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1. 发明授权

US06337410B2 Antibiotic TKR459, production method, and microorganism 失效
标题翻译：抗生素TKR459，生产方法和微生物
公开(公告)号：US06337410B2
公开(公告)日：2002-01-08
申请号：US09731041
申请日：2000-12-07
申请人： Kazutoh Takesako , Mitsuhiro Ueno , Naoyuki Awazu , Kazuo Shimanaka , Ikunoshin Kato
发明人： Kazutoh Takesako , Mitsuhiro Ueno , Naoyuki Awazu , Kazuo Shimanaka , Ikunoshin Kato
IPC分类号： C07D31500
CPC分类号： C07D313/00 , C12P17/08
摘要： The present invention has its object to provide a noble antifungal substance which is use of as clinical medicine in the therapy of fungal infectious diseases. The present invention is related to an antibiotic TKR459 having the following chemical formula (1) or its pharmacologically acceptable salt.
摘要翻译：本发明的目的是提供一种在真菌感染性疾病的治疗中用作临床药物的贵重抗真菌物质。本发明涉及具有以下化学式（1）或其药理学上可接受的盐的抗生素TKR459。

2. 发明授权

US06303350B1 Physiologically active substances TKR2449, process for producing the same, and microorganism 失效
标题翻译：生理活性物质TKR2449，其生产方法和微生物
公开(公告)号：US06303350B1
公开(公告)日：2001-10-16
申请号：US09445543
申请日：2000-03-07
申请人： Kazutoh Takesako , Mitsuhiro Ueno , Naoyuki Awazu , Yoko Uno , Ikunoshin Kato
发明人： Kazutoh Takesako , Mitsuhiro Ueno , Naoyuki Awazu , Yoko Uno , Ikunoshin Kato
IPC分类号： C12P1302
CPC分类号： C07C235/76 , C12P13/02 , Y10S435/911
摘要： The present invention has for its object to provide novel biologically active substances which is of value as a therapeutic agent for fungal infections and immune disorders. This invention is related to a biologically active substance TKR2449 analog(s) which is represented by the following general formula (A); (In the formula, R1, R2 and R3 are the same or differ each other, and each represents hydrogen or an alkyl group of carbon number of 1 to 4. R4 is a linear or branched alkyl or alkenyl group of carbon number of 1 to 8.).
摘要翻译：本发明的目的是提供新的生物活性物质，其作为真菌感染和免疫疾病的治疗剂是有价值的。本发明涉及由以下通式（A）表示的生物活性物质TKR2449类似物：（式中，R 1，R 2和R 3相同或不同，各自表示氢或碳数为1〜4的烷基.R 4为碳原子数为1〜8的直链或支链烷基或烯基。

3. 发明授权

US06333305B1 Antibiotic TKR2999, process for the preparation thereof and microbe 失效
标题翻译：抗生素TKR2999，其制备方法和微生物
公开(公告)号：US06333305B1
公开(公告)日：2001-12-25
申请号：US09582025
申请日：2000-08-02
申请人： Kazutoh Takesako , Naoyuki Awazu , Mitsuhiro Ueno , Yoshimi Onishi , Ikunoshin Kato
发明人： Kazutoh Takesako , Naoyuki Awazu , Mitsuhiro Ueno , Yoshimi Onishi , Ikunoshin Kato
IPC分类号： A01N3718
CPC分类号： C12R1/645 , A61K38/00 , C07K4/06 , C12P21/02
摘要： The antibiotic TKR2999 having the physicochemical properties described below and its pharmacologically acceptable salt: (1) FAB-MS m/z 971 [M+H)]+, (2) the molecular formula: C44H78N10O14, and high-resolution FAB-MS m/z 971.5776 [M+H]+, (3) the ultraviolet absorption spectrum in methanol has an end absorption, (4) the infrared absorption spectrum by KBr method shows the major absorption wave numbers at 3320, 2920, 1680, 1540, 1210, 1140, 840, 800, and 720 cm−1, (5) aspartic acid, threonine, serine, glycine, alanine, &bgr;-alanine, and ornithine are detected by the amino acid analysis using ninhydrin reaction, and (6) the solubility is that it is soluble in methanol, and practically insoluble in hexane, chloroform, and water.
摘要翻译：具有下述物理化学性质的抗生素TKR2999及其药理学上可接受的盐：（1）FAB-MS m / z 971 [M + H]] +，（2）分子式：C44H78N10O14和高分辨率FAB-MS m / z 971.5776 [M + H] +，（3）甲醇中的紫外吸收光谱具有终点吸收，（4）通过KBr方法的红外吸收光谱显示3320,2920,1680,1540,1210的主要吸收波数，1140,840,800和720cm -1，（5）通过使用茚三酮反应的氨基酸分析检测天冬氨酸，苏氨酸，丝氨酸，甘氨酸，丙氨酸，β-丙氨酸和鸟氨酸，和（6）溶解度它是溶于甲醇，几乎不溶于己烷，氯仿和水。

4. 发明授权

US06261826B1 Antibiotic TKR2648 and process for producing the same 失效
标题翻译：抗生素TKR2648及其生产方法
公开(公告)号：US06261826B1
公开(公告)日：2001-07-17
申请号：US09269437
申请日：1999-03-26
申请人： Kazutoh Takesako , Hideharu Saito , Mitsuhiro Ueno , Naoyuki Awazu , Ikunoshin Kato
发明人： Kazutoh Takesako , Hideharu Saito , Mitsuhiro Ueno , Naoyuki Awazu , Ikunoshin Kato
IPC分类号： C12N114
CPC分类号： A61K31/366 , C07D309/32 , C12P17/06
摘要： Antibitic TKR2648 having the following chemical formula (I) or its pharmacologically acceptable salt.
摘要翻译：具有以下化学式（I）的抗生素TKR2648或其药理学上可接受的盐。

5. 发明授权

US06235912B1 Sphingosine analogues 失效
标题翻译：鞘氨醇类似物
公开(公告)号：US06235912B1
公开(公告)日：2001-05-22
申请号：US09380647
申请日：1999-10-15
申请人： Kazutoh Takesako , Toru Kurome , Naoyuki Awazu , Ikunoshin Kato
发明人： Kazutoh Takesako , Toru Kurome , Naoyuki Awazu , Ikunoshin Kato
IPC分类号： C07C23100
CPC分类号： C07D307/33 , C07C215/10 , C07C215/24 , C07C229/22 , C07C229/30 , C07C237/08 , C07C237/22 , C07C251/08 , C07C271/22 , C07D263/06 , Y02P20/55
摘要： The present invention aims to provide a novel sphingosine analogue, which is useful as an intermediate for syntheses of novel lipid derivatives such as sphingolipid derivatives and the like that can regulate the effects of sphingolipid. The present invention relates to a sphingosine analogue represented by the general formula (I) described below. In the formula, as for Q1, Q2 and Q3, Q1 and Q2, which are the same or different each other, are hydrogen, alkyl groups having 1-4 of carbon atoms, acyl groups having 2-5 of carbon atoms, or protecting groups of the amino group, and Q3 is a hydrogen or a protecting group of the hydroxyl group; or Q2 and Q3 make up an isopropylidene group and Q1 is a hydrogen or a protecting group of the amino group. Q4 and Q5, which are the same or different each other, are hydroxyl groups, acyl groups having 2-5 of carbon atoms, —O—Q6, or hydrogen; or Q4 and Q5 make up a covalent bond. Q6 is a protecting group of the hydroxyl group. X1 is —COOH, —CONH2, —CO—Q7, —CH2OH, or —CH2O—Q8. Q7 is a protecting group of the carboxyl group, and Q8 is a protecting group of the hydroxyl group.
摘要翻译：本发明的目的在于提供一种新颖的鞘氨醇类似物，其可用作合成新型脂质衍生物的中间体，例如可以调节鞘脂的作用的鞘脂衍生物等。本发明涉及一般的鞘氨醇类似物在该式中，对于Q1，Q2和Q3，Q1和Q2彼此相同或不同，为氢，具有1-4个碳原子的烷基，酰基具有2- 5个碳原子或氨基的保护基，Q3为氢或羟基的保护基; 或Q2和Q3构成异亚丙基，Q 1为氢或氨基的保护基。 Q4和Q5彼此相同或不同，是羟基，具有2-5个碳原子的酰基，-O-Q6或氢; 或Q4和Q5构成共价键。 Q6是羟基的保护基。 X 1是-COOH，-CONH 2，-CO-Q 7，-CH 2 OH或-CH 2 O-Q 8。 Q7是羧基的保护基，Q8是羟基的保护基。

6. 发明授权

US07442683B2 Cyclic peptide 失效
标题翻译：循环肽
公开(公告)号：US07442683B2
公开(公告)日：2008-10-28
申请号：US10470918
申请日：2002-02-14
申请人： Toru Kurome , Naoyuki Awazu , Kazutoh Takesako , Ikunoshin Kato
发明人： Toru Kurome , Naoyuki Awazu , Kazutoh Takesako , Ikunoshin Kato
IPC分类号： A61K38/12
CPC分类号： C07K7/06 , A61K38/00 , C07K7/54
摘要： A novel cyclic peptide having an antifungal activity, its pharmacologically acceptable salts and antifungal medicinal compositions containing the same.
摘要翻译：具有抗真菌活性的新型环肽，其药理学上可接受的盐和含有它们的抗真菌药用组合物。

7. 发明授权

US6103767A Physiologically active substances TKR1785's, process for the preparation thereof, and microbe 失效
标题翻译：生理活性物质TKR1785的制备方法和微生物
公开(公告)号：US6103767A
公开(公告)日：2000-08-15
申请号：US142689
申请日：1998-10-29
申请人： Kazutoh Takesako , Naoyuki Awazu , Yoshie Yoshikawa , Eiko Koyama , Ikunoshin Kato
发明人： Kazutoh Takesako , Naoyuki Awazu , Yoshie Yoshikawa , Eiko Koyama , Ikunoshin Kato
IPC分类号： C07C237/12 , C12P13/02 , C12P21/02 , A01N37/18 , A61K31/16
CPC分类号： C07C237/12 , C12P13/02 , C12P21/02
摘要： The object of the present invention is to provide a novel bioactive substance of value as a therapeutic agent for mycosis, and the like.This invention relates to the bioactive substance TKR1785 of the following general formula (A): ##STR1## (wherein R represents --CH(CH.sub.3).sub.2 or --CH(CH.sub.3)C.sub.2 H.sub.5).
摘要翻译： PCT No.PCT / JP97 / 00770 Sec。 371日期：1998年10月29日第 102（e）日期1998年10月29日PCT 1997年3月12日PCT公布。出版物WO97 / 3401200 日本公报1997年9月18日本发明的目的是提供一种作为真菌病治疗剂的价值的新型生物活性物质等。本发明涉及以下通式（A）的生物活性物质TKR1785：（其中R表示-CH（CH3）2或-CH（CH3）C2H5）。

8. 发明授权

US06239297B1 Sphingosine derivatives and medicinal composition 失效
标题翻译：鞘氨醇衍生物和药用组合物
公开(公告)号：US06239297B1
公开(公告)日：2001-05-29
申请号：US09508462
申请日：2000-04-28
申请人： Kazutoh Takesako , Toru Kurome , Naoyuki Awazu , Ikunoshin Kato
发明人： Kazutoh Takesako , Toru Kurome , Naoyuki Awazu , Ikunoshin Kato
IPC分类号： C07C23300
CPC分类号： C07C219/06 , C07C229/08 , C07C235/12 , C07C237/12 , C07C237/22
摘要： The present invention intends to provide a derivative of sphingosine analogue that is able to regulate the functions of sphigolipid, and its pharmaceutical compositions. The present invention is the derivatives of sphingosine analogues represented by the general formula (I) described below. In the formula, R1 and R2, which are the same or different each other, are hydrogen, alkyl groups having 1-4 carbon atoms, or acyl groups having 2-5 carbon atoms. R3 and R4, which are the same or different each other, are hydrogen or hydroxyl groups; or R3 and R4 make up a covalent bond. X1 is —(CH2)n—CO—NH—CH(R5)—R6 or —(CH2)m—O—CO—CH(R7)—R8.
摘要翻译：本发明旨在提供能够调节鞘脂类功能的鞘氨醇类似物的衍生物及其药物组合物。本发明是由下述通式（I）表示的鞘氨醇类似物的衍生物。在式中， R 1和R 2彼此相同或不同，为氢，具有1-4个碳原子的烷基或具有2-5个碳原子的酰基。 R3和R4彼此相同或不同，是氢或羟基; 或R3和R4组成共价键。 X1是 - （CH2）n-CO-NH-CH（R5）-R6或 - （CH2）m-O-CO-CH（R7）-R8。

9. 发明授权

US06294651B1 Gene regulating aubeobasidin sensitivity 失效
标题翻译：基因调控aubeobasidin敏感性
公开(公告)号：US06294651B1
公开(公告)日：2001-09-25
申请号：US09368431
申请日：1999-08-05
申请人： Takashi Okado , Kazutoh Takesako , Ikunoshin Kato
发明人： Takashi Okado , Kazutoh Takesako , Ikunoshin Kato
IPC分类号： C02N1500
CPC分类号： C07K14/37 , A61K38/00 , C07K14/38 , C07K14/40 , C07K16/14 , C12N15/80 , C12N15/90
摘要： The invention is directed to isolated DNAs having nucleic acid sequences which encode proteins which regulate aureobasidin sensitivity. Also disclosed are recombinant plasmids containing the DNAs, transformants containing the plasmids, and methods of producing the proteins.
摘要翻译：本发明涉及具有编码调节金黄担子素敏感性的蛋白质的核酸序列的分离的DNA。还公开了含有DNA的重组质粒，含有质粒的转化体和产生蛋白质的方法。

10. 发明申请

US20080069829A1 Antigenic protein originating in Malassezia 失效
标题翻译：起源于马拉色霉菌的抗原蛋白
公开(公告)号：US20080069829A1
公开(公告)日：2008-03-20
申请号：US11116371
申请日：2005-04-28
申请人： Kazutoh Takesako , Takashi Okado , Tomoko Yagihara , Masanobu Kuroda , Yoshimi Onishi , Ikunoshin Kato , Kazuo Akiyama , Hiroshi Yasueda , Hideyo Yamaguchi
发明人： Kazutoh Takesako , Takashi Okado , Tomoko Yagihara , Masanobu Kuroda , Yoshimi Onishi , Ikunoshin Kato , Kazuo Akiyama , Hiroshi Yasueda , Hideyo Yamaguchi
IPC分类号： A61K39/00 , C07H21/04 , C07K14/39 , C07K16/14
CPC分类号： A61K39/0002 , A61K38/00 , A61K39/00 , C07K14/37 , C07K16/14 , Y10S530/858
摘要： A substantially pure, isolated, antigenic protein from fungi of the genus Malassezia, characterized in that said antigenic protein has a binding ability to IgE antibodies from patients with allergoses; an antigenic fragment derived from the antigenic protein; and an antibody against the antigenic protein or fragments thereof. According to the present invention, there can be provided an isolated and purified antigenic protein having high purity from Malassezia, antigenic fragments thereof, and a specific antibody against those antigenic protein or fragments thereof. In addition, there can be provided a diagnostic agent, a therapeutic agent, or a prophylactic drug for Malassezia allergoses, wherein the agent includes, as an active ingredient, the antigenic protein or fragments thereof.
摘要翻译：从马拉色氏菌属真菌的基本上纯的，分离的抗原性蛋白质，其特征在于所述抗原蛋白质具有与过敏原患者的IgE抗体的结合能力; 衍生自抗原蛋白的抗原片段; 和针对抗原蛋白或其片段的抗体。根据本发明，可以提供从马拉色霉属，其抗原性片段和针对那些抗原性蛋白质或其片段的特异性抗体具有高纯度的分离和纯化的抗原性蛋白质。此外，可以提供用于马拉色氏菌过敏原的诊断剂，治疗剂或预防药物，其中所述药剂包含抗原蛋白或其片段作为活性成分。

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