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41. 发明授权

US3098016A Process for producing sterile vials containing culture media and a carbon dioxide atmosphere 失效
标题翻译：用于生产含有培养基和二氧化碳气氛的无菌小瓶的方法
公开(公告)号：US3098016A
公开(公告)日：1963-07-16
申请号：US12687861
申请日：1961-07-26
申请人： AMERICAN CYANAMID CO
发明人： SAM COOPER MURRAY , DI BENEDETTO VITO ANTHONY
IPC分类号： A61L2/00 , C12M1/04 , C12N1/00 , C12N1/20
CPC分类号： A61L2/0094 , C12M29/26 , C12N1/00 , C12N1/20 , Y10S435/822 , Y10S435/842 , Y10S435/871

42. 发明授权

US3049476A Fermentation process for producing novobiocin 失效
标题翻译：发酵生产新生霉素的方法
公开(公告)号：US3049476A
公开(公告)日：1962-08-14
申请号：US57913356
申请日：1956-04-19
申请人： MERCK & CO INC
发明人： MILLER IAN M
IPC分类号： C07H17/075
CPC分类号： C07H17/075 , Y10S435/822 , Y10S435/839 , Y10S435/843 , Y10S435/844 , Y10S435/859 , Y10S435/871 , Y10S435/886

43. 发明申请

US20030104502A1 Two-component system that controls bacterial membrane synthesis 有权
公开(公告)号：US20030104502A1
公开(公告)日：2003-06-05
申请号：US10288986
申请日：2002-11-05
申请人： University of Iowa Research Foundation
发明人： Michael A. Apicella , Andrew Preston
IPC分类号： G01N033/554 , G01N033/569 , C07H021/04 , C12N009/50 , C12P021/02 , C12N001/21 , C12N015/74
CPC分类号： C12R1/36 , C07K14/22 , G01N33/56911 , G01N33/571 , G01N2333/22 , Y10S435/871
摘要： The present invention discloses a mutant Neisseria having extensive membrane blebbing, both an indicium and a cause of virulence in the gonococcus and meningococcus. Methods are disclosed for making and characterizing the mutant, bmrRS. Methods are disclosed for isolating bmrRS membranes for use as a vaccine. Methods are also disclosed for the use of the mutant for determining the virulence of clinical samples of N. gonorrhoeae and N. meningitidis. Methods are also disclosed for the screening of antibiotics targeted to virulent Neisseria.

44. 发明授权

US06379933B1 Method of transferring at least two saccharide units with a polyglycosyltransferase 失效
标题翻译：用多糖基转移酶转移至少两个糖单元的方法
公开(公告)号：US06379933B1
公开(公告)日：2002-04-30
申请号：US09338943
申请日：1999-06-24
申请人： Karl F. Johnson , Stephen Roth , Stephanie L. Buczala
发明人： Karl F. Johnson , Stephen Roth , Stephanie L. Buczala
IPC分类号： C12P1918
CPC分类号： C12P19/18 , C12N9/1048 , Y10S435/871
摘要： The present invention relates to a method of transferring at least two saccharide units with a polyglycosyltransferase, a polyglycosyltransferase and a gene encoding such a polyglycosyltransferase.
摘要翻译：本发明涉及用多糖基转移酶，多糖基转移酶和编码这种多糖基转移酶的基因转移至少两个糖单元的方法。

45. 发明申请

US20010016349A1 TWO-COMPONENT SYSTEM THAT CONTROLS BACTERIAL MEMBRANE SYNTHESIS 有权
标题翻译：控制细菌膜合成的双组分体系
公开(公告)号：US20010016349A1
公开(公告)日：2001-08-23
申请号：US09439226
申请日：1999-11-12
发明人： MICHAEL A. APICELLA , ANDREW PRESTON
IPC分类号： C12N001/00 , C12N001/12
CPC分类号： C12R1/36 , C07K14/22 , G01N33/56911 , G01N33/571 , G01N2333/22 , Y10S435/871
摘要： The present invention discloses a mutant Neisseria having extensive membrane blebbing, both an indicium and a cause of virulence in the gonococcus and meningococcus. Methods are disclosed for making and characterizing the mutant, bmrRS. Methods are disclosed for isolating bmrRS membranes for use as a vaccine. Methods are also disclosed for the use of the mutant for determining the virulence of clinical samples of N. gonorrhoeae and N. meningitidis. Methods are also disclosed for the screening of antibiotics targeted to virulent Neisseria.
摘要翻译：本发明公开了具有广泛的膜泡的突变型奈瑟氏球菌，它们是淋球菌和脑膜炎球菌中的毒性和毒力原因。公开了制备和表征突变体bmrRS的方法。公开了用于分离用作疫苗的bmrRS膜的方法。还公开了使用该突变体测定淋病奈瑟氏球菌和脑膜炎奈瑟氏球菌的临床样品的毒力的方法。还公开了筛选针对有毒奈瑟氏球菌的抗生素的方法。

46. 发明授权

US6020461A Hexapeptides of Neisseria gonorrhoeae 失效
标题翻译：淋病奈瑟氏球菌的六肽
公开(公告)号：US6020461A
公开(公告)日：2000-02-01
申请号：US452915
申请日：1995-05-30
申请人： Charles Garrett Miyada , Teresa L. Born
发明人： Charles Garrett Miyada , Teresa L. Born
IPC分类号： C07K7/06 , C07K16/12 , C12N15/31 , C12Q1/68
CPC分类号： C12Q1/689 , Y10S435/822 , Y10S435/871
摘要： A nucleotide sequence characteristic of Neisseria gonorrhoeae is disclosed. The sequence can be the basis for hybridization type, nucleic acid-based, rapid, in vitro diagnostic assays. The unique nature of the sequence makes it possible to clearly discriminate N. gonorrhoeae from other Neisseria species thus eliminating or substantially reducing the number of false positive readings. A 350 base pair N. gonorrhoeae DNA restriction fragment was cloned after subtractive hybridization to Neisseria meningitidis DNA. In further cloning experiments the sequences adjacent to the original 350 base pair fragment were determined. A portion of this sequence was shown to detect 105 of 106 N. gonorrhoeae strains and no other Neisseria species. In addition to use as detection probes, all or portions of the nucleotide sequence can be used as a ligand for the sandwich capture of N. gonorrhoeae sequences and as primers for in vitro amplification of N. gonorrhoeae sequences. The polypeptides encoded by the presently disclosed sequence, including antibodies thereto, are also disclosed as are their uses.
摘要翻译：披露了淋病奈瑟氏球菌特征的核苷酸序列。该序列可以是杂交类型，基于核酸，快速，体外诊断测定的基础。序列的独特性质使得可以清楚地区分淋病奈瑟氏球菌与其他奈瑟氏菌属物种，从而消除或显着减少假阳性读数的数量。在与奈瑟氏球菌脑膜炎奈瑟菌DNA消减杂交后克隆了350碱基对淋病奈瑟氏球菌DNA限制性片段。在进一步克隆实验中，确定与原始350碱基对片段相邻的序列。该序列的一部分显示检测到106个淋病奈瑟氏球菌菌株中的105个，并且没有其他的奈瑟球菌属物种。除了用作检测探针之外，核苷酸序列的全部或部分可以用作奈氏淋病奈瑟氏球菌序列的夹心捕获的配体，并且用作用于体外扩增淋病奈瑟氏球菌序列的引物。本文公开的序列编码的多肽（包括其抗体）也被用于其用途。

47. 发明授权

US5928650A Subunit vaccine against Neisseria meningitidis infections and corresponding subunits in the purified state 失效
标题翻译：亚单位疫苗针对脑膜炎奈瑟菌感染和相应的亚单位处于纯化状态
公开(公告)号：US5928650A
公开(公告)日：1999-07-27
申请号：US449733
申请日：1995-05-25
申请人： Marie Jose Quentin-Millet , Ling Lissolo
发明人： Marie Jose Quentin-Millet , Ling Lissolo
IPC分类号： A61K39/095 , A61K38/00 , A61K39/00 , A61P31/04 , C07K1/00 , C07K1/22 , C07K14/195 , C07K14/22 , C07K14/41 , C07K14/81 , C12P21/02 , C12R1/36
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , Y10S435/871
摘要： The present invention relates to the lower molecular weight subunit of the human transferrin receptor of a strain of N. meningitidis, in purified form, as well as to a vaccinal pharmaceutical composition intended for the prevention or attenuation of the effects of an N. meningitidis infection, containing the said subunit in purified form.
摘要翻译：本发明涉及纯化形式的脑膜炎奈瑟氏球菌菌株的人转铁蛋白受体的较低分子量亚基，以及旨在预防或减弱脑膜炎奈瑟菌感染影响的疫苗药物组合物，含有纯化形式的所述亚基。

48. 发明授权

US5731162A Method and analytical device for simultaneous immunoassay 失效
标题翻译：用于同步免疫测定的方法和分析装置
公开(公告)号：US5731162A
公开(公告)日：1998-03-24
申请号：US549805
申请日：1995-12-06
申请人： Guido Gatti , Laura Arcioni
发明人： Guido Gatti , Laura Arcioni
IPC分类号： C07K14/22 , C07K14/295 , C07K14/30 , G01N33/554 , G01N33/569 , G01N33/571
CPC分类号： G01N33/571 , C07K14/22 , C07K14/295 , C07K14/30 , G01N33/56911 , Y10S435/87 , Y10S435/871 , Y10S435/961 , Y10S435/975 , Y10S436/808 , Y10T436/25125
摘要： The present invention concerns a method and an analytical device for the simultaneous detection of at least two organisms selected from the group consisting of Chlamydia trachomatis (CT), Neisseria gonorrhea (NG), and Mycoplasma (M) from a single specimen.
摘要翻译： PCT No.PCT / EP94 / 01723 Sec。 371 1995年12月6日第 102（e）日期1995年12月6日PCT 1994年5月27日PCT PCT。第WO94 / 29729号公报日期1994年12月22日本发明涉及一种用于同时检测选自沙眼衣原体（CT），淋病奈瑟氏球菌（NG）和支原体（M））中的至少两种生物的方法和分析装置标本。

49. 发明授权

US5162199A Neisseria-specific DNA probe 失效
标题翻译： NEISSERIA-SPECIFIC DNA探针
公开(公告)号：US5162199A
公开(公告)日：1992-11-10
申请号：US531226
申请日：1990-05-31
申请人： Anne Stern , Karin Wolff
发明人： Anne Stern , Karin Wolff
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , Y10S435/822 , Y10S435/871
摘要： A Neisseria-specific DNA probe is chosen from the group of the oligonucleotides Opa 1, Opa 2, Opa 3, P III, Pil 1, IgA 1 and IgA 2 or from sequences complementary to these and it can have up to 5 further nucleotides at the 5' and/or 3' end. The probe is suitable for the detection of at least one of the pathogenic Neisseria species N. gonorrhoeae and N. meningitidis under hybridization conditions by the detection of the hybrid formation.
摘要翻译：奈瑟氏球菌特异性DNA探针选自寡核苷酸Opa 1，Opa 2，Opa 3，P III，Pil 1，IgA 1和IgA 2组，或者与这些序列互补的序列，并且其可以具有至多5个另外的核苷酸 5'和/或3'端。该探针适用于通过杂交形成的检测在杂交条件下检测至少一种病原性奈瑟氏球菌淋球菌和脑膜炎奈瑟氏球菌。

50. 发明授权

US5147800A Host expressing NgoAIII restriction endonuclease and modification methylase from neisseria 失效
标题翻译：主要表达NGOAIII限制性内切酶和修饰来自NEISSERIA的甲基化酶
公开(公告)号：US5147800A
公开(公告)日：1992-09-15
申请号：US535021
申请日：1990-06-08
申请人： Alan W. Hammond , Deb K. Chatterjee
发明人： Alan W. Hammond , Deb K. Chatterjee
IPC分类号： C12N1/21 , C12N9/10 , C12N9/22 , C12N15/09 , C12R1/36
CPC分类号： C12N9/1007 , C12N9/22 , Y10S435/871
摘要： The present invention is directed to recombinant hosts which contain and express various Type II restriction endonuclease and/or modification methylase genes. In particular, the present invention is concerned with the cloned restriction endonucleases, NgoAIII and NgoAI, which recognize and cleave within or near the double-stranded DNA sequence, 5' CCGCGG 3' and 5' PuGCGCPy 3', respectively. Also provided in this invention are cloned modification methylase genes corresponding to said restriction endonucleases. This invention is further concerned with a cloned modification methylase, M.NgoAII. One source of these enzymes is Neisseria gonorrhoeae, although other microorganisms may be used to isolate the restriction endonuclease isoschizomers and modification methylase isoschizomers of this invention.
摘要翻译：本发明涉及含有并表达各种II型限制性内切核酸酶和/或修饰甲基化酶基因的重组宿主。特别地，本发明涉及克隆的限制性内切核酸酶NgoAIII和NgoAI，其分别在双链DNA序列内或其附近识别和切割5'CCGCGG 3'和5'PuGCGCPy 3'。本发明还提供了与所述限制性内切核酸酶相应的克隆的修饰甲基化酶基因。本发明还涉及克隆的修饰甲基化酶M.NgoAII。这些酶的一个来源是淋病奈瑟氏球菌，尽管其他微生物可用于分离本发明的限制性内切核酸酶异构体和修饰甲基化酶同位异构体。

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