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41. 发明申请

US20130296323A1 GGA AND GGA DERIVATIVES COMPOSITIONS THEREOF AND METHODS FOR TREATING NEURODEGENERATIVE DISEASES INCLUDING PARALYSIS INCLUDING THEM 有权
公开(公告)号：US20130296323A1
公开(公告)日：2013-11-07
申请号：US13779568
申请日：2013-02-27
申请人： COYOTE PHARMACEUTICALS, INC.
发明人： Hiroaki Serizawa , Ankush B. Argade , Akash Datwani , Natalie Spencer , Yonghua Pan , Florian Ermini
IPC分类号： C07C49/203 , C07C69/02 , C07C69/24 , C07C69/743 , C07C69/74 , C07D295/13 , C07C309/66 , C07C309/73 , C07C333/04 , C07C333/06 , C07C333/08 , C07D211/26 , C07C69/145 , C07C69/75
CPC分类号： C07C49/203 , C07C33/02 , C07C33/14 , C07C47/21 , C07C49/21 , C07C49/255 , C07C49/557 , C07C49/647 , C07C57/03 , C07C57/66 , C07C69/007 , C07C69/02 , C07C69/145 , C07C69/24 , C07C69/587 , C07C69/608 , C07C69/738 , C07C69/74 , C07C69/743 , C07C69/75 , C07C69/757 , C07C69/76 , C07C69/92 , C07C205/57 , C07C211/08 , C07C211/35 , C07C211/38 , C07C217/08 , C07C251/40 , C07C251/60 , C07C271/12 , C07C271/22 , C07C271/24 , C07C271/28 , C07C271/30 , C07C309/66 , C07C309/73 , C07C333/04 , C07C333/06 , C07C333/08 , C07C333/10 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07C2603/18 , C07C2603/74 , C07D211/26 , C07D213/75 , C07D263/32 , C07D263/38 , C07D271/10 , C07D295/13 , C07D307/46 , C07D307/52 , C07D413/04
摘要： This invention relates to geranylgeranyl acetone (GGA) derivatives and the use of GGA, its isomers, and GGA derivatives in methods for inhibiting neural death, increasing neural activity, increasing axon growth and cell viability, and increasing the survival rate of subjects administered the GGA or GGA derivatives.

42. 发明申请

US20130281736A1 SYNTHESIS OF PERETINOIN 有权
公开(公告)号：US20130281736A1
公开(公告)日：2013-10-24
申请号：US13877241
申请日：2011-09-29
申请人： Raphael Beumer
发明人： Raphael Beumer
IPC分类号： C07C51/377
CPC分类号： C07C51/377 , C07C51/353 , C07C67/343 , C07F9/11 , C07F9/4015 , C07F9/5004 , C07F9/5022 , C07F9/5428 , C07F9/5442 , C07C57/03 , C07C69/587
摘要： The present invention relates to a new and improved synthesis of peretinoin.

43. 发明申请

US20130267571A1 TERPENOID ANALOGUES AND USES THEREOF FOR TREATING NEUROLOGICAL CONDITIONS 审中-公开
标题翻译： TERPENOID类似物及其用于治疗神经病症的用途
公开(公告)号：US20130267571A1
公开(公告)日：2013-10-10
申请号：US13822826
申请日：2011-09-14
申请人： Mark A. Reed , Donald Weaver , Shengguo Sun , Alexander McLellan , Erhu Lu
发明人： Mark A. Reed , Donald Weaver , Shengguo Sun , Alexander McLellan , Erhu Lu
IPC分类号： C07C233/09 , C07C43/166 , C07C57/03 , C07D257/04 , C07C233/65 , C07C233/05 , C07C233/07 , C07C235/60 , C07C43/15 , C07C211/21
CPC分类号： C07C233/09 , A61K31/045 , A61K31/08 , A61K31/10 , A61K31/12 , A61K31/13 , A61K31/16 , A61K31/18 , A61K31/201 , A61K31/41 , C07C43/15 , C07C43/166 , C07C57/03 , C07C211/21 , C07C233/05 , C07C233/07 , C07C233/65 , C07C235/60 , C07D257/04
摘要： The present application provides a terpene analogue of Formula (I) or a pharmaceutically acceptable isomer, salt or ester thereof, and methods and uses thereof for treating neurological conditions such as pain in general and neuropathic pain. These terpene analogues can also be used to treat other electrical disorders in the central and peripheral nervous system. Also provided are methods of synthesizing the terpene analogues of Formula I.
摘要翻译：本申请提供了式（I）的萜烯类似物或其药学上可接受的异构体，盐或酯，以及其用于治疗神经学病症如一般疼痛和神经性疼痛的方法和用途。这些萜烯类似物也可用于治疗中枢和外周神经系统中的其他电疗障碍。还提供了合成式I的萜烯类似物的方法。

44. 发明申请

US20130253211A1 METHODS FOR THE PRODUCTION OF DIESTERS FROM TRIACYLGLYCERIDE ESTERS 有权
标题翻译：从三氯乙酸酯生产柴油的方法
公开(公告)号：US20130253211A1
公开(公告)日：2013-09-26
申请号：US13430090
申请日：2012-03-26
申请人： Tapsak Mark Allan
发明人： Tapsak Mark Allan
IPC分类号： C07C51/347 , C07C51/44
CPC分类号： C07C51/44 , C07C51/353 , C07C67/475 , C07C67/54 , C07C57/03 , C07C69/593
摘要： Efficient methods for the production of long-chain unsaturated dicarboxylic compounds are disclosed. Unsaturated dicarboxylic compounds may be prepared from a reaction mixture containing unsaturated carboxylic compounds in the presence of one or more catalysts. In addition to the unsaturated dicarboxylic compounds, alkene compounds may also be produced. The alkene compounds may be removed from the reaction mixture under reduced pressure. The method may also use a wiped-film still as a means to remove the alkene compounds from the reaction mixture. Reaction conditions may be monitored and/or controlled through the use of one or more electronic system(s) in communication with a variety of sensors and controllable devices.
摘要翻译：公开了生产长链不饱和二羧酸化合物的有效方法。不饱和二羧酸化合物可以在一种或多种催化剂的存在下由含有不饱和羧酸化合物的反应混合物制备。除了不饱和二羧酸化合物之外，还可以生产烯烃化合物。可以在减压下从反应混合物中除去烯烃化合物。该方法还可以使用擦拭膜作为从反应混合物中除去烯烃化合物的手段。可以通过使用与各种传感器和可控设备通信的一个或多个电子系统来监视和/或控制反应条件。

45. 发明授权

US08492436B2 Inhibitors of yeast filamentous growth and method of their manufacture 有权
标题翻译：酵母丝状生长抑制剂及其制备方法
公开(公告)号：US08492436B2
公开(公告)日：2013-07-23
申请号：US12965482
申请日：2010-12-10
申请人： Lian-Hui Wang , Lian-Hui Zhang
发明人： Lian-Hui Wang , Lian-Hui Zhang
IPC分类号： A61K31/20 , C07C61/08 , C07C61/00
CPC分类号： C07C57/03 , A61K31/201
摘要： The invention broadly relates to the use of α,β-unsaturated fatty acids to inhibit the filamentous growth of fungi and yeasts and to a method for producing same. In particular the invention relates to the use of optionally substituted C8 to CI5 α,β-unsaturated fatty acids or salts, esters or amides thereof for inhibiting or retarding the yeast-to-mycelium transition of organisms having a dimorphic life cycle.
摘要翻译：本发明广泛涉及α，β-不饱和脂肪酸用于抑制真菌和酵母的丝状生长及其制备方法。特别地，本发明涉及任选取代的C 8至C 5aα，β-不饱和脂肪酸或其盐，酯或酰胺用于抑制或延缓具有二形生命周期的生物的酵母与菌丝体转变的用途。

46. 发明授权

US08470879B2 Fatty acid inhibitors 失效
标题翻译：脂肪酸抑制剂
公开(公告)号：US08470879B2
公开(公告)日：2013-06-25
申请号：US12917847
申请日：2010-11-02
申请人： Bruce Branchaud
发明人： Bruce Branchaud
IPC分类号： A61K31/336 , C07D315/00
CPC分类号： C07D303/48 , C07C57/03 , C07C205/55 , C07C2601/02 , C07D203/08 , C07D205/04 , C07D303/38 , C07D305/04 , C07D305/06 , C07D305/08 , C07D331/02 , C07D331/04
摘要： Fatty acid inhibitors, pharmaceutical compositions including fatty acid inhibitors, methods for using fatty acid inhibitors to treat a variety of diseases, and methods for preparing fatty acid inhibitors are provided herein.
摘要翻译：本文提供了脂肪酸抑制剂，包括脂肪酸抑制剂的药物组合物，使用脂肪酸抑制剂治疗各种疾病的方法以及制备脂肪酸抑制剂的方法。

47. 发明授权

US08383837B2 Reaction with a gold catalyst 有权
标题翻译：与金催化剂反应
公开(公告)号：US08383837B2
公开(公告)日：2013-02-26
申请号：US12600859
申请日：2008-06-05
申请人： Werner Bonrath , Jocelyn Fischesser
发明人： Werner Bonrath , Jocelyn Fischesser
IPC分类号： C07D307/00 , C07D307/02 , C07D307/62 , C07C63/00 , C07C51/16 , C07C51/00
CPC分类号： C07H3/02 , C07B2200/07 , C07C51/235 , C07H7/027 , C07H9/04 , C07C57/03 , C07C63/06
摘要： The invention relates to a process for the catalytic conversion of a carbohydrate, an alcohol, an aldehyde or a polyhydroxy compound in the presence of a catalyst containing gold in a solvent.
摘要翻译：本发明涉及在溶剂中含有金的催化剂存在下，碳水化合物，醇，醛或多羟基化合物的催化转化方法。

48. 发明授权

US08362296B2 Process for preparing 4-pentenoic acid 有权
标题翻译：制备4-戊烯酸的方法
公开(公告)号：US08362296B2
公开(公告)日：2013-01-29
申请号：US12859622
申请日：2010-08-19
申请人： Joaquim Henrique Teles , Michael Schelper , Kai Gumlich , Mathieu Chabanas , Christian Müller , Anton Meier
发明人： Joaquim Henrique Teles , Michael Schelper , Kai Gumlich , Mathieu Chabanas , Christian Müller , Anton Meier
IPC分类号： C07C51/235
CPC分类号： C07C51/235 , C07C57/03
摘要： The present invention relates to a process for preparing 4-pentenoic acid, at least comprising the oxidation of a mixture (G) comprising 4-pentenal, 3-methyl-2-butanone and cyclopentene oxide, and to the use of a mixture (G) comprising 4-pentenal, 3-methyl-2-butanone and cyclopentene oxide for preparing 4-pentenoic acid. In the context of the present invention, the mixture (G) is preferably obtained as a by-product of the oxidation of cyclopentene to cyclopentanone by means of dinitrogen monoxide.
摘要翻译：本发明涉及一种制备4-戊烯酸的方法，至少包括包含4-戊烯醛，3-甲基-2-丁酮和环戊烯氧化物的混合物（G）的氧化和使用混合物（G ），其包含4-戊烯醛，3-甲基-2-丁酮和环戊烯氧化物，用于制备4-戊烯酸。在本发明的上下文中，优选通过一氧化二氮作为环戊烯氧化成环戊酮的副产物获得混合物（G）。

49. 发明申请

US20130023684A1 OIL OR FAT COMPOSITION 有权
标题翻译：油或脂肪组合物
公开(公告)号：US20130023684A1
公开(公告)日：2013-01-24
申请号：US13638865
申请日：2011-02-25
申请人： Junya Moriwaki , Masao Shimizu , Rika Homma
发明人： Junya Moriwaki , Masao Shimizu , Rika Homma
IPC分类号： C11C3/00
CPC分类号： A23D9/007 , A23D7/0053 , A23D7/0056 , A61Q19/00 , C07C57/03 , C11C3/00
摘要： Provided is an oil or fat composition, which has an MCPD-FS content X (ppm) and a hydroxyl value Y (mg-KOH/g) satisfying a relationship of the following expression (1), the content X being measured by a Deutsche Gesellschaft für Fettwissenschaft (DGF) standard method CIII 18(09), and has a content (%) of trans isomers of linoleic acids in constituent fatty acids of an oil or fat, of 2 or more. Y≧1.25X+4 where Y≦88 (1)
摘要翻译：本发明提供一种油或脂肪组合物，其具有满足以下表达式（1）的关系的MCPD-FS含量X（ppm）和羟基值Y（mg-KOH / g），其含量X由德国 GesellschaftfürFettwissenschaft（DGF）标准方法CIII 18（09），并且具有2或更多的油或脂肪的构成脂肪酸中的亚油酸的反式异构体的含量（％）。 Y≥1.25X+ 4其中Y＆NlE; 88（1）

50. 发明申请

US20120330043A1 SIMULATED MOVING BED CHROMATOGRAPHIC SEPARATION PROCESS 有权
标题翻译：模拟移动板色谱分离过程
公开(公告)号：US20120330043A1
公开(公告)日：2012-12-27
申请号：US13519618
申请日：2010-12-24
申请人： Adam Kelliher , Angus Morrison , Anil Oroskar , Rakesh Vikraman Nair Rema , Abhilesh Agarwal
发明人： Adam Kelliher , Angus Morrison , Anil Oroskar , Rakesh Vikraman Nair Rema , Abhilesh Agarwal
IPC分类号： C07C51/47 , C07C57/03
CPC分类号： C07C51/47 , B01D15/185 , C07C57/03 , C11B3/10 , C11B3/12
摘要： The present invention provides a chromatographic separation process for recovering a polyunsaturated fatty acid (PUFA) product, from a feed mixture, which process comprises introducing the feed mixture to a simulated or actual moving bed chromatography apparatus having a plurality of linked chromatography columns containing, as eluent, an aqueous alcohol, wherein the apparatus has a plurality of zones comprising at least a first zone and second zone, each zone having an extract stream and a raffinate stream from which liquid can be collected from said plurality of linked chromatography columns, and wherein (a) a raffinate stream containing the PUFA product together with more polar components is collected from a column in the first zone and introduced to a nonadjacent column in the second zone, and/or (b) an extract stream containing the PUFA product together with less polar components is collected from a column in the second zone and introduced to a nonadjacent column in the first zone, said PUFA product being separated from different components of the feed mixture in each zone.
摘要翻译：本发明提供了一种用于从进料混合物中回收多不饱和脂肪酸（PUFA）产物的色谱分离方法，该方法包括将进料混合物引入到具有多个连接色谱柱的模拟或实际移动床层析装置中，洗脱液，含水醇，其中所述装置具有包括至少第一区和第二区的多个区，每个区具有提取物流和可从所述多个连接的色谱柱从其中收集液体的萃余液流，并且其中（a）从第一区域的塔中收集含有PUFA产物和更极性组分的萃余液流，并将其引入第二区域中的不相邻的塔，和/或（b）含有PUFA产物的萃取物流与从第二区域中的塔收集较少的极性组分，并将其引入第一区域中的不相邻的塔，所述PUFA产物在每个区域中与进料混合物的不同组分分离。

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