCCA.
摘要翻译：公开了通过将胶体体嵌入热可逆胶凝聚合物制备的新型材料的热可逆合成。聚合物可以是物理交联的PVA水凝胶。 PVA水凝胶是无毒的，生物相容的，机械坚固的和弹性的。本发明TGCCA衍射与光聚合PCCA相似。本发明TGCCA可以用戊二醛不可逆地共价交联。通过官能化水凝胶羟基，交联TGCCA可以对化学刺激作出反应。监测羧基或胺官能化TGCCA的衍射作为pH的函数，并用官能团的pKa测定衍射波长滴定度。还表明，TGCCA可以以任意大的体积和形状制造。本发明方法制造廉价的均匀衍射化学修饰的TGCCA。

42. 发明申请

US20090286693A1 MICROARRAYS OF TAGGED COMBINATORIAL TRIAZINE LIBRARIES 审中-公开
标题翻译：标签组合图书馆的微观
公开(公告)号：US20090286693A1
公开(公告)日：2009-11-19
申请号：US12469517
申请日：2009-05-20
申请人： Young-Tae CHANG , Ho-Sang Moon
发明人： Young-Tae CHANG , Ho-Sang Moon
IPC分类号： C40B30/04 , C40B40/04
CPC分类号： C07D251/40 , C07B2200/11 , C07D251/48 , C07D251/54 , C40B40/04 , G01N33/54353 , G01N33/6803
摘要： Triazine linkers can be used to prepare universal small molecule chips for functional proteomics and sensors. These triazine linker compounds are prepared by making a first building block by adding a first amine by reductive amination of triazine, making a second building block by adding a second amine to cyanuric chloride, and combining the first and second building blocks by aminating the first building block onto one of the chloride positions of the second building block. These triazine linkers are then linked to a substrate for determining binding affinity of proteins.
摘要翻译：三嗪接头可用于制备功能蛋白质组学和传感器的通用小分子芯片。这些三嗪连接体化合物是通过通过三嗪的还原胺化加入第一胺制备第一组合物来制备的，通过向氰尿酰氯中加入第二种胺而形成第二种结构单元，并将第一和第二组合物通过胺化第一建筑物阻挡在第二构建块的氯化物位置之一上。然后将这些三嗪接头连接到底物以确定蛋白质的结合亲和力。

43. 发明申请

US20090264317A1 Functionalized nanostructure, methods of manufacture thereof and articles comprising the same 审中-公开
标题翻译：官能化纳米结构体，其制造方法和包含其的制品
公开(公告)号：US20090264317A1
公开(公告)日：2009-10-22
申请号：US12421259
申请日：2009-04-09
申请人： Yuval Ofir , Vincent Martin Rotello , Brian John Jordan , Kenneth Raymond Carter
发明人： Yuval Ofir , Vincent Martin Rotello , Brian John Jordan , Kenneth Raymond Carter
IPC分类号： C40B50/14 , C40B30/00 , C40B40/04 , C40B40/06 , C40B40/10 , B29C35/08 , B32B3/00
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y30/00 , B82Y40/00 , H05K3/102 , H05K3/389 , H05K2201/0257 , H05K2203/0108 , H05K2203/0522 , Y10T428/24802
摘要： Disclosed is a method comprising disposing a functionalized patternable material on a substrate, wherein the functionalized patternable material comprises a first click chemical moiety; patterning the functionalized patternable material; and reacting the first click chemical moiety with a complementary reactant to form an functionalized patterned surface, the complementary reactant comprising a second click chemical moiety that reacts with the first click chemical moiety; the complementary reactant comprising an functional group.
摘要翻译：公开了一种方法，包括将功能化的可图案材料设置在基底上，其中所述官能化可图案材料包括第一点击化学部分; 图案化功能化图案化材料; 并且使所述第一点击化学部分与互补反应物反应以形成官能化图案化表面，所述互补反应物包含与所述第一点击化学部分反应的第二点击化学部分; 包含官能团的互补反应物。

44. 发明申请

US20090137411A1 Methods and biochips for detecting small molecule compounds 审中-公开
标题翻译：检测小分子化合物的方法和生物芯片
公开(公告)号：US20090137411A1
公开(公告)日：2009-05-28
申请号：US10593908
申请日：2005-03-28
申请人： Yimin Sun , Wanli Xing , Guoqing Wang , Hongwu Du , Rong Zhang , Yuan Lu , Yan Wang , Jing Cheng
发明人： Yimin Sun , Wanli Xing , Guoqing Wang , Hongwu Du , Rong Zhang , Yuan Lu , Yan Wang , Jing Cheng
IPC分类号： C40B30/04 , C40B40/04 , C40B50/18
CPC分类号： G01N33/543 , B01J2219/00387 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00659 , B01J2219/0072 , C40B60/14 , G01N33/54366
摘要： The present invention discloses methods for detection of small molecule compounds and its specific biochips. Biochips of the present invention comprise a solid support and carrier-linked small molecules immobilized onto the solid support. The invention also provides methods and kits for detection of small molecule compounds using the biochips of the invention.
摘要翻译：本发明公开了小分子化合物及其特定生物芯片的检测方法。本发明的生物芯片包含固体支持物和固定在固体支持物上的载体连接的小分子。本发明还提供了使用本发明的生物芯片检测小分子化合物的方法和试剂盒。

45. 发明申请

US20090136932A1 FIBERS WITH ISOLATED BIOMOLECULES AND USES THEREOF 审中-公开
标题翻译：具有分离生物分子的纤维及其用途
公开(公告)号：US20090136932A1
公开(公告)日：2009-05-28
申请号：US12049149
申请日：2008-03-14
申请人： Harold G. Craighead , Leon M. Bellan
发明人： Harold G. Craighead , Leon M. Bellan
IPC分类号： C12Q1/68 , C07H21/00 , C07H21/02 , C07H21/04 , C07K2/00 , C07C53/00 , B32B5/02 , C40B40/04 , B01J19/00 , G01N21/00 , B29C47/00 , C07H1/00 , C07K1/00
CPC分类号： C12Q1/6874 , B01J2219/00511 , B01J2219/00524 , B01J2219/00576 , B01J2219/00596 , B01J2219/00657 , B01J2219/00666 , B01J2219/00702 , B01J2219/00722 , C07H1/00 , C07H21/00 , C07H21/02 , C07H21/04 , C07K1/14 , D01D5/0007 , G01N2021/6432 , G01N2021/7723 , G01N2021/773 , G01N2021/7786 , H01J47/00 , Y10T428/298
摘要： The present invention relates to compositions, methods, and uses for isolated biomolecule-containing fibers. The invention also relates to isolated, elongated biopolymers such as nucleic acids, polypeptides, lipids, and carbohydrates within fibers. The invention relates to methods of detecting and analyzing biomolecules in fibers using light, electrons, and neutrons. The invention further relates to methods of determining the sequence, structure, and properties of isolated, elongated biopolymers fixed within fibers.
摘要翻译：本发明涉及用于分离的含有生物分子的纤维的组合物，方法和用途。本发明还涉及分离的细长生物聚合物，例如纤维内的核酸，多肽，脂质和碳水化合物。本发明涉及使用光，电子和中子检测和分析纤维中生物分子的方法。本发明还涉及确定固定在纤维内的分离的细长生物聚合物的顺序，结构和性质的方法。

46. 发明申请

US20090048123A1 Reagentless and Reusable Biosensors with Tunable Differential Binding Affinities and Methods of Making 有权
标题翻译：具有可调节差异结合亲和力的制剂和可重复使用的生物传感器和制备方法
公开(公告)号：US20090048123A1
公开(公告)日：2009-02-19
申请号：US12103778
申请日：2008-04-16
申请人： Igor L. Medintz , Ellen R. Goldman , George P. Anderson , J. Matthew Mauro
发明人： Igor L. Medintz , Ellen R. Goldman , George P. Anderson , J. Matthew Mauro
IPC分类号： C40B40/04 , G01N21/64 , C12M1/00 , C40B50/00
CPC分类号： C12Q1/6818 , B82Y5/00 , B82Y10/00 , C12Q1/6825 , G01N21/6428 , G01N2021/6441 , C12Q2565/607 , C12Q2565/101
摘要： The biosensor comprises a modular biorecognition element and a modular flexible arm element. The biorecognition element and the flexible arm element are each labeled with a signaling element. The flexible arm contains an analog of an analyte of interest that binds with the biorecognition element, bringing the two signaling elements in close proximity, which establishes a baseline fluorescence resonance energy transfer (FRET). When an analyte of interest is provided to the biosensor, the analyte will displace the analyte analog, and with it, the signaling module of the modular flexible arm, causing a measurable change in the FRET signal in a analyte concentration dependent manner. The modularity of different portions of the biosensor allows functional flexibility. The biosensor operates without additional development reagents, requiring only the presence of analyte or target for function.
摘要翻译：生物传感器包括模块化生物识别元件和模块化柔性臂元件。生物识别元件和柔性臂元件各自用信号元件标记。柔性臂包含与生物识别元件结合的感兴趣分析物的类似物，使得两个信号元件紧密相邻，这建立了基线荧光共振能量转移（FRET）。当感兴趣的分析物被提供给生物传感器时，分析物将置换分析物类似物，并且借助于该模块化柔性臂的信号模块，以分析物浓度依赖的方式引起FRET信号的可测量的变化。生物传感器的不同部分的模块化允许功能灵活性。生物传感器无需额外的开发试剂即可运行，仅需要分析物或靶标的存在才能发挥作用。

47. 发明申请

US20090023601A1 GEL HAVING BIOSUBSTANCE FIXED THERETO AND MICROARRAY UTILIZING THE GEL 审中-公开
标题翻译：凝胶生物固定凝胶和微量元素使用凝胶
公开(公告)号：US20090023601A1
公开(公告)日：2009-01-22
申请号：US12014251
申请日：2008-01-15
申请人： Chiaki NAGAHAMA , Chiho Itou
发明人： Chiaki NAGAHAMA , Chiho Itou
IPC分类号： C40B40/04 , C40B50/00 , B32B1/06
CPC分类号： B01J19/0046 , B01J2219/00317 , B01J2219/0052 , B01J2219/00524 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00639 , B01J2219/00641 , B01J2219/00644 , B01J2219/00659 , B01J2219/00673 , B01J2219/00722
摘要： The present invention provides a biological substance-immobilized gel which comprises a gel containing 2%-7% by mass of N,N-dimethylacrylamide and a biological substance immobilized on and/or in the gel.
摘要翻译：本发明提供一种生物物质固定凝胶，其包含含有2％-7质量％的N，N-二甲基丙烯酰胺和固定在凝胶上和/或上的生物物质的凝胶。

48. 发明申请

US20080242558A1 FABRICATED BIOFILM STORAGE DEVICE 审中-公开
标题翻译：制造的生物存储设备
公开(公告)号：US20080242558A1
公开(公告)日：2008-10-02
申请号：US11782036
申请日：2007-07-24
申请人： Angela M. Belcher , Seung-Wuk Lee , Brent L. Iverson , Soo-Kwan Lee
发明人： Angela M. Belcher , Seung-Wuk Lee , Brent L. Iverson , Soo-Kwan Lee
IPC分类号： C40B40/08 , C40B40/00 , C40B40/04 , C40B40/06 , C40B40/10 , C40B40/14 , C40B50/00
CPC分类号： A01N1/0231 , A01N1/02 , C12M23/20 , C12M45/22
摘要： The present invention includes a method and composition of storing and preserving biofilms for input and output of high-density information. One form of the present invention is a fabricated biofilm storage device with a biologic material applied to a substrate to form, e.g., a dry thin film stable at room temperature for extended periods of time. Another form of the present invention is a method of fabricating a biofilm storage device in which a biologic material is applied to a substrate under conditions that promote alignment of the biologic material on the substrate. The composition, method, and kit of the present invention have universal application in biologics, magnetics, optics and microelectronics.
摘要翻译：本发明包括存储和保存用于输入和输出高密度信息的生物膜的方法和组合物。本发明的一种形式是制造的生物膜存储装置，其具有施加到基底的生物材料以形成例如在室温下长时间稳定的干薄膜。本发明的另一形式是制造生物膜存储装置的方法，其中在促进生物材料在基底上的对准的条件下将生物材料施加到基底上。本发明的组合物，方法和试剂盒在生物制剂，磁性材料，光学和微电子学方面具有普遍的应用。

49. 发明授权

US07413538B1 Epitopes formed by non-covalent association of conjugates 失效
标题翻译：由非共价缔合共轭体形成的表位
公开(公告)号：US07413538B1
公开(公告)日：2008-08-19
申请号：US10019052
申请日：2000-06-27
申请人： Roger New , Istvan Toth
发明人： Roger New , Istvan Toth
IPC分类号： C40B40/00 , C40B40/04 , C40B40/10 , G01N33/53
CPC分类号： G01N33/5041 , A61K9/1271 , C07K1/1077 , C07K5/0606 , C07K5/1013 , C07K7/06 , G01N33/5008 , G01N33/5432 , G01N2333/525
摘要： A composition for interacting with a ligand, which composition comprises a non-covalent association of a plurality of distinct conjugates, each conjugate comprising a head group and a tail group, wherein the tail groups of the conjugates form a hydrophobic aggregation and the conjugates are movable within the association so that, in the presence of a ligand, at least two of the head groups are appropriately positioned to form an epitope capable of interacting with the ligand more strongly than each of head groups individually.
摘要翻译：用于与配体相互作用的组合物，该组合物包含多个不同缀合物的非共价缔合，每个缀合物包含头基和尾基，其中缀合物的尾基形成疏水性聚集体，并且缀合物是可移动的在配体中，使得在配体存在下，适当地定位至少两个头部基团，以形成能够比每个头部基团更强烈地与配体相互作用的表位。

50. 发明申请

US20080167201A1 Method For Synthesizing Derivative, Compound Library and Method For Constructing the Same, and Method For Screening 审中-公开
标题翻译：合成衍生物，化合物库及其构建方法的方法和筛选方法
公开(公告)号：US20080167201A1
公开(公告)日：2008-07-10
申请号：US11663082
申请日：2005-09-27
申请人： Masaya Imoto , Hiromichi Ohta , Kenji Miyamoto
发明人： Masaya Imoto , Hiromichi Ohta , Kenji Miyamoto
IPC分类号： C40B30/10 , C12P1/00 , C12P1/04 , C12P1/02 , C40B50/06 , C40B40/04 , C40B30/00
CPC分类号： C12P17/16 , C07D405/06 , G01N2500/00
摘要： [Object] To provide a method for synthesizing derivatives of natural compounds; a method for constructing a compound library containing derivatives of natural compounds; a compound library containing derivatives of natural compounds; and a screening method using a compound library, which are useful for a HTS random screening, a search for drugs or agricultural chemicals, or a search for a lead compound of a drug or an agricultural chemical.[Solving Means] A derivative of an organic compound can be synthesized by culturing a microorganism producing the organic compound in a predetermined culture broth, and reacting the organic compound obtained by the culturing with a reaction reagent for synthesizing the derivative of the organic compound in the culturing broth. By constructing a library containing the thus obtained organic compound derivative, a HTS (high-throughput) random screening, a search for a drug or agricultural chemical, or a search for a lead compound of a drug or agricultural chemical can be performed.
摘要翻译：提供合成天然化合物衍生物的方法; 一种构建含有天然化合物衍生物的化合物文库的方法; 含有天然化合物衍生物的化合物库; 以及使用化合物文库的筛选方法，其可用于HTS随机筛选，寻找药物或农药，或搜索药物或农药的铅化合物。 [解决方案]有机化合物的衍生物可以通过在预定的培养肉汤中培养产生有机化合物的微生物来合成，并将通过培养获得的有机化合物与用于合成有机化合物的衍生物的反应试剂反应培养肉汤通过构建含有这样得到的有机化合物衍生物的文库，可以进行HTS（高通量）随机筛选，药物或农药的检索，或者寻找药物或农药的铅化合物。

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