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41. 发明申请

US20050153326A1 Method for synthesizing cDNA 审中-公开
标题翻译： cDNA合成方法
公开(公告)号：US20050153326A1
公开(公告)日：2005-07-14
申请号：US10995005
申请日：2004-11-23
申请人： Junko Yamamoto , Kazue Miyake , Hiroyuki Mukai , Fumitsugu Hino , Ikunoshin Kato
发明人： Junko Yamamoto , Kazue Miyake , Hiroyuki Mukai , Fumitsugu Hino , Ikunoshin Kato
IPC分类号： C12N15/10 , C12Q1/68 , C12N9/22 , C12P19/34
CPC分类号： C12Q1/6844 , C12N15/10 , C12Q1/686 , C12Q2521/319 , C12Q2521/107
摘要： A method for synthesizing cDNA characterized by performing a reverse transcription reaction in the presence of an enzyme having a reverse transcriptional activity and another enzyme different from the former one which as a 3′-5′ exonuclease activity.
摘要翻译：一种合成cDNA的方法，其特征在于在具有逆转录活性的酶的存在下进行逆转录反应，另一种不同于前者的3'-5'核酸外切酶活性的酶。

42. 发明授权

US06897042B2 Low-temperature inducible expression vector 失效
标题翻译：低温诱导表达载体
公开(公告)号：US06897042B2
公开(公告)日：2005-05-24
申请号：US10268229
申请日：2002-10-10
申请人： Masanori Takayama , Yoshiko Nomura , Ikunoshin Kato
发明人： Masanori Takayama , Yoshiko Nomura , Ikunoshin Kato
IPC分类号： C07K14/245 , C12N9/24 , C12N15/00 , C12N15/63 , C12N15/67 , C12N15/70 , C12N15/72 , C12P21/06 , C07H17/00
CPC分类号： C12N15/72 , C07K14/245 , C12N9/2471 , C12N15/00 , C12N15/635 , C12N15/67 , C12N15/70 , C12Y302/01023
摘要： A vector which is characterized in containing each of the following elements: (1) a promoter which shows its action in the host to be used; (2) regulatory region for regulating the action of the promoter of (1); and (3) a region which codes for the 5′-untranslated region derived from cold-shock protein gene mRNA or a region which codes for the region where substitution, deletion, insertion or addition of at least one base is applied to the said untranslated region.
摘要翻译：一种载体，其特征在于含有以下元素：（1）在宿主中显示其作用的启动子; （2）调节（1）启动子作用的调节区; 和（3）编码来自冷休克蛋白基因mRNA的5'非翻译区的区域或编码至少一个碱基的取代，缺失，插入或添加的区域的区域，该区域应用于所述非翻译区地区。

43. 发明申请

US20050048480A1 Method of detecting cancer 审中-公开
标题翻译：检测癌症的方法
公开(公告)号：US20050048480A1
公开(公告)日：2005-03-03
申请号：US10333015
申请日：2001-07-18
申请人： Yasuhhiro Tsubosa , Kazuhiko Aoyagi , Hiroki Sasaki , Masaaki Terada , Junichi Mineno , Kiyozo Asada , Ikunoshin Kato
发明人： Yasuhhiro Tsubosa , Kazuhiko Aoyagi , Hiroki Sasaki , Masaaki Terada , Junichi Mineno , Kiyozo Asada , Ikunoshin Kato
IPC分类号： C12N15/12 , C12Q1/68 , C12Q1/6837 , C12Q1/6886
CPC分类号： C12Q1/6886 , C12Q1/6837 , C12Q2600/158
摘要： To provide a method for selecting a marker gene useful for cancer classification; a method for classifying cancer using the gene; a method for detecting cancer; a kit usable for the classification method or detection method; and a DNA array carrying the gene. According to the present invention, there can be obtained a gene, wherein expression of the above gene is altered independently from genes each of which expression is altered specifically during cell proliferation and expression level of the above gene is specifically altered depending on every type of cancer samples to be tested, whereby the classification or detection of cancer can be carried out conveniently and quickly without giving surgical treatment. Therefore, the present invention is useful for the diagnosis, the treatment, and the like of cancer.
摘要翻译：提供选择用于癌症分类的标记基因的方法; 使用该基因分类癌症的方法; 一种检测癌症的方法; 可用于分类方法或检测方法的试剂盒; 和携带该基因的DNA阵列。根据本发明，可以获得上述基因的表达独立于在细胞增殖期间特异性改变的基因的各基因的变化，并且根据每种类型的癌症特异性地改变上述基因的表达水平待测试的样品，从而可以方便快捷地进行癌症的分类或检测，而无需外科治疗。因此，本发明对癌症的诊断，治疗等有用。

44. 发明授权

US06548543B1 Remedies or preventives containing cyclopentenone compounds as the active ingredient 失效
标题翻译：含环戊烯酮化合物作为活性成分的补救措施或预防措施
公开(公告)号：US06548543B1
公开(公告)日：2003-04-15
申请号：US09763244
申请日：2001-02-20
申请人： Eiji Kobayashi , Hiromu Ohnogi , Hiroaki Sagawa , Takanari Tominaga , Eiji Nishiyama , Nobuto Koyama , Katsushige Ikai , Ikunoshin Kato
发明人： Eiji Kobayashi , Hiromu Ohnogi , Hiroaki Sagawa , Takanari Tominaga , Eiji Nishiyama , Nobuto Koyama , Katsushige Ikai , Ikunoshin Kato
IPC分类号： A61K31215
CPC分类号： A61K31/215 , A61K31/22 , C07C69/013 , C07C2601/10 , Y02A50/411
摘要： Remedies or preventives for diseases with a need for immunoregulation, diseases with a need for inhibition of inflammation, diseases with a need for regulation of tumor necrosis factor production, diseases with a need for regulation of fungal growth, diseases with a need for regulation of cell adhesion or disease with a deed for induction of heat-shock protein, which contain as the active ingredient at least one compound selected from among cyclopentenone derivatives represented by general formula [I], optically active isomers and salts thereof, wherein R1 and R2 are the same or different and each represents hydrogen, an aliphatic group, an aromatic group or an aromatic aliphatic group.
摘要翻译：需要免疫调节的疾病的治疗或预防措施，需要抑制炎症的疾病，需要调节肿瘤坏死因子产生的疾病，需要调节真菌生长的疾病，需要调节细胞的疾病含有作为活性成分的至少一种选自通式[I]表示的环戊烯酮衍生物的化合物，其光学活性异构体和盐，其中R 1和R 2为相同或不同，各自表示氢，脂族基，芳基或芳族脂族基。

45. 发明授权

US06432664B1 Processes of screening for an antimycotic agent 失效
标题翻译：筛选抗真菌剂的方法
公开(公告)号：US06432664B1
公开(公告)日：2002-08-13
申请号：US09447223
申请日：1999-11-23
申请人： Takashi Okado , Kazutoh Takesako , Ikunoshin Kato
发明人： Takashi Okado , Kazutoh Takesako , Ikunoshin Kato
IPC分类号： C12Q118
CPC分类号： C07K14/40 , A61K38/00 , C07K14/37 , C07K16/14 , Y10S435/822 , Y10S435/911 , Y10S530/824
摘要： The invention provides an isolated gene coding for a protein regulating aureobasidin sensitivity; a process for cloning the gene with the use of the gene or a part of the same as a probe; a nucleic acid probe being hybridizable with the gene; an antisense DNA or RNA of the gene; a recombinant or transformant having the gene contained therein; an isolated protein regulating aureobasidin sensitivity and a process for producing the same by using the transformant; an antibody for the protein; a process for detecting the protein or the gene; and a process for screening an antimycotic by using the protein or the transformant. The invention is useful in the diagnosis and treatment of diseases including mycoses.
摘要翻译：本发明提供编码调节金黄担子素敏感性蛋白质的分离基因; 使用该基因或其一部分作为探针克隆该基因的方法; 核酸探针可与该基因杂交; 该基因的反义DNA或RNA; 其中含有该基因的重组体或转化体; 调节金丝桃素敏感性的分离蛋白质及其使用该转化体的方法。蛋白质的抗体; 检测蛋白质或基因的方法; 以及通过使用蛋白质或转化体筛选抗真菌药物的方法。本发明可用于诊断和治疗包括真菌病的疾病。

46. 发明授权

US06348577B1 Regulation of aureobasidin sensitivity in fungus 有权
标题翻译：调控真菌中金黄色葡萄球菌敏感性
公开(公告)号：US06348577B1
公开(公告)日：2002-02-19
申请号：US09414006
申请日：1999-10-07
申请人： Takashi Okado , Kazutoh Takesako , Ikunoshin Kato
发明人： Takashi Okado , Kazutoh Takesako , Ikunoshin Kato
IPC分类号： C07K1400
CPC分类号： C07K14/38 , A61K38/00 , C07K14/37 , C07K14/40 , C07K16/14 , C12N15/80 , C12N15/90 , Y10S530/824
摘要： The present invention provides a protein regulating the sensitivity of fungus to an antimycotic aureobasidin, a gene coding for this protein, the use thereof, an antibody for the protein and the use thereof. The invention is useful in the diagnosis and treatment for diseases including mycoses. The invention also provides a novel chromosome integration vector capable of imparting a novel selective marker of a drug resistance to a fungal transformant, a transformant transformed with this vector and a process for producing the same. In particular, it provides a protein capable of imparting the resistance to aureobasidin and acting as a selective marker and a DNA coding for the same.
摘要翻译：本发明提供调节真菌对抗真菌金黄色列生素的敏感性的蛋白质，编码该蛋白质的基因，其用途，蛋白质的抗体及其用途。本发明可用于包括真菌病在内的疾病的诊断和治疗。本发明还提供了一种新颖的染色体整合载体，其能够赋予对真菌转化体的耐药性的新型选择性标记，用该载体转化的转化体及其制备方法。特别地，它提供能够赋予金黄担子素抗性并作为选择性标记的蛋白质和编码它们的DNA。

47. 发明授权

US06337410B2 Antibiotic TKR459, production method, and microorganism 失效
标题翻译：抗生素TKR459，生产方法和微生物
公开(公告)号：US06337410B2
公开(公告)日：2002-01-08
申请号：US09731041
申请日：2000-12-07
申请人： Kazutoh Takesako , Mitsuhiro Ueno , Naoyuki Awazu , Kazuo Shimanaka , Ikunoshin Kato
发明人： Kazutoh Takesako , Mitsuhiro Ueno , Naoyuki Awazu , Kazuo Shimanaka , Ikunoshin Kato
IPC分类号： C07D31500
CPC分类号： C07D313/00 , C12P17/08
摘要： The present invention has its object to provide a noble antifungal substance which is use of as clinical medicine in the therapy of fungal infectious diseases. The present invention is related to an antibiotic TKR459 having the following chemical formula (1) or its pharmacologically acceptable salt.
摘要翻译：本发明的目的是提供一种在真菌感染性疾病的治疗中用作临床药物的贵重抗真菌物质。本发明涉及具有以下化学式（1）或其药理学上可接受的盐的抗生素TKR459。

48. 发明授权

US06194190B1 Amino-terminal deblocking enzyme 失效
标题翻译：氨基末端解封酶
公开(公告)号：US06194190B1
公开(公告)日：2001-02-27
申请号：US09202832
申请日：1998-12-21
申请人： Yukiko Izu , Tetsuki Tanaka , Masaru Miyagi , Tetsuo Tanigawa , Jun Tomono , Susumu Tsunasawa , Ikunoshin Kato
发明人： Yukiko Izu , Tetsuki Tanaka , Masaru Miyagi , Tetsuo Tanigawa , Jun Tomono , Susumu Tsunasawa , Ikunoshin Kato
IPC分类号： C12N950
CPC分类号： C12N9/48
摘要： To provide an amino terminal protecting group-releasing enzyme characterized in that the enzyme possesses an activity for releasing a protecting group by acting on a peptide of which amino terminal is blocked by the protecting group, and exhibits the activity for two or more protecting groups, or a functional equivalent thereof; a DNA encoding the same; a method for producing the enzyme; a method for removing amino terminal protecting group including the step of subjecting to a reaction with the enzyme to release amino terminal protecting group; and a method for analyzing an amino acid sequence. The above enzyme is useful in the analysis of an amino acid sequence of peptides, particularly proteins and peptides, of which amino terminal is blocked by unknown protecting groups.
摘要翻译：提供氨基末端保护基释放酶，其特征在于该酶具有通过作用于氨基末端被保护基阻断的肽而释放保护基的活性，并表现出两个或更多个保护基的活性，或其功能等同物; 编码该DNA的DNA; 一种生产该酶的方法; 一种除去氨基末端保护基的方法，包括与酶反应释放氨基末端保护基的步骤; 以及分析氨基酸序列的方法。上述酶可用于分析肽，特别是蛋白质和肽的氨基酸序列，其氨基末端被未知保护基团阻断。

49. 发明授权

US6165749A Plasmid 失效
标题翻译：质粒
公开(公告)号：US6165749A
公开(公告)日：2000-12-26
申请号：US952089
申请日：1997-11-10
申请人： Hiroaki Sagawa , Harumi Ueno , Atsushi Oshima , Ikunoshin Kato
发明人： Hiroaki Sagawa , Harumi Ueno , Atsushi Oshima , Ikunoshin Kato
IPC分类号： C12N15/09 , C12N1/21 , C12N9/10 , C12N9/16 , C12N9/22 , C12N15/55 , C12N15/69 , C12R1/19 , C12P21/06
CPC分类号： C12N15/69 , C12N9/1007 , C12N9/22
摘要： A plasmid vector characterized by comprising a promoter sequence that can be recognized by an RNA polymerase which is not inherent in a host and that controls the expression of desired genes and a replication origin that increases the number of copies under the induction by exogenous factors; methods for expression and isolation of target genes by using the vector; a polypeptide having the activity of an AccIII restriction endonuclease; and a DNA encoding the polypeptide. The invention provides for the first time a plasmid vector which can introduce an exogenous desired gene encoding proteins which are lethal or harmful to hosts into the hosts, a method for efficiently expressing the proteins by using the vector, and also a method for permitting a restriction endonuclease gene constituting a restriction-modification system to be isolated even in the absence of a modification enzyme gene, which has been difficult in the prior arts.
摘要翻译： PCT No.PCT / JP97 / 00748 Sec。 371日期：1997年11月10日 102（e）日期1997年11月10日PCT 1997年3月10日PCT公布。第WO97 / 34006号公报日期1997年9月18日一种质粒载体，其特征在于包含可由RNA聚合酶识别的启动子序列，其不是宿主中固有的并且控制所需基因的表达和增加诱导下拷贝数的复制起点由外生因素; 通过使用载体表达和分离靶基因的方法; 具有AccIII限制性内切核酸酶活性的多肽; 和编码该多肽的DNA。本发明首次提供能够将编码对宿主具有致死性或有害性的蛋白质的外源性所需基因导入宿主的质粒载体，使用该载体有效表达蛋白质的方法，以及允许限制的方法构成即使在不存在修饰酶基因的情况下分离的限制性修饰系统的核酸内切酶基因，这在现有技术中是困难的。

50. 发明授权

US6136854A Cyclopentenone derivative 失效
标题翻译：环戊烯酮衍生物
公开(公告)号：US6136854A
公开(公告)日：2000-10-24
申请号：US359069
申请日：1999-07-21
申请人： Nobuto Koyama , Katsushige Ikai , Eiji Kobayashi , Ikunoshin Kato
发明人： Nobuto Koyama , Katsushige Ikai , Eiji Kobayashi , Ikunoshin Kato
IPC分类号： C07C69/013 , A61K31/235 , C07C69/52 , C07C69/76
CPC分类号： C07C69/013
摘要： Cyclopentenone derivative having a structure of 5-(R.sub.1 COO--)-4-(R.sub.2 COO--)--substituted 2-cyclopenten-1-one (R.sub.1 and R.sub.2 are some or different and each is alkyl group, alkenyl group or aryl group) or an optically active substance thereof; a method for the manufacture of the cyclopentenone derivative by the reaction of 4,5-dihydroxy-2-cyclopenten-1-one with the corresponding carboxylic acid or a reactive derivative thereof; and anticancer agent, apoptosis-inducing agent and antibacterial agent containing said derivative.
摘要翻译：具有5-（R 1 COO - ） - 4-（R 2 COO - ） - 取代的2-环戊烯-1-酮的结构的环戊烯酮衍生物（R 1和R 2有一些或不同，各自为烷基，烯基或芳基）或其光学活性物质; 通过4,5-二羟基-2-环戊烯-1-酮与相应的羧酸或其活性衍生物的反应制备环戊烯酮衍生物的方法; 和抗癌剂，凋亡诱导剂和含有所述衍生物的抗菌剂。

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