专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

41. 发明授权

US07345209B2 Processes for synthesis of 1,3,3,3-tetrafluoropropene 失效
标题翻译：合成1,3,3,3-四氟丙烯的方法
公开(公告)号：US07345209B2
公开(公告)日：2008-03-18
申请号：US11118503
申请日：2005-04-29
申请人： Sudip Mukhopadhyay , Haridasan K. Nair , Hsueh S. Tung , Michael Van Der Puy
发明人： Sudip Mukhopadhyay , Haridasan K. Nair , Hsueh S. Tung , Michael Van Der Puy
IPC分类号： C07C17/278 , C07C17/10 , C07C17/23 , C07C17/25 , C07C17/04
CPC分类号： C07C17/206 , C07C17/00 , C07C17/25 , C07C17/275 , C07C17/278 , C07C21/18 , C07C19/10 , C07C19/16 , C07C19/14 , C07C19/01
摘要： Disclosed is a process for the synthesis of 1,3,3,3-tetrafluoropropene that comprises, in one preferred embodiment, providing a compound of the formula CF3CH2CHFX, wherein X is a selected from the group consisting of chlorine, bromine and iodine, and exposing said compound to reaction conditions effective to convert said compound to 1,3,3,3-tetrafluoropropene. Other processes for forming 1,3,3,3-tetrafluoropropene are also disclosed.
摘要翻译：公开了一种合成1,3,3,3-四氟丙烯的方法，其在一个优选的实施方案中包括提供式CF 3 CH 2 CHFX的化合物其中X选自氯，溴和碘，并将所述化合物暴露于有效将所述化合物转化为1,3,3,3-四氟丙烯的反应条件下。还公开了形成1,3,3,3-四氟丙烯的其它方法。

42. 发明申请

US20080044322A1 Halocarbon production systems 审中-公开
标题翻译：卤代烃生产系统
公开(公告)号：US20080044322A1
公开(公告)日：2008-02-21
申请号：US11977404
申请日：2007-10-24
申请人： Mitchel Cohn , John Chien
发明人： Mitchel Cohn , John Chien
IPC分类号： B01J19/00
CPC分类号： B01J19/2465 , B01J8/025 , B01J8/06 , B01J19/02 , B01J2219/00006 , B01J2219/0245 , B01J2219/0286 , C07C17/00 , C07C17/206 , C07C17/21 , C07C17/25 , C07C17/275 , C07C17/278 , C07C17/38 , C07C17/383 , C07C17/386 , C07C17/395 , C07C19/08 , C07C21/04 , C07C19/01 , C07C21/18
摘要： Halocarbon production processes are provided that can include reacting at least one C-2 halocarbon with at least one C-1 halocarbon in the presence of a phosphate to produce at least one C-3 chlorocarbon. The processes can include reacting ethylene with carbon tetrachloride in the presence of a phosphate. Halocarbon separation processes are provided that can include providing a reaction product that includes at least one saturated fluorocarbon and at least one unsaturated fluorocarbon and adding at least one hydrohalogen to produce a distillation mixture. Methods and materials are provided for the production and purification of halogenated compounds and intermediates in the production of 1,1,1,3,3-pentafluoropropane.
摘要翻译：提供卤代烃生产方法，其可以包括在磷酸盐存在下使至少一种C-2卤代烃与至少一种C-1卤代烃反应以产生至少一种C-3氯化碳。该方法可包括在磷酸盐存在下使乙烯与四氯化碳反应。提供了卤代烃分离方法，其可以包括提供包含至少一种饱和碳氟化合物和至少一种不饱和氟碳化合物的反应产物，并加入至少一种氢卤素以产生蒸馏混合物。提供了生产和提纯卤代化合物和中间产物1,1,1,3,3-五氟丙烷的方法和材料。

43. 发明申请

US20070129392A1 Novel therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders 有权
标题翻译：用于治疗癌症，代谢疾病和皮肤病症的新型治疗剂
公开(公告)号：US20070129392A1
公开(公告)日：2007-06-07
申请号：US10514381
申请日：2004-06-03
申请人： Borcherng Hong , Sepehr Sarshar , Bruno Tse
发明人： Borcherng Hong , Sepehr Sarshar , Bruno Tse
IPC分类号： A61K31/44 , A61K31/336 , A61K31/4433
CPC分类号： C07D213/53 , C07C17/16 , C07C17/2632 , C07C45/46 , C07C45/64 , C07C45/68 , C07C45/72 , C07C49/747 , C07C49/83 , C07C49/835 , C07C251/48 , C07C251/86 , C07C2601/02 , C07C2601/10 , C07C2601/16 , C07C2602/10 , C07D213/50 , C07D303/32 , C07D317/26 , C07D319/06 , C07D405/04 , C07C19/01 , C07C25/24 , C07C49/813
摘要： The present invention is directed to compounds having the structure (I) wherein R1, R2, R3, R4, R5 and m are as defined herein. The compounds of this invention are novel therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders in mammalian subjects. These compounds are also useful modulators of gene expression. They exert their activity by interfering with certain cellular signal transduction cascades. The compounds of the invention are thus also useful for regulating cell differentiation and cell cycle processes that are controlled or regulated by various hormones or cytokines. In particular, the invention relates to compounds that induce apoptosis of cancer cells and therefore may be used for the treatment or prevention of cancer, including advanced cancers and pre-cancerous cells. The invention also discloses pharmaceutical compositions and methods of treatment of disease in mammals.
摘要翻译：本发明涉及具有结构（I）的化合物，其中R 1，R 2，R 3，R 4， R 5和M如本文所定义。本发明的化合物是用于治疗哺乳动物受试者的癌症，代谢疾病和皮肤病症的新型治疗剂。这些化合物也是基因表达的有用调节剂。它们通过干扰某些细胞信号转导级联发挥其活性。因此，本发明的化合物也可用于调节由各种激素或细胞因子控制或调节的细胞分化和细胞周期过程。特别地，本发明涉及诱导癌细胞凋亡的化合物，因此可用于治疗或预防癌症，包括晚期癌症和癌前细胞。本发明还公开了哺乳动物疾病的药物组合物和治疗方法。

44. 发明申请

US20070106086A1 PROCESS FOR THE PREPARATION OF 3,3-DIMETHYLBUTANAL 有权
标题翻译：制备3,3-二甲基吡啶的方法
公开(公告)号：US20070106086A1
公开(公告)日：2007-05-10
申请号：US11552395
申请日：2006-10-24
申请人： Jerry Ebner , Zhi Guo , Arnold Hershman , Loraine Klein , William McGhee , Mark Paster , Indra Prakash
发明人： Jerry Ebner , Zhi Guo , Arnold Hershman , Loraine Klein , William McGhee , Mark Paster , Indra Prakash
IPC分类号： C07C45/29 , C07K5/04
CPC分类号： C07C303/24 , C07C17/275 , C07C29/095 , C07C29/12 , C07C29/124 , C07C29/132 , C07C29/147 , C07C29/149 , C07C45/002 , C07C45/38 , C07C47/02 , C07K5/06113 , Y02P20/127 , C07C19/01 , C07C305/08 , C07C31/125
摘要： 3,3-Dimethylbutanal is prepared from 3,3-dimethylbutanol. Intermediate 3,3-dimethylbutanol is obtained by reacting ethylene, isopropylene and a mineral acid to produce a 3,3-dimethylbutyl ester which is hydrolyzed to the alcohol. The hydrolysis step is effectively carried out by reactive distillation. Alternatively, 3,3-dimethylbutanal is prepared from 3,3-dimethylbutanol obtained by reduction of the corresponding carboxylic acid or 1,2-epoxy-3,3-dimethylbutane, or by hydrolysis of 1-halo-3,3-dimethylbutane. Fixed bed gas phase and stirred tank liquid phase processes are provided for converted 3,3-dimethylbutanol to 3,3-dimethylbutanal by catalytic dehydrogenation.
摘要翻译： 3,3-二甲基丁醛由3,3-二甲基丁醇制备。中间体3,3-二甲基丁醇通过使乙烯，异丙烯和无机酸反应得到3,3-二甲基丁酯，将其水解成醇。水解步骤通过反应蒸馏有效地进行。或者，通过还原相应的羧酸或1,2-环氧-3,3-二甲基丁烷或通过1-卤代-3,3-二甲基丁烷的水解得到的3,3-二甲基丁醇制备3,3-二甲基丁醛。提供固定床气相和搅拌釜液相方法，通过催化脱氢将3,3-二甲基丁醇转化为3,3-二甲基丁醛。

45. 发明申请

US20060161029A1 Production and purification processes 审中-公开
标题翻译：生产和净化过程
公开(公告)号：US20060161029A1
公开(公告)日：2006-07-20
申请号：US11323365
申请日：2005-12-29
申请人： Stephen Owens , Andrew Jackson , Vimal Sharma , Mitchel Cohn , John Qian , Julia Sacarias , Yuichi Iikubo
发明人： Stephen Owens , Andrew Jackson , Vimal Sharma , Mitchel Cohn , John Qian , Julia Sacarias , Yuichi Iikubo
IPC分类号： C07C17/32 , C07C17/26
CPC分类号： C07C19/08 , C07C17/00 , C07C17/21 , C07C17/25 , C07C17/278 , C07C17/38 , C07C17/383 , C07C17/386 , C07C21/18 , C07C21/04 , C07C19/01
摘要： Methods and materials are provided for the production and purification of halogenated compounds and intermediates in the production of 1,1,1,3,3-pentafluoropropane. In a preferred embodiment, the process steps include: (1) reacting carbon tetrachloride with vinyl chloride to produce 1,1,1,3,3-pentachloropropane; (2) dehydrochlorinating the 1,1,1,3,3-pentachloropropane with a Lewis acid catalyst to produce 1,1,3,3-tetrachloropropene; (3) fluorinating the 1,1,3,3-tetrachloroprope-ne to produce 1-chloro-3,3,3-trifluoropropene; (4) fluorinating the 1-chloro-3,3,3-trifluoropropene to produce a product mixture containing 1,1,1,3,3-pentafluoropropane; and (5) separating 1,1,1,3,3-pentafluoropro-pane from by-products.
摘要翻译：提供了生产和提纯卤代化合物和中间产物1,1,1,3,3-五氟丙烷的方法和材料。在优选的实施方案中，方法步骤包括：（1）使四氯化碳与氯乙烯反应，生成1,1,1,3,3-五氯丙烷; （2）用路易斯酸催化剂对1,1,1,3,3-五氯丙烷进行脱氯化氢以制备1,1,3,3-四氯丙烯; （3）使1,1,3,3-四氯丙炔氟化，生成1-氯-3,3,3-三氟丙烯; （4）氟化1-氯-3,3,3-三氟丙烯以制备含有1,1,1,3,3-五氟丙烷的产物混合物; 和（5）从副产物中分离1,1,1,3,3-五氟平板。

46. 发明申请

US20050177012A1 Halocarbon production processes, halocarbon separation processes, and halocarbon separation systems 审中-公开
标题翻译：卤代烃生产工艺，卤代烃分离工艺和卤代烃分离系统
公开(公告)号：US20050177012A1
公开(公告)日：2005-08-11
申请号：US11038982
申请日：2005-01-19
申请人： Mitchel Cohn , John Chien
发明人： Mitchel Cohn , John Chien
IPC分类号： C07C17/00 , C07C17/21 , C07C17/25 , C07C17/278 , C07C17/38 , C07C17/383 , C07C17/386 , C07C19/08
CPC分类号： B01J19/2465 , B01J8/025 , B01J8/06 , B01J19/02 , B01J2219/00006 , B01J2219/0245 , B01J2219/0286 , C07C17/00 , C07C17/206 , C07C17/21 , C07C17/25 , C07C17/275 , C07C17/278 , C07C17/38 , C07C17/383 , C07C17/386 , C07C17/395 , C07C19/08 , C07C21/04 , C07C19/01 , C07C21/18
摘要： Halocarbon production processes are provided that can include reacting at least one C-2 halocarbon with at least one C-1 halocarbon in the presence of a phosphate to produce at least one C-3 chlorocarbon. The processes can include reacting ethylene with carbon tetrachloride in the presence of a phosphate. Halocarbon separation processes are provided that can include providing a reaction product that includes at least one saturated fluorocarbon and at least one unsaturated fluorocarbon and adding at least one hydrohalogen to produce a distillation mixture. Methods and materials are provided for the production and purification of halogenated compounds and intermediates in the production of 1,1,1,3,3-pentafluoropropane.
摘要翻译：提供卤代烃生产方法，其可以包括在磷酸盐存在下使至少一种C-2卤代烃与至少一种C-1卤代烃反应，以生产至少一种C-3氯化碳。该方法可包括在磷酸盐存在下使乙烯与四氯化碳反应。提供了卤代烃分离方法，其可以包括提供包含至少一种饱和碳氟化合物和至少一种不饱和氟碳化合物的反应产物，并加入至少一种氢卤素以产生蒸馏混合物。提供了生产和提纯卤代化合物和中间产物1,1,1,3,3-五氟丙烷的方法和材料。

47. 发明申请

US20050101810A1 Processes for separating 1,1,1,3,3-pentafluoropropane from a mixture comprising 1,1,1,3,3-pentafluoropropane and 1-chloro-3,3,3-trifluoropropene 审中-公开
标题翻译：从1,1,1,3,3-五氟丙烷和1-氯-3,3,3-三氟丙烯的混合物中分离1,1,1,3,3-五氟丙烷的方法
公开(公告)号：US20050101810A1
公开(公告)日：2005-05-12
申请号：US11006987
申请日：2004-12-08
申请人： Stephen Owens , Andrew Jackson , Vimal Sharma , Mitchel Cohn , John Qian , Julia Sacarias , Yuichi Iikubo
发明人： Stephen Owens , Andrew Jackson , Vimal Sharma , Mitchel Cohn , John Qian , Julia Sacarias , Yuichi Iikubo
IPC分类号： C07C17/00 , C07C17/21 , C07C17/25 , C07C17/278 , C07C17/38 , C07C17/383 , C07C17/386 , C07C19/08
CPC分类号： C07C19/08 , C07C17/00 , C07C17/21 , C07C17/25 , C07C17/278 , C07C17/38 , C07C17/383 , C07C17/386 , C07C21/18 , C07C21/04 , C07C19/01
摘要： Methods and materials are provided for the production and purification of halogenated compounds and intermediates in the production of 1,1,1,3,3-pentafluoropropane. In a preferred embodiment, the process steps include: (1) reacting carbon tetrachloride with vinyl chloride to produce 1,1,1,3,3-pentachloropropane; (2) dehydrochlorinating the 1,1,1,3,3 -pentachloropropane with a Lewis acid catalyst to produce 1,1,3,3-tetrachloropropene; (3) fluorinating the 1,1,3,3-tetrachloropropene to produce 1-chloro-3,3,3-trifluoropropene; (4) fluorinating the 1-chloro-3,3,3-trifluoropropene to produce a product mixture containing 1,1,1,3,3 -pentafluoropropane; and (5) separating 1,1,1,3,3-pentafluoropropane from by-products.
摘要翻译：提供了生产和提纯卤代化合物和中间产物1,1,1,3,3-五氟丙烷的方法和材料。在优选的实施方案中，方法步骤包括：（1）使四氯化碳与氯乙烯反应，生成1,1,1,3,3-五氯丙烷; （2）用路易斯酸催化剂对1,1,1,3,3-三氯丙烷进行脱氯化氢，得到1,1,3,3-四氯丙烯; （3）使1,1,3,3-四氯丙烯氟化，得到1-氯-3,3,3-三氟丙烯; （4）氟化1-氯-3,3,3-三氟丙烯以制备含有1,1,1,3,3-五氟丙烷的产物混合物; 和（5）从副产物中分离1,1,1,3,3-五氟丙烷。

48. 发明申请

US20050080302A1 Process for the manufacture of halocarbons and selected compounds and azeotropes with HF 有权
标题翻译：用于制造卤代烃和所选化合物以及与HF共沸的方法
公开(公告)号：US20050080302A1
公开(公告)日：2005-04-14
申请号：US10956672
申请日：2004-10-01
申请人： Ralph Baker , Ralph Miller , Viacheslav Petrov , Velliyur Rao , Allen Sievert
发明人： Ralph Baker , Ralph Miller , Viacheslav Petrov , Velliyur Rao , Allen Sievert
IPC分类号： C07C17/20 , C07C17/275 , C07C17/278 , C07C17/38 , C07C17/386 , C07C19/08 , C07C19/10
CPC分类号： C07C19/10 , C01B7/191 , C07C17/206 , C07C17/275 , C07C17/278 , C07C17/38 , C07C17/386 , C07C19/08 , Y02P20/582 , C07C19/01 , C07C19/16
摘要： A liquid phase process is disclosed for producing halogenated alkane adducts of the formula CAR1R2CBR3R4 (where A, B, R1, R2, R3, and R4 are as defined in the specification) which involves contacting a corresponding halogenated alkane, AB, with a corresponding olefin, CR1R2═CR3R4 in a dinitrile or cyclic carbonate ester solvent which divides the reaction mixture into two liquid phases and in the presence of a catalyst system containing (i) at least one catalyst selected from monovalent and divalent copper; and optionally (ii) a promoter selected from aromatic or aliphatic heterocyclic compounds which contain at least one carbon-nitrogen double bond in the heterocyclic ring. When hydrochlorofluorocarbons are formed, the chlorine content may be reduced by reacting the hydrochlorofluorocarbons with HF. New compounds disclosed include CF3CF2CCl2CH2CCl3, CF3CCl2CH2CH2Cl and CF3CCl2CH2CHClF. These compounds are useful as intermediates for producing hydrofluorocarbons. Azeotropes of CClF2CH2CF3 with HF and azeotropes of CF3CH2CHF2 with HF are also disclosed; as are process for producing such azeotropes. A process for purification of certain hydrofluorocarbons and/or chloro-precursors thereof from mixtures of such compounds with HF is also disclosed.
摘要翻译：公开了用于制备式CAR 1 R 2 CBR 3 R 4的卤代烷烃加成物的液相方法（其中A，B，R 1，R 2，R 3，和R 4如说明书中所定义），其包括将相应的卤代烷烃AB与相应的烯烃CR 1 R 2 = CR 3 R 4在二腈或环状碳酸酯溶剂，其将反应混合物分成两个液相，并且在含有（i）至少一种选自一价和二价铜的催化剂的催化剂体系的存在下，和任选地（ii）选自在杂环中含有至少一个碳 - 氮双键的芳族或脂族杂环化合物的促进剂。当形成氢氯氟烃时，可以通过氢氯氟烃与HF反应来降低氯含量。所公开的新化合物包括CF 3 CF 2 CCl 2 CH 2 ClCl 3，CF 3 CCl 2 CH 2 CH 2 Cl和CF 3 CCl 2 CH 2 CHClF。这些化合物可用作生产氢氟烃的中间体。还公开了CClF 2 CH 2 CF 3与HF的共沸物和CF 3 CH 2 CHF 2与HF的共沸物质; 生产这种共沸物的方法也是如此。还公开了从这种化合物与HF的混合物中纯化某些氢氟烃和/或其氯前体的方法。

49. 发明申请

US20040225166A1 Method for producing 1,1,1,3-tetrachloropropane and other haloalkanes with iron catalyst 审中-公开
标题翻译：用铁催化剂生产1,1,1,3-四氯丙烷和其他卤代烷烃的方法
公开(公告)号：US20040225166A1
公开(公告)日：2004-11-11
申请号：US10648709
申请日：2003-08-26
申请人： VULCAN CHEMICALS A BUSINESS GROUP OF VULCAN MATERIALS COMPANY
发明人： Richard L. Wilson , John L. Dawkins
IPC分类号： C07C017/266
CPC分类号： C07C17/275 , C07C17/383 , C07C19/01
摘要： A continuous process is provided for the manufacture of haloalkanes by the reaction of carbon tetrachloride with olefins in the presence of iron metal, trialkylphosphate, and ferric chloride. A fraction of the catalyst and co-catalyst are separated after the reaction and recycled. In a preferred application, the olefin is ethene, and the haloalkane product is 1,1,1,3-tetrachloropropane. Two distillation steps take place in order to enhance the production of 1,1,1,3-tetrachloropropane.
摘要翻译：提供了在铁金属，三烷基磷酸盐和氯化铁存在下通过四氯化碳与烯烃的反应制备卤代烷烃的连续方法。催化剂和助催化剂的一部分在反应后分离并再循环。在优选的应用中，烯烃是乙烯，卤代烷烃产物是1,1,1,3-四氯丙烷。进行两个蒸馏步骤以增强1,1,1,3-四氯丙烷的生产。

50. 发明申请

US20040215041A1 Process for producing isopropyl chloride 失效
标题翻译：生产异丙基氯的方法
公开(公告)号：US20040215041A1
公开(公告)日：2004-10-28
申请号：US10851154
申请日：2004-05-24
申请人： KASHIMA CHEMICAL COMPANY LIMITED , ASAHI GLASS COMPANY LIMITED
发明人： Tomoko Matsumoto , Tateo Nakano , Yutaka Yokoyama , Tomoji Makiguchi
IPC分类号： C07C021/02
CPC分类号： C07C17/08 , C07C19/01
摘要： The present invention is an industrially advantageous process for isopropyl chloride production in which the catalytic activity can be maintained under the milder reaction conditions than in the conventional processes, and which requires no special reactor. Propylene and hydrogen chloride is reacted in a gas phase, in the presence of iron or a halogenated aluminum oxide (preferably, aluminum oxide reacted with hydrogen chloride). Preferably, a temperature during the reaction is 20 to 100null C., and a pressure of the reaction is 1013 to 3039 hPa (absolute pressure).
摘要翻译：本发明是工业上有利的异丙基氯生产方法，其中催化活性可以在比常规方法更温和的反应条件下保持，并且不需要特殊的反应器。丙烯和氯化氢在铁或卤化氧化铝（优选与氯化氢反应的氧化铝）的存在下在气相中反应。优选地，反应期间的温度为20〜100℃，反应压力为1013〜3039hPa（绝对压力）。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式